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Article: Serology Testing for SARS-CoV-2: Benefits and Challenges.

Jalali Nadoushan, Mohammadreza / Ahmadi, Soha / Jalali Nadoushan, Paniz

2020 Volume 15, Issue 3, Page(s) 154–155

Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	Iran
Document type	Editorial
ZDB-ID	2478278-6
ISSN	1735-5303
ISSN	1735-5303
DOI	10.30699/IJP.2020.39841
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Article: Evaluation of Cytokeratin-7 and Cytokeratin-19 Expression Relationship with Gleason Score in Prostatic Adenocarcinoma.

Soltanipur, Masood / Jalali Nadoushan, Mohammadreza / Yarmohammadi, Hossein

Iranian journal of pathology

2023 Volume 18, Issue 3, Page(s) 363–369

Abstract: Background & objective: Prostatic adenocarcinoma (PAC) is one of the most common tumors worldwide. Immunohistochemical expression of cytokeratins has been evaluated in the diagnosis and prognosis of tumors. The aim of the present study is the evaluation ...

Abstract	Background & objective: Prostatic adenocarcinoma (PAC) is one of the most common tumors worldwide. Immunohistochemical expression of cytokeratins has been evaluated in the diagnosis and prognosis of tumors. The aim of the present study is the evaluation of Cytokeratin-7 (Ck-7) and Cytokeratin-19 (Ck-19) expression and its relationship with Gleason score in patients with PAC. Methods: In this cross-sectional study, 78 samples from 78 patients with PAC referred to Mostafa Khomeini Hospital were gathered. Samples were immunohistochemically stained by Ck-7 and Ck-19 markers. The percentage of each marker in tumor cells was determined, and its relationship with Gleason scores and Gleason grade groups was analysed by SPSS version 24. Results: The expression of Ck-7 and Ck-19 were seen in 37.2% and 82.1% of samples, respectively. The mean of Ck-7 expression in tumor cells was 4.98%±7.19 (ranged 0 to 26%), while the mean of Ck-19 expression was 41.02%±23.36 (ranged 0 to 78%). There was no relationship between Ck-7 expression with Gleason scores and Gleason grade groups. However, Ck-19 expression was increased in higher Gleason scores and Gleason grade groups ( Conclusion: The Ck-7 expression in PAC samples is weak and focal and had no relationship with the Gleason scores and Gleason grade groups. However, Ck-19 expression in PAC was high and was associated with tumor dedifferentiation of samples. There was no relationship between the expression of both markers with the patient's age.
Language	English
Publishing date	2023-08-18
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2478278-6
ISSN	1735-5303 ; 2345-3656
ISSN	1735-5303 ; 2345-3656
DOI	10.30699/IJP.2023.2002657.3116
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Article ; Online: A two-protein cocktail elicits a protective immune response against Acinetobacter baumannii in a murine infection model.

Mirali, Mohammadhassan / Jahangiri, Abolfazl / Jalali Nadoushan, Mohammadreza / Rasooli, Iraj

Microbial pathogenesis

2023 Volume 182, Page(s) 106262

Abstract: Purpose: Due to its high drug resistance, Acinetobacter baumannii is a priority for new therapeutic measures like vaccines. In this study, the protectivity of a combination cocktail of Omp34 and BauA as a vaccine against A. baumannii was studied in a ... ...

Abstract	Purpose: Due to its high drug resistance, Acinetobacter baumannii is a priority for new therapeutic measures like vaccines. In this study, the protectivity of a combination cocktail of Omp34 and BauA as a vaccine against A. baumannii was studied in a murine sepsis model. Methods: The antibody titers were raised to Omp34 and BauA in BALB/c mice and assessed by indirect ELISA. The immunized mice were challenged with A. baumannii ATCC 19606. The bacterial loads in the liver, spleen, and lungs were also determined. Results: A significant increase in survival of the immunized mice was noted. In active immunity, the survival rates in mice receiving Omp34 and BauA alone or in combination were 100%. A significant decrease in the bacterial load was observed in the spleens, livers, and lungs of vaccinated mice. Anti-BauA and anti-Omp34 sera crossly detected Omp34 and BauA respectively. The decrease in bacterial load in body organs of mice vaccinated with a combination of the two proteins was significantly higher than those of the single proteins in both actively and passively immunized mice. In passive immunity, the survival rate of mice receiving specific sera raised to the combination of these proteins was 85.7%. Conclusion: Higher protection by a combination of Omp34 and BauA than Omp34 or BauA could be attributed to targeting simultaneously both surface antigens indicating the synergistic effect of Omp34 and BauA as suitable vaccine candidates in the prevention or treatment of A. baumannii infections.
MeSH term(s)	Animals ; Mice ; Acinetobacter baumannii ; Bacterial Outer Membrane Proteins ; Lung ; Immunity ; Vaccines ; Bacterial Vaccines
Chemical Substances	Bacterial Outer Membrane Proteins ; Vaccines ; Bacterial Vaccines
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106262
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Article ; Online: Anti-OmpA antibodies as potential inhibitors of Acinetobacter baumannii biofilm formation, adherence to, and proliferation in A549 human alveolar epithelial cells.

Barati, Hamideh / Fekrirad, Zahra / Jalali Nadoushan, Mohammadreza / Rasooli, Iraj

Microbial pathogenesis

2023 Volume 186, Page(s) 106473

Abstract: Outer membrane protein A (OmpA) is a critical virulence factor in Acinetobacter baumannii, influencing adhesion, biofilm formation, host immune response, and host cell apoptosis. We investigated the invasion of A549 alveolar epithelial cells by A. ... ...

Abstract	Outer membrane protein A (OmpA) is a critical virulence factor in Acinetobacter baumannii, influencing adhesion, biofilm formation, host immune response, and host cell apoptosis. We investigated the invasion of A549 alveolar epithelial cells by A. baumannii and examined how anti-OmpA antibodies impact these interactions. OmpA was expressed and purified, inducing anti-OmpA antibodies in BALB/c mice. The potential toxicity of OmpA was evaluated in mice by analyzing histology from six organs. A549 cells were exposed to A. baumannii strains 19606 and a clinical isolate. Using cell culture and light microscopy, we scrutinized the effects of anti-OmpA sera on serum resistance, adherence, internalization, and proliferation of A. baumannii in A549 cells. The viability of A549 cells was assessed upon exposure to live A. baumannii and anti-OmpA sera. OmpA-induced antibody demonstrated potent bactericidal effects on both strains of A. baumannii. Both strains formed biofilms, which were reduced by anti-OmpA serum, along with decreased bacterial adherence, internalization, and proliferation in A549 cells. Anti-OmpA serum improved the survival of A549 cells post-infection. Pre-treatment with cytochalasin D hindered bacterial internalization, highlighting the role of actin polymerization in invasion. Microscopic examination revealed varied interactions encompassing adherence, apoptosis, membrane alterations, vacuolization, and damage. A549 cells treated with anti-OmpA serum exhibited improved structures and reduced damage. The findings indicate that A. baumannii can adhere to and proliferate within epithelial cells with OmpA playing a pivotal role in these interactions, and the complex nature of these interactions shapes the intricate course of A. baumannii infection in host cells.
MeSH term(s)	Humans ; Animals ; Mice ; Acinetobacter baumannii/metabolism ; Alveolar Epithelial Cells ; Biofilms ; Bacteria ; Cell Proliferation
Chemical Substances	OMPA outer membrane proteins (149024-69-1)
Language	English
Publishing date	2023-12-03
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106473
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of Relationship between CD38 Expression and Gleason Score in Prostatic Carcinoma

Mohsen Besharati Rad / Mohammadreza Jalali Nadoushan

Journal of Mazandaran University of Medical Sciences, Vol 33, Iss 2, Pp 316-

2023 Volume 322

Abstract: Background and purpose: Prostate cancer is the most prevalent non-cutaneous malignancy in men. The Gleason grading system is an important prognostic factor in prostatic carcinoma. Nowadays, identifying biomarkers indicating high-risk patients and ... ...

Abstract	Background and purpose: Prostate cancer is the most prevalent non-cutaneous malignancy in men. The Gleason grading system is an important prognostic factor in prostatic carcinoma. Nowadays, identifying biomarkers indicating high-risk patients and targeted therapy is considered. The CD38 is a membranous glycoprotein involved in adenosine generation, and in this way, it plays a role in tumorigenesis and progression of various tumors. Therefore, this study aimed to evaluate the relationship between CD38 expression and Gleason score in prostatic carcinoma. Materials and methods: In this cross-sectional retrospective study, 85 paraffin blocks from prostatic carcinoma tissue samples were immunohistochemically stained by CD38 monoclonal antibody. The percentage of CD38 expression in tumor cells was determined, and its relation with primary and secondary Gleason grade and total Gleason score in evaluated samples was analyzed by SPSS (version 16). Results: The mean of evaluated patients’ age was 70.67 ± 8.84 years, and 40% were in the range of 71-80 years. The mean of CD38 expression percentage in prostatic carcinoma tumor cells was .18 ± 16.58 and in the range of 8%-84%. A significant reverse relationship was found between CD38 expression percentage with primary Gleason grade (P<0.001), secondary Gleason grade (P=0.002), and total Gleason score (P<0.001). Conclusion: It seems that the loss of CD38 expression plays a role in the development, progression, and aggressive behaviour of prostatic carcinoma. Therefore, it is possible that treatments inducing CD38 expression in tumour cells of prostatic carcinoma could effectively treat and prevent tumour progression.
Keywords	cd38 ; gleason grade ; prognosis ; prostate carcinoma ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Mazandaran University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Serology testing for sars-cov-2: Benefits and challenges

Nadoushan, Mohammadreza Jalali / Ahmadi, Soha / Nadoushan, Paniz Jalali

Iran. J. Pathol.

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #695896
Database	COVID19

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Article ; Online: Synergistic immunoprotection by Oma87 and Bap against Acinetobacter baumannii sepsis model.

Mansouri, Mobina / Sadeghpoor, Masoomeh / Abdollahi, Marziyeh / Vafaei, Amir Javad / Jalali Nadoushan, Mohammadreza / Rasooli, Iraj

International immunopharmacology

2023 Volume 122, Page(s) 110650

Abstract: Acinetobacter baumannii is the leading cause of nosocomial infection. A surface protein commonly known as biofilm associate protein (Bap) has been identified in a bloodstream isolate of A. baumannii. Bap of A. baumannii is involved in intercellular ... ...

Abstract	Acinetobacter baumannii is the leading cause of nosocomial infection. A surface protein commonly known as biofilm associate protein (Bap) has been identified in a bloodstream isolate of A. baumannii. Bap of A. baumannii is involved in intercellular adhesion within the mature biofilm. Outer membrane protein Acinetobacter 87 kDa (Oma87) or β-barrel assembly machinery A (BamA) has been introduced as an immunogenic outer membrane protein via in silico reverse vaccinology. Current research examines the synergistic effect of immunization of mice with both recombinant proteins viz., Oma87 and Bap. Antibodies were raised to the proteins. The mice were challenged with A. baumannii ATCC 19606 and the bacterial burden was enumerated in the mice's livers, spleens, and lungs followed by histological examination. IgG levels significantly increased, and a significant (p < 0.0001) difference was observed between bacterial burdens in the internal organs of the actively and passively immunized groups. Female BALB/c mice weighing 20-25 g, were divided into 4 groups of 14 mice each viz., control, Oma87, Bap, Oma87-Bap groups. The proteins were individually immunogenic, but the combination of both proteins had a synergistic protection property. This is further supported by the histological examination. Based on the results, the combination of Oma87 and Bap may be considered a promising vaccine candidate against A. baumannii .
MeSH term(s)	Female ; Animals ; Mice ; Membrane Proteins ; Acinetobacter baumannii ; Acinetobacter Infections/prevention & control ; Acinetobacter Infections/microbiology ; Sepsis ; Biofilms ; Bacterial Vaccines ; Bacterial Outer Membrane Proteins
Chemical Substances	Membrane Proteins ; Bacterial Vaccines ; Bacterial Outer Membrane Proteins
Language	English
Publishing date	2023-07-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2023.110650
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Article ; Online: L–arginine alleviates postmenopausal complications in female rats by stimulating ovarian dopamine beta hydroxylase

Fatemeh Lakzaei / Manizheh Karami / Mohammadreza Jalali Nadoushan

Asian Pacific Journal of Reproduction, Vol 11, Iss 6, Pp 276-

2022 Volume 284

Abstract: Objective: To evaluate the levels of estrogen, albumin and gonadotropins (luteinizing hormone, follicle-stimulating hormone) as well as the activity of dopamine beta hydroxylase (DAß H) in aged female rats treated with nitric oxide precursor L-arginine ... ...

Abstract	Objective: To evaluate the levels of estrogen, albumin and gonadotropins (luteinizing hormone, follicle-stimulating hormone) as well as the activity of dopamine beta hydroxylase (DAß H) in aged female rats treated with nitric oxide precursor L-arginine and neuronal nitric oxide synthase antagonist L-NAME. Methods: A total of 224 Wistar rats (36 weeks old, weighing 250 g) based on a random sampling were divided into the control and experimental groups after Pap smear test. The control group received only saline (1 mL/kg) intraperitoneally (i.p.). The experiential groups were treated with L-arginine (5, 25 and 50 mg/kg, i.p.) and L-NAME (5 and 25 mg/kg, i.p.) for 3 to 21 days, once a day. Blood samples were taken from the rats and the levels of estrogen and albumin and gonadotropins in the serum were monitored by enzyme-linked immunosorbent assay kit, and the ovaries were examined immunohistopathologically for DAßH activity. Results: L-arginine (5 mg/kg) significantly increased estrogen level (P<0.05), which was associated with DAßH activation in the ovaries. L-NAME reduced this effect when administered prior to L-arginine dose. L-arginine caused no significant change in the levels of luteinizing hormone and follicle-stimulating hormone. Except for the lowest dose of L-arginine in the shortest period, albumin levels significantly decreased in other treatments compared to the control group (P<0.05). Conclusions: L-arginine is likely to reduce postmenopausal problems due to an increased nitric oxide level.
Keywords	postmenopausal ; estrogen ; albumin ; dopamine beta-hydroxlase ; l-arginine ; nitric oxide ; Medicine ; R
Subject code	571
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Factors associated with suicidal ideation among medical residents in Tehran during the COVID-19 pandemic: A multicentric cross-sectional survey.

Saeed, Fahimeh / Ghalehnovi, Elaheh / Saeidi, Mahdieh / Ali Beigi, Neda / Vahedi, Mohsen / Shalbafan, Mohammadreza / Kamalzadeh, Leila / Nazeri Astaneh, Ali / Jalali Nadoushan, Amir Hossein / Shoib, Sheikh

PloS one

2024 Volume 19, Issue 3, Page(s) e0300394

Abstract: Background: The mental health of medical residents, challenged by their intensive training, is of utmost concern. In light of reported suicides among Iranian medical residents in 2021, this study investigates the factors behind suicidal ideation among ... ...

Abstract	Background: The mental health of medical residents, challenged by their intensive training, is of utmost concern. In light of reported suicides among Iranian medical residents in 2021, this study investigates the factors behind suicidal ideation among medical residents during the COVID-19 pandemic in Tehran. Methods: This study conducted a cross-sectional online survey among medical residents in various specialties in Tehran, Iran, amidst the COVID-19 pandemic. Suicidal ideation was assessed using the Beck Scale for Suicidal Ideation (BSSI), while depression, anxiety, and stress were measured using the DASS-21. It also collected demographic and clinical data from the participants. The data were analyzed using descriptive statistics, the Chi-square test, and multiple linear regression to examine the prevalence and determinants of suicidal ideation among medical residents. Results: The study enrolled 353 medical residents and found that 34.3% of them had suicidal ideation, with 10.2% indicating a high risk. The study also found high levels of depression, anxiety, and stress among the participants. The variables that significantly predicted suicidal ideation were depression, history of alcohol/substance use, personal history of suicide attempts, history of self-mutilation, family history of suicide attempts, number of shifts in a month, death of close persons because of COVID-19, and income. Depression was the strongest predictor of suicidal ideation. Conclusion: These findings underscore the urgent need for effective interventions and support systems to address the mental health needs of medical residents in Iran. The strategies should prioritize destigmatizing mental health, promoting access to mental health services, fostering a supportive training environment, and enhancing income opportunities.
MeSH term(s)	Humans ; Suicidal Ideation ; Cross-Sectional Studies ; Iran/epidemiology ; Internship and Residency ; Pandemics ; Risk Factors ; COVID-19/epidemiology ; Depression/epidemiology ; Depression/psychology
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0300394
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Article ; Online: A two-protein cocktail elicits a protective immune response against Acinetobacter baumannii in a murine infection model

Mirali, Mohammadhassan / Jahangiri, Abolfazl / Jalali Nadoushan, Mohammadreza / Rasooli, Iraj

Microbial Pathogenesis. 2023 Sept., v. 182 p.106262-

2023

Abstract: Due to its high drug resistance, Acinetobacter baumannii is a priority for new therapeutic measures like vaccines. In this study, the protectivity of a combination cocktail of Omp34 and BauA as a vaccine against A. baumannii was studied in a murine ... ...

Abstract	Due to its high drug resistance, Acinetobacter baumannii is a priority for new therapeutic measures like vaccines. In this study, the protectivity of a combination cocktail of Omp34 and BauA as a vaccine against A. baumannii was studied in a murine sepsis model. The antibody titers were raised to Omp34 and BauA in BALB/c mice and assessed by indirect ELISA. The immunized mice were challenged with A. baumannii ATCC 19606. The bacterial loads in the liver, spleen, and lungs were also determined. A significant increase in survival of the immunized mice was noted. In active immunity, the survival rates in mice receiving Omp34 and BauA alone or in combination were 100%. A significant decrease in the bacterial load was observed in the spleens, livers, and lungs of vaccinated mice. Anti-BauA and anti-Omp34 sera crossly detected Omp34 and BauA respectively. The decrease in bacterial load in body organs of mice vaccinated with a combination of the two proteins was significantly higher than those of the single proteins in both actively and passively immunized mice. In passive immunity, the survival rate of mice receiving specific sera raised to the combination of these proteins was 85.7%. Higher protection by a combination of Omp34 and BauA than Omp34 or BauA could be attributed to targeting simultaneously both surface antigens indicating the synergistic effect of Omp34 and BauA as suitable vaccine candidates in the prevention or treatment of A. baumannii infections.
Keywords	Acinetobacter baumannii ; active immunity ; antibodies ; drug resistance ; immune response ; liver ; mice ; microbial load ; models ; passive immunity ; pathogenesis ; spleen ; survival rate ; synergism ; therapeutics ; vaccines ; Cocktail vaccine ; Immunogenicity ; Omp34 ; BauA
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106262
Database	NAL-Catalogue (AGRICOLA)

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