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  1. Article: Special Issue: 'Pathogenesis of Emerging Zoonotic Viral Infections'.

    Foster, Toshana L / Khaiboullina, Svetlana F

    Pathogens (Basel, Switzerland)

    2022  Volume 11, Issue 7

    Abstract: Emerging zoonotic infections present a serious global health threat [ ... ]. ...

    Abstract Emerging zoonotic infections present a serious global health threat [...].
    Language English
    Publishing date 2022-06-29
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens11070736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Implications of NLRP3 Suppression Using Glibenclamide and miR-223 against Colorectal Cancer.

    Hamza, Shaimaa / Garanina, Ekaterina E / Shkair, Layaly / Alsaadi, Mohammad / Khaiboullina, Svetlana F / Tezcan, Gulcin

    Pharmaceuticals (Basel, Switzerland)

    2024  Volume 17, Issue 3

    Abstract: The NLR family pyrin domain containing 3 (NLRP3) promotes the growth of colorectal cancer (CRC). However, the therapeutic effect of NLRP3 inhibition on CRC cell progression is controversial. This study comparatively investigated the therapeutic effect of ...

    Abstract The NLR family pyrin domain containing 3 (NLRP3) promotes the growth of colorectal cancer (CRC). However, the therapeutic effect of NLRP3 inhibition on CRC cell progression is controversial. This study comparatively investigated the therapeutic effect of a pharmacological NLRP3 inhibitor, glibenclamide (gli), and the post-translational suppression of NLRP3 by miR-223 on CRC cell progression in HCT-116 and HCT-15 cells. LPS and ATP were used to activate Gli-treated and LSB-hsa-miR-223-3p (WT
    Language English
    Publishing date 2024-02-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph17030299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Special Issue

    Toshana L. Foster / Svetlana F. Khaiboullina

    Pathogens, Vol 11, Iss 736, p

    ‘Pathogenesis of Emerging Zoonotic Viral Infections’

    2022  Volume 736

    Abstract: Emerging zoonotic infections present a serious global health threat [.] ...

    Abstract Emerging zoonotic infections present a serious global health threat [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Blocking the Hormone Receptors Modulates NLRP3 in LPS-Primed Breast Cancer Cells.

    Hamza, Shaimaa / Garanina, Ekaterina E / Alsaadi, Mohammad / Khaiboullina, Svetlana F / Tezcan, Gulcin

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: NOD-like receptor protein 3 (NLRP3) may contribute to the growth and propagation of breast cancer (BC). The effect of estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) on NLRP3 activation in BC ... ...

    Abstract NOD-like receptor protein 3 (NLRP3) may contribute to the growth and propagation of breast cancer (BC). The effect of estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) on NLRP3 activation in BC remains unknown. Additionally, our knowledge of the effect of blocking these receptors on NLRP3 expression is limited. We used GEPIA, UALCAN, and the Human Protein Atlas for transcriptomic profiling of NLRP3 in BC. Lipopolysaccharide (LPS) and adenosine 5'-triphosphate (ATP) were used to activate NLRP3 in luminal A MCF-7 and in TNBC MDA-MB-231 and HCC1806 cells. Tamoxifen (Tx), mifepristone (mife), and trastuzumab (Tmab) were used to block ER-α, PR, and HER2, respectively, on inflammasome activation in LPS-primed MCF7 cells. The transcript level of
    MeSH term(s) Female ; Humans ; Adenosine Triphosphate/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Interleukin-8/metabolism ; Lipopolysaccharides ; MCF-7 Cells ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Tamoxifen/pharmacology ; Estrogen Receptor alpha/antagonists & inhibitors ; Estrogen Receptor alpha/metabolism ; Receptors, Progesterone/antagonists & inhibitors ; Receptor, ErbB-2/antagonists & inhibitors ; Estrogen Antagonists/pharmacology
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE) ; Interleukin-8 ; Lipopolysaccharides ; NLR Family, Pyrin Domain-Containing 3 Protein ; Tamoxifen (094ZI81Y45) ; Estrogen Receptor alpha ; Receptors, Progesterone ; Receptor, ErbB-2 (EC 2.7.10.1) ; Estrogen Antagonists
    Language English
    Publishing date 2023-03-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Immunological Perspective for Ebola Virus Infection and Various Treatment Measures Taken to Fight the Disease.

    Jain, Sahil / Khaiboullina, Svetlana F / Baranwal, Manoj

    Pathogens (Basel, Switzerland)

    2020  Volume 9, Issue 10

    Abstract: Ebolaviruses, discovered in 1976, belongs to ... ...

    Abstract Ebolaviruses, discovered in 1976, belongs to the
    Keywords covid19
    Language English
    Publishing date 2020-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9100850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Blocking the Hormone Receptors Modulates NLRP3 in LPS-Primed Breast Cancer Cells

    Shaimaa Hamza / Ekaterina E. Garanina / Mohammad Alsaadi / Svetlana F. Khaiboullina / Gulcin Tezcan

    International Journal of Molecular Sciences, Vol 24, Iss 4846, p

    2023  Volume 4846

    Abstract: NOD-like receptor protein 3 (NLRP3) may contribute to the growth and propagation of breast cancer (BC). The effect of estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) on NLRP3 activation in BC ... ...

    Abstract NOD-like receptor protein 3 (NLRP3) may contribute to the growth and propagation of breast cancer (BC). The effect of estrogen receptor-α (ER-α), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) on NLRP3 activation in BC remains unknown. Additionally, our knowledge of the effect of blocking these receptors on NLRP3 expression is limited. We used GEPIA, UALCAN, and the Human Protein Atlas for transcriptomic profiling of NLRP3 in BC. Lipopolysaccharide (LPS) and adenosine 5′-triphosphate (ATP) were used to activate NLRP3 in luminal A MCF-7 and in TNBC MDA-MB-231 and HCC1806 cells. Tamoxifen (Tx), mifepristone (mife), and trastuzumab (Tmab) were used to block ER-α, PR, and HER2, respectively, on inflammasome activation in LPS-primed MCF7 cells. The transcript level of NLRP3 was correlated with ER-ɑ encoding gene ESR1 in luminal A (ER-α + , PR + ) and TNBC tumors. NLRP3 protein expression was higher in untreated and LPS/ATP-treated MDA-MB-231 cells than in MCF7 cells. LPS/ATP-mediated NLRP3 activation reduced cell proliferation and recovery of wound healing in both BC cell lines. LPS/ATP treatment prevented spheroid formation in MDA-MB-231 cells but did not affect MCF7. HGF, IL-3, IL-8, M-CSF, MCP-1, and SCGF-b cytokines were secreted in both MDA-MB-231 and MCF7 cells in response to LPS/ATP treatment. Tx (ER-α inhibition) promoted NLRP3 activation and increased migration and sphere formation after LPS treatment of MCF7 cells. Tx-mediated activation of NLRP3 was associated with increased secretion of IL-8 and SCGF-b compared to LPS-only-treated MCF7 cells. In contrast, Tmab (Her2 inhibition) had a limited effect on NLRP3 activation in LPS-treated MCF7 cells. Mife (PR inhibition) opposed NLRP3 activation in LPS-primed MCF7 cells. We have found that Tx increased the expression of NLRP3 in LPS-primed MCF7. These data suggest a link between blocking ER-α and activation of NLRP3, which was associated with increased aggressiveness of the ER-α + BC cells.
    Keywords breast cancer ; estrogen receptor alpha ; tamoxifen ; progesterone receptor ; mifepristone ; NLRP3 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 630 ; 616
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Puumala Orthohantavirus Reassortant Genome Variants Likely Emerging in the Watershed Forests.

    Kabwe, Emmanuel / Shamsutdinov, Anton F / Suleimanova, Setora / Martynova, Ekaterina V / Ismagilova, Ruzilya K / Shakirova, Venera G / Savitskaya, Tatiana A / Isaeva, Guzel S / Rizvanov, Albert A / Khaiboullina, Svetlana F / Morzunov, Sergey P / Davidyuk, Yuriy N

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Hemorrhagic fever with renal syndrome (HFRS) remains a prevalent zoonosis in the Republic of Tatarstan (RT), Russian Federation. ...

    Abstract Hemorrhagic fever with renal syndrome (HFRS) remains a prevalent zoonosis in the Republic of Tatarstan (RT), Russian Federation.
    MeSH term(s) Animals ; Humans ; Hemorrhagic Fever with Renal Syndrome/epidemiology ; Puumala virus/genetics ; Zoonoses ; Forests ; Arvicolinae
    Language English
    Publishing date 2023-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Immunological Perspective for Ebola Virus Infection and Various Treatment Measures Taken to Fight the Disease

    Sahil Jain / Svetlana F. Khaiboullina / Manoj Baranwal

    Pathogens, Vol 9, Iss 850, p

    2020  Volume 850

    Abstract: Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known species identified to date. Ebola virus (EBOV) is a member of Zaire ebolavirus ... ...

    Abstract Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known species identified to date. Ebola virus (EBOV) is a member of Zaire ebolavirus species and can cause the Ebola virus disease (EVD), an emerging zoonotic disease that results in homeostatic imbalance and multi-organ failure. There are three EBOV outbreaks documented in the last six years resulting in significant morbidity (> 32,000 cases) and mortality (> 13,500 deaths). The potential factors contributing to the high infectivity of this virus include multiple entry mechanisms, susceptibility of the host cells, employment of multiple immune evasion mechanisms and rapid person-to-person transmission. EBOV infection leads to cytokine storm, disseminated intravascular coagulation, host T cell apoptosis as well as cell mediated and humoral immune response. In this review, a concise recap of cell types targeted by EBOV and EVD symptoms followed by detailed run-through of host innate and adaptive immune responses, virus-driven regulation and their combined effects contributing to the disease pathogenesis has been presented. At last, the vaccine and drug development initiatives as well as challenges related to the management of infection have been discussed.
    Keywords T-cell immunity ; bystander apoptosis ; cytokines response ; host immune evasion ; Ebola vaccines ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Inter-library loan at ZB MED

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  9. Article: Immunological Perspective for Ebola Virus Infection and Various Treatment Measures Taken to Fight the Disease

    Jain, Sahil / Khaiboullina, Svetlana F / Baranwal, Manoj

    Pathogens. 2020 Oct. 17, v. 9, no. 10

    2020  

    Abstract: Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known species identified to date. Ebola virus (EBOV) is a member of Zaire ebolavirus ... ...

    Abstract Ebolaviruses, discovered in 1976, belongs to the Filoviridae family, which also includes Marburg and Lloviu viruses. They are negative-stranded RNA viruses with six known species identified to date. Ebola virus (EBOV) is a member of Zaire ebolavirus species and can cause the Ebola virus disease (EVD), an emerging zoonotic disease that results in homeostatic imbalance and multi-organ failure. There are three EBOV outbreaks documented in the last six years resulting in significant morbidity (>32,000 cases) and mortality (>13,500 deaths). The potential factors contributing to the high infectivity of this virus include multiple entry mechanisms, susceptibility of the host cells, employment of multiple immune evasion mechanisms and rapid person-to-person transmission. EBOV infection leads to cytokine storm, disseminated intravascular coagulation, host T cell apoptosis as well as cell mediated and humoral immune response. In this review, a concise recap of cell types targeted by EBOV and EVD symptoms followed by detailed run-through of host innate and adaptive immune responses, virus-driven regulation and their combined effects contributing to the disease pathogenesis has been presented. At last, the vaccine and drug development initiatives as well as challenges related to the management of infection have been discussed.
    Keywords T-lymphocytes ; Zaire Ebola virus ; administrative management ; apoptosis ; coagulation ; cytokines ; drug development ; employment ; humoral immunity ; immune evasion ; infection ; morbidity ; mortality ; pathogenesis ; pathogenicity ; pathogens ; vaccines ; viruses ; zoonoses
    Language English
    Dates of publication 2020-1017
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens9100850
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Identification of conserved immunogenic peptides of SARS-CoV-2 nucleocapsid protein.

    Verma, Jigyasa / Kaushal, Neha / Manish, Manish / Subbarao, Naidu / Shakirova, Venera / Martynova, Ekaterina / Liu, Rongzeng / Hamza, Shaimaa / Rizvanov, Albert A / Khaiboullina, Svetlana F / Baranwal, Manoj

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–17

    Abstract: The emergence of the new SARS-CoV-2 variants has led to major concern regarding the efficacy of approved vaccines. Nucleocapsid is a conserved structural protein essential for replication of the virus. This study focuses on identifying conserved epitopes ...

    Abstract The emergence of the new SARS-CoV-2 variants has led to major concern regarding the efficacy of approved vaccines. Nucleocapsid is a conserved structural protein essential for replication of the virus. This study focuses on identifying conserved epitopes on the nucleocapsid (N) protein of SARS-CoV-2. Using 510 unique amino acid sequences of SARS-CoV-2 N protein, two peptides (193 and 215 aa) with 90% conservancy were selected for T cell epitope prediction. Three immunogenic peptides containing multiple T cell epitopes were identified which were devoid of autoimmune and allergic immune response. These peptides were also conserved (100%) in recent Omicron variants reported in Jan-August 2023. HLA analysis reveals that these peptides are predicted as binding to large number of HLA alleles and 71-90% population coverage in six continents. Identified peptides displayed good binding score with both HLA class I and HLA class II molecules in the docking study. Also, a vaccine construct docked with TLR-4 receptor displays strong interaction with 20 hydrogen bonds and molecular simulation analysis reveals that docked complex are stable. Additionally, the immunogenicity of these N protein peptides was confirmed using SARS-CoV-2 convalescent serum samples. We conclude that the identified N protein peptides contain highly conserved and antigenic epitopes which could be used as a target for the future vaccine development against SARS-CoV-2.Communicated by Ramaswamy H. Sarma.
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2260484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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