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Article ; Online: Daytime aspartame intake results in larger influences on body weight, serum corticosterone level, serum/cerebral cytokines levels and depressive-like behaviors in mice than nighttime intake.

Ma, Haiyuan / Deng, Jiapeng / Liu, Jing / Jin, Xiaobao / Yang, Junhua

2024 Volume 102, Page(s) 37–47

Abstract: Aspartame (APM) is one of the most widely used artificial sweeteners worldwide. Studies have revealed that consuming APM may negatively affect the body, causing oxidative stress damage to multiple organs and leading to various neurophysiological symptoms. ...

Abstract	Aspartame (APM) is one of the most widely used artificial sweeteners worldwide. Studies have revealed that consuming APM may negatively affect the body, causing oxidative stress damage to multiple organs and leading to various neurophysiological symptoms. However, it's still unclear if consuming APM and one's daily biological rhythm have an interactive effect on health. In this study, healthy adult C57BL/6 mice were randomly divided into four groups: Control group (CON), oral gavage sham group (OGS), daytime APM intragastric group (DAI) and nighttime APM intragastric group (NAI). DAI and NAI groups were given 80 mg/kg body weight daily for 4 weeks. We found that DAI and NAI groups had significantly increased mean body weight, higher serum corticosterone levels, up-regulated pro-inflammatory responses in serum and brain, and exacerbated depressive-like behaviors than the CON and the two APM intake groups. Moreover, all these changes induced by APM intake were more significant in the DAI group than in the NAI group. The present study, for the first time, revealed that the intake of APM and daily biological rhythm have an interactive effect on health. This suggests that more attention should be paid to the timing of APM intake in human beings, and this study also provides an intriguing clue to the circadian rhythms of experimental animals that researchers should consider more when conducting animal experiments.
Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800820-6
ISSN	1872-9711 ; 0161-813X
ISSN (online)	1872-9711
ISSN	0161-813X
DOI	10.1016/j.neuro.2024.03.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1547: Show issues

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Article ; Online: Recommendation model based on generative adversarial network and social reconstruction.

Gu, Junhua / Deng, Xu / Zhang, Ningjing / Zhang, Suqi

Mathematical biosciences and engineering : MBE

2023 Volume 20, Issue 6, Page(s) 9670–9692

Abstract: Social relations can effectively alleviate the data sparsity problem in recommendation, but how to make effective use of social relations is a difficulty. However, the existing social recommendation models have two deficiencies. First, these models ... ...

Abstract	Social relations can effectively alleviate the data sparsity problem in recommendation, but how to make effective use of social relations is a difficulty. However, the existing social recommendation models have two deficiencies. First, these models assume that social relations are applicable to various interaction scenarios, which does not match the reality. Second, it is believed that close friends in social space also have similar interests in interactive space and then indiscriminately adopt friends' opinions. To solve the above problems, this paper proposes a recommendation model based on generative adversarial network and social reconstruction (SRGAN). We propose a new adversarial framework to learn interactive data distribution. On the one hand, the generator selects friends who are similar to the user's personal preferences and considers the influence of friends on users from multiple angles to get their opinions. On the other hand, friends' opinions and users' personal preferences are distinguished by the discriminator. Then, the social reconstruction module is introduced to reconstruct the social network and constantly optimize the social relations of users, so that the social neighborhood can assist the recommendation effectively. Finally, the validity of our model is verified by experimental comparison with multiple social recommendation models on four datasets.
MeSH term(s)	Humans ; Learning ; Interpersonal Relations
Language	English
Publishing date	2023-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2265126-3
ISSN	1551-0018 ; 1551-0018
ISSN (online)	1551-0018
ISSN	1551-0018
DOI	10.3934/mbe.2023424
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: One-pot synthesis of ion-imprinted three-dimensional porous material based on graphene oxide for the selective adsorption of copper(II).

Xu, Zhifeng / Li, Lizhen / Li, Junhua / Deng, Peihong

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering

2023 Volume 58, Issue 6, Page(s) 515–524

Abstract: Molecularly imprinted polymers (MIPs) are synthetic polymers with predetermined selectivity for a given analyte. One major problem associated with MIPs is the inaccessibility of a large fraction of the recognition sites that remain buried within the ... ...

Abstract	Molecularly imprinted polymers (MIPs) are synthetic polymers with predetermined selectivity for a given analyte. One major problem associated with MIPs is the inaccessibility of a large fraction of the recognition sites that remain buried within the polymeric matrix. To address this problem, the high selectivity imparted by the imprinting technique and the porosity of three-dimensional (3D) graphene oxide (GO)-based porous materials were utilized in this work to prepare a 3D GO-based Cu(II)-ion-imprinted material (hereafter denoted as IIM) via one-pot reactions of GO, chitosan (CS), and glutaraldehyde in the presence of Cu(II). Results of equilibrium binding experiments show that IIM has a high template-ion binding capacity (1.75 mmol g
MeSH term(s)	Molecular Imprinting/methods ; Copper/chemistry ; Porosity ; Adsorption ; Polymers/chemistry ; Ions
Chemical Substances	Copper (789U1901C5) ; graphene oxide ; Polymers ; Ions
Language	English
Publishing date	2023-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	196584-0
ISSN	1532-4117 ; 0360-1226 ; 1077-1204 ; 1093-4529
ISSN (online)	1532-4117
ISSN	0360-1226 ; 1077-1204 ; 1093-4529
DOI	10.1080/10934529.2023.2199650
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 1217: Show issues

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Article: Cascaded molecular logic gates using antibiotics as inputs based on exonuclease III and DNAzyme

Deng, Fang / Pan, Jiafeng / Liu, Zhi / Chen, Junhua

Talanta. 2023 Jan. 15, v. 252

2023

Abstract: We successfully constructed several cascaded molecular logic gates (2INHIBIT-2AND, 2AND-2OR, and 2OR-2INHIBIT) using three different antibiotics as the inputs. In the presence of kanamycin (KAN), chloramphenicol (CHL), or oxytetracycline (OXY), the ... ...

Abstract	We successfully constructed several cascaded molecular logic gates (2INHIBIT-2AND, 2AND-2OR, and 2OR-2INHIBIT) using three different antibiotics as the inputs. In the presence of kanamycin (KAN), chloramphenicol (CHL), or oxytetracycline (OXY), the aptamer-antibiotic recognition will release the trigger DNA to active the hairpin DNA hybridization. Exonuclease III (Exo III)-mediated catalysis reaction was introduced in the logic system to generate Mg²⁺-dependent DNAzyme, which was used to cleave the fluorescence signal reporter probe. For input, the presence and absence of the antibiotic was defined as 1 and 0, respectively. For output, the fluorescence intensity higher or lower than the threshold value was defined as 1 and 0, respectively. In the 2INHIBIT-2AND logic circuit, the 101 input combination generates an output of 1 and other input combinations generate an output of 0. In the 2AND-2OR logic circuit, the input combinations of 001, 011, 110, 101, and 111 generate an output of 1 and other input combinations generate an output of 0. In the 2OR-2INHIBIT logic circuit, the input combinations of 010, 100, and 110 generate an output of 1 and other input combinations generate an output of 0. Our constructed logic system exhibits high selectivity and can work even in complex water samples. With the advantages of multiple biocomputation capabilities, high flexibility, and easy scalability, this logic gate system provides a new analytical method for the intelligent detection of different antibiotics.
Keywords	DNA ; analytical methods ; catalytic activity ; chloramphenicol ; fluorescence ; kanamycin ; nucleic acid hybridization ; oxytetracycline
Language	English
Dates of publication	2023-0115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1500969-5
ISSN	1873-3573 ; 0039-9140
ISSN (online)	1873-3573
ISSN	0039-9140
DOI	10.1016/j.talanta.2022.123832
Database	NAL-Catalogue (AGRICOLA)

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Article: Generation of Stable Cell Lines Expressing Akabane Virus N Protein and Insight into Its Function in Viral Replication.

Wang, Jingjing / Chen, Dongjie / Wei, Fang / Deng, Junhua / Su, Jia / Lin, Xiangmei / Wu, Shaoqiang

Pathogens (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Akabane virus (AKAV) is a world wide epidemic arbovirus belonging to ... ...

Abstract	Akabane virus (AKAV) is a world wide epidemic arbovirus belonging to the
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens12081058
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A fluorescent biosensor for Cd

Pan, Jiafeng / Deng, Fang / Chen, Junhua

The Science of the total environment

2022 Volume 864, Page(s) 161046

Abstract: A fluorescent biosensor was developed for ... ...

Abstract	A fluorescent biosensor was developed for Cd
MeSH term(s)	DNA, Catalytic ; Cadmium ; Reproducibility of Results ; Coloring Agents ; Biosensing Techniques ; Water ; Limit of Detection
Chemical Substances	DNA, Catalytic ; Cadmium (00BH33GNGH) ; Coloring Agents ; Water (059QF0KO0R)
Language	English
Publishing date	2022-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.161046
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Zs.A 949: Show issues

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Article ; Online: The first complete mitochondrial genome of the genus

Zhen, Wenquan / Wu, Xuwen / Hao, Erwei / Xu, Wanru / Deng, Jiagang / Zhu, Junhua / Xu, Youhou

Mitochondrial DNA. Part B, Resources

2022 Volume 7, Issue 2, Page(s) 393–395

Abstract: ... The ... ...

Abstract	The genus
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ISSN	2380-2359
ISSN (online)	2380-2359
DOI	10.1080/23802359.2022.2040389
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: CCL2- and Notch2-mediated Central Sensitization in a Rat Chronic Pelvic Pain Model.

Deng, Juan / Liang, Junhua / Cao, Yungui / Tong, Xiaowen / Li, Huaifang

In vivo (Athens, Greece)

2023 Volume 38, Issue 1, Page(s) 205–212

Abstract: Background/aim: Chronic pelvic pain (CPP) is a common gynecological condition in women with multifactorial etiology. Some studies have revealed that patients with CPP have the same structural and functional changes in the pain matrix in the brain to ... ...

Abstract	Background/aim: Chronic pelvic pain (CPP) is a common gynecological condition in women with multifactorial etiology. Some studies have revealed that patients with CPP have the same structural and functional changes in the pain matrix in the brain to patients with other types of chronic pain. However, the relationship between localized pelvic pain and changes in the structure and function of the central nervous system is still unclear. Materials and methods: In this study, a rat model of CPP was established by pelvic nerve ligation and behavioral tests were used to validate the model. Afterwards, we compared the expression of CCL2 in CPP and control rats and observed the changes in their behavioral patterns by blocking the expression of CCL2 in the former group. In addition, we upregulated the expression of CCL2 in human microglia cells (HMC3) to further observe the effect of CCL2 on the Notch2 pathway. Results: Our results showed that the expression of chemokine ligand 2 (CCL2) in the serum exosomes, pelvic vascular endothelial cells, and cerebrospinal fluid was higher in the CPP group than the control group (p<0.05). In HMC3 treated with recombinant CCL2 protein, a significant increase in the mRNA and protein expression of Notch2 was observed. Conclusion: CCL2 can activate the Notch2 signaling pathway and plays an important role in the central sensitization of chronic pelvic pain.
MeSH term(s)	Animals ; Female ; Humans ; Rats ; Central Nervous System Sensitization/physiology ; Chemokine CCL2/genetics ; Chemokines ; Chronic Pain/genetics ; Endothelial Cells/metabolism ; Ligands ; Pelvic Pain/etiology ; Pelvic Pain/therapy ; Receptor, Notch2
Chemical Substances	CCL2 protein, human ; Chemokine CCL2 ; Chemokines ; Ligands ; Notch2 protein, rat ; Receptor, Notch2 ; Ccl2 protein, rat
Language	English
Publishing date	2023-12-24
Publishing country	Greece
Document type	Journal Article
ZDB-ID	807031-3
ISSN	1791-7549 ; 0258-851X
ISSN (online)	1791-7549
ISSN	0258-851X
DOI	10.21873/invivo.13427
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2288: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
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Article ; Online: Antagonisms of ASFV towards Host Defense Mechanisms: Knowledge Gaps in Viral Immune Evasion and Pathogenesis.

Yu, Liangzheng / Zhu, Zhenbang / Deng, Junhua / Tian, Kegong / Li, Xiangdong

Viruses

2023 Volume 15, Issue 2

Abstract: African swine fever (ASF) causes high morbidity and mortality of both domestic pigs and wild boars and severely impacts the swine industry worldwide. ASF virus (ASFV), the etiologic agent of ASF epidemics, mainly infects myeloid cells in swine ... ...

Abstract	African swine fever (ASF) causes high morbidity and mortality of both domestic pigs and wild boars and severely impacts the swine industry worldwide. ASF virus (ASFV), the etiologic agent of ASF epidemics, mainly infects myeloid cells in swine mononuclear phagocyte system (MPS), including blood-circulating monocytes, tissue-resident macrophages, and dendritic cells (DCs). Since their significant roles in bridging host innate and adaptive immunity, these cells provide ASFV with favorable targets to manipulate and block their antiviral activities, leading to immune escape and immunosuppression. To date, vaccines are still being regarded as the most promising measure to prevent and control ASF outbreaks. However, ASF vaccine development is delayed and limited by existing knowledge gaps in viral immune evasion, pathogenesis, etc. Recent studies have revealed that ASFV can employ diverse strategies to interrupt the host defense mechanisms via abundant self-encoded proteins. Thus, this review mainly focuses on the antagonisms of ASFV-encoded proteins towards IFN-I production, IFN-induced antiviral response, NLRP3 inflammasome activation, and GSDMD-mediated pyroptosis. Additionally, we also make a brief discussion concerning the potential challenges in future development of ASF vaccine.
MeSH term(s)	Animals ; Swine ; African Swine Fever ; Immune Evasion ; Monocytes ; Adaptive Immunity ; Antiviral Agents ; Sus scrofa
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020574
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Lightweight Helmet Detection Algorithm Using an Improved YOLOv4.

Chen, Junhua / Deng, Sihao / Wang, Ping / Huang, Xueda / Liu, Yanfei

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 3

Abstract: Safety helmet wearing plays a major role in protecting the safety of workers in industry and construction, so a real-time helmet wearing detection technology is very necessary. This paper proposes an improved YOLOv4 algorithm to achieve real-time and ... ...

Abstract	Safety helmet wearing plays a major role in protecting the safety of workers in industry and construction, so a real-time helmet wearing detection technology is very necessary. This paper proposes an improved YOLOv4 algorithm to achieve real-time and efficient safety helmet wearing detection. The improved YOLOv4 algorithm adopts a lightweight network PP-LCNet as the backbone network and uses deepwise separable convolution to decrease the model parameters. Besides, the coordinate attention mechanism module is embedded in the three output feature layers of the backbone network to enhance the feature information, and an improved feature fusion structure is designed to fuse the target information. In terms of the loss function, we use a new SIoU loss function that fuses directional information to increase detection precision. The experimental findings demonstrate that the improved YOLOv4 algorithm achieves an accuracy of 92.98%, a model size of 41.88 M, and a detection speed of 43.23 pictures/s. Compared with the original YOLOv4, the accuracy increases by 0.52%, the model size decreases by about 83%, and the detection speed increases by 88%. Compared with other existing methods, it performs better in terms of precision and speed.
Language	English
Publishing date	2023-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23031256
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