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Article ; Online: Umpolung reactivity of strained C-C σ-bonds without transition-metal catalysis.

Bai, Dachang / Guo, Xiuli / Wang, Xinghua / Xu, Wenjie / Cheng, Ruoshi / Wei, Donghui / Lan, Yu / Chang, Junbiao

2024 Volume 15, Issue 1, Page(s) 2833

Abstract: ... derivatives, the umpolung reactivity of polarized C-C σ-bonds still needs to explore. Herein, we report ... an umpolung reaction of bicyclo[1.1.0]butanes (BCBs) with electron-deficient alkenes to construct the C(sp ...

Abstract	Umpolung is an old and important concept in organic chemistry, which significantly expands the chemical space and provides unique structures. While, previous research focused on carbonyls or imine derivatives, the umpolung reactivity of polarized C-C σ-bonds still needs to explore. Herein, we report an umpolung reaction of bicyclo[1.1.0]butanes (BCBs) with electron-deficient alkenes to construct the C(sp
Language	English
Publishing date	2024-04-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47169-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photoenzymes for Radical C-C Coupling.

Guo, Rui / Chen, Heyu / Yang, Yang

Nature catalysis

2022 Volume 5, Issue 7, Page(s) 582–583

Abstract: ... as highly efficient photoenzymes to catalyse asymmetric radical C-C couplings. ...

Abstract	General catalytic methods for free radical-mediated asymmetric transformations have long eluded synthetic organic chemists. Now, NAD(P)H-dependent ketoreductases (KREDs) are repurposed and engineered as highly efficient photoenzymes to catalyse asymmetric radical C-C couplings.
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article
ISSN	2520-1158
ISSN (online)	2520-1158
DOI	10.1038/s41929-022-00813-3
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Article ; Online: Thiocyanate promoted difunctionalization and cyclization of unsaturated C-C bonds to construct 1-sulfur-2-nitrogen-functionalized alkenes and 2-thiocyanate indolines.

Qin, Hong / Chen, Feng / Du, Jinze / Yang, Xiaobing / Huang, Yiping / Zhu, Kai / Yue, Changhai / Fang, Zheng / Guo, Kai

Organic & biomolecular chemistry

2024 Volume 22, Issue 6, Page(s) 1213–1218

Abstract: ... of thiocyanate (SCN) and isothiocyanate (NCS) groups simultaneously forms C-N and C-S bonds in this metal-free ...

Abstract	An unprecedented one-pot route to achieve highly regioselective 1-sulfur-functionalized 2-nitrogen-functionalized alkenes and 2-thiocyanate indolines from unsymmetrical ynamides (readily and generally available amides) using the commercially available inexpensive iodobenzene diacetate (PIDA) as the oxidant and potassium thiocyanate (KSCN) as the thiocyanate (SCN) source has been developed. The interconversion of thiocyanate (SCN) and isothiocyanate (NCS) groups simultaneously forms C-N and C-S bonds in this metal-free approach, while introducing important functional groups into homemade alkynes. A radical-chain mechanism, involving competing kinetically controlled chain transfer at the S atom and sterically-controlled chain transfer at the N atom of the thiocyanogen molecule in this mild approach, is proposed.
Language	English
Publishing date	2024-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d3ob01864d
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Article ; Online: C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape.

Guo, Yangkun / Zhao, Chong / Dai, Wenting / Wang, Bowen / Lai, Enjiang / Xiao, Yang / Tang, Chengwei / Huang, Zhiyin / Gao, Jinhang

International journal of biological sciences

2023 Volume 19, Issue 8, Page(s) 2572–2587

Abstract: ... end-stage liver cirrhosis. C-C motif chemokine receptor 2 (CCR2) is an attractive target for treating ...

Abstract	The accumulation of extracellular matrix (ECM) proteins in the liver leads to liver fibrosis and end-stage liver cirrhosis. C-C motif chemokine receptor 2 (CCR2) is an attractive target for treating liver fibrosis. However, limited investigations have been conducted to explore the mechanism by which CCR2 inhibition reduces ECM accumulation and liver fibrosis, which is the focus of this study. Liver injury and liver fibrosis were induced by carbon tetrachloride (CCl
MeSH term(s)	Animals ; Humans ; Mice ; Chemokines/metabolism ; Liver/metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/drug therapy ; Liver Cirrhosis/metabolism ; Macrophages/metabolism ; Monocytes/metabolism ; Receptors, CCR2/metabolism
Chemical Substances	Chemokines ; CCR2 protein, human ; Ccr2 protein, mouse ; Receptors, CCR2
Language	English
Publishing date	2023-05-08
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2179208-2
ISSN	1449-2288 ; 1449-2288
ISSN (online)	1449-2288
ISSN	1449-2288
DOI	10.7150/ijbs.83530
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Article ; Online: Rh(III)-Catalyzed Double C-H Functionalization of Indoles with Cyclopropenones via Sequential C-H/C-C/C-H Bond Activation.

Zhang, Yan-Bo / Li, Bin-Shi / Xu, Guo-Jie / Sun, Wei / Sun, Meng

Organic letters

2023 Volume 25, Issue 21, Page(s) 3922–3926

Abstract: An unprecedented Rh(III)-catalyzed double C-H functionalization of indoles with cyclopropenones via ... sequential C-H/C-C/C-H bond activation has been developed. This procedure represents the first example ...

Abstract	An unprecedented Rh(III)-catalyzed double C-H functionalization of indoles with cyclopropenones via sequential C-H/C-C/C-H bond activation has been developed. This procedure represents the first example for assembling of cyclopenta[
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c01292
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Article ; Online: Current state and future perspectives of cytochrome P450 enzymes for C-H and C=C oxygenation.

Yan, Yu / Wu, Jing / Hu, Guipeng / Gao, Cong / Guo, Liang / Chen, Xiulai / Liu, Liming / Song, Wei

Synthetic and systems biotechnology

2022 Volume 7, Issue 3, Page(s) 887–899

Abstract: Cytochrome P450 enzymes (CYPs) catalyze a series of C-H and C=C oxygenation reactions, including ... overview of the C-H and C=C oxygenation reactions catalyzed by CYPs and the various strategies ... for achieving higher selectivity and enzymatic activity. Furthermore, we discuss the application of C-H and C=C ...

Abstract	Cytochrome P450 enzymes (CYPs) catalyze a series of C-H and C=C oxygenation reactions, including hydroxylation, epoxidation, and ketonization. They are attractive biocatalysts because of their ability to selectively introduce oxygen into inert molecules under mild conditions. This review provides a comprehensive overview of the C-H and C=C oxygenation reactions catalyzed by CYPs and the various strategies for achieving higher selectivity and enzymatic activity. Furthermore, we discuss the application of C-H and C=C oxygenation catalyzed by CYPs to obtain the desired chemicals or pharmaceutical intermediates in practical production. The rapid development of protein engineering for CYPs provides excellent biocatalysts for selective C-H and C=C oxygenation reactions, thereby promoting the development of environmentally friendly and sustainable production processes.
Language	English
Publishing date	2022-05-08
Publishing country	China
Document type	Journal Article
ISSN	2405-805X
ISSN (online)	2405-805X
DOI	10.1016/j.synbio.2022.04.009
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Article ; Online: Search for Λ[over ¯]-Λ Baryon-Number-Violating Oscillations in the Decay J/ψ→pK^{-}Λ[over ¯]+c.c.

Ablikim, M / Achasov, M N / Adlarson, P / Ahmed, S / Albrecht, M / Aliberti, R / Amoroso, A / An, Q / Bai, Y / Bakina, O / Ferroli, R Baldini / Balossino, I / Ban, Y / Begzsuren, K / Berger, N / Bertani, M / Bettoni, D / Bianchi, F / Bloms, J /

Bortone, A / Boyko, I / Briere, R A / Cai, H / Cai, X / Calcaterra, A / Cao, G F / Cao, N / Cetin, S A / Chang, J F / Chang, W L / Chelkov, G / Chen, G / Chen, H S / Chen, M L / Chen, S J / Chen, X R / Chen, Y B / Chen, Z J / Cheng, W S / Cibinetto, G / Cossio, F / Dai, H L / Dai, J P / Dai, X C / Dbeyssi, A / de Boer, R E / Dedovich, D / Deng, Z Y / Denig, A / Denysenko, I / Destefanis, M / De Mori, F / Ding, Y / Dong, J / Dong, L Y / Dong, M Y / Dong, X / Du, S X / Fang, J / Fang, S S / Fang, Y / Farinelli, R / Fava, L / Feldbauer, F / Felici, G / Feng, C Q / Fritsch, M / Fu, C D / Gao, Y N / Gao, Ya / Gao, Yang / Garzia, I / Gersabeck, E M / Gilman, A / Goetzen, K / Gong, L / Gong, W X / Gradl, W / Greco, M / Gu, L M / Gu, M H / Gu, S / Gu, Y T / Guan, C Y / Guo, A Q / Guo, L B / Guo, R P / Guo, Y P / Guskov, A / Han, T T / Hao, X Q / Harris, F A / He, K L / Heinsius, F H H / Heinz, C H / Heng, Y K / Herold, C / Himmelreich, M / Holtmann, T / Hou, Y R / Hou, Z L / Hu, H M / Hu, J F / Hu, T / Hu, Y / Huang, G S / Huang, L Q / Huang, X T / Huang, Y P / Hussain, T / Imoehl, W / Irshad, M / Jaeger, S / Janchiv, S / Ji, Q / Ji, Q P / Ji, X B / Ji, X L / Jiang, X S / Jiao, J B / Jiao, Z / Jin, S / Jin, Y / Johansson, T / Kalantar-Nayestanaki, N / Kang, X S / Kappert, R / Kavatsyuk, M / Ke, B C / Keshk, I K / Khoukaz, A / Kiese, P / Kiuchi, R / Kliemt, R / Kolcu, O B / Kopf, B / Kuemmel, M / Kuessner, M K / Kupsc, A / Kurth, M G / Kühn, W / Lane, J J / Larin, P / Lavania, A / Lavezzi, L / Lei, Z H / Leithoff, H / Lellmann, M / Lenz, T / Li, C / Li, C H / Li, Cheng / Li, D M / Li, F / Li, G / Li, H / Li, H B / Li, H J / Li, J Q / Li, J W / Li, Ke / Li, L K / Li, Lei / Li, P L / Li, P R / Li, S Y / Li, W D / Li, W G / Li, X H / Li, X L / Li, Z Y / Liang, H / Liang, Y F / Liang, Y T / Liao, G R / Liao, L Z / Libby, J / Limphirat, A / Liu, B J / Liu, C X / Liu, D / Liu, F H / Liu, Fang / Liu, Feng / Liu, H B / Liu, H M / Liu, Huanhuan / Liu, Huihui / Liu, J B / Liu, J Y / Liu, K / Liu, K Y / Liu, L / Liu, M H / Liu, Q / Liu, S B / Liu, Shuai / Liu, T / Liu, W M / Liu, X / Liu, Y B / Liu, Z A / Liu, Z Q / Lou, X C / Lu, F X / Lu, H J / Lu, J D / Lu, J G / Lu, X L / Lu, Y / Lu, Y P / Luo, C L / Luo, M X / Luo, T / Luo, X L / Lusso, S / Lyu, X R / Ma, F C / Ma, H L / Ma, L L / Ma, M M / Ma, Q M / Ma, R Q / Ma, R T / Ma, X X / Ma, X Y / Maas, F E / Maggiora, M / Maldaner, S / Malde, S / Malik, Q A / Mangoni, A / Mao, Y J / Mao, Z P / Marcello, S / Meng, Z X / Messchendorp, J G / Mezzadri, G / Min, T J / Mitchell, R E / Mo, X H / Muchnoi, N Yu / Muramatsu, H / Nakhoul, S / Nefedov, Y / Nerling, F / Nikolaev, I B / Ning, Z / Nisar, S / Olsen, S L / Ouyang, Q / Pacetti, S / Pan, X / Pan, Y / Pathak, A / Patteri, P / Pelizaeus, M / Peng, H P / Peters, K / Ping, J L / Ping, R G / Pitka, A / Poling, R / Prasad, V / Qi, H / Qi, H R / Qi, M / Qi, T Y / Qian, S / Qian, W B / Qiao, C F / Qin, L Q / Qin, X P / Qin, X S / Qin, Z H / Qiu, J F / Qu, S Q / Ravindran, K / Redmer, C F / Rivetti, A / Rodin, V / Rolo, M / Rong, G / Rosner, Ch / Sarantsev, A / Schelhaas, Y / Schnier, C / Schoenning, K / Scodeggio, M / Shan, D C / Shan, W / Shan, X Y / Shao, M / Shen, C P / Shen, P X / Shen, X Y / Shi, H C / Shi, R S / Shi, X / Shi, X D / Song, W M / Song, Y X / Sosio, S / Spataro, S / Su, K X / Sun, G X / Sun, J F / Sun, L / Sun, S S / Sun, T / Sun, W Y / Sun, Y J / Sun, Y K / Sun, Y Z / Sun, Z T / Tan, Y H / Tan, Y X / Tang, C J / Tang, G Y / Tang, J / Teng, J X / Thoren, V / Uman, I / Wang, B / Wang, B L / Wang, C W / Wang, D Y / Wang, H P / Wang, K / Wang, L L / Wang, M / Wang, Meng / Wang, W H / Wang, W P / Wang, X / Wang, X F / Wang, X L / Wang, Y / Wang, Y D / Wang, Y F / Wang, Y Q / Wang, Z / Wang, Z Y / Wang, Ziyi / Wang, Zongyuan / Wei, D H / Weidenkaff, P / Weidner, F / Wen, S P / White, D J / Wiedner, U W / Wilkinson, G / Wolke, M / Wollenberg, L / Wu, J F / Wu, L H / Wu, L J / Wu, X / Wu, Z / Xia, L / Xiao, H / Xiao, S Y / Xiao, Z J / Xie, X H / Xie, Y G / Xie, Y H / Xing, T Y / Xu, G F / Xu, J J / Xu, Q J / Xu, W / Xu, X P / Xu, Y C / Yan, F / Yan, L / Yan, W B / Yan, W C / Yan, Xu / Yang, H J / Yang, H X / Yang, L / Yang, S L / Yang, Y H / Yang, Yifan / Ye, M / Ye, M H / Yin, J H / You, Z Y / Yu, B X / Yu, C X / Yu, G / Yu, J S / Yu, T / Yuan, C Z / Yuan, L / Yuan, W / Yuan, Y / Yuan, Z Y / Yue, C X / Zafar, A A / Zeng, Y / Zhang, B X / Zhang, G Y / Zhang, H / Zhang, H H / Zhang, H Y / Zhang, J J / Zhang, J Q / Zhang, J W / Zhang, J Y / Zhang, J Z / Zhang, Jianyu / Zhang, Jiawei / Zhang, Lei / Zhang, S F / Zhang, X D / Zhang, X Y / Zhang, Y / Zhang, Y T / Zhang, Y H / Zhang, Yan / Zhang, Yao / Zhang, Z Y / Zhao, G / Zhao, J / Zhao, J Y / Zhao, J Z / Zhao, Lei / Zhao, Ling / Zhao, M G / Zhao, Q / Zhao, S J / Zhao, Y B / Zhao, Y X / Zhao, Z G / Zhemchugov, A / Zheng, B / Zheng, J P / Zheng, Y H / Zhong, B / Zhong, C / Zhou, L P / Zhou, Q / Zhou, X / Zhou, X K / Zhou, X R / Zhu, A N / Zhu, J / Zhu, K / Zhu, K J / Zhu, S H / Zhu, W J / Zhu, Y C / Zhu, Z A / Zou, B S / Zou, J H

Physical review letters

2023 Volume 131, Issue 12, Page(s) 121801

Abstract: We report on the first search for Λ[over ¯]-Λ oscillations in the decay J/ψ→pK^{-}Λ[over ¯]+c.c ... hyperons is determined to be P(Λ)=[B(J/ψ→pK^{-}Λ+c.c.)/B(J/ψ→pK^{-}Λ[over ¯]+c.c.)]<4.4×10^{-6 ...

Abstract	We report on the first search for Λ[over ¯]-Λ oscillations in the decay J/ψ→pK^{-}Λ[over ¯]+c.c. by analyzing 1.31×10^{9} J/ψ events accumulated with the BESIII detector at the BEPCII collider. The J/ψ events are produced using e^{+}e^{-} collisions at a center of mass energy sqrt[s]=3.097 GeV. No evidence for hyperon oscillations is observed. The upper limit for the oscillation rate of Λ[over ¯] to Λ hyperons is determined to be P(Λ)=[B(J/ψ→pK^{-}Λ+c.c.)/B(J/ψ→pK^{-}Λ[over ¯]+c.c.)]<4.4×10^{-6} corresponding to an oscillation parameter δm_{ΛΛ[over ¯]} of less than 3.8×10^{-18} GeV at the 90% confidence level.
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.121801
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Article ; Online: Iron-Catalyzed Alkoxyl Radical-Induced C-C Bond Cleavage/

Zhang, Tian-Yu / Wu, Yong / Liu, Shuai / Tao, Jing-Qi / Yang, Xu / Wang, Xue-Qi / Duan, Xin-Hua / Guo, Li-Na

Organic letters

2023 Volume 25, Issue 23, Page(s) 4329–4334

Abstract: An inexpensive iron-catalyzed alkoxyl radical-induced C-C bond cleavage/ ...

Abstract	An inexpensive iron-catalyzed alkoxyl radical-induced C-C bond cleavage/
MeSH term(s)	Iron ; Ketones ; Lactones ; Catalysis
Chemical Substances	alkoxyl radical ; Iron (E1UOL152H7) ; Ketones ; Lactones
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c01427
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Article ; Online: Aromatic C-C Bond Cleavage in a Curved π-System of Aminocorannulene.

Guo, Weijie / Ding, Wanjian / Yao, Yuqing / Rajca, Suchada / Li, Qiaolian / Jiang, Hua / Rajca, Andrzej / Wang, Ying

Organic letters

2023 Volume 25, Issue 21, Page(s) 3972–3977

Abstract: We report a metal- and oxidant-free aromatic C-C bond cleavage in the curved corannulene skeleton ...

Abstract	We report a metal- and oxidant-free aromatic C-C bond cleavage in the curved corannulene skeleton. Reaction of 1-aminocorannulene with hydrazonyl chloride generates an amidrazone intermediate that undergoes facile intramolecular proton migrations and ring annulation to give a 1,2,4-triazole derivative of planar benzo[
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c01107
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Article ; Online: A multifunctional flavoprotein monooxygenase HspB for hydroxylation and C-C cleavage of 6-hydroxy-3-succinoyl-pyridine.

Ouyang, Xingyu / Liu, Gongquan / Guo, Lihua / Wu, Geng / Xu, Ping / Zhao, Yi-Lei / Tang, Hongzhi

Applied and environmental microbiology

2024 Volume 90, Issue 3, Page(s) e0225523

Abstract: Flavoprotein monooxygenases catalyze reactions, including hydroxylation and epoxidation, involved in the catabolism, detoxification, and biosynthesis of natural substrates and industrial contaminants. Among them, the 6-hydroxy-3-succinoyl-pyridine (HSP) ... ...

Abstract	Flavoprotein monooxygenases catalyze reactions, including hydroxylation and epoxidation, involved in the catabolism, detoxification, and biosynthesis of natural substrates and industrial contaminants. Among them, the 6-hydroxy-3-succinoyl-pyridine (HSP) monooxygenase (HspB) from
MeSH term(s)	Mixed Function Oxygenases/metabolism ; Nicotine/metabolism ; Flavin-Adenine Dinucleotide/metabolism ; Flavoproteins/metabolism ; Hydroxylation ; Pyridines/metabolism ; Succinates
Chemical Substances	6-hydroxy-3-succinoyl-pyridine ; Mixed Function Oxygenases (EC 1.-) ; Nicotine (6M3C89ZY6R) ; Flavin-Adenine Dinucleotide (146-14-5) ; Flavoproteins ; Pyridines ; Succinates
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.02255-23
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