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Article ; Online: Intestinal tissue-resident T cell activation depends on metabolite availability.

Konjar, Špela / Ferreira, Cristina / Carvalho, Filipa Sofia / Figueiredo-Campos, Patrícia / Fanczal, Júlia / Ribeiro, Sofia / Morais, Vanessa Alexandra / Veldhoen, Marc

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 34, Page(s) e2202144119

Abstract: The metabolic capacity of many cells is tightly regulated and can adapt to changes in metabolic resources according to environmental changes. Tissue-resident memory ( ... ...

Abstract	The metabolic capacity of many cells is tightly regulated and can adapt to changes in metabolic resources according to environmental changes. Tissue-resident memory (T
MeSH term(s)	CD8-Positive T-Lymphocytes/cytology ; Intestinal Mucosa/cytology ; Intestines/cytology ; Intraepithelial Lymphocytes/cytology ; Lymphocyte Activation ; Memory T Cells/cytology ; Oxidative Phosphorylation
Language	English
Publishing date	2022-08-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2202144119
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Article: Eimeria vermiformis

Figueiredo-Campos, Patrícia / Ferreira, Cristina / Blankenhaus, Birte / Veldhoen, Marc

Bio-protocol

2019 Volume 8, Issue 24

Abstract: ... Eimeria ... ...

Abstract	Eimeria vermiformis
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.3122
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Article ; Online: CD8

Barros, Leandro / Piontkivska, Daryna / Figueiredo-Campos, Patrícia / Fanczal, Júlia / Ribeiro, Sofia Pereira / Baptista, Marta / Ariotti, Silvia / Santos, Nuno / Amorim, Maria João / Pereira, Cristina Silva / Veldhoen, Marc / Ferreira, Cristina

Nature communications

2023 Volume 14, Issue 1, Page(s) 5579

Abstract: Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, ... ...

Abstract	Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8
MeSH term(s)	T-Lymphocytes, Regulatory ; Memory T Cells ; CD4-Positive T-Lymphocytes ; Cell Differentiation ; CD8-Positive T-Lymphocytes
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41364-w
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Article ; Online: Type 1 T

Ferreira, Cristina / Barros, Leandro / Baptista, Marta / Blankenhaus, Birte / Barros, André / Figueiredo-Campos, Patrícia / Konjar, Špela / Lainé, Alexandra / Kamenjarin, Nadine / Stojanovic, Ana / Cerwenka, Adelheid / Probst, Hans C / Marie, Julien C / Veldhoen, Marc

Nature immunology

2020 Volume 21, Issue 7, Page(s) 766–776

Abstract: Tissue-resident memory T ( ... ...

Abstract	Tissue-resident memory T (T
MeSH term(s)	Adoptive Transfer ; Animals ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/transplantation ; Cell Communication/immunology ; Cell Differentiation/immunology ; Coccidiosis/immunology ; Coccidiosis/parasitology ; Disease Models, Animal ; Eimeria/immunology ; Female ; Humans ; Immunologic Memory ; Integrin beta Chains/metabolism ; Male ; Mice ; Mice, Transgenic ; Receptors, CXCR3/metabolism ; T-Box Domain Proteins/genetics ; T-Box Domain Proteins/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/transplantation ; Transforming Growth Factor beta/metabolism
Chemical Substances	Cxcr3 protein, mouse ; Integrin beta Chains ; Receptors, CXCR3 ; T-Box Domain Proteins ; T-box transcription factor TBX21 ; Transforming Growth Factor beta ; integrin beta8
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-020-0674-9
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article ; Online: Humoral Immune Response of SARS-CoV-2-Infected Patients with Cancer: Influencing Factors and Mechanisms.

Esperança-Martins, Miguel / Gonçalves, Lisa / Soares-Pinho, Inês / Gomes, Andreia / Serrano, Marta / Blankenhaus, Birte / Figueiredo-Campos, Patrícia / Catarina-Marques, Ana / Castro-Barbosa, Ana / Cardoso, Ana / Antunes-Meireles, Pedro / Atalaia-Barbacena, Henrique / Gaspar, Pedro / Howell-Monteiro, Patrícia / Pais-de-Lacerda, António / Mota, Catarina / Veldhoen, Marc

The oncologist

2021 Volume 26, Issue 9, Page(s) e1619–e1632

Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well ... ...

Abstract	Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients with cancer show worse outcomes compared with patients without cancer. The humoral immune response (HIR) of patients with cancer against SARS-CoV-2 is not well characterized. To better understand it, we conducted a serological study of hospitalized patients with cancer infected with SARS-CoV-2. Materials and methods: This was a unicentric, retrospective study enrolling adult patients with SARS-CoV-2 admitted to a central hospital from March 15 to June 17, 2020, whose serum samples were quantified for anti-SARS-CoV-2 receptor-binding domain or spike protein IgM, IgG, and IgA antibodies. The aims of the study were to assess the HIR to SARS-CoV-2; correlate it with different cancer types, stages, and treatments; clarify the interplay between the HIR and clinical outcomes of patients with cancer; and compare the HIR of SARS-CoV-2-infected patients with and without cancer. Results: We included 72 SARS-CoV-2-positive subjects (19 with cancer, 53 controls). About 90% of controls revealed a robust serological response. Among patients with cancer, a strong response was verified in 57.9%, with 42.1% showing a persistently weak response. Treatment with chemotherapy within 14 days before positivity was the only factor statistically shown to be associated with persistently weak serological responses among patients with cancer. No significant differences in outcomes were observed between patients with strong and weak responses. All IgG, IgM, IgA, and total Ig antibody titers were significantly lower in patients with cancer compared with those without. Conclusion: A significant portion of patients with cancer develop a proper HIR. Recent chemotherapy treatment may be associated with weak serological responses among patients with cancer. Patients with cancer have a weaker SARS-CoV-2 antibody response compared with those without cancer. Implications for practice: These results place the spotlight on patients with cancer, particularly those actively treated with chemotherapy. These patients may potentially be more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, so it is important to provide oncologists further theoretical support (with concrete examples and respective mechanistic correlations) for the decision of starting, maintaining, or stopping antineoplastic treatments (particularly chemotherapy) not only on noninfected but also on infected patients with cancer in accordance with cancer type, stage and prognosis, treatment agents, treatment setting, and SARS-CoV-2 infection risks.
MeSH term(s)	Antibodies, Viral ; COVID-19 ; Humans ; Immunity, Humoral ; Immunoglobulin G ; Neoplasms/complications ; Neoplasms/drug therapy ; Retrospective Studies ; SARS-CoV-2
Chemical Substances	Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2021-06-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1002/onco.13828
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Zs.A 4845: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 494: Show issues

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Article: Malnutrition and Nutrition Support in Latin American PICUs: The Nutrition in PICU (NutriPIC) Study.

Campos-Miño, Santiago / Figueiredo-Delgado, Artur / Zárate, Patricia / Zamberlan, Patricia / Muñoz-Benavides, Eliana / Coss-Bu, Jorge A

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

2023 Volume 24, Issue 12, Page(s) 1033–1042

Abstract: Objectives: To characterize the nutritional status of children admitted to Latin American (LA) PICUs and to describe the adequacy of nutrition support in reference to contemporary international recommendations.: Design: The Nutrition in PICU ( ... ...

Abstract	Objectives: To characterize the nutritional status of children admitted to Latin American (LA) PICUs and to describe the adequacy of nutrition support in reference to contemporary international recommendations. Design: The Nutrition in PICU (NutriPIC) study was a combined point-prevalence study of malnutrition carried out on 1 day in 2021 (Monday 8 November) and a retrospective cohort study of adequacy of nutritional support in the week preceding. Setting: Four-one PICUs in 13 LA countries. Patients: Patients already admitted to the PICU of 1 month to 18 years old on the study day were included in the point-prevalence study. For the retrospective arm, we included patients receiving nutritional support on the study day and with a PICU length of stay (LOS) greater than or equal to 72 hours. Exclusion criteria were being a neonate, conditions that precluded accurate anthropometric measurements, and PICU LOS greater than 14 days. Interventions: None. Measurements and main results: Of 316 patients screened, 5 did not meet age criteria. There were 191 of 311 patients who were included in the point-prevalence study and underwent anthropometric evaluation. Underweight and length for age less than -2 z scores were present in 42 of 88 children (47.7%) and 41 of 88 children (46.6%) less than 24 months old, and 14 of 103 (13.6%) and (23/103) 22.3% of 103 children greater than or equal to 24 months, respectively. Evidence of obesity (body mass index > 2 z score) was present in 7 of 88 children (5.7%) less than 24 months old and 13 of 103 children (12.6%) greater than or equal to 24 months. In the 115 of 311 patients meeting criteria for the retrospective arm, a total of 98 patients reported complete nutritional data. The 7-day median (interquartile range) adequacy for delivered versus recommended enteral energy and protein requirement was 114% (75, 154) and 99% (60, 133), respectively. Conclusions: The NutriPIC study found that in 2021 malnutrition was highly prevalent especially in PICU admissions of less than 24 months old. Retrospectively, the 7-day median nutritional support appears to meet both energy and protein requirements.
MeSH term(s)	Child ; Infant, Newborn ; Humans ; Infant ; Child, Preschool ; Retrospective Studies ; Latin America/epidemiology ; Nutritional Support ; Malnutrition/diagnosis ; Malnutrition/epidemiology ; Length of Stay ; Intensive Care Units, Pediatric ; Critical Illness
Language	English
Publishing date	2023-08-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2052349-X
ISSN	1947-3893 ; 1529-7535
ISSN (online)	1947-3893
ISSN	1529-7535
DOI	10.1097/PCC.0000000000003337
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Zs.A 5600: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 472: Show issues

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Article: Gellan-Based Hydrogel as a Drug Delivery System for Caffeic Acid Phenethyl Ester in the Treatment of Oral

Garcia, Maíra Terra / Carmo, Paulo Henrique Fonseca do / Figueiredo-Godoi, Lívia Mara Alves / Gonçalves, Natália Inês / Lima, Patrícia Michelle Nagai de / Ramos, Lucas de Paula / Oliveira, Luciane Dias de / Borges, Alexandre Luiz Souto / Shukla, Anita / Junqueira, Juliana Campos

Pharmaceutics

2024 Volume 16, Issue 3

Abstract: ... Candida ... ...

Abstract	Candida albicans
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics16030298
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Article ; Online: Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onset.

European journal of immunology

2020 Volume 50, Issue 12, Page(s) 2025–2040

Abstract: SARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia-COVID-19-but may remain mild or asymptomatic. To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the ... ...

Abstract	SARS-CoV-2 has emerged as a human pathogen, causing clinical signs, from fever to pneumonia-COVID-19-but may remain mild or asymptomatic. To understand the continuing spread of the virus, to detect those who are and were infected, and to follow the immune response longitudinally, reliable and robust assays for SARS-CoV-2 detection and immunological monitoring are needed. We quantified IgM, IgG, and IgA antibodies recognizing the SARS-CoV-2 receptor-binding domain (RBD) or the Spike (S) protein over a period of 6 months following COVID-19 onset. We report the detailed setup to monitor the humoral immune response from over 300 COVID-19 hospital patients and healthcare workers, 2500 University staff, and 198 post-COVID-19 volunteers. Anti-SARS-CoV-2 antibody responses follow a classic pattern with a rapid increase within the first three weeks after symptoms. Although titres reduce subsequently, the ability to detect anti-SARS-CoV-2 IgG antibodies remained robust with confirmed neutralization activity for up to 6 months in a large proportion of previously virus-positive screened subjects. Our work provides detailed information for the assays used, facilitating further and longitudinal analysis of protective immunity to SARS-CoV-2. Importantly, it highlights a continued level of circulating neutralising antibodies in most people with confirmed SARS-CoV-2.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; SARS-CoV-2/immunology ; Seroepidemiologic Studies ; Spike Glycoprotein, Coronavirus/immunology ; Time Factors
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-10
Publishing country	Germany
Document type	Clinical Trial ; Journal Article
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202048970
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article: Surgical, oncologic, and obstetric outcomes of radical trachelectomy in early-stage cervical cancer: results from a retrospective cohort study at Brazil National Cancer Institute.

Bellotti, José Augusto / Gutierres, Isabella Gonçalves / Furtado, Yara Lúcia / Patury, Patricia / Figueiredo, Juliana de Almeida / Guitmann, Gustavo / Fiorelli, Rossano Keppler Alvin / da Silva, Fernanda Campos

Frontiers in oncology

2024 Volume 14, Page(s) 1267625

Abstract: Objective: to analyze oncological, obstetrical, and surgical results of young early-stage cervical cancer patients who underwent radical trachelectomy (RT) surgery and wished to maintain their fertility.: Methodology: a retrospective cohort study was ...

Abstract	Objective: to analyze oncological, obstetrical, and surgical results of young early-stage cervical cancer patients who underwent radical trachelectomy (RT) surgery and wished to maintain their fertility. Methodology: a retrospective cohort study was carried out concerning cases attended at the Brazilian National Cancer Institute Gynecology Oncology Service. Patients who underwent RT between January 2005 and January 2021 were included. Results: A total of 32 patients with median age of 32 years old, 62.5% of whom were nulliparous, were assessed. Concerning cancer type, 65.6% squamous cell carcinoma (SCC) cases, 31.2% adenocarcinoma cases and 3.1% adenosquamous carcinoma cases were verified. Stage IA2 was evidenced in 12.5% of the patients and stage IB < 4 cm in 87.5%. Regarding surgical approaches, 68.25% of the patients underwent vaginal RT (VRT), 18.75%, abdominal RT (ART), 9.3%, the robotic radical trachelectomy (RORT) and 3.1%, video laparoscopy radical trachelectomy (VLRT). The median number of removed lymph nodes was 14, with only two detected as positive. Two cases of positive surgical margins were noted. A total of 3.1% intraoperative and 31.25% postoperative complications were observed, with cervical stenosis being the most common. The recurrence rate of the study was 3.1%, with a median follow-up time of 87 months, where 3.1% deaths occurred. The pregnancy rate of the study was 17.85% (5/28), with 54.5% evolving to live births and 45.5% evolving to abortion. Conclusion: Radical trachelectomy is a feasible procedure presenting good oncological results and acceptable pregnancy rates.
Language	English
Publishing date	2024-03-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1267625
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Article ; Online: Consensus of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (ABHH) and the Brazilian Ministry of Health - General management of blood and blood products on the tests necessary for the release of exceptional medicines for sickle cell disease.

Lobo, Clarisse / Araújo, Aderson / Antunes, Alexandre de Albuquerque / Pinto, Ana Cristina Silva / Godinho, Ariadne Carvalho / Pires, Cassia Silvestre Mariano / Matheus, Cinthia Cristina / Albuquerque, Xerez de / Neves, Daniele Campos Fontes / Moreno, Fábio de Lima / Baldanzi, Giorgio / Siufi, Grazziella Curado / Miranda, Heloisa Helena Pereira / Hankins, Jane / Aragão, Joice / Braga, Josefina Aparecida Pellegrini / Martins, Juliana Touguinha Neves / Souza, Luciana Campos Costa Machado de / Figueiredo, Maria Stella /

Oliveira, Mirella Rodrigues / Cardoso, Patricia Santos Resende / Pinto, Patricia Costa Alves / Moura, Patricia Gomes / Cançado, Rodolfo Delfini / Araujo, Paulo Ivo Cortez de / Saad, Sara Olalla / Loggetto, Sandra Regina / Fonseca, Teresa Cristina Cardoso

Hematology, transfusion and cell therapy

2024 Volume 46, Issue 1, Page(s) 67–71

Abstract: To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso- ... ...

Abstract	To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety.
Language	English
Publishing date	2024-02-01
Publishing country	Brazil
Document type	Journal Article
ISSN	2531-1387
ISSN (online)	2531-1387
DOI	10.1016/j.htct.2024.01.001
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