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Article: Toward the accumulation of evidence for a novel high-sensitivity hepatitis B core-related antigen assay in patients with hepatitis B virus infection.

Joshita, Satoru

Hepatology research : the official journal of the Japan Society of Hepatology

2022 Volume 52, Issue 9, Page(s) 743–744

Language	English
Publishing date	2022-09-01
Publishing country	Netherlands
Document type	Editorial
ZDB-ID	1387041-5
ISSN	1386-6346 ; 0928-4346
ISSN	1386-6346 ; 0928-4346
DOI	10.1111/hepr.13815
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Article ; Online: Editorial: FAST score- a new predictive marker for HCC after SVR.

Joshita, Satoru / Umemura, Takeji

Alimentary pharmacology & therapeutics

2020 Volume 52, Issue 7, Page(s) 1222–1223

MeSH term(s)	Biomarkers ; Carcinoma, Hepatocellular/diagnosis ; Fatty Liver ; Hepatitis C ; Humans ; Liver Neoplasms/diagnosis
Chemical Substances	Biomarkers
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.16012
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Article ; Online: Quantitative changes of lipoprotein(a) in chronic hepatitis C patients achieving a sustained virological response by direct-acting antivirals.

Okumura, Taiki / Joshita, Satoru / Sugiura, Ayumi / Ota, Masao / Umemura, Takeji

Clinics and research in hepatology and gastroenterology

2022 Volume 46, Issue 8, Page(s) 102011

MeSH term(s)	Antiviral Agents/therapeutic use ; Hepacivirus/genetics ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Lipoprotein(a) ; Ribavirin/therapeutic use ; Sustained Virologic Response
Chemical Substances	Antiviral Agents ; Lipoprotein(a) ; Ribavirin (49717AWG6K)
Language	English
Publishing date	2022-08-27
Publishing country	France
Document type	Letter
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2022.102011
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Article ; Online: Immune thrombocytopenic purpura in primary biliary cholangitis and localized cutaneous systemic sclerosis: case report and literature review.

Okumura, Taiki / Kimura, Takefumi / Hihara, Yu / Inoue, Katsuaki / Maruyama, Atsushi / Joshita, Satoru / Umemura, Takeji

Clinical journal of gastroenterology

2023 Volume 16, Issue 3, Page(s) 432–437

Abstract: Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease of uncertain etiology. Although PBC is frequently complicated by Sjögren's syndrome and chronic thyroiditis, it can also be associated with a variety of other autoimmune ...

Abstract	Primary biliary cholangitis (PBC) is a chronic progressive cholestatic liver disease of uncertain etiology. Although PBC is frequently complicated by Sjögren's syndrome and chronic thyroiditis, it can also be associated with a variety of other autoimmune disorders. We herein describe a rare case of immune thrombocytopenic purpura (ITP) coexistence with PBC and localized cutaneous systemic sclerosis (LcSSc). A 47-year-old woman with PBC and LcSSc who was positive for antiphospholipid antibody experienced a rapid decrease in platelet count to 1.8 × 10
MeSH term(s)	Female ; Humans ; Middle Aged ; Purpura, Thrombocytopenic, Idiopathic/complications ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Liver Cirrhosis, Biliary/diagnosis ; Thrombocytopenia ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis ; Antibodies, Antiphospholipid ; Cholangitis/complications
Chemical Substances	Antibodies, Antiphospholipid
Language	English
Publishing date	2023-03-04
Publishing country	Japan
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2429411-1
ISSN	1865-7265 ; 1865-7257
ISSN (online)	1865-7265
ISSN	1865-7257
DOI	10.1007/s12328-023-01776-z
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Article ; Online: Kinetics of serum O-glycosylated M-hepatitis B surface antigen with hepatocellular carcinoma history and nucleos(t)ide analogue therapy in hepatitis B patients.

Okumura, Taiki / Joshita, Satoru / Iwadare, Takanobu / Wakabayashi, Shun-Ichi / Kobayashi, Hiroyuki / Yamashita, Yuki / Sugiura, Ayumi / Kimura, Takefumi / Umemura, Takeji

Journal of viral hepatitis

2023 Volume 30, Issue 9, Page(s) 731–739

Abstract: A newly developed O-glycosylated M-hepatitis B surface antigen (HBsAgGi) measurement system can detect hepatitis B surface antigen (HBsAg) associated with infectious particles. We investigated the association of HBsAgGi levels with clinical parameters ... ...

Abstract	A newly developed O-glycosylated M-hepatitis B surface antigen (HBsAgGi) measurement system can detect hepatitis B surface antigen (HBsAg) associated with infectious particles. We investigated the association of HBsAgGi levels with clinical parameters and a history of hepatocellular carcinoma (HCC) development in a cross-sectional cohort analysis (Study 1) as well as the quantitative changes in HBsAgGi during nucleos(t)ide analogue (NA) therapy in a longitudinal cohort analysis (Study 2). A total of 124 patients with genotype C chronic HBV infection were analysed in Study 1 to evaluate correlations of HBsAgGi with conventional HBV markers and HCC history. Among those, 36 patients receiving NA therapy were enrolled in Study 2 for quantitative comparisons between pre-treatment baseline and 48 weeks of NA therapy. In Study 1, serum HBsAgGi was significantly associated with HBsAg (r = .5857, p < .00001) and weakly but significantly correlated with HBV DNA (r = .2936, p = .001). Although HBsAgGi (p = .111) was comparable between HCC history (+) group and HCC history (-) group, the HBsAgGi/HBsAg ratio (p = .011) was significantly higher in HCC history (+) patients. In Study 2, HBsAgGi was significantly decreased after 48 weeks of NA therapy (p < .001). HBsAg findings were similar (p = .005) along with an HBV DNA reduction (p < .001). In the baseline hepatitis B e antigen (HBeAg) (+) subgroup, HBsAgGi decreased significantly between baseline and 48 weeks of NA (p = .005), while HBsAg was comparable (p = .051). Low HBsAg and high HBsAgGi were associated with a history of HCC development. HBsAgGi decreased significantly by 48-week NA therapy.
MeSH term(s)	Humans ; Hepatitis B Surface Antigens ; Carcinoma, Hepatocellular/drug therapy ; Hepatitis B, Chronic/complications ; Hepatitis B, Chronic/drug therapy ; Antiviral Agents/therapeutic use ; DNA, Viral ; Kinetics ; Cross-Sectional Studies ; Liver Neoplasms/drug therapy ; Hepatitis B/complications ; Hepatitis B virus/genetics ; Hepatitis B e Antigens
Chemical Substances	Hepatitis B Surface Antigens ; Antiviral Agents ; DNA, Viral ; Hepatitis B e Antigens
Language	English
Publishing date	2023-06-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1212497-7
ISSN	1365-2893 ; 1352-0504
ISSN (online)	1365-2893
ISSN	1352-0504
DOI	10.1111/jvh.13869
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Article ; Online: Serum autotaxin is a prognostic indicator of liver-related events in patients with non-alcoholic fatty liver disease.

Iwadare, Takanobu / Kimura, Takefumi / Okumura, Taiki / Wakabayashi, Shun-Ichi / Nakajima, Taro / Kondo, Shohei / Kobayashi, Hiroyuki / Yamashita, Yuki / Sugiura, Ayumi / Fujimori, Naoyuki / Yamazaki, Tomoo / Kunimoto, Hideo / Shimamoto, Satoshi / Igarashi, Koji / Joshita, Satoru / Tanaka, Naoki / Umemura, Takeji

Communications medicine

2024 Volume 4, Issue 1, Page(s) 73

Abstract: Background: Circulating autotaxin (ATX) levels have been reported to correlate with liver inflammation activity and liver fibrosis severity in patients with non-alcoholic fatty liver disease (NAFLD). The objective of this study is to investigate whether ...

Abstract	Background: Circulating autotaxin (ATX) levels have been reported to correlate with liver inflammation activity and liver fibrosis severity in patients with non-alcoholic fatty liver disease (NAFLD). The objective of this study is to investigate whether serum ATX could predict liver-related events (LRE) in NAFLD patients. Methods: This retrospective investigation includes 309 biopsy-proven NAFLD patients registered at Shinshu University Hospital. All patients are followed for at least 1 year, during which time the prevalence of LRE, including newly developing hepatocellular carcinoma, hepatic encephalopathy, ascites, and esophagogastric varices, is investigated in relation to ATX levels at the time of liver biopsy. Results: During the median follow-up period of 7.0 years, LRE are observed in 20 patients (6.5%). The area under the receiver operating characteristic curve and cut-off value of serum ATX for predicting LRE are 0.81 and 1.227 mg/l, respectively. Multivariate Cox proportional hazards models for LRE determine ATX and advanced fibrosis as independently associated factors. Furthermore, in a competing risk analysis that considered non-liver-related death as a competing event, ATX (HR 2.29, 95% CI 1.22-4.30, p = 0.010) is identified as an independent factor associated with LRE, along with advanced fibrosis (HR 8.01, 95% CI 2.10-30.60, p = 0.002). The predictive utility of ATX for LRE is validated in an independent cohort. Conclusions: Serum ATX may serve as a predictive marker for LRE in patients with NAFLD.
Language	English
Publishing date	2024-04-16
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-024-00499-7
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Article ; Online: Prognostic utility of albumin-bilirubin grade in Japanese patients with primary biliary cholangitis.

Yamashita, Yuki / Umemura, Takeji / Kimura, Takefumi / Joshita, Satoru / Hirohara, Junko / Nakano, Toshiaki / Komori, Atsumasa / Tanaka, Atsushi

JHEP reports : innovation in hepatology

2022 Volume 5, Issue 4, Page(s) 100662

Abstract: Background & aims: The albumin-bilirubin (ALBI) score is calculated using serum levels of total bilirubin and albumin as a simple method to assess liver function. This study investigated the ability of baseline ALBI score/grade measurements to assess ... ...

Abstract	Background & aims: The albumin-bilirubin (ALBI) score is calculated using serum levels of total bilirubin and albumin as a simple method to assess liver function. This study investigated the ability of baseline ALBI score/grade measurements to assess histological stage and disease progression in individuals with primary biliary cholangitis (PBC) in a large Japanese nationwide cohort. Methods: A total of 8,768 Japanese patients with PBC were enrolled between 1980 and 2016 from 469 institutions, among whom 83% received ursodeoxycholic acid (UDCA) only, 9% received UDCA and bezafibrate, and 8% were given neither drug. Baseline clinical and laboratory parameters were retrospectively retrieved and reviewed from a central database. Associations of ALBI score/grade with histological stage, mortality, and need for liver transplantation (LT) were evaluated using Cox proportional hazards models. Results: During the median follow-up period of 5.3 years, 1,227 patients died (including 789 from liver-related causes) and 113 underwent LT. ALBI score and ALBI grade were significantly associated with Scheuer's classification (both Conclusions: This large nationwide study of patients with PBC suggested that baseline measurements of ALBI grade were a simple non-invasive predictor of prognosis in PBC. Impact and implications: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts. This study examined the ability of albumin-bilirubin (ALBI) score/grade to estimate histological findings and disease progression in PBC by means of a large-scale nationwide cohort in Japan. ALBI score/grade were significantly associated with Scheuer's classification stage. Baseline ALBI grade measurements may be a simple non-invasive predictor of prognosis in PBC.
Language	English
Publishing date	2022-12-24
Publishing country	Netherlands
Document type	Journal Article
ISSN	2589-5559
ISSN (online)	2589-5559
DOI	10.1016/j.jhepr.2022.100662
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Article ; Online: The levels of IL-1β and soluble IL-1 receptors in patients with IgG4-related periaortitis/periarteritis.

Ashihara, Norihiro / Ota, Masao / Fujinaga, Yasunari / Ozawa, Makiko / Kuraishi, Yasuhiro / Watanabe, Takayuki / Hamano, Hideaki / Joshita, Satoru / Kawa, Shigeyuki / Umemura, Takeji

Advances in medical sciences

2022 Volume 67, Issue 2, Page(s) 257–261

Abstract: Purpose: IgG4-related disease (IgG4-RD) is a chronic fibrotic inflammatory and an immune-mediated disease characterized by high serum IgG4 concentration and IgG4-bearing plasma cell infiltration in affected organs. IgG4-related periaortitis/ ... ...

Abstract	Purpose: IgG4-related disease (IgG4-RD) is a chronic fibrotic inflammatory and an immune-mediated disease characterized by high serum IgG4 concentration and IgG4-bearing plasma cell infiltration in affected organs. IgG4-related periaortitis/periarteritis is a recently identified disease entity in IgG4-RD that affects the cardiovascular system, and its pathogenesis and characteristics remain unclear. The inflammatory cytokine IL-1β is involved in a variety of cellular activities including inflammation, fibrosis, and angiogenesis. The present study compared the levels of the inflammatory cytokine IL-1β and two soluble IL-1 receptors, IL-1R1 and IL-1R2, between IgG4-RD patients with and without IgG4-related periaortitis/periarteritis. Methods: The patients with IgG4-related periaortitis/periarteritis (n = 38), those without (n = 66) and healthy (n = 33) were recruited to measure cytokines of IL-1β and soluble receptors (sIL-1R1 and sIL-1R2) in sera by ELISA assay. Results: Serum IgG4 was significantly higher in patients with periaortitis/periarteritis compared to non-periaortitis/periarteritis (p = 0.0074), while serum IL-1β was significantly lower in patients with periaortitis/periarteritis (p = 0.00037). The three groups did not show significant difference in sIL1-R1, while sIL-1R2 in the periaortitis/periarteritis and healthy group was higher than in the group without periaortitis/periarteritis (p = 0.00001). Conclusions: The characteristic changes in IL-1β, sIL-1R1, and sIL-1R2 levels in IgG4-RD patients with and without IgG4-related periaortitis/periarteritis may indicate an active phase of the inflammatory process in these diseases.
MeSH term(s)	Humans ; Cytokines ; Immunoglobulin G ; Immunoglobulin G4-Related Disease ; Inflammation ; Receptors, Interleukin-1 ; Receptors, Interleukin-1 Type II
Chemical Substances	Cytokines ; Immunoglobulin G ; Receptors, Interleukin-1 ; Receptors, Interleukin-1 Type II ; IL1B protein, human
Language	English
Publishing date	2022-07-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2022.06.003
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Article ; Online: Symptom-based portopulmonary hypertension screening questionnaire in Japanese patients with chronic liver disease.

Wakabayashi, Shun-Ichi / Joshita, Satoru / Kimura, Kazuhiro / Motoki, Hirohiko / Okumura, Taiki / Kobayashi, Hiroyuki / Yamashita, Yuki / Sugiura, Ayumi / Yamazaki, Tomoo / Kimura, Takefumi / Kuwahara, Koichiro / Umemura, Takeji

JGH open : an open access journal of gastroenterology and hepatology

2023 Volume 7, Issue 8, Page(s) 527–536

Abstract: Background and aim: As the exact prevalence of portopulmonary hypertension (PoPH) and the etiology of chronic liver disease (CLD) remain unknown, the present study aimed to clarify these points in Japanese patients with CLD using symptom-based ... ...

Abstract	Background and aim: As the exact prevalence of portopulmonary hypertension (PoPH) and the etiology of chronic liver disease (CLD) remain unknown, the present study aimed to clarify these points in Japanese patients with CLD using symptom-based questionnaire screening. Methods: Patients with CLD were asked to complete an eight-item written questionnaire on pulmonary hypertension (PH) symptoms. If at least one item response was "yes," the patient was offered ultrasonic echocardiography (UCG). Patients identified as having an intermediate or high risk of PH by UCG were referred to a cardiologist for further evaluation, whereby a definitive diagnosis of PoPH was made using right heart catheterization (RHC) findings. Results: A total of 1111 patients with CLD completed the survey. Of the 566 symptomatic patients with at least one question answered as "yes," approximately half agreed to undergo UCG ( Conclusion: This symptom-based PoPH screening study clarified the prevalence of PoPH in CLD patients according to a PH symptom questionnaire, UCG, and RHC. Patients with HCV and PBC may have a higher risk of PoPH.
Language	English
Publishing date	2023-07-25
Publishing country	Australia
Document type	Journal Article
ISSN	2397-9070
ISSN (online)	2397-9070
DOI	10.1002/jgh3.12939
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Article: Prognostic Significance of C-Reactive Protein in Lenvatinib-Treated Unresectable Hepatocellular Carcinoma: A Multi-Institutional Study.

Okumura, Taiki / Kimura, Takefumi / Iwadare, Takanobu / Wakabayashi, Shun-Ichi / Kobayashi, Hiroyuki / Yamashita, Yuki / Sugiura, Ayumi / Joshita, Satoru / Fujimori, Naoyuki / Kunimoto, Hideo / Komatsu, Michiharu / Fukushima, Hideki / Mori, Hiromitsu / Umemura, Takeji

Cancers

2023 Volume 15, Issue 22

Abstract: Background: Serum C-reactive protein (CRP) is an established biomarker for acute inflammation and has been identified as a prognostic indicator for hepatocellular carcinoma (HCC). However, the significance of the serum CRP level, specifically in HCC ... ...

Abstract	Background: Serum C-reactive protein (CRP) is an established biomarker for acute inflammation and has been identified as a prognostic indicator for hepatocellular carcinoma (HCC). However, the significance of the serum CRP level, specifically in HCC patients treated with lenvatinib, remains unclear. Methods: We retrospectively analyzed 125 HCC patients who received lenvatinib treatment at six centers. Clinical characteristics were assessed to identify clinical associations between serum CRP and HCC prognosis. Results: The median overall serum CRP level was 0.29 mg/dL. The cohort was divided into two groups: the low-CRP group with a serum CRP < 0.5 mg/dL and the high-CRP group with a serum CRP ≥ 0.5 mg/dL. The low-CRP group exhibited significantly longer overall survival (OS) than the high-CRP group (22.9 vs. 7.8 months, Conclusion: A baseline serum CRP level exceeding 0.5 mg/dL was identified as an unfavorable prognostic factor in HCC patients receiving lenvatinib treatment.
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15225343
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