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  1. Article: Endoscopic Ultrasound-Guided Gallbladder Drainage versus Percutaneous Gallbladder Drainage for Acute Cholecystitis: A Systematic Review and Meta-Analysis.

    Boregowda, Umesha / Chen, Millie / Saligram, Shreyas

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 4

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13040657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Risk of Metachronous Neoplasia with High-Risk Adenoma and Synchronous Sessile Serrated Adenoma: A Systematic Review and Meta-Analysis.

    Boregowda, Umesha / Umapathy, Chandraprakash / Echavarria, Juan / Saligram, Shreyas

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 9

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13091569
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Risk of Metachronous Neoplasia with High-Risk Adenoma and Synchronous Sessile Serrated Adenoma

    Umesha Boregowda / Chandraprakash Umapathy / Juan Echavarria / Shreyas Saligram

    Diagnostics, Vol 13, Iss 1569, p

    A Systematic Review and Meta-Analysis

    2023  Volume 1569

    Abstract: Background: Sessile serrated adenomas are important precursors to colorectal cancers and account for 30% of colorectal cancers. The United States Multi-Society Task Force recommends that patients with sessile serrated adenomas undergo surveillance ... ...

    Abstract Background: Sessile serrated adenomas are important precursors to colorectal cancers and account for 30% of colorectal cancers. The United States Multi-Society Task Force recommends that patients with sessile serrated adenomas undergo surveillance similar to tubular adenomas. However, the risk of metachronous neoplasia when the high-risk adenoma co-exists with sessile serrated adenomas is poorly defined. Objective: To examine the risk of metachronous neoplasia in the presence of high-risk adenoma and synchronous sessile serrated adenomas compared with isolated high-risk adenoma. Data sources: PubMed, Embase, Scopus, Cochrane Library. Study selection: A literature search for studies evaluating the risk of metachronous neoplasia in patients with high-risk adenoma alone and those with synchronous high-risk adenoma and sessile serrated adenomas during surveillance colonoscopy was conducted on online databases. Main outcome measures: The primary outcome of interest was the presence of metachronous neoplasia. Results: Of the 1164 records reviewed, six (four retrospective and two prospective) studies met inclusion criteria with 2490 patients (1607 males, mean age 59.98 ± 3.23 years). Average follow-up was 47.5 ± 12.5 months. There were 2068 patients with high-risk adenoma on index colonoscopy and 422 patients with high-risk adenoma and synchronous sessile serrated adenomas. Pooled estimates showed a significantly elevated risk for metachronous neoplasia in patients with high-risk adenoma and synchronous sessile serrated adenomas (pooled odds ratio 2.21; 95% confidence intervals 1.65–2.96; p < 0.01). There was low heterogeneity (I 2 = 11%) among the studies. Sensitivity analysis of the prospective studies alone also showed elevated risk of metachronous neoplasm (pooled odds ratio 2.56; 95%, confidence intervals 1.05–6.23; p = 0.04). Limitations: Inclusion of a small number of retrospective studies. Conclusions: The presence of high-risk adenomas and synchronous sessile serrated adenomas is associated with an ...
    Keywords colorectal cancer ; serrated polyps ; high-risk adenoma ; metachronous neoplasm ; high-grade dysplasia ; surveillance colonoscopy ; Medicine (General) ; R5-920
    Subject code 610 ; 332
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Endoscopy versus early surgery for the management of chronic pancreatitis: a systematic review and meta-analysis.

    Boregowda, Umesha / Echavarria, Juan / Umapathy, Chandraprakash / Rosenkranz, Laura / Sayana, Hari / Patel, Sandeep / Saligram, Shreyas

    Surgical endoscopy

    2022  Volume 36, Issue 12, Page(s) 8753–8763

    Abstract: Background and aim: Endoscopic stone removal and stenting of pancreatic strictures are the initial treatment for treating chronic pancreatitis-related pain. Surgery is considered when endoscopic interventions fail to improve symptoms. In this meta- ... ...

    Abstract Background and aim: Endoscopic stone removal and stenting of pancreatic strictures are the initial treatment for treating chronic pancreatitis-related pain. Surgery is considered when endoscopic interventions fail to improve symptoms. In this meta-analysis, we have compared early surgery versus endoscopic interventions.
    Methods: The study was performed as per the PRISMA statement. The literature search was conducted on online databases to identify studies that compared endoscopy and surgery for the management of chronic pancreatitis symptoms. Primary outcomes of interest were pain relief, complications, and exocrine/endocrine insufficiency. Secondary outcomes were mean length of stay and mean number of procedures. Pooled odds ratio (OR) was calculated using random-effects model with 95% confidence interval (CI).
    Results: Of a total of 9880 articles that were screened, three randomized controlled trials and two retrospective studies with 602 patients (71.4% males) were found to be eligible. Endoscopic interventions were performed in 317 patients and 285 patients underwent early surgery. Early surgery provided significantly better pain relief compared to endoscopy (OR 0.46; 95%CI 0.27-0.80; p = 0.01; I
    Conclusion: Compared to endoscopy, early surgery appears to be better in controlling chronic pancreatitis-related pain, with no significant difference in procedure-related complications. However, larger randomized controlled trials are needed to ascertain their efficacy.
    MeSH term(s) Male ; Humans ; Female ; Retrospective Studies ; Pancreatitis, Chronic/complications ; Pancreatitis, Chronic/surgery ; Endoscopy, Gastrointestinal/methods ; Pain Management/methods ; Pain/etiology
    Language English
    Publishing date 2022-08-03
    Publishing country Germany
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 639039-0
    ISSN 1432-2218 ; 0930-2794
    ISSN (online) 1432-2218
    ISSN 0930-2794
    DOI 10.1007/s00464-022-09425-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Serum Activity of Liver Enzymes Is Associated With Higher Mortality in COVID-19: A Systematic Review and Meta-Analysis.

    Boregowda, Umesha / Aloysius, Mark M / Perisetti, Abhilash / Gajendran, Mahesh / Bansal, Pardeep / Goyal, Hemant

    Frontiers in medicine

    2020  Volume 7, Page(s) 431

    Abstract: Background: ...

    Abstract Background:
    Keywords covid19
    Language English
    Publishing date 2020-07-22
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Addition of Tocilizumab to the Standard of Care Reduces Mortality in Severe COVID-19: A Systematic Review and Meta-Analysis.

    Boregowda, Umesha / Perisetti, Abhilash / Nanjappa, Arpitha / Gajendran, Mahesh / Kutti Sridharan, Gurusaravanan / Goyal, Hemant

    Frontiers in medicine

    2020  Volume 7, Page(s) 586221

    Abstract: Introduction: ...

    Abstract Introduction:
    Keywords covid19
    Language English
    Publishing date 2020-10-02
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.586221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Comprehensive Literature Review and Evidence evaluation of Experimental Treatment in COVID 19 Contagion.

    Boregowda, Umesha / Gandhi, Darshan / Jain, Nitin / Khanna, Kanika / Gupta, Nishant

    Clinical medicine insights. Circulatory, respiratory and pulmonary medicine

    2020  Volume 14, Page(s) 1179548420964140

    Abstract: Importance: Coronavirus 2019 pandemic (COVID 19) is caused by the Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) virus. The pandemic is affecting the livelihood of millions of people all over the world. At the time of preparing this report, ...

    Abstract Importance: Coronavirus 2019 pandemic (COVID 19) is caused by the Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) virus. The pandemic is affecting the livelihood of millions of people all over the world. At the time of preparing this report, the pandemic has affected 1 827 284 patients, with 113 031 deaths in 185 countries as per Johns Hopkins University. With no proven treatment for the disease, prevention of the disease in the community and healthcare setting is need of the hour.
    Objective: To perform a comprehensive literature search for preventive measures and experimental treatment options. In this review, we have focused our discussion on the risk of disease transmission, supportive treatment, and possible treatment options based on available evidence.
    Evidence review: We performed a literature search on google scholar, PubMed, and society guidelines for literature related to COVID 19 and previous coronavirus pandemics. We included data review articles, observational studies, and controlled trials to synthesize the treatment options for COVID 19.
    Findings: In this article, we have extensively reviewed and discussed recommendations from various world organizations for the public and healthcare workers. We have also discussed currently available experimental treatments since there is no proven treatment for COVID 19. The best method of dealing with the current outbreak is to reduce the community spread and thus "flatten the curve." Although Hydroxychloroquine, Remdesivir, Lopinavir/Ritonavir, and Azithromycin have been tried, passive immunity through convalescent serum and vaccine is still at an experimental stage. Patients with severe COVID 19 infections could be considered for this experimental treatment through various national randomized control trials, which may eventually lead to an evidence-based treatment strategy.
    Conclusions and relevance: Awareness of currently available experimental treatment among healthcare providers and exploration of possible treatment options through evidence is need of the hour. We have discussed the most recently available literature and evidence behind experimental treatment in this article.
    Language English
    Publishing date 2020-10-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2583465-4
    ISSN 1179-5484
    ISSN 1179-5484
    DOI 10.1177/1179548420964140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: COVID-19 and gastrointestinal endoscopies: Current insights and emergent strategies.

    Perisetti, Abhilash / Gajendran, Mahesh / Boregowda, Umesha / Bansal, Pardeep / Goyal, Hemant

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2020  Volume 32, Issue 5, Page(s) 715–722

    Abstract: A new coronavirus emerged in December 2019 in Wuhan city of China, named as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the disease was called coronavirus disease-2019 (COVID-19). The infection due to this virus spread ... ...

    Abstract A new coronavirus emerged in December 2019 in Wuhan city of China, named as the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the disease was called coronavirus disease-2019 (COVID-19). The infection due to this virus spread exponentially throughout China and then spread across >205 nations, including the United States (US). Gastrointestinal (GI) endoscopies are routinely performed in the US and globally. Previous reports of isolated infection outbreaks were reported with endoscopes acting as potential vectors. While multidrug-resistant organisms have been reported to be spread by endoscopes, few cases of viruses such as hepatitis B and C are noted in the literature. COVID-19 is predominately spread by droplet transmission, although recent evidence has showed that shedding in feces and feco-oral transmission could also be possible. It is unclear if COVID-19 could be transmitted by endoscopes, but it could theoretically happen due to contact with mucous membranes and body fluids. GI endoscopies involve close contact with oral and colonic contents exposing endoscopy staff to respiratory and oropharyngeal secretions. This can increase the risk of contamination and contribute to virus transmission. Given these risks, all major GI societies have called for rescheduling elective non-urgent procedures and perform only emergent or urgent procedures based on the clinical need. Furthermore, pre-screening of all individuals prior to endoscopy is recommended. This article focuses on the risk of COVID-19 transmission by GI shedding, the potential role of endoscopes as a vector of this novel virus, including transmission during endoscopies, and prevention strategies including deferral of elective non-urgent endoscopy procedures.
    MeSH term(s) COVID-19 ; COVID-19 Testing ; China ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Endoscopy, Gastrointestinal/methods ; Female ; Humans ; Infection Control/methods ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Male ; Occupational Health ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Patient Isolation/methods ; Personal Protective Equipment/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Safety Management
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.13693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Clinical Insights into the Gastrointestinal Manifestations of COVID-19.

    Kopel, Jonathan / Perisetti, Abhilash / Gajendran, Mahesh / Boregowda, Umesha / Goyal, Hemant

    Digestive diseases and sciences

    2020  Volume 65, Issue 7, Page(s) 1932–1939

    Abstract: The month of December 2019 became a critical part of the time of humanity when the first case of coronavirus disease 2019 (COVID-19) was reported in the Wuhan, Hubei Province in China. As of April 13th, 2020, there have been approximately 1.9 million ... ...

    Abstract The month of December 2019 became a critical part of the time of humanity when the first case of coronavirus disease 2019 (COVID-19) was reported in the Wuhan, Hubei Province in China. As of April 13th, 2020, there have been approximately 1.9 million cases and 199,000 deaths across the world, which were associated with COVID-19. The COVID-19 is the seventh coronavirus to be identified to infect humans. In the past, Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome were the two coronaviruses that infected humans with a high fatality, particularly among the elderly. Fatalities due to COVID-19 are higher in patients older than 50 years of age or those with multimorbid conditions. The COVID-19 is mainly transmitted through respiratory droplets, with the most common symptoms being high fever, cough, myalgia, atypical symptoms included sputum production, headache, hemoptysis and diarrhea. However, the incubation period can range from 2 to 14 days without any symptoms. It is particularly true with gastrointestinal (GI) symptoms in which patients can still shed the virus even after pulmonary symptoms have resolved. Given the high percentage of COVID-19 patients that present with GI symptoms (e.g., nausea and diarrhea), screening patients for GI symptoms remain essential. Recently, cases of fecal-oral transmission of COVID-19 have been confirmed in the USA and China, indicating that the virus can replicate in both the respiratory and digestive tract. Moreover, the epidemiology, clinical characteristics, diagnostic procedures, treatments and prevention of the gastrointestinal manifestations of COVID-19 remain to be elucidated.
    MeSH term(s) Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Cytokine Release Syndrome/immunology ; Cytokines/immunology ; Diarrhea/immunology ; Diarrhea/physiopathology ; Endoscopy, Digestive System ; Feces/virology ; Humans ; Nausea/immunology ; Nausea/physiopathology ; Pandemics/prevention & control ; Pneumonia, Viral/immunology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; SARS-CoV-2 ; Viral Tropism ; Virus Shedding ; Vomiting/immunology ; Vomiting/physiopathology
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-05-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-020-06362-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impact of feedback on adenoma detection rate: a systematic review and meta-analysis.

    Boregowda, Umesha / Desai, Madhav / Nutalapati, Venkat / Paleti, Swathi / Olyaee, Mojtaba / Rastogi, Amit

    Annals of gastroenterology

    2021  Volume 34, Issue 2, Page(s) 214–223

    Abstract: Background: Adenoma detection rate (ADR) is one of the most important quality indicators of colonoscopy. Monitoring endoscopists and providing feedback has shown to improve ADR. We performed a systematic review of the literature and meta-analysis to ... ...

    Abstract Background: Adenoma detection rate (ADR) is one of the most important quality indicators of colonoscopy. Monitoring endoscopists and providing feedback has shown to improve ADR. We performed a systematic review of the literature and meta-analysis to determine the effect of any form of feedback on ADR.
    Methods: A literature search for comparative studies that employed any form of feedback to assess the impact on ADR before and after the feedback was done on MEDLINE, EMBASE, and Cochrane Database. The primary outcome of interest was ADR. Secondary outcomes included polyp detection rate, advanced adenoma detection rate, sessile serrated adenoma detection rate, withdrawal time, and cecal intubation rate. Cochrane Revman 5.3 software was used for statistical analysis.
    Results: A total of 12 studies met the inclusion criteria for the analysis of primary outcomes. There were 78,355 subjects (45.42% male) with a mean age of 59.52 years. There was a significant improvement in ADR after any form of feedback compared to no feedback: 36.18% vs. 26.75%; pooled odds ratio 1.51, 95% confidence interval 1.37-1.66; P<0.001. There was a substantial heterogeneity (I
    Conclusions: Monitoring and providing feedback to endoscopists in any form leads to improvement in ADR. Feedback is an easy and effective way of improving the ADR of endoscopists, especially in those not achieving the recommended benchmarks.
    Language English
    Publishing date 2021-01-27
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2032850-3
    ISSN 1108-7471
    ISSN 1108-7471
    DOI 10.20524/aog.2021.0591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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