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  1. Article ; Online: Neutralizing antibodies as key players in preventing BK polyomavirus replication: Insights from bench to bedside.

    Benotmane, Ilies / Caillard, Sophie / Fafi-Kremer, Samira / Solis, Morgane

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2024  

    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Letter
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1016/j.ajt.2024.01.031
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    Zs.A 5542: Show issues Location:
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  2. Article: Antigen specificities of HIV-infected cells: A role in infection and persistence?

    Faua, Clayton / Fafi-Kremer, Samira / Gantner, Pierre

    Journal of virus eradication

    2023  Volume 9, Issue 2, Page(s) 100329

    Abstract: Antigen-experienced memory ... ...

    Abstract Antigen-experienced memory CD4
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2868549-0
    ISSN 2055-6659 ; 2055-6640
    ISSN (online) 2055-6659
    ISSN 2055-6640
    DOI 10.1016/j.jve.2023.100329
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  3. Article ; Online: Antigen specificities of HIV-infected cells

    Clayton Faua / Samira Fafi-Kremer / Pierre Gantner

    Journal of Virus Eradication, Vol 9, Iss 2, Pp 100329- (2023)

    A role in infection and persistence?

    2023  

    Abstract: Antigen-experienced memory CD4+ T cells are the major target of HIV infection and support both productive and latent infections, thus playing a key role in HIV dissemination and persistence, respectively. Here, we reviewed studies that have shown direct ... ...

    Abstract Antigen-experienced memory CD4+ T cells are the major target of HIV infection and support both productive and latent infections, thus playing a key role in HIV dissemination and persistence, respectively. Here, we reviewed studies that have shown direct association between HIV infection and antigen specificity. During untreated infection, some HIV-specific cells host productive infection, while other pathogen-specific cells such as cytomegalovirus (CMV) and Mycobacterium tuberculosis also contribute to viral persistence on antiretroviral therapy (ART). These patterns could be explained by phenotypic features differing between these pathogen-specific cells. Mechanisms involved in these preferential infection and selection processes include HIV entry and restriction, cell exhaustion, survival, self-renewal and immune escape. For instance, MIP-1β expressing cells such as CMV-specific memory cells were shown to resist infection by HIV CCR5 coreceptor downregulation/inhibition. Conversely, HIV-infected CMV-specific cells undergo clonal expansion during ART. We have identified several research areas that need further focus such as the role of other pathogens, viral genome intactness, inducibility and phenotypic features. However, given the sheer diversity of both the CD4+ T cell repertoire and antigenic history of each individual, studying HIV-infected, antigen-experienced cells still imposes numerous challenges.
    Keywords HIV ; Antigen-specificity ; Productive infection ; Latent infection ; Memory CD4+ T cells ; Persistence ; Microbiology ; QR1-502 ; Public aspects of medicine ; RA1-1270
    Subject code 570
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Torque teno virus viral load predicts SARS-CoV-2 vaccine response in kidney transplant recipients.

    Solis, Morgane / Benotmane, Ilies / Gallais, Floriane / Caillard, Sophie / Fafi-Kremer, Samira

    Journal of medical virology

    2023  Volume 95, Issue 7, Page(s) e28936

    Abstract: Transplant recipients display poor responses to SARS-CoV-2 mRNA vaccines. In this retrospective study, we investigate torque teno virus (TTV) viral load (VL), a ubiquitous virus reflecting global immune response levels, as a predictive factor of vaccine ... ...

    Abstract Transplant recipients display poor responses to SARS-CoV-2 mRNA vaccines. In this retrospective study, we investigate torque teno virus (TTV) viral load (VL), a ubiquitous virus reflecting global immune response levels, as a predictive factor of vaccine response in kidney transplant recipients (KTR). Four hundred and fifty-nine KTR having received two SARS-CoV-2 mRNA vaccine doses were enrolled, and 241 of them subsequently received a third vaccine dose. Antireceptor-binding domain (RBD) IgG response was assessed after each vaccine dose and TTV VL was measured in pre-vaccine samples. Prevaccine TTV VL > 6.2 log
    MeSH term(s) Humans ; Torque teno virus/genetics ; COVID-19 Vaccines ; Transplant Recipients ; Kidney Transplantation ; Viral Load ; Retrospective Studies ; COVID-19/prevention & control ; SARS-CoV-2 ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.28936
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    Zs.A 1320: Show issues Location:
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  5. Article ; Online: A fourth dose of the mRNA-1273 SARS-CoV-2 vaccine improves serum neutralization against the Delta variant in kidney transplant recipients.

    Benotmane, Ilies / Bruel, Timothée / Planas, Delphine / Fafi-Kremer, Samira / Schwartz, Olivier / Caillard, Sophie

    Kidney international

    2022  Volume 101, Issue 5, Page(s) 1073–1076

    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Kidney Transplantation ; SARS-CoV-2 ; Transplant Recipients
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2022.02.011
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  6. Article ; Online: Molecular evolution of the SARS-CoV-2 omicron BA.2 variant in kidney transplant recipients with prolonged viral shedding.

    Caillard, Sophie / Laugel, Elodie / Benotmane, Ilies / Fafi Kremer, Samira

    The Journal of infection

    2023  Volume 86, Issue 5, Page(s) 513–515

    MeSH term(s) Humans ; COVID-19 ; Kidney Transplantation/adverse effects ; SARS-CoV-2/genetics ; Virus Shedding ; Evolution, Molecular ; Antibodies, Viral ; Transplant Recipients
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-02-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.02.001
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    Zs.MG 48: Show issues

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  7. Article ; Online: Two cases of viral re-suppression after M184V + R263 K selection on DTG/3TC without treatment modification.

    Ursenbach, Axel / Ruch, Yvon / Hoellinger, Baptiste / Fuchs, Anne / Caspar, Stéphanie / Jegou, Frédérick / Rey, David / Fafi-Kremer, Samira / Mesplede, Thibault / Gantner, Pierre

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: DTG/3TC has a high genetic barrier against the development of HIV drug resistance. We report two cases of R263K + M184 V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we ... ...

    Abstract DTG/3TC has a high genetic barrier against the development of HIV drug resistance. We report two cases of R263K + M184 V mutations during DTG/3TC failure followed by viral suppression after adherence intervention without treatment change that we attribute to residual drug activity, reduced viral fitness, and robust immune competence.
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae006
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    Zs.MO 480: Show issues

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  8. Article ; Online: Tick-borne encephalitis in pediatrics: An often overlooked diagnosis.

    Parfut, Assilina / Laugel, Elodie / Baer, Sarah / Gonzalez, Gaëlle / Hansmann, Yves / Wendling, Marie-Josée / Fafi-Kremer, Samira / Velay, Aurélie

    Infectious diseases now

    2023  Volume 53, Issue 2, Page(s) 104645

    Abstract: Tick-borne encephalitis (TBE) is a vector-borne disease caused by a flavivirus, the tick-borne encephalitis virus (TBEV), and transmitted by the bite of infected Ixodes ricinus ticks. The European subtype (TBEV-Eu) is endemic in 27 European countries. ... ...

    Abstract Tick-borne encephalitis (TBE) is a vector-borne disease caused by a flavivirus, the tick-borne encephalitis virus (TBEV), and transmitted by the bite of infected Ixodes ricinus ticks. The European subtype (TBEV-Eu) is endemic in 27 European countries. During the last decade, increased TBE incidence was observed in many countries, including some of those believed to be of low endemicity/devoid of TBEV circulation. However, data dealing with TBE in children are far less profuse than with adults. Historically, children are known to have mild TBEV infection with favorable outcomes. That said, recent case reports and observational studies on pediatric cohorts have challenged this point of view. Like adults, children may present severe forms and fail to completely recover following TBE infection, at times leading to long-term cognitive impairment. In this review, we comprehensively describe the incidence, exposure factors, and transmission routes of TBEV in children, as well as the clinical and biological manifestations of TBE and imaging findings in this population. We also harness new data on long-term outcomes and sequelae in pediatric cohorts. Finally, we provide an overview of vaccination recommendations for children in European countries.
    MeSH term(s) Animals ; Humans ; Child ; Encephalitis, Tick-Borne/diagnosis ; Encephalitis, Tick-Borne/epidemiology ; Ixodes ; Encephalitis Viruses, Tick-Borne ; Vaccination ; Incidence
    Language English
    Publishing date 2023-01-13
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.01.005
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  9. Article ; Online: HIV Productively Infects Highly Differentiated and Exhausted CD4+ T Cells During AIDS.

    Faua, Clayton / Ursenbach, Axel / Fuchs, Anne / Caspar, Stéphanie / Jegou, Frédérick / Ruch, Yvon / Hoellinger, Baptiste / Laugel, Elodie / Velay, Aurélie / Rey, David / Fafi-Kremer, Samira / Gantner, Pierre

    Pathogens & immunity

    2024  Volume 8, Issue 2, Page(s) 92–114

    Abstract: Background: Throughout HIV infection, productively infected cells generate billions of viral particles and are thus responsible for body-wide HIV dissemination, but their phenotype during AIDS is unknown. As AIDS is associated with immunological changes, ...

    Abstract Background: Throughout HIV infection, productively infected cells generate billions of viral particles and are thus responsible for body-wide HIV dissemination, but their phenotype during AIDS is unknown. As AIDS is associated with immunological changes, analyzing the phenotype of productively infected cells can help understand HIV production during this terminal stage.
    Methods: Blood samples from 15 untreated viremic participants (recent infection, n=5; long-term infection, n=5; active opportunistic AIDS-defining disease, n=5) and 5 participants virologically controlled on antiretroviral therapy (ART) enrolled in the Analysis of the Persistence, Reservoir and HIV Latency (APRIL) study (NCT05752318) were analyzed. Cells expressing the capsid protein p24 (p24+ cells) after 18 hours of resting or 24 hours of stimulation (HIV-Flow) revealed productively infected cells from viremic participants or translation-competent reservoir cells from treated participants, respectively.
    Results: The frequency of productively infected cells tended to be higher during AIDS in comparison with recent and long-term infections (median, 340, 72, and 32/million CD4+ T cells, respectively) and correlated with the plasma viral load at all stages of infection. Altogether, these cells were more frequently CD4
    Conclusions: In long-term infection and AIDS, productively infected cells were differentiated and exhausted. This could indicate that cells with these given features are responsible for HIV production and dissemination in an immune dysfunction environment occurring during the last stages of infection.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 2469-2964
    ISSN (online) 2469-2964
    DOI 10.20411/pai.v8i2.638
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  10. Article ; Online: Impact of anti-HDV reflex testing at HBs antigen positive discovery in a single center France: Support for primary HDV screening in France.

    Parfut, Assilina / Tripon, Simona / Gantner, Pierre / Chaffraix, Fréderic / Laugel, Elodie / Wendling, Marie-Josée / Erol, Furkan / Wiedemer, Carine / Doffoel, Michel / Saviano, Antonio / Royant, Maude / Habersetzer, François / Fafi-Kremer, Samira / Velay, Aurélie

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2024  Volume 171, Page(s) 105650

    Abstract: Background: Hepatitis Delta virus (HDV) infection is a major cause of liver-related morbidity and mortality in patients infected with HBV, with a global HDV prevalence uncertain. In France, 2 to 5 % of HBs antigen (HBsAg) carriers present anti-HDV ... ...

    Abstract Background: Hepatitis Delta virus (HDV) infection is a major cause of liver-related morbidity and mortality in patients infected with HBV, with a global HDV prevalence uncertain. In France, 2 to 5 % of HBs antigen (HBsAg) carriers present anti-HDV antibodies (anti-HDV). The EASL recommends testing for anti-HDV in all HBsAg-positive patients. Since January 2022, we have systematically carried out anti-HDV serology when a positive HBsAg is discovered (new HBsAg carriers).
    Objectives: We evaluated the benefit of anti-HDV reflex testing after one year of practice by comparing anti-HDV and HBsAg serology data over the last six years, among the new HBsAg carriers and all the HBsAg carriers.
    Study design: HBsAg and anti-HDV were screened using the Abbott Architect HBsAg quanti kit and the DIA.PRO HDVAb kit. Serological, demographic, virological, and clinical data were analyzed.
    Results: Implementing anti-HDV reflex testing leads to more than a 2-fold increase in diagnoses of HDV infection among all HBsAg carriers. If the anti-HDV positive rate remains stable among the new HBsAg carriers, a significant increase in the anti-HDV positive rate from 6.8 % to 10.3 % was observed considering all HBsAg carriers. Interestingly, the discovery of anti-HDV carriage increased from 3.9 % to 6.5 % in 2022, allowing earlier identification of HBV-HDV-infected patients and a fast referral to hepatologists for adequate clinical management and, in some cases, the introduction of bulevirtide-based therapy.
    Conclusions: Our preliminary results at one year seem promising and evaluating the cost-effectiveness of reflex tests in real life with feedback would be helpful.
    MeSH term(s) Humans ; Hepatitis B Surface Antigens ; Hepatitis Delta Virus ; Hepatitis Antibodies ; France/epidemiology ; Reflex ; Hepatitis B virus
    Chemical Substances Hepatitis B Surface Antigens ; Hepatitis Antibodies
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2024.105650
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    Zs.A 3790: Show issues Location:
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