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  1. Article: Impact de la première année de la pandémie de COVID-19 sur l’épidémiologie des infections invasives (bactériémies) dans les hôpitaux de l’Assistance Publique–Hôpitaux de Paris.

    Amarsy, R / Robert, J / Jarlier, V

    Bulletin de l'Academie nationale de medecine

    2022  Volume 207, Issue 2, Page(s) 131–135

    Abstract: Introduction: The COVID-19 pandemic has led to a massive influx of patients suffering from severe forms of the disease into hospitals, often requiring intensive care (vascular catheters, ventilation, etc.) which exposes them to high risks of nosocomial ... ...

    Title translation Impact of the first year of the COVID-19 pandemic on the epidemiology of invasive infections (bacteremia) in the hospitals of the Assistance Publique-Hôpitaux de Paris.
    Abstract Introduction: The COVID-19 pandemic has led to a massive influx of patients suffering from severe forms of the disease into hospitals, often requiring intensive care (vascular catheters, ventilation, etc.) which exposes them to high risks of nosocomial infections, particularly invasive infections (bacteremia).
    Method: The impact of the COVID-19 pandemic on the epidemiology of bacteremia in 2020 was analysed in 25 hospitals of the Assistance Publique-Hôpitaux de Paris (AP-HP, approximately 14,000 beds, covering the Île-de-France region). Up to a quarter of patients admitted to AP-HP during the March-April period (peak of the 1st wave) were infected with COVID-19. The incidence over 100 admissions of bacteraemia increased overall compared to previous years: by 24% in March 2020 and by 115% in April.
    Results: The evolution of the incidence of bacteremia was not the same for 2 groups of microorganisms with very different ecologies. For the "hospital" type microorganisms classically responsible for nosocomial infections, the incidence increased significantly in March-April 2020:
    Conclusion: The COVID-19 pandemic which had a strong impact on hospital management and social organization in the general population, had opposite impacts on the incidence of bacteremia depending on the pathogens and their mode of transmission.
    Language French
    Publishing date 2022-12-13
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 213227-8
    ISSN 0001-4079
    ISSN 0001-4079
    DOI 10.1016/j.banm.2022.11.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: May confusion be a misleading initial clinical presentation of COVID-19 in individuals with mood disorders?

    Vorspan, Florence / Amarsy, Rishma / Etain, Bruno

    Psychiatry research

    2021  Volume 297, Page(s) 113710

    MeSH term(s) COVID-19 ; Catatonia/epidemiology ; Coronavirus Infections ; Humans ; Mood Disorders/epidemiology ; Mood Disorders/etiology ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-01-04
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2021.113710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Novel scores relevant to antimicrobial resistance and hospital-acquired infections developed with data from a multi-hospital consortium in the Parisian region of France.

    Amarsy, R / Granger, B / Fournier, S / Monteil, C / Trystram, D / Siorat, V / Jarlier, V / Robert, J

    The Journal of hospital infection

    2023  Volume 143, Page(s) 97–104

    Abstract: Purpose: Indicators for comparing and understanding differences in antimicrobial resistance (AMR) and healthcare-associated infections (HAIs) for benchmarking are essential to identify priorities for hospitals.: Methods: This study measured the ... ...

    Abstract Purpose: Indicators for comparing and understanding differences in antimicrobial resistance (AMR) and healthcare-associated infections (HAIs) for benchmarking are essential to identify priorities for hospitals.
    Methods: This study measured the incidence of hospital-acquired or resistant Gram-negative bacilli bloodstream infections (GNB-BSIs) in a large public healthcare consortium in the Parisian region of France.
    Results: Within each hospital, there was a strong positive correlation between the incidence of GNB-BSIs due to resistant GNB and the incidence of hospital-acquired GNB-BSIs. Two scores measuring AMR and HAI rates by combining different GNB-BSI incidence rates were developed as indicators. These scores were highly variable within the hospital consortium. On multi-variate analysis, AMR and HAI scores were significantly associated with the proportion of surgical beds, staff absenteeism and the consumption of alcohol-based hand rub, with the latter two characteristics being amenable to interventions. Carbapenem use was also linked to AMR, but this may be because carbapenems are the preferred drug for treating resistant infections.
    Conclusion: These results shed light on the incidence of HAIs and AMR in the study hospitals, and suggest possibilities for targeted interventions at healthcare facility level.
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Multiple, Bacterial ; Drug Resistance, Bacterial ; Cross Infection/epidemiology ; Cross Infection/drug therapy ; Gram-Negative Bacteria ; Hospitals ; Carbapenems/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Carbapenems
    Language English
    Publishing date 2023-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 779366-2
    ISSN 1532-2939 ; 0195-6701
    ISSN (online) 1532-2939
    ISSN 0195-6701
    DOI 10.1016/j.jhin.2023.09.022
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  4. Article ; Online: Decrease of hospital- and community-acquired bloodstream infections due to Streptococcus pneumoniae and Streptococcus pyogenes during the first year of the COVID-19 pandemic: A time-series analysis in Paris region.

    Amarsy, Rishma / Fournier, Sandra / Trystram, David / Monteil, Catherine / Raynaud, Xavier / Jarlier, Vincent / Robert, Jérôme

    American journal of infection control

    2022  Volume 51, Issue 4, Page(s) 475–477

    Abstract: The impact of the COVID-19 pandemic on bloodstream infections (BSIs) due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals of Paris. Monthly BSIs incidence rates that appeared stable in 2018 and 2019, ... ...

    Abstract The impact of the COVID-19 pandemic on bloodstream infections (BSIs) due to Streptococcus pneumoniae and Streptococcus pyogenes was assessed in 25 university hospitals of Paris. Monthly BSIs incidence rates that appeared stable in 2018 and 2019, decreased for the 2 pathogens during the 2 COVID-19 lockdown periods of 2020. Containment policies, including social distancing, masking and hand hygiene strengthening in both community and hospital settings are likely to reduce BSIs due to these pathogens.
    MeSH term(s) Humans ; Streptococcus pneumoniae ; Streptococcus pyogenes ; Pandemics ; Bacteremia/epidemiology ; COVID-19/epidemiology ; Communicable Disease Control ; Community-Acquired Infections/epidemiology ; Hospitals
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2022.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.

    Amarsy, Rishma / Jacquier, Hervé / Munier, Anne-Lise / Merimèche, Manel / Berçot, Béatrice / Mégarbane, Bruno

    American journal of infection control

    2021  Volume 49, Issue 10, Page(s) 1324–1326

    Abstract: An outbreak of Klebsiella pneumoniae producing the carbapenemase NDM-1 occurred in our ICU during the last COVID-19 wave. Twelve patients were tested positive, seven remained asymptomatic whereas 5 developed an infection. Resistome and in silico ... ...

    Abstract An outbreak of Klebsiella pneumoniae producing the carbapenemase NDM-1 occurred in our ICU during the last COVID-19 wave. Twelve patients were tested positive, seven remained asymptomatic whereas 5 developed an infection. Resistome and in silico multilocus sequence typing confirmed the clonal origin of the strains. The identification of a possible environmental reservoir suggested that difficulties in observing optimal bio-cleaning procedures due to workload and exhaustion contributed to the outbreak besides the inappropriate excessive glove use.
    MeSH term(s) Anti-Bacterial Agents ; Bacterial Proteins/genetics ; COVID-19 ; Disease Outbreaks ; Dreams ; Humans ; Intensive Care Units ; Klebsiella Infections/epidemiology ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Pandemics ; SARS-CoV-2 ; beta-Lactamases/genetics
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; beta-lactamase NDM-1 (EC 3.5.2.6)
    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2021.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Serratia marcescens outbreak in the intensive care unit during the COVID-19 pandemic: A paradoxical risk?

    Amarsy, R / Pean de Ponfilly, G R / Benmansour, H A / Jacquier, H / Cambau, E E / Mégarbane, B

    Medecine et maladies infectieuses

    2020  Volume 50, Issue 8, Page(s) 750–751

    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/microbiology ; Catheter-Related Infections/diagnosis ; Catheter-Related Infections/microbiology ; Coinfection/diagnosis ; Coinfection/epidemiology ; Cross Infection/complications ; Cross Infection/diagnosis ; Cross Infection/epidemiology ; Disease Outbreaks ; Drug Resistance, Multiple, Bacterial ; France/epidemiology ; Humans ; Infection Control/methods ; Intensive Care Units ; Pandemics ; Paris/epidemiology ; Risk Factors ; SARS-CoV-2/physiology ; Serratia Infections/complications ; Serratia Infections/epidemiology ; Serratia Infections/transmission ; Serratia marcescens/isolation & purification
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country France
    Document type Case Reports ; Letter
    ZDB-ID 423536-8
    ISSN 1769-6690 ; 0399-077X ; 1166-8237
    ISSN (online) 1769-6690
    ISSN 0399-077X ; 1166-8237
    DOI 10.1016/j.medmal.2020.05.004
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  7. Article ; Online: Impact of 24/7 loading of blood culture bottles in a new automated incubator on the diagnosis of bloodstream infections.

    Péan de Ponfilly, Gauthier / Benmansour, H / Manda, V / Lecorche, E / Mougari, F / Munier, A L / Temim, S / Amarsy, R / Jacquier, H / Cambau, E

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2021  Volume 40, Issue 12, Page(s) 2639–2643

    Abstract: Blood culturing (BC) remains the gold standard for bloodstream diagnosis but its workflow is slow. We aimed reducing this time by implementing a new automated incubator with a 24/7 BC workflow. With this new strategy, time to incubation was shorter (1.52 ...

    Abstract Blood culturing (BC) remains the gold standard for bloodstream diagnosis but its workflow is slow. We aimed reducing this time by implementing a new automated incubator with a 24/7 BC workflow. With this new strategy, time to incubation was shorter (1.52 h vs 6.82 h), positivity rates were higher (10.6% vs 8.9%, p<0.05), and the number of BSI diagnostics increased (16.1% vs 13.8% patients and 2.3 vs 1.9 density episode per 1000 hospital days). Our results show that implementing automatic loading of BC bottles with a 24/7 strategy not only shortened time to diagnosis but significantly increased the BSI diagnosis rate.
    MeSH term(s) Automation/instrumentation ; Automation/methods ; Bacteremia/diagnosis ; Bacteremia/microbiology ; Bacteria/growth & development ; Bacteria/isolation & purification ; Blood Culture/instrumentation ; Blood Culture/methods ; Humans ; Incubators ; Time Factors
    Language English
    Publishing date 2021-06-01
    Publishing country Germany
    Document type Evaluation Study ; Journal Article
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-021-04283-6
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  8. Article: Serratia marcescens outbreak in the intensive care unit during the COVID-19 pandemic: a paradoxical risk?

    Amarsy, Rishma / de Ponfilly, Gauthier Pean / Benmansour, Hanaa / Jacquier, Herve / Cambau, Emmanuelle / Megarbane, Bruno

    Med Mal Infect

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #359625
    Database COVID19

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  9. Article ; Online: Surging bloodstream infections and antimicrobial resistance during the first wave of COVID-19: a study in a large multihospital institution in the Paris region.

    Amarsy, Rishma / Trystram, David / Cambau, Emmanuelle / Monteil, Catherine / Fournier, Sandra / Oliary, Juliette / Junot, Helga / Sabatier, Pierre / Porcher, Raphaël / Robert, Jérôme / Jarlier, Vincent

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 114, Page(s) 90–96

    Abstract: Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March-April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique - Hôpitaux de Paris (APHP), the largest multisite public healthcare ... ...

    Abstract Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March-April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique - Hôpitaux de Paris (APHP), the largest multisite public healthcare institution in France.
    Methods: The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds).
    Results: Up to a fourth of patients admitted in March-April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March-April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred.
    Conclusions: The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/epidemiology ; COVID-19 ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Drug Resistance, Bacterial ; Humans ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-10-22
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.10.034
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  10. Article: Correction to: Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients.

    Manquat, Elsa / Le Dorze, Matthieu / Pean De Ponflly, Gauthier / Benmansour, Hanaa / Amarsy, Rishma / Cambau, Emmanuelle / Soyer, Benjamin / Chousterman, Benjamin Glenn / Jacquier, Hervé

    Annals of intensive care

    2021  Volume 11, Issue 1, Page(s) 84

    Language English
    Publishing date 2021-05-26
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-021-00864-y
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