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Article ; Online: Guizhi Fuling Wan ameliorates concanavalin A-induced autoimmune hepatitis in mice.

Kuo, Shun-Li / Su, Chun-Han / Lai, Kuei-Hung / Chang, Yu-Chia / You, Jyh-Sheng / Peng, Hsin-Hsin / Chen, Chun-Hong / Lin, Chi-Chen / Chen, Po-Jen / Hwan, Tsong-Long

Biomedical journal

2024 , Page(s) 100731

Abstract: ... with intense complications. AIH is more common in females and needs effective drugs to treat. Guizhi Fuling Wan ...

Abstract	Background: Autoimmune hepatitis (AIH) is an immune-mediated hepatic disease associated with intense complications. AIH is more common in females and needs effective drugs to treat. Guizhi Fuling Wan (GZFLW) is a traditional Chinese herbal formula used to treat various gynecologic diseases. In this study, we aim to extend the new use of GZFLW for AIH. Methods: The tandem MS-based analysis was used to identify secondary metabolites in GZFLW. Therapeutic effects of GZFLW were tested in a concanavalin A (Con A)-induced AIH model in mice. Ethnopharmacological mechanisms underlying the antiapoptotic, antioxidant, and immunomodulatory protective effects were determined. Results: Oral administration of GZFLW attenuates AIH in a Con A-induced hepatotoxic model in vivo. The tandem MS-based analysis identified 15 secondary metabolites in GZFLW. The Con A-induced AIH syndromes, including hepatic apoptosis, inflammation, reactive oxygen species accumulation, function failure, and mortality, were significantly alleviated by GZFLW in mice. Mechanistically, GZFLW restrained the caspase-dependent apoptosis, restored the antioxidant system, and decreased pro-inflammatory cytokine production in the livers of Con A-treated mice. Besides, GZFLW repressed the Con A-induced hepatic infiltration of inflammatory cells, splenic T cell activation, and splenomegaly in mice. Conclusions: Our findings demonstrate the applicable potential of GZFLW in treating AIH. It prompts further investigation of GZFLW as a treatment option for AIH and possibly other hepatic diseases.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698541-X
ISSN	2320-2890 ; 2320-2890
ISSN (online)	2320-2890
ISSN	2320-2890
DOI	10.1016/j.bj.2024.100731
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan: A Nationwide Study.

Chen, Hsin-Hung / Wu, Chien-Tung / Tsai, Yueh-Ting / Ho, Chun-Wei / Hsieh, Ming-Chia / Lai, Jung-Nien

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 1298487

Abstract: ... commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence ...

Abstract	Introduction: Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. Materials and methods: This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. Results: In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56-0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82-0.90) and presented a dose-dependent effect. Conclusion: The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes.
Language	English
Publishing date	2021-08-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/1298487
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Zs.A 5995: Show issues

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Article ; Online: Liu Wei Di Huang Wan and the Delay of Insulin Use in Patients with Type 2 Diabetes in Taiwan

Hsin-Hung Chen / Chien-Tung Wu / Yueh-Ting Tsai / Chun-Wei Ho / Ming-Chia Hsieh / Jung-Nien Lai

Evidence-Based Complementary and Alternative Medicine, Vol

A Nationwide Study

2021 Volume 2021

Abstract: ... commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence ...

Abstract	Introduction. Patients with type 2 diabetes are widely prescribed metformin for controlling blood glucose levels to avoid related comorbidities. In Taiwan, traditional Chinese medicine (TCM) is also commonly used, especially Liu Wei Di Huang Wan (LWDHW), which has been reported to delay the occurrence of kidney failure. However, the effect of combinational therapy of TCM and oral antidiabetic drugs is still unclear. This study aims to estimate their efficacy in delaying insulin use. Materials and Methods. This case-control study was conducted using one million randomized samples from the National Health Insurance Research Database in Taiwan. The effects of TCM and LWDHW were estimated using the Cox proportional hazards model. Results. In this study, 70,036 diabetic patients were enrolled; of them, 17,451 (24.9%) used insulin, while the rest (52,585, 75.1%) did not. TCM users had a lower risk for insulin use (HR: 0.58, 95% CI: 0.56–0.60). LWDHW users had a lower risk compared with patients who used other TCM (HR: 0.86, 95% CI: 0.82–0.90) and presented a dose-dependent effect. Conclusion. The use of LWDHW and oral antidiabetic drugs is highly associated with the delay in the use of insulin. Clinical practitioners may take them into consideration when treating patients with type 2 diabetes.
Keywords	Other systems of medicine ; RZ201-999
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate ketamine-induced cystitis by modulating neuroreceptors, inflammatory mediators, and fibrogenesis in a rat model.

Lee, Wei-Chia / Tain, You-Lin / Chuang, Yao-Chi / Tsai, Cheng-Nan / Yu, Chun-Chieh / Su, Chia-Hao

Neurourology and urodynamics

2019 Volume 38, Issue 8, Page(s) 2159–2169

Abstract: Aim: We investigated the effects of Ba-Wei-Die-Huang-Wan (BWDHW) on ketamine-induced cystitis (KIC ...

Abstract	Aim: We investigated the effects of Ba-Wei-Die-Huang-Wan (BWDHW) on ketamine-induced cystitis (KIC) in a rat model. Methods: Female Sprague-Dawley rats were distributed into three groups: control (saline), ketamine (25 mg/kg/day for 28 days), or ketamine (25 mg/kg/day for 28 days) plus BWDHW (90 mg/kg/day, started from day 14). Functional magnetic resonance imaging (fMRI), metabolic cage study, and cystometry were evaluated. Bladder histology was evaluated. Western blots of the bladder proteins were carried out. Results: Compared with controls, ketamine-treated rats showed stronger fMRI intensity in the periaqueductal gray area and bladder overactivity in the bladder functional study, but the ketamine/BWDHW-treated rats did not. Furthermore, ketamine breached the uroplakin III membrane at the apical surface of the urothelium, enhanced substance P spread over the urothelium, induced suburothelial hemorrhage and monocyte/macrophage infiltration, and caused interstitial fibrosis deposition. By contrast, the BWDHW-treated rats exhibited less substance P spread, lower suburothelial monocyte/macrophage infiltration, and lower interstitial fibrosis deposition. The ketamine group showed significant overexpression of neuroreceptors in the bladder mucosa (the transient receptor potential vanilloid 1 and M Conclusion: BWDHW could exert therapeutic effects by inhibiting the upregulation of neuroreceptors, modulating inflammatory mediators, suppressing fibrogenesis, and ameliorating bladder overactivity in rats with KIC.
MeSH term(s)	Animals ; Collagen/drug effects ; Collagen/metabolism ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2/metabolism ; Cystitis/chemically induced ; Cystitis/metabolism ; Cystitis/pathology ; Cystitis/physiopathology ; Drugs, Chinese Herbal/pharmacology ; Female ; Fibronectins/drug effects ; Fibronectins/metabolism ; Functional Neuroimaging ; Intercellular Adhesion Molecule-1/drug effects ; Intercellular Adhesion Molecule-1/metabolism ; Interleukin-1beta/drug effects ; Interleukin-1beta/metabolism ; Interleukin-6/metabolism ; Ketamine/adverse effects ; Magnetic Resonance Imaging ; NF-kappa B/drug effects ; NF-kappa B/metabolism ; Periaqueductal Gray/diagnostic imaging ; Rats ; Rats, Sprague-Dawley ; Receptors, Muscarinic/drug effects ; Receptors, Muscarinic/metabolism ; Sensory Receptor Cells ; Substance P/drug effects ; Substance P/metabolism ; TRPV Cation Channels/drug effects ; TRPV Cation Channels/metabolism ; Transforming Growth Factor beta1/drug effects ; Transforming Growth Factor beta1/metabolism ; Tumor Necrosis Factor-alpha/drug effects ; Tumor Necrosis Factor-alpha/metabolism ; Urinary Bladder/drug effects ; Urinary Bladder/metabolism ; Urinary Bladder/pathology ; Urinary Bladder/physiopathology ; Urinary Bladder, Overactive/chemically induced ; Urinary Bladder, Overactive/metabolism ; Urinary Bladder, Overactive/pathology ; Urinary Bladder, Overactive/physiopathology ; Urothelium/drug effects ; Urothelium/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Fibronectins ; IL1B protein, rat ; Il6 protein, rat ; Interleukin-1beta ; Interleukin-6 ; NF-kappa B ; Receptors, Muscarinic ; TRPV Cation Channels ; TRPV1 receptor ; Tgfb1 protein, rat ; Transforming Growth Factor beta1 ; Tumor Necrosis Factor-alpha ; hachimijiogan ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Substance P (33507-63-0) ; Ketamine (690G0D6V8H) ; Collagen (9007-34-5) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ptgs2 protein, rat (EC 1.14.99.1)
Language	English
Publishing date	2019-09-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604904-7
ISSN	1520-6777 ; 0733-2467
ISSN (online)	1520-6777
ISSN	0733-2467
DOI	10.1002/nau.24165
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Zs.A 1828: Show issues

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Article ; Online: Traditional Chinese Medicine Yang-Gan-Wan Alleviated Experimental Hepatic Damage by Inhibiting Oxidation, Inflammation, and Apoptosis in Cell and Mouse Models

Chia-Wen Yeh / Wan-Jhen Wu / Chen-Wen Lu / Sheue-Er Wang / Wu-Chang Chuang / Ming-Chung Lee / Chung-Hsin Wu

Evidence-Based Complementary and Alternative Medicine, Vol

2021 Volume 2021

Abstract: A hepatoprotective medicine, Yang-Gan-Wan (YGW), was used to treat hepatic damage in cell and mouse ...

Abstract	A hepatoprotective medicine, Yang-Gan-Wan (YGW), was used to treat hepatic damage in cell and mouse models. We performed a 1,1-diphenyl-2- picrylhydrazyl (DPPH) assay and found that YGW exhibited a significantly high free radical scavenging ability. Furthermore, the results of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay revealed that YGW treatment could alleviate lipopolysaccharide (LPS)-induced damage in Kupffer cells (liver macrophages). Enzyme-linked immunosorbent assay results demonstrated that YGW treatment could alleviate LPS-induced inflammation in Kupffer cells by inhibiting the expression of tumor necrosis factor (TNF)-α and interleukin (IL)-1β. By quantifying the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), we found that YGW treatment could alleviate hepatic damage and improve immunity in acetaminophen- (APAP-) treated mice by inhibiting the expression of ALT and AST. The findings of hematoxylin and eosin and Masson’s trichrome staining indicated that YGW treatment could alleviate hepatic damage and reduce collagen fiber formation in the liver tissue of APAP-treated mice. Furthermore, immunohistochemistry staining and Western blot results showed that YGW treatment could alleviate oxidative stress, inflammation, and apoptosis in the liver tissue of APAP-treated mice by enhancing superoxide dismutase 2 (SOD2) expression but inhibiting TNF-α and caspase 3 expression. Our results suggest that YGW treatment exerted hepatoprotective effects on LPS-treated Kupffer cells and APAP-treated mice by inhibiting oxidation, inflammation, and apoptosis.
Keywords	Other systems of medicine ; RZ201-999
Subject code	616
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Guizhi Fuling Wan as a Novel Agent for Intravesical Treatment for Bladder Cancer in a Mouse Model.

Lu, Chi-Chen / Shen, Cheng-Huang / Chang, Chia-Bin / Hsieh, Hsiao-Yen / Wu, Jiann-Der / Tseng, Ling-Huei / Hwang, Dennis W / Chen, Syue-Yi / Wu, Shu-Fen / Chan, Michael W Y / Hsu, Cheng-Da

Molecular medicine (Cambridge, Mass.)

2016 Volume 22, Page(s) 64–73

Abstract: ... Fuling Wan (GFW) as an intravesical agent. The effects of GFW were compared with those of mitomycin-C ...

Abstract	Alternative intravesical agents are required to overcome the side effects currently associated with the treatment of bladder cancer. This study used an orthotopic bladder cancer mouse model to evaluate Guizhi Fuling Wan (GFW) as an intravesical agent. The effects of GFW were compared with those of mitomycin-C (Mito-C) and bacille Calmette-Guérin (BCG). We began by evaluating the response of the mouse bladder cancer cell line MB49 to GFW treatment, with regard to cell viability, cell cycle progression and apoptosis. MB49 cells were subsequently implanted into the urothelial walls of the bladder in female C57BL/6 mice. The success of the model was confirmed by the appearance of hematuria and tumor growth in the bladder. Intravesical chemotherapy was administered in accordance with a published protocol.
Language	English
Publishing date	2016-01-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1283676-x
ISSN	1528-3658 ; 1076-1551
ISSN (online)	1528-3658
ISSN	1076-1551
DOI	10.2119/molmed.2015.00085
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Zs.A 4456: Show issues

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Article ; Online: Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate cyclophosphamide-induced ongoing bladder overactivity and acidic adenosine triphosphate solution-induced hyperactivity on rats prestimulated bladder.

Lee, Wei-Chia / Wu, Chia-Ching / Chuang, Yao-Chi / Tain, You-Lin / Chiang, Po-Hui

Journal of ethnopharmacology

2016 Volume 184, Page(s) 1–9

Abstract: Ethnopharmacological relevance: Ba-Wei-Die-Huang-Wan (BWDHW) is the traditional Chinese medicine ...

Abstract	Ethnopharmacological relevance: Ba-Wei-Die-Huang-Wan (BWDHW) is the traditional Chinese medicine formula containing eight ingredients, namely Rehmannia glutinosa (Gaetn.) DC., root, steamed & dried; Cornus officinalis Siebold & Zucc., fructus, dried; Dioscorea oppositifolia L., root, dried; Alisma plantago-aquatica, subsp. orientale (Sam.) Sam., tuber, dried; Poria cocos (Fr.) Wolf., sclerotium, dried; Paeonia×suffruticosa Andrews, bark, dried; Cinnamomum cassia (Nees & T.Nees) J. Presl, bark, dried; Aconitum carmichaeli Debeaux, lateral root, dried & processed. It has been used for diabetes and urinary frequency treatments. Aim of the study: We investigate effects of BWDHW on cyclophosphamide (CYP)-induced ongoing bladder overactivity and acidic adenosine triphosphate (ATP) solution-induced hyperactivity on rat's prestimulated bladder. Material and methods: Female Wistar rats were injected with intraperitoneal CYP (100mg/kg) or saline respectively. Rats were treated with BWDHW (90mg/kg/day) or vehicle for the next five days. After treatments animals were evaluated both in metabolic cage model and then by cystometry. Acidic ATP solution (5mM, pH 3.3) was instilled to provoke bladder hyperactivity. Bladder mucosa and muscle proteins were assessed by Western blotting. Results: As compared to the controls, the CYP group showed significantly decreased mean cystometric intercontractile interval and increased micturition frequency, whereas the CYP/BWDWH group did not. The CYP group had significant protein overexpression in mucosal M2, M3, P2X2, and P2X3 receptors as well as detrusor M2 and M3 receptors. However, the CYP/BWDWH group had insignificant changes from controls. In the provoking test, the control/BWDHW and CYP/BWDHW groups were less affected by acidic ATP stimulation of intercontractile interval changes than the control group. Compared to the control group, the control/BWDHW group showed significantly lower mucosal P2X3 protein expression and the CYP group showed significant mucosal TRPV1 protein upregulation after the provoking test. Conclusion: BWDHW treatment can ameliorate CYP-induced ongoing bladder overactivity and suppress mucosal P2X2, P2X3, M2, and M3 receptor protein overexpression, as well as detrusor M2 and M3 receptor protein overexpression. BWDHW pretreatment can reduce acidic ATP solution-provoked hyperactivity by preventing TRPV1 receptor overexpression in CYP-treated bladder mucosa and inhibiting P2X3 receptor overexpression in naïve bladder mucosa.
MeSH term(s)	Adenosine Triphosphate ; Animals ; Cyclophosphamide ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Hydrogen-Ion Concentration ; Medicine, Chinese Traditional ; Mucous Membrane/drug effects ; Mucous Membrane/metabolism ; Phytotherapy ; Rats, Wistar ; Receptor, Muscarinic M2/metabolism ; Receptor, Muscarinic M3/metabolism ; Receptors, Purinergic P2X2/metabolism ; Receptors, Purinergic P2X3/metabolism ; Solutions ; TRPV Cation Channels/metabolism ; Urinary Bladder/drug effects ; Urinary Bladder/metabolism ; Urinary Bladder/physiology ; Urinary Bladder, Overactive/chemically induced ; Urinary Bladder, Overactive/drug therapy ; Urinary Bladder, Overactive/metabolism ; Urinary Bladder, Overactive/physiopathology
Chemical Substances	Drugs, Chinese Herbal ; Receptor, Muscarinic M2 ; Receptor, Muscarinic M3 ; Receptors, Purinergic P2X2 ; Receptors, Purinergic P2X3 ; Solutions ; TRPV Cation Channels ; Trpv1 protein, rat ; hachimijiogan ; Adenosine Triphosphate (8L70Q75FXE) ; Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2016-05-26
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2015.12.026
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Zs.A 1494: Show issues

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Article: Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate cyclophosphamide-induced ongoing bladder overactivity and acidic adenosine triphosphate solution-induced hyperactivity on rats prestimulated bladder

Lee, Wei-Chia / Chia-Ching Wu / Po-Hui Chiang / Yao-Chi Chuang / You-Lin Tain

Journal of ethnopharmacology. 2016 May 26, v. 184

2016

Abstract: Ba-Wei-Die-Huang-Wan (BWDHW) is the traditional Chinese medicine formula containing eight ...

Abstract	Ba-Wei-Die-Huang-Wan (BWDHW) is the traditional Chinese medicine formula containing eight ingredients, namely Rehmannia glutinosa (Gaetn.) DC., root, steamed & dried; Cornus officinalis Siebold & Zucc., fructus, dried; Dioscorea oppositifolia L., root, dried; Alisma plantago-aquatica, subsp. orientale (Sam.) Sam., tuber, dried; Poria cocos (Fr.) Wolf., sclerotium, dried; Paeonia×suffruticosa Andrews, bark, dried; Cinnamomum cassia (Nees & T.Nees) J. Presl, bark, dried; Aconitum carmichaeli Debeaux, lateral root, dried & processed. It has been used for diabetes and urinary frequency treatments.We investigate effects of BWDHW on cyclophosphamide (CYP)-induced ongoing bladder overactivity and acidic adenosine triphosphate (ATP) solution-induced hyperactivity on rat’s prestimulated bladder.Female Wistar rats were injected with intraperitoneal CYP (100mg/kg) or saline respectively. Rats were treated with BWDHW (90mg/kg/day) or vehicle for the next five days. After treatments animals were evaluated both in metabolic cage model and then by cystometry. Acidic ATP solution (5mM, pH 3.3) was instilled to provoke bladder hyperactivity. Bladder mucosa and muscle proteins were assessed by Western blotting.As compared to the controls, the CYP group showed significantly decreased mean cystometric intercontractile interval and increased micturition frequency, whereas the CYP/BWDWH group did not. The CYP group had significant protein overexpression in mucosal M2, M3, P2X2, and P2X3 receptors as well as detrusor M2 and M3 receptors. However, the CYP/BWDWH group had insignificant changes from controls. In the provoking test, the control/BWDHW and CYP/BWDHW groups were less affected by acidic ATP stimulation of intercontractile interval changes than the control group. Compared to the control group, the control/BWDHW group showed significantly lower mucosal P2X3 protein expression and the CYP group showed significant mucosal TRPV1 protein upregulation after the provoking test.BWDHW treatment can ameliorate CYP-induced ongoing bladder overactivity and suppress mucosal P2X2, P2X3, M2, and M3 receptor protein overexpression, as well as detrusor M2 and M3 receptor protein overexpression. BWDHW pretreatment can reduce acidic ATP solution-provoked hyperactivity by preventing TRPV1 receptor overexpression in CYP-treated bladder mucosa and inhibiting P2X3 receptor overexpression in naïve bladder mucosa.
Keywords	Aconitum carmichaelii ; adenosine triphosphate ; Alisma plantago-aquatica ; bark ; bladder ; cages ; Cinnamomum aromaticum ; Cornus officinalis ; cyclophosphamide ; diabetes ; Dioscorea oppositifolia ; ingredients ; laboratory animals ; models ; mucosa ; muscle protein ; Oriental traditional medicine ; pH ; protein synthesis ; rats ; receptors ; Rehmannia glutinosa ; tubers ; Wolfiporia cocos
Language	English
Dates of publication	2016-0526
Size	p. 1-9.
Publishing place	Elsevier Ireland Ltd
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2015.12.026
Database	NAL-Catalogue (AGRICOLA)

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Book: T'ai-wan che tso chih tsai p'ei

Ho, Chia-ch'ing

(Nung yeh t'ui kuang ts'ung k'an ; ti 3 hao)

1947

Title translation	Cultivation of sugarcane in Taiwan.
Institution	Taiwan. / Nong lin ting
Author's details	Ho Chia-ch'ing chu ; T'ai-wan sheng cheng fu nung li ch'u nung yeh t'ui kuang wei-yüan-hui pien
Series title	Nung yeh t'ui kuang ts'ung k'an ; ti 3 hao
Keywords	Sugarcane
Language	Chinese
Size	66 p. :, ill. ;, 21 cm.
Publisher	s.n.
Publishing place	T'ai-pei
Document type	Book
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Article ; Online: Evaluating Recurrence Risk in Patients Undergoing Breast-conserving Surgery Using E-cadherin Staining as a Biomarker.

Kao, Chieh-Ni / Chen, Chia-Chi / Chu, Wan-Ling / Luo, Chi-Wen / Huang, Wei-Lun / Moi, Sin-Hua / Hou, Ming-Feng / Pan, Mei-Ren

In vivo (Athens, Greece)

2024 Volume 38, Issue 3, Page(s) 1143–1151

Abstract: Background/aim: Following the National Comprehensive Cancer Network guidelines, radiotherapy is administered after breast-conserving surgery (BCS) in patients with more than four positive lymph nodes. Four positive lymph nodes are typically considered ... ...

Abstract	Background/aim: Following the National Comprehensive Cancer Network guidelines, radiotherapy is administered after breast-conserving surgery (BCS) in patients with more than four positive lymph nodes. Four positive lymph nodes are typically considered an indicator to assess disease spread and patient prognosis. However, the subjective counting of positive axillary lymph nodes underscores the need for biomarkers to improve diagnostic precision and reduce the risk of unnecessary treatments. Loss of E-cadherin expression is associated with cancer metastasis, but its potential as a predictive marker for cancer treatment remains uncertain. This study aimed to investigate the validity of E-cadherin as a reference for adjuvant radiotherapy in breast cancer patients with positive lymph nodes post-mastectomy. Materials and methods: Immunohistochemistry was performed on 60 clinical tissue specimens to assess these implications. Results: Although no significant result was found in a single E-cadherin subgroup (low, medium, and high subgroups according to the X-tile algorithm), the proposed multivariate model, including the E-cadherin category, breast cancer subtype, and tumor size, yielded satisfactory recurrence risk estimation results for patients undergoing BCS. Patients with a low E-cadherin category, triple-negative breast cancers, and tumor size over 5 cm could have an increased risk of recurrence. Conclusion: Our study proposed a multivariate model that serves as a candidate prognostic factor for recurrence-free survival in patients undergoing BCS and radiotherapy. Utilizing this model for patient stratification in high-risk diseases and as a standard for assessing postoperative intensified therapy can potentially improve patient outcomes.
MeSH term(s)	Humans ; Female ; Cadherins/metabolism ; Biomarkers, Tumor/metabolism ; Mastectomy, Segmental ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Breast Neoplasms/metabolism ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/metabolism ; Middle Aged ; Prognosis ; Aged ; Adult ; Immunohistochemistry ; Lymphatic Metastasis ; Neoplasm Staging
Chemical Substances	Cadherins ; Biomarkers, Tumor
Language	English
Publishing date	2024-04-30
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13549
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In stock of ZB MED Cologne/Königswinter

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