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  1. Article: Effect of Small and Large Energy Surpluses on Strength, Muscle, and Skinfold Thickness in Resistance-Trained Individuals: A Parallel Groups Design.

    Helms, Eric R / Spence, Alyssa-Joy / Sousa, Colby / Kreiger, James / Taylor, Steve / Oranchuk, Dustin J / Dieter, Brad P / Watkins, Casey M

    Sports medicine - open

    2023  Volume 9, Issue 1, Page(s) 102

    Abstract: Background: Many perform resistance training (RT) to increase muscle mass and strength. Energy surpluses are advised to support such gains; however, if too large, could cause unnecessary fat gain. We randomized 21 trained lifters performing RT 3 d/wk ... ...

    Abstract Background: Many perform resistance training (RT) to increase muscle mass and strength. Energy surpluses are advised to support such gains; however, if too large, could cause unnecessary fat gain. We randomized 21 trained lifters performing RT 3 d/wk for eight weeks into maintenance energy (MAIN), moderate (5% [MOD]), and high (15% [HIGH]) energy surplus groups to determine if skinfold thicknesses (ST), squat and bench one-repetition maximum (1-RM), or biceps brachii, triceps brachii, or quadriceps muscle thicknesses (MT) differed by group. COVID-19 reduced our sample, leaving 17 completers. Thus, in addition to Bayesian ANCOVA comparisons, we analyzed changes in body mass (BM) with ST, 1-RM, and MT changes via regression. We reported Bayes factors (BF
    Results: ANCOVAs provided no evidence supporting the group model for MT or squat 1-RM. However, moderate (BF
    Conclusions: While some group-based differences were found, our larger N regression provides the most generalizable evidence. Therefore, we conclude faster rates of BM gain (and by proxy larger surpluses) primarily increase rates of fat gain rather than augmenting 1-RM or MT. However, biceps brachii, the muscle which received the greatest stimulus in this study, may have been positively impacted by greater BM gain, albeit slightly. Our findings are limited to the confines of this study, where a group of lifters with mixed training experience performed moderate volumes 3 d/wk for 8 weeks. Thus, future work is needed to evaluate the relationship between BM gains, increases in ST and RT adaptations in other contexts.
    Language English
    Publishing date 2023-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2809942-4
    ISSN 2198-9761 ; 2199-1170
    ISSN (online) 2198-9761
    ISSN 2199-1170
    DOI 10.1186/s40798-023-00651-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dietary strategies for cardiovascular health.

    Dieter, Brad P / Tuttle, Katherine R

    Trends in cardiovascular medicine

    2017  Volume 27, Issue 5, Page(s) 295–313

    Abstract: Cardiovascular disease is developed across a lifetime accumulation of risk. Numerous independent and synergistic cardiovascular risk factors can be induced by unhealthy dietary patterns. Epidemiological, mechanistic, clinical, and translational research ... ...

    Abstract Cardiovascular disease is developed across a lifetime accumulation of risk. Numerous independent and synergistic cardiovascular risk factors can be induced by unhealthy dietary patterns. Epidemiological, mechanistic, clinical, and translational research point to refined sugars, processed and fatty meats, synthetic oils, and sodium as major dietary risk factors. The purpose of this review is to integrate these learnings into key principles for dietary frameworks aimed at improving overall cardiovascular health.
    MeSH term(s) Animals ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Diet/adverse effects ; Disease-Free Survival ; Feeding Behavior ; Female ; Healthy Diet ; Humans ; Male ; Nutritional Status ; Nutritive Value ; Protective Factors ; Recommended Dietary Allowances ; Risk Factors ; Risk Reduction Behavior
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2016.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The data do not seem to support a benefit to BCAA supplementation during periods of caloric restriction.

    Dieter, Brad P / Schoenfeld, Brad Jon / Aragon, Alan A

    Journal of the International Society of Sports Nutrition

    2016  Volume 13, Page(s) 21

    Abstract: J Int Soc Sports Nutr 13:1-015-0112-9, 2016 describe the efficacy of branched chain amino acid (BCAA) supplementation and resistance training for maintaining lean body mass during a calorie-restricted diet, and claim that this occurs with concurrent ... ...

    Abstract J Int Soc Sports Nutr 13:1-015-0112-9, 2016 describe the efficacy of branched chain amino acid (BCAA) supplementation and resistance training for maintaining lean body mass during a calorie-restricted diet, and claim that this occurs with concurrent losses in fat mass. However, the reported results appear to be at odds with the data presented on changes in fat mass. This letter discusses the issues with the paper.
    MeSH term(s) Amino Acids, Branched-Chain/administration & dosage ; Body Composition ; Caloric Restriction/methods ; Dietary Supplements ; Humans ; Resistance Training
    Chemical Substances Amino Acids, Branched-Chain
    Language English
    Publishing date 2016-05-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2162810-5
    ISSN 1550-2783 ; 1550-2783
    ISSN (online) 1550-2783
    ISSN 1550-2783
    DOI 10.1186/s12970-016-0128-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: GLP-1 receptor agonists in diabetic kidney disease: from the patient-side to the bench-side.

    Dieter, Brad P / Alicic, Radica Z / Tuttle, Katherine R

    American journal of physiology. Renal physiology

    2018  Volume 315, Issue 6, Page(s) F1519–F1525

    Abstract: Diabetic kidney disease (DKD), one of the most common and severe microvascular complications of diabetes, is the leading cause of chronic kidney disease and end-stage kidney disease worldwide. Since the development of renin-angiotensin system inhibition ... ...

    Abstract Diabetic kidney disease (DKD), one of the most common and severe microvascular complications of diabetes, is the leading cause of chronic kidney disease and end-stage kidney disease worldwide. Since the development of renin-angiotensin system inhibition nearly three decades ago, no new therapeutic agents have received regulatory approval for treatment of DKD. Glucagon-like peptide-1 (GLP-1) receptor agonists, a class of newer antihyperglycemic agents, have shown promise for prevention of DKD onset and progression. This perspective summarizes clinical and experimental observations to give insight into biological mechanisms beyond glycemic control, such as natriuresis and anti-inflammatory actions, for preservation of kidney function in patients with diabetes.
    MeSH term(s) Animals ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Diabetic Nephropathies/physiopathology ; Glucagon-Like Peptide-1 Receptor/agonists ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/therapeutic use ; Incretins/adverse effects ; Incretins/therapeutic use ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney/physiopathology ; Signal Transduction/drug effects ; Translational Medical Research
    Chemical Substances GLP1R protein, human ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Incretins
    Language English
    Publishing date 2018-08-15
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00211.2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Effect of Small and Large Energy Surpluses on Strength, Muscle, and Skinfold Thickness in Resistance-Trained Individuals

    Eric R. Helms / Alyssa-Joy Spence / Colby Sousa / James Kreiger / Steve Taylor / Dustin J. Oranchuk / Brad P. Dieter / Casey M. Watkins

    Sports Medicine - Open, Vol 9, Iss 1, Pp 1-

    A Parallel Groups Design

    2023  Volume 14

    Abstract: Abstract Background Many perform resistance training (RT) to increase muscle mass and strength. Energy surpluses are advised to support such gains; however, if too large, could cause unnecessary fat gain. We randomized 21 trained lifters performing RT 3 ... ...

    Abstract Abstract Background Many perform resistance training (RT) to increase muscle mass and strength. Energy surpluses are advised to support such gains; however, if too large, could cause unnecessary fat gain. We randomized 21 trained lifters performing RT 3 d/wk for eight weeks into maintenance energy (MAIN), moderate (5% [MOD]), and high (15% [HIGH]) energy surplus groups to determine if skinfold thicknesses (ST), squat and bench one-repetition maximum (1-RM), or biceps brachii, triceps brachii, or quadriceps muscle thicknesses (MT) differed by group. COVID-19 reduced our sample, leaving 17 completers. Thus, in addition to Bayesian ANCOVA comparisons, we analyzed changes in body mass (BM) with ST, 1-RM, and MT changes via regression. We reported Bayes factors (BF10) indicating odds ratios of the relative likelihood of hypotheses (e.g., BF10 = 2 indicates the hypothesis is twice as likely as another) and coefficients of determination (R 2) for regressions. Results ANCOVAs provided no evidence supporting the group model for MT or squat 1-RM. However, moderate (BF10 = 9.9) and strong evidence (BF10 = 14.5) indicated HIGH increased bench 1-RM more than MOD and MAIN, respectively. Further, there was moderate evidence (BF10 = 4.2) HIGH increased ST more than MAIN and weak evidence (BF10 = 2.4) MOD increased ST more than MAIN. Regression provided strong evidence that BM change predicts ST change (BF10 = 14.3, R 2 = 0.49) and weak evidence predicting biceps brachii MT change (BF10 = 1.4, R 2 = 0.24). Conclusions While some group-based differences were found, our larger N regression provides the most generalizable evidence. Therefore, we conclude faster rates of BM gain (and by proxy larger surpluses) primarily increase rates of fat gain rather than augmenting 1-RM or MT. However, biceps brachii, the muscle which received the greatest stimulus in this study, may have been positively impacted by greater BM gain, albeit slightly. Our findings are limited to the confines of this study, where a group of lifters with mixed ...
    Keywords Resistance training ; Body composition ; Hypertrophy ; Energy surplus ; Sports medicine ; RC1200-1245
    Subject code 796
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The data do not seem to support a benefit to BCAA supplementation during periods of caloric restriction

    Dieter, Brad P / Schoenfeld, Brad Jon / Aragon, Alan A

    Journal of the International Society of Sports Nutrition. 2016 Dec., v. 13, no. 1

    2016  

    Abstract: J Int Soc Sports Nutr 13:1-015-0112-9, 2016 describe the efficacy of branched chain amino acid (BCAA) supplementation and resistance training for maintaining lean body mass during a calorie-restricted diet, and claim that this occurs with concurrent ... ...

    Abstract J Int Soc Sports Nutr 13:1-015-0112-9, 2016 describe the efficacy of branched chain amino acid (BCAA) supplementation and resistance training for maintaining lean body mass during a calorie-restricted diet, and claim that this occurs with concurrent losses in fat mass. However, the reported results appear to be at odds with the data presented on changes in fat mass. This letter discusses the issues with the paper.
    Keywords lean body mass ; low calorie diet ; sports ; sports nutrition ; strength training
    Language English
    Dates of publication 2016-12
    Size p. 21.
    Publishing place BioMed Central
    Document type Article
    Note Letter
    ZDB-ID 2162810-5
    ISSN 1550-2783
    ISSN 1550-2783
    DOI 10.1186/s12970-016-0128-9
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Is an Energy Surplus Required to Maximize Skeletal Muscle Hypertrophy Associated With Resistance Training.

    Slater, Gary John / Dieter, Brad P / Marsh, Damian James / Helms, Eric Russell / Shaw, Gregory / Iraki, Juma

    Frontiers in nutrition

    2019  Volume 6, Page(s) 131

    Abstract: Resistance training is commonly prescribed to enhance strength/power qualities and is achieved via improved neuromuscular recruitment, fiber type transition, and/ or skeletal muscle hypertrophy. The rate and amount of muscle hypertrophy associated with ... ...

    Abstract Resistance training is commonly prescribed to enhance strength/power qualities and is achieved via improved neuromuscular recruitment, fiber type transition, and/ or skeletal muscle hypertrophy. The rate and amount of muscle hypertrophy associated with resistance training is influenced by a wide array of variables including the training program, plus training experience, gender, genetic predisposition, and nutritional status of the individual. Various dietary interventions have been proposed to influence muscle hypertrophy, including manipulation of protein intake, specific supplement prescription, and creation of an energy surplus. While recent research has provided significant insight into optimization of dietary protein intake and application of evidence based supplements, the specific energy surplus required to facilitate muscle hypertrophy is unknown. However, there is clear evidence of an anabolic stimulus possible from an energy surplus, even independent of resistance training. Common textbook recommendations are often based solely on the assumed energy stored within the tissue being assimilated. Unfortunately, such guidance likely fails to account for other energetically expensive processes associated with muscle hypertrophy, the acute metabolic adjustments that occur in response to an energy surplus, or individual nuances like training experience and energy status of the individual. Given the ambiguous nature of these calculations, it is not surprising to see broad ranging guidance on energy needs. These estimates have never been validated in a resistance training population to confirm the "sweet spot" for an energy surplus that facilitates optimal rates of muscle gain relative to fat mass. This review not only addresses the influence of an energy surplus on resistance training outcomes, but also explores other pertinent issues, including "how much should energy intake be increased," "where should this extra energy come from," and "when should this extra energy be consumed." Several gaps in the literature are identified, with the hope this will stimulate further research interest in this area. Having a broader appreciation of these issues will assist practitioners in the establishment of dietary strategies that facilitate resistance training adaptations while also addressing other important nutrition related issues such as optimization of fuelling and recovery goals. Practical issues like the management of satiety when attempting to increase energy intake are also addressed.
    Language English
    Publishing date 2019-08-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2019.00131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A proposed mechanism for exercise attenuated methylglyoxal accumulation: activation of the ARE-Nrf pathway and increased glutathione biosynthesis.

    Dieter, Brad P / Vella, Chantal A

    Medical hypotheses

    2013  Volume 81, Issue 5, Page(s) 813–815

    Abstract: The dicarbonyl methylglyoxal (MGO) is an endogenous metabolite and a known intracellular precursor of advanced glycation endproducts (AGEs). High serum levels of MGO have been correlated with MGO-derived AGEs in individuals with type 2 diabetes (T2DM). ... ...

    Abstract The dicarbonyl methylglyoxal (MGO) is an endogenous metabolite and a known intracellular precursor of advanced glycation endproducts (AGEs). High serum levels of MGO have been correlated with MGO-derived AGEs in individuals with type 2 diabetes (T2DM). Furthermore, there is human and animal evidence to suggest that MGO is causal in copious pathologies related to AGE accumulation including heart disease, hypertension, nephropathy and insulin resistance. MGO is detoxified through the glutathione (GSH) dependent glyoxalase system and diminished glutathione status results in impaired MGO detoxification. Individuals with uncontrolled T2DM have diminished GSH status, suggesting the increase in serum MGO can be partially attributed to impaired MGO detoxification. GSH biosynthesis is heavily dependent upon the antioxidant response element-nuclear respiratory factor pathway (ARE-Nrf) and pharmacological and dietary intervention studies have demonstrated that activation of the ARE-Nrf pathway increases intracellular GSH and glyoxalase enzymes and reduces MGO levels. Acute and chronic exercise has also been shown to increase activation of the ARE-Nrf pathway and GSH biosynthesis, and to improve GSH status. Therefore, we propose that exercise improves MGO detoxification and attenuates MGO accumulation by increasing GSH biosynthesis and improving GSH status through activation of the ARE-Nrf pathway.
    MeSH term(s) Antioxidant Response Elements/physiology ; Diabetes Mellitus, Type 2/metabolism ; Exercise/physiology ; Glutathione/biosynthesis ; Glutathione/metabolism ; Humans ; Models, Biological ; Nuclear Respiratory Factors/physiology ; Pyruvaldehyde/blood ; Signal Transduction/physiology
    Chemical Substances Nuclear Respiratory Factors ; Pyruvaldehyde (722KLD7415) ; Glutathione (GAN16C9B8O)
    Language English
    Publishing date 2013-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2013.08.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Evidence for distinct effects of exercise in different cardiac hypertrophic disorders.

    Johnson, Emily J / Dieter, Brad P / Marsh, Susan A

    Life sciences

    2015  Volume 123, Page(s) 100–106

    Abstract: Aerobic exercise training (AET) attenuates or reverses pathological cardiac remodeling after insults such as chronic hypertension and myocardial infarction. The phenotype of the pathologically hypertrophied heart depends on the insult; therefore, it is ... ...

    Abstract Aerobic exercise training (AET) attenuates or reverses pathological cardiac remodeling after insults such as chronic hypertension and myocardial infarction. The phenotype of the pathologically hypertrophied heart depends on the insult; therefore, it is likely that distinct types of pathological hypertrophy require different exercise regimens. However, the mechanisms by which AET improves the structure and function of the pathologically hypertrophied heart are not well understood, and exercise research uses highly inconsistent exercise regimens in diverse patient populations. There is a clear need for systematic research to identify precise exercise prescriptions for different conditions of pathological hypertrophy. Therefore, this review synthesizes existing evidence for the distinct mechanisms by which AET benefits the heart in different pathological hypertrophy conditions, suggests strategic exercise prescriptions for these conditions, and highlights areas for future research.
    MeSH term(s) Cardiomegaly/physiopathology ; Cardiomegaly/therapy ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/physiopathology ; Diabetic Cardiomyopathies/therapy ; Exercise/physiology ; Exercise Therapy/methods ; Humans ; Myocardium/metabolism ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2015-02-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2015.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Plausible ergogenic effects of vitamin D on athletic performance and recovery.

    Dahlquist, Dylan T / Dieter, Brad P / Koehle, Michael S

    Journal of the International Society of Sports Nutrition

    2015  Volume 12, Page(s) 33

    Abstract: The purpose of this review is to examine vitamin D in the context of sport nutrition and its potential role in optimizing athletic performance. Vitamin D receptors (VDR) and vitamin D response elements (VDREs) are located in almost every tissue within ... ...

    Abstract The purpose of this review is to examine vitamin D in the context of sport nutrition and its potential role in optimizing athletic performance. Vitamin D receptors (VDR) and vitamin D response elements (VDREs) are located in almost every tissue within the human body including skeletal muscle. The hormonally-active form of vitamin D, 1,25-dihydroxyvitamin D, has been shown to play critical roles in the human body and regulates over 900 gene variants. Based on the literature presented, it is plausible that vitamin D levels above the normal reference range (up to 100 nmol/L) might increase skeletal muscle function, decrease recovery time from training, increase both force and power production, and increase testosterone production, each of which could potentiate athletic performance. Therefore, maintaining higher levels of vitamin D could prove beneficial for athletic performance. Despite this situation, large portions of athletic populations are vitamin D deficient. Currently, the research is inconclusive with regards to the optimal intake of vitamin D, the specific forms of vitamin D one should ingest, and the distinct nutrient-nutrient interactions of vitamin D with vitamin K that affect arterial calcification and hypervitaminosis. Furthermore, it is possible that dosages exceeding the recommendations for vitamin D (i.e. dosages up to 4000-5000 IU/day), in combination with 50 to 1000 mcg/day of vitamin K1 and K2 could aid athletic performance. This review will investigate these topics, and specifically their relevance to athletic performance.
    MeSH term(s) Athletic Performance ; Dietary Supplements ; Dose-Response Relationship, Drug ; Humans ; Muscle Strength/drug effects ; Muscle, Skeletal/drug effects ; Performance-Enhancing Substances/blood ; Performance-Enhancing Substances/pharmacology ; Sports Nutritional Physiological Phenomena ; Vitamin D/blood ; Vitamin D/pharmacology ; Vitamin D Deficiency/drug therapy ; Vitamin K/pharmacology
    Chemical Substances Performance-Enhancing Substances ; Vitamin K (12001-79-5) ; Vitamin D (1406-16-2)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2508294-2
    ISSN 1550-2783
    ISSN 1550-2783
    DOI 10.1186/s12970-015-0093-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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