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  1. Article: Case Report: Acute Splenic Artery Thrombosis in a COVID 19, Postpartum Patient.

    Trancǎ, Sebastian Daniel / Antal, Oana / Farcaş, Anca Daniela

    Frontiers in medicine

    2021  Volume 8, Page(s) 698627

    Abstract: The incidence of thromboembolic disease is reported to be high in SARS- ... ...

    Abstract The incidence of thromboembolic disease is reported to be high in SARS-CoV
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.698627
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  2. Article ; Online: Case Report

    Sebastian Daniel Trancǎ / Oana Antal / Anca Daniela Farcaş

    Frontiers in Medicine, Vol

    Acute Splenic Artery Thrombosis in a COVID 19, Postpartum Patient

    2021  Volume 8

    Abstract: The incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease. Pregnancy, an already physiologically hypercoagulable state, associated to COVID 19, generates even more concern regarding the potentially increased risk of thrombotic ... ...

    Abstract The incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease. Pregnancy, an already physiologically hypercoagulable state, associated to COVID 19, generates even more concern regarding the potentially increased risk of thrombotic events. The exact incidence of such complications is yet unknown, but there is data suggesting that coagulopathy and thromboembolism are both increased in pregnancies affected by COVID-19. Since the outbreak of the COVID 19 pandemics, the most common described thrombotic events associated with SARS-COV2 infection have been venous thromboembolism and disseminated intravascular coagulation, while arterial thrombotic events are less commonly described. Splenic infarction is a rare disorder that can be secondary to a hypercoagulable state. There are only few cases of splenic infraction described, but none with splenic artery thrombosis, in a post-partum patient, on therapeutic anticoagulation regimen. We present the case of a 31-year-old Caucasian, 26 weeks pregnant woman, with no prior medical history, admitted to the hospital with a severe form of COVID 19 pneumonia and who, during the course of the disease, developed a massive splenic infarction with splenic artery thrombosis.
    Keywords splenic artery thrombosis ; splenic infarction ; post-partum ; COVID 19 complications ; case report ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Macrophage activation syndrome: A diagnostic challenge (Review).

    Bojan, Anca / Parvu, Andrada / Zsoldos, Iulia-Andrea / Torok, Tunde / Farcas, Anca Daniela

    Experimental and therapeutic medicine

    2021  Volume 22, Issue 2, Page(s) 904

    Abstract: Macrophage activation syndrome (MAS) represents an acute and severe inflammatory syndrome, idiopathic (primary) or secondary to infections, rheumatic diseases, malignancies, or drugs. MAS is underdiagnosed, being confused with sepsis, adverse effects of ... ...

    Abstract Macrophage activation syndrome (MAS) represents an acute and severe inflammatory syndrome, idiopathic (primary) or secondary to infections, rheumatic diseases, malignancies, or drugs. MAS is underdiagnosed, being confused with sepsis, adverse effects of anti-arthritic drugs or exacerbated symptoms of evolving rheumatologic or infectious diseases. Because of the late diagnosis, most patients do not benefit from effective therapy, leading to death. Elucidation of valid early diagnostic criteria of MAS would be a particularly important step in reducing the mortality due to this pathology. Thus, the purpose of this review based on 40 studies centered on the diagnostic criteria of MAS. We detailed the main diagnostic criteria and the few diagnostic scores or sets of criteria that have been recently published. The criteria most frequently encountered in the literature include: Fever, hepatosplenomegaly, hyperferritinemia, hepatopathy, coagulopathy, thrombocytopenia, hypertriglyceridemia, decrease in erythrocyte sedimentation rate and bone marrow hemophagocytosis. The most elaborate diagnostic score will result following an ongoing international project and consensus, the Delphi International Survey.
    Language English
    Publishing date 2021-06-24
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.10336
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Modern markers for evaluating bone disease in multiple myeloma (Review).

    Pop, Vlad / Parvu, Andrada / Craciun, Alexandra / Farcas, Anca Daniela / Tomoaia, Gheorghe / Bojan, Anca

    Experimental and therapeutic medicine

    2021  Volume 22, Issue 5, Page(s) 1329

    Abstract: Multiple myeloma (MM) is a bone marrow neoplasia with increasing incidence compared to previous years. Although new therapeutic molecules have been introduced, it remains an incurable disease with severe repercussions to patients. For many patients, bone ...

    Abstract Multiple myeloma (MM) is a bone marrow neoplasia with increasing incidence compared to previous years. Although new therapeutic molecules have been introduced, it remains an incurable disease with severe repercussions to patients. For many patients, bone disease represents a severe problem often causing pain, pathological bone fractures, and spinal cord compression, which affects the quality of life. This article analyzes the main markers of bone destruction in MM as well as risk factors for severe bone damage. Bone complications have a negative impact on the quality of life of patients with MM, along with other associated complications (renal failure, hypogammaglobulinemia, osteolytic bone disease, hypercalcemia, anemia). The markers of bone destruction described in this article include: interleukin (IL)-6, tumor necrosis factor (TNF)-α, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), amino- and carboxy-terminal cross-linking telopeptide of type I collagen (NTX, CTX), human bone sialoprotein (BSP) and dickkopf-1 secreted glycoprotein (DKK1). The future practical applicability of this literature review would be the large-scale determination of markers of bone destruction that correlate with the negative evolution to complications of bone disease or the implications that these markers have in regards to treatment.
    Language English
    Publishing date 2021-09-20
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 2683844-8
    ISSN 1792-1015 ; 1792-0981
    ISSN (online) 1792-1015
    ISSN 1792-0981
    DOI 10.3892/etm.2021.10764
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Severe Thrombocytopenia as a Manifestation of COVID-19 Infection

    Mihaela Mocan / Roxana Mihaela Chiorescu / Andrada Tirnovan / Botond Sandor Buksa / Anca Daniela Farcaș

    Journal of Clinical Medicine, Vol 11, Iss 1088, p

    2022  Volume 1088

    Abstract: Clinical manifestations of COVID-19 infection can range from an asymptomatic clinical form to acute respiratory distress depending on the virus gateway, viral load, host immunity, and existing comorbidities. Some patients with COVID-19 infection can ... ...

    Abstract Clinical manifestations of COVID-19 infection can range from an asymptomatic clinical form to acute respiratory distress depending on the virus gateway, viral load, host immunity, and existing comorbidities. Some patients with COVID-19 infection can present hematological changes depending on the patient’s immune response and the severity of the infection. We present two different manifestations of thrombotic disorders related to COVID-19: one severe form of immune thrombocytopenia in a young woman with no comorbidities and a severe form of thrombocytopenia along with disseminated intravascular coagulation and acute urinary obstructive disease. Interestingly, both patients presented no signs of COVID-19 pneumonia. Failure to diagnose thrombocytopenia rapidly may lead to severe complications. Management with immunosuppressive corticosteroids in high doses should carefully balance the risk of bleeding versus deterioration due to infection.
    Keywords severe thrombocytopenia ; COVID-19 infection ; disseminated intravascular coagulation ; Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Severe Thrombocytopenia as a Manifestation of COVID-19 Infection.

    Mocan, Mihaela / Chiorescu, Roxana Mihaela / Tirnovan, Andrada / Buksa, Botond Sandor / Farcaș, Anca Daniela

    Journal of clinical medicine

    2022  Volume 11, Issue 4

    Abstract: Clinical manifestations of COVID-19 infection can range from an asymptomatic clinical form to acute respiratory distress depending on the virus gateway, viral load, host immunity, and existing comorbidities. Some patients with COVID-19 infection can ... ...

    Abstract Clinical manifestations of COVID-19 infection can range from an asymptomatic clinical form to acute respiratory distress depending on the virus gateway, viral load, host immunity, and existing comorbidities. Some patients with COVID-19 infection can present hematological changes depending on the patient's immune response and the severity of the infection. We present two different manifestations of thrombotic disorders related to COVID-19: one severe form of immune thrombocytopenia in a young woman with no comorbidities and a severe form of thrombocytopenia along with disseminated intravascular coagulation and acute urinary obstructive disease. Interestingly, both patients presented no signs of COVID-19 pneumonia. Failure to diagnose thrombocytopenia rapidly may lead to severe complications. Management with immunosuppressive corticosteroids in high doses should carefully balance the risk of bleeding versus deterioration due to infection.
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11041088
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  7. Article ; Online: ACE2 and Apelin-13: Biomarkers with a Prognostic Value in Congestive Heart Failure.

    Goidescu, Cerasela Mihaela / Chiorescu, Roxana Mihaela / Diana, Mocan-Hognogi Larisa / Mocan, Mihaela / Stoia, Mirela Anca / Anton, Florin Petru / Farcaş, Anca Daniela

    Disease markers

    2021  Volume 2021, Page(s) 5569410

    Abstract: The progression of heart failure is the result of the interaction of several pathogenetic processes that involve the activation of biomarkers belonging to the renin angiotensin aldosterone system (RAAS), to its counterregulatory mechanisms, to the ... ...

    Abstract The progression of heart failure is the result of the interaction of several pathogenetic processes that involve the activation of biomarkers belonging to the renin angiotensin aldosterone system (RAAS), to its counterregulatory mechanisms, to the sympathetic nervous system and inflammation, and to oxidative stress. This study is aimed at determining the prognostic role of biomarkers in the evolution of patients with heart failure. These biomarkers are representative of different pathogenetic pathways involved in the progression of heart failure and the possible interrelationships between them and heart remodelling.
    MeSH term(s) Adult ; Aged ; Angiotensin-Converting Enzyme 2/blood ; Apelin/blood ; Biomarkers/blood ; Female ; Follow-Up Studies ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/mortality ; Humans ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prognosis ; Prospective Studies ; ROC Curve
    Chemical Substances APLN protein, human ; Apelin ; Biomarkers ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 604951-5
    ISSN 1875-8630 ; 0278-0240
    ISSN (online) 1875-8630
    ISSN 0278-0240
    DOI 10.1155/2021/5569410
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1856: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
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  8. Article ; Online: Arguments for Using Direct Oral Anticoagulants in Cancer-Related Venous Thromboembolism

    Roxana Mihaela Chiorescu / Mihaela Mocan / Mirela Anca Stoia / Anamaria Barta / Cerasela Mihaela Goidescu / Stefan Chiorescu / Anca Daniela Farcaş

    Healthcare, Vol 9, Iss 1287, p

    2021  Volume 1287

    Abstract: 1) Background: Patients with cancer with a hypercoagulable state present an increased incidence of venous thromboembolism (VTE). Neoplastic patients with concurrent VTE undergoing anticoagulant treatment face a series of issues. (2) The aim of the ... ...

    Abstract (1) Background: Patients with cancer with a hypercoagulable state present an increased incidence of venous thromboembolism (VTE). Neoplastic patients with concurrent VTE undergoing anticoagulant treatment face a series of issues. (2) The aim of the present paper is to systematically summarize current VTE management in patients with neoplasia and to review the current clinical evidence from meta-analyses of randomized controlled trials and guidelines regarding the administration of direct oral anticoagulants (DOACs) for cancer-associated VTE. (3) Search Strategy: We performed a review on meta-analyses of randomized controlled trials and guidelines in favor of the administration of DOACs in patients with cancer-associated VTE published in the last 6 years in the Medline (PubMed) and Embase databases. (4) Results: 21 meta-analyses, 14 randomized controlled studies comparing DOACs to VKAs and LMWH, and 7 national and international guidelines were identified. We identified five studies that show the antineoplastic effect of DOAC on experimental models. (5) Conclusions: DOACs can be seen as the first choice for VTE treatment in neoplastic patients who have a low risk of bleeding, who do not have severe renal impairment, and who are not undergoing treatments that could interact with DOAC’s mechanism of action.
    Keywords direct oral anticoagulants ; cancer-associated venous thromboembolism ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: U-Healthcare Solution for Monitoring Heart Failure

    Anca Daniela FĂRCAȘ / Florin Petru ANTON / Cristian BOLOGA / Lucia RUSU

    Journal of Applied Computer Science & Mathematics, Vol 14, Iss 2, Pp 28-

    2020  Volume 32

    Abstract: Healthcare system evolved past two decades from e-health to m-health and nowadays u-healthcare systems which ubiquitous technologies in the medical field. The aim of this paper is to offer an architecture solution for Ill Heart care Ubiquitous Platform, ... ...

    Abstract Healthcare system evolved past two decades from e-health to m-health and nowadays u-healthcare systems which ubiquitous technologies in the medical field. The aim of this paper is to offer an architecture solution for Ill Heart care Ubiquitous Platform, called Heart@Mo. This solution is focused on monitoring ambulatory treatment of chronical heart patients using most common and suitable solution on wearables technology and mobile devices as main tools in data exchange between patients and physician specialists.
    Keywords u-health ; m-health ; heart failure ; patient monitoring ; Mathematics ; QA1-939 ; Electronic computers. Computer science ; QA75.5-76.95
    Language English
    Publishing date 2020-07-01T00:00:00Z
    Publisher Stefan cel Mare University of Suceava
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Biochemical and Histo-Anatomical Responses of

    Tanase, Corneliu / Ștefănescu, Ruxandra / Darkó, Béla / Muntean, Daniela Lucia / Fărcaş, Anca Corina / Socaci, Sonia Ancuţa

    Plants (Basel, Switzerland)

    2020  Volume 9, Issue 7

    Abstract: This paper aims to assess the biological responses ... ...

    Abstract This paper aims to assess the biological responses of
    Language English
    Publishing date 2020-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants9070859
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