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Book ; Online: Advancements in Biomass Recalcitrance: The Use of Lignin for the Production of Fuels and Chemicals

Yoo, Chang Geun / Ragauskas, Arthur J.

2019

Keywords	Biotechnology ; Engineering (General). Civil engineering (General)
Size	1 electronic resource (103 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020101979
ISBN	9782889457069 ; 2889457060
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Seasonal Testing, Results, and Effect of the Pandemic on Coxsackievirus Serum Studies.

Kordi, Ramesh / Chang, Arthur J / Hicar, Mark D

Microorganisms

2024 Volume 12, Issue 2

Abstract: Coxsackieviruses (CVs) are common causes of infections and can be life-threatening. Unfortunately, rigorous studies guiding the clinician in interpreting CV serum antibody titer testing is lacking. To explore the epidemiology of circulating CVs and the ... ...

Abstract	Coxsackieviruses (CVs) are common causes of infections and can be life-threatening. Unfortunately, rigorous studies guiding the clinician in interpreting CV serum antibody titer testing is lacking. To explore the epidemiology of circulating CVs and the serological test utility in aiding diagnosis of CV infections in our community, we obtained results of CV immunologic diagnostic tests between 2018 and 2022 from a regional healthcare database. For CV type A, rare individuals had positive CF (complement fixation) tests whereas all 16 individuals with IFA testing showed at least one positive serotype. For CV type B CF testing, 52.2% of 222 patients had at least one serotype positive, with B5 being most common and also the most common with higher titers (14.8% with ≥1:32). We found a significant reduction in seropositivity rate during the pandemic in 2020 compared to 2018, which continued through 2022 (OR: 0.2, 95% CI: 0.08-0.49,
Language	English
Publishing date	2024-02-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12020367
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Robust humoral immune response after boosting in children with Multisystem Inflammatory Syndrome in Children.

Chang, Arthur J / Baron, Sarah / Hicar, Mark D

IDCases

2022 Volume 29, Page(s) e01569

Abstract: The exact pathogenesis of Multisystem Inflammatory Syndrome in Children (MIS-C) is unknown. Reports on response to vaccination in children who had MIS-C are lacking. Using prospectively enrolled children, we report on humoral immune responses prior to ... ...

Abstract	The exact pathogenesis of Multisystem Inflammatory Syndrome in Children (MIS-C) is unknown. Reports on response to vaccination in children who had MIS-C are lacking. Using prospectively enrolled children, we report on humoral immune responses prior to and after SARS-CoV-2 immune rechallenge. Recurrent auricular chondritis was also noted in one child.
Language	English
Publishing date	2022-07-13
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2022.e01569
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Article ; Online: Cholangiocytes express an isoform of soluble adenylyl cyclase that is N-linked glycosylated and secreted in extracellular vesicles.

Go, Simei / Li, Hang Lam / Chang, Jung-Chin / Verhoeven, Arthur J / Elferink, Ronald P J Oude

Traffic (Copenhagen, Denmark)

2023 Volume 24, Issue 9, Page(s) 413–430

Abstract: Soluble adenylyl cyclase (sAC)-derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels remains underexplored. We consistently observed a 85 kD ( ... ...

Abstract	Soluble adenylyl cyclase (sAC)-derived cAMP regulates various cellular processes; however, the regulatory landscape mediating sAC protein levels remains underexplored. We consistently observed a 85 kD (sAC
MeSH term(s)	Adenylyl Cyclases/metabolism ; Epithelial Cells/metabolism ; Protein Isoforms ; Glucose/metabolism ; Extracellular Vesicles/metabolism
Chemical Substances	Adenylyl Cyclases (EC 4.6.1.1) ; Protein Isoforms ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-06-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483852-7
ISSN	1600-0854 ; 1398-9219
ISSN (online)	1600-0854
ISSN	1398-9219
DOI	10.1111/tra.12904
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Article ; Online: Decreased Clinical Severity of Pediatric Acute COVID-19 and MIS-C and Increase of Incidental Cases during the Omicron Wave in Comparison to the Delta Wave.

Kenney, Patrick O / Chang, Arthur J / Krabill, Lorna / Hicar, Mark D

Viruses

2023 Volume 15, Issue 1

Abstract: This study describes differences in clinical presentation in hospitalized children with acute COVID-19 and MIS-C between the Delta and Omicron (BA.1.1) waves in a tertiary children's hospital. This retrospective cohort study with case adjudication of ... ...

Abstract	This study describes differences in clinical presentation in hospitalized children with acute COVID-19 and MIS-C between the Delta and Omicron (BA.1.1) waves in a tertiary children's hospital. This retrospective cohort study with case adjudication of hospitalized children with SARS-CoV-2-positive testing or MIS-C diagnosis occurred during the Delta and Omicron waves, from August 2021 until February 2022. There were no differences noted by race, but both waves disproportionally affected black children (24% and 25%). Assigned by a three-person expert panel, incidental diagnoses were higher in the Omicron wave (34% versus 19%). Hospitalization rates of non-incidental cases were higher during Omicron (3.8 versus 5.9 per 1000 PCR-positive community cases). Respiratory-related admissions were prominent during Delta, while Omicron clinical presentations varied, including a high number of cases of croup and seizures. Length of stay and ICU use during Omicron was significantly less than Delta for MIS-C and acute cases. Estimation of vaccination efficacy for preventing hospital admissions was 85.1-91.7% in the early Omicron period. Our estimates suggest that a protective role for vaccination continues into the Omicron wave. The high rate of incidental cases during the Omicron wave should be considered when reviewing more cursory summative data sets. This study emphasizes the need for continued clinical suspicion of COVID-19 even when lower respiratory symptoms are not dominant.
MeSH term(s)	Humans ; Child ; COVID-19/diagnosis ; COVID-19/epidemiology ; Retrospective Studies ; SARS-CoV-2 ; Black People
Language	English
Publishing date	2023-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15010180
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Article ; Online: Identifying Key Financial, Environmental, Social, Governance (ESG), Bond, and COVID-19 Factors Affecting Global Shipping Companies—A Hybrid Multiple-Criteria Decision-Making Method

Arthur J. Lin / Hai-Yen Chang / Brian Hung

Sustainability, Vol 14, Iss 5148, p

2022 Volume 5148

Abstract: The international shipping industry is the largest transportation system in the world. However, shipping stock prices were highly volatile during the 2020–2021 COVID-19 pandemic. The purpose of this study is to identify the causal relationships of the ... ...

Abstract	The international shipping industry is the largest transportation system in the world. However, shipping stock prices were highly volatile during the 2020–2021 COVID-19 pandemic. The purpose of this study is to identify the causal relationships of the four dimensions (financial performance, bond financing, environmental, social, governance, and COVID-19) and 20 criteria affecting the sustainability of global shipping companies. The research scope includes a sample of nine listed international shipping companies accounting for 49% of the global market share with data collected from 2010 to 2020. Survey responses from 15 investment experts were also obtained. We applied a hybrid multiple criteria decision-making (MCDM) method integrating the Decision-Making Trial and Evaluation Laboratory (DEMATEL), analytic network process, and modified VlseKriterijumska Optimizacija I Kompromisno techniques to be the DANP-mV model to identify the causal relationships among the dimensions and criteria, providing ways of narrowing the performance gaps of shipping companies. The results indicate that financial performance is the main cause affecting COVID-19 and ESG practices. The ESG practices influence bond financing. The largest performance gaps across shipping companies include earnings per share (EPS), yield to maturity, corporate social responsibility (CSR), and timely delivery. The findings of this study suggest that shipping companies may focus on gross profit margin to improve EPS, term to maturity to enhance yield to maturity, social distancing policy to meet timely delivery, and the board size to enhance corporate social responsibility (CSR). The outcome of this study aids shipping companies in prioritizing their resources and investors in selecting shipping company stocks in response to COVID-19.
Keywords	shipping company ; financial performance ; COVID-19 ; ESG ; bond financing ; multiple-criteria decision making ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	650
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clonal expansion and markers of directed mutation of IGHV4-34 B cells in plasmablasts during Kawasaki disease.

Chang, Arthur J / Baron, Sarah / Hoffman, Jonathon / Hicar, Mark D

Molecular immunology

2022 Volume 145, Page(s) 67–77

Abstract: Kawasaki disease (KD) is the leading cause of acquired heart disease in children. The cause remains unknown; however, epidemiologic and demographic data support a single preceding infectious agent may lead to KD. A variety of pathophysiologic responses ... ...

Abstract	Kawasaki disease (KD) is the leading cause of acquired heart disease in children. The cause remains unknown; however, epidemiologic and demographic data support a single preceding infectious agent may lead to KD. A variety of pathophysiologic responses have been proposed, including direct invasion of the coronary arteries, a superantigen response, and a post-infectious autoimmune phenomenon. A role for B cell responses during KD are supported by numerous findings including B cell specific markers identified in genome wide association studies. We have recently published data showing children with KD have similar plasmablast (PB) responses to children with infections. Since during other infections, cells expressing antibodies against the preceding infection are enriched in PBs, we sought to explore the specific antibodies encoded by PBs during KD. In one child we see a massive expansion in IGHV4-34 utilizing antibodies, which has been associated with autoimmunity in the past. We further explored this expansion of IGHV4-34 utilization during the peripheral PB rise with next generation sequencing (NGS) analysis and utilizing newer techniques of chromium chip single cell separation (10x Genomics®). We also utilized peptide array screening to attempt to identify an antigen to the most prolific clones.
MeSH term(s)	Antibodies/genetics ; B-Lymphocytes ; Biomarkers ; Child ; Genome-Wide Association Study ; Humans ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/genetics ; Mutation ; Plasma Cells
Chemical Substances	Antibodies ; Biomarkers
Language	English
Publishing date	2022-03-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2022.03.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mice Regulate Dietary Amino Acid Balance and Energy Intake by Selecting between Complementary Protein Sources.

Zaman, Kamrul / Mun, Hee-Chang / Solon-Biet, Samantha M / Senior, Alistair M / Raubenheimer, David / Simpson, Stephen J / Conigrave, Arthur D

The Journal of nutrition

2024

Abstract: Background: A balanced intake of protein and constituent amino acids (AAs) requires adjustments to total food intake (protein leverage [PL]) and food selection to balance deficits and excesses (complementary feeding). We provided mice with choices of ... ...

Abstract	Background: A balanced intake of protein and constituent amino acids (AAs) requires adjustments to total food intake (protein leverage [PL]) and food selection to balance deficits and excesses (complementary feeding). We provided mice with choices of casein and whey, 2 protein sources that are complementary in AA balance, across a range of protein concentrations (P%) of digestible energy (DE). Objectives: We aimed to determine if: 1) PL operates similarly for casein and whey; 2) one protein source is preferred at control P%; 3) the preference changes as P% falls; and 4) AA intakes under control and low P% levels identify AAs that drive changes in protein selection. Methods: Food intake and plasma fibroblast growth factor-21 (FGF21) concentrations were measured in mice at various P% (P7.5%-P33%). For direct comparisons, defined diets were used in which the protein source was either casein or whey. In food choice studies, mice had access to foods in which both casein and whey were provided at the same P% level at the same time. Results: PL operated at different P% thresholds in casein (13%)- and whey (10%)-based diets, and the magnitude of PL was greater for casein. Although mice preferred casein under control conditions (P23%), a pronounced preference shift to whey occurred as P% fell to P13% and P10%. At low P%, increases in food intake were accompanied by increases in plasma FGF21, a protein hunger signal. Among AAs deficient in casein and enriched in whey, the intake of Cys was the most invariant as P% changed between P23% and P10%, appearing to drive the switch in protein preference. Conclusions: Mice selected between complementary protein sources, casein and whey, achieving stable total energy intake and regulated intake of AAs as P% varied. Supplementation of low P% casein diets with one whey-enriched AA, Cys, suppressed plasma FGF21 and total food intake.
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	218373-0
ISSN	1541-6100 ; 0022-3166
ISSN (online)	1541-6100
ISSN	0022-3166
DOI	10.1016/j.tjnut.2024.04.007
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Article ; Online: Opposite regulation of glycogen metabolism by cAMP produced in the cytosol and at the plasma membrane.

Bizerra, Paulo F V / Gilglioni, Eduardo H / Li, Hang Lam / Go, Simei / Oude Elferink, Ronald P J / Verhoeven, Arthur J / Chang, Jung-Chin

Biochimica et biophysica acta. Molecular cell research

2023 Volume 1871, Issue 1, Page(s) 119585

Abstract: Cyclic AMP is produced in cells by two different types of adenylyl cyclases: at the plasma membrane by the transmembrane adenylyl cyclases (tmACs, ADCY1~ADCY9) and in the cytosol by the evolutionarily more conserved soluble adenylyl cyclase (sAC, ADCY10). ...

Abstract	Cyclic AMP is produced in cells by two different types of adenylyl cyclases: at the plasma membrane by the transmembrane adenylyl cyclases (tmACs, ADCY1~ADCY9) and in the cytosol by the evolutionarily more conserved soluble adenylyl cyclase (sAC, ADCY10). By employing high-resolution extracellular flux analysis in HepG2 cells to study glycogen breakdown in real time, we showed that cAMP regulates glycogen metabolism in opposite directions depending on its location of synthesis within cells and the downstream cAMP effectors. While the canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, we demonstrate here that the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. Mechanistically, suppression of sAC-cAMP-Epac1 leads to Ser-15 phosphorylation and thereby activation of the liver-form glycogen phosphorylase to promote glycogenolysis. Our findings highlight the importance of cAMP microdomain organization for distinct metabolic regulation and establish sAC as a novel regulator of glycogen metabolism.
MeSH term(s)	Adenylyl Cyclases/genetics ; Adenylyl Cyclases/metabolism ; Cytosol/metabolism ; Glycogenolysis ; Cell Membrane/genetics ; Cell Membrane/metabolism ; Glycogen/metabolism
Chemical Substances	Adenylyl Cyclases (EC 4.6.1.1) ; Glycogen (9005-79-2)
Language	English
Publishing date	2023-09-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbamcr.2023.119585
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Article: Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells.

Cepika, Alma-Martina / Amaya, Laura / Waichler, Colin / Narula, Mansi / Mantilla, Michelle M / Thomas, Benjamin C / Chen, Pauline P / Freeborn, Robert Arthur / Pavel-Dinu, Mara / Nideffer, Jason / Porteus, Matthew / Bacchetta, Rosa / Müller, Fabian / Greenleaf, William J / Chang, Howard Y / Roncarolo, Maria Grazia

bioRxiv : the preprint server for biology

2024

Abstract: Human adaptive immunity is orchestrated by effector and regulatory T (Treg) cells. Natural Tregs arise in the thymus where they are shaped to recognize self-antigens, while type 1 Tregs or Tr1 cells are induced from conventional peripheral ... ...

Abstract	Human adaptive immunity is orchestrated by effector and regulatory T (Treg) cells. Natural Tregs arise in the thymus where they are shaped to recognize self-antigens, while type 1 Tregs or Tr1 cells are induced from conventional peripheral CD4
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.07.582969
Database	MEDical Literature Analysis and Retrieval System OnLINE

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