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  1. Article: Editorial: Sarcoidosis and autoimmunity: From bench to bedside.

    d'Alessandro, Miriana

    Frontiers in medicine

    2023  Volume 10, Page(s) 1147529

    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1147529
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cluster analysis for clinical sarcoidosis' phenotyping.

    d'Alessandro, Miriana / Bargagli, Elena

    European journal of internal medicine

    2020  Volume 77, Page(s) 32

    MeSH term(s) Cluster Analysis ; Cohort Studies ; Humans ; Phenotype ; Prospective Studies ; Sarcoidosis
    Language English
    Publishing date 2020-05-29
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2020.05.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2608: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Author reply.

    d'Alessandro, Miriana / Vietri, Lucia / Bergantini, Laura / Bargagli, Elena

    Internal medicine journal

    2021  Volume 51, Issue 7, Page(s) 1197

    Language English
    Publishing date 2021-07-19
    Publishing country Australia
    Document type Letter ; Comment
    ZDB-ID 2045436-3
    ISSN 1445-5994 ; 1444-0903
    ISSN (online) 1445-5994
    ISSN 1444-0903
    DOI 10.1111/imj.15406
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 792: Show issues Location:
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    Zs.MO 424: Show issues

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  4. Article ; Online: Characterization of natural killer and T cells in bronchoalveolar lavage and peripheral blood of sarcoidosis patients.

    Bergantini, Laura / d'Alessandro, Miriana / Del Zotto, Genny / Marcenaro, Emanuela / Bargagli, Elena

    Frontiers in immunology

    2023  Volume 13, Page(s) 1080556

    Abstract: The characterization of frequency and phenotypes of natural killer (NK) cells and T cells in BAL and peripheral blood of patients with sarcoidosis was evaluated, to discriminate the differential status of these cells in these two compartments. The ... ...

    Abstract The characterization of frequency and phenotypes of natural killer (NK) cells and T cells in BAL and peripheral blood of patients with sarcoidosis was evaluated, to discriminate the differential status of these cells in these two compartments. The analysis revealed that CD56
    MeSH term(s) Humans ; Sarcoidosis/metabolism ; Killer Cells, Natural/metabolism ; Bronchoalveolar Lavage ; Bronchoalveolar Lavage Fluid ; Phenotype
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1080556
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  5. Article ; Online: Benralizumab affects NK cell maturation and proliferation in severe asthmatic patients.

    Bergantini, Laura / d'Alessandro, Miriana / Pianigiani, Tommaso / Cekorja, Behar / Bargagli, Elena / Cameli, Paolo

    Clinical immunology (Orlando, Fla.)

    2023  Volume 253, Page(s) 109680

    Abstract: Introduction: The mechanism of action of benralizumab is determined by its afucosylated constant fragment that binds CD16a receptors on the membrane of natural killer cells. Here we analysed changes in Natural Killer and T-cells in Severe asthmatic ... ...

    Abstract Introduction: The mechanism of action of benralizumab is determined by its afucosylated constant fragment that binds CD16a receptors on the membrane of natural killer cells. Here we analysed changes in Natural Killer and T-cells in Severe asthmatic patients, before and after benralizumab.
    Methods: Natural Killer and T-cell subsets were detected through multiparametric flow cytometry. The concentrations of serum cytokines levels were detected through multiplex assay. Functional proliferation assay was performed in follow-up samples in severe asthmatic patients.
    Results: At baseline, severe asthmatic patients showed higher percentages of immature Natural Killer cells when compared with healthy controls. We demonstrate the proliferative capacity of these cells and their activation after benralizumab administration. Benralizumab shifted Natural Killer cell phenotypes towards maturity. Correlation between the Natural Killer cells and functional parameters and with steroid-sparing was observed.
    Conclusion: Together this data contributes to our understanding of the mechanisms of action of benralizumab in the resolution of inflammation in severe asthma patients.
    MeSH term(s) Humans ; Anti-Asthmatic Agents/therapeutic use ; Asthma ; Killer Cells, Natural ; Cell Proliferation
    Chemical Substances benralizumab (71492GE1FX) ; Anti-Asthmatic Agents
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2023.109680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Immunological Similarities and Differences between Post-COVID-19 Lung Sequelae and Idiopathic Pulmonary Fibrosis.

    Gangi, Sara / Bergantini, Laura / Cameli, Paolo / Paggi, Irene / Spalletti, Marco / Mezzasalma, Fabrizio / Bargagli, Elena / d'Alessandro, Miriana

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: Introduction: Pulmonary fibrosis is an irreversible condition that may be caused by known (including viral triggers such as SARS-CoV-2) and unknown insults. The latter group includes idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive ... ...

    Abstract Introduction: Pulmonary fibrosis is an irreversible condition that may be caused by known (including viral triggers such as SARS-CoV-2) and unknown insults. The latter group includes idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive fibrosing interstitial pneumonia of unknown cause. The longer the insult acts on lung tissue, the lower the probability of a complete resolution of the damage. An emerging clinical entity post-COVID-19 is pulmonary fibrosis (PCPF), which shares many pathological, clinical, and immunological features with IPF. The fibrotic response in both diseases-IPF and PCPF-is orchestrated in part by the immune system. An important role regarding the inhibitory or stimulatory effects on immune responses is exerted by the immune checkpoints (ICs). The aim of the present study was to analyse the similarities and differences between CD4+, CD8+, and NK cells in the peripheral blood of patients affected by fibrotic disease, IPF, and PCPF compared with sarcoidosis patients and healthy controls. The second aim was to evaluate the expression and co-expression of PD-1 and TIGIT on CD4, CD8, and NK cells from our patient cohort.
    Methods: One hundred and fifteen patients affected by IPF, PCPF, and sarcoidosis at the rare pulmonary disease centre of the University of Siena were enrolled. Forty-eight patients had an IPF diagnosis, 55 had PCPF, and 12 had sarcoidosis. Further, ten healthy controls were enrolled. PCPF patients were included between 6 and 9 months following hospital discharge for COVID-19. The peripheral blood samples were collected, and through flow cytometric analysis, we analysed the expression of CD4, CD8, NK cells, PD-1, and TIGIT.
    Results: The results show a greater depletion of CD4 and NK cells in IPF patients compared to other groups (
    Language English
    Publishing date 2024-03-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030630
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  7. Article ; Online: Diagnostic Value of Krebs von den Lungen (KL-6) for Interstitial Lung Disease: A European Prospective Cohort.

    Millan-Billi, Paloma / Castellví, Iván / Martinez-Martinez, Laura / Mariscal, Anais / Barril, Silvia / D'Alessandro, Miriana / Franquet, Tomás / Castillo, Diego

    Archivos de bronconeumologia

    2024  

    Abstract: Introduction: Krebs von den Lungen 6 (KL-6) is a mucin-1 glycoprotein produced by type II pneumocytes. High levels of KL-6 in blood may be found in patients with lung fibrosis. In Asia this biomarker is used for diagnosis and prognosis in interstitial ... ...

    Abstract Introduction: Krebs von den Lungen 6 (KL-6) is a mucin-1 glycoprotein produced by type II pneumocytes. High levels of KL-6 in blood may be found in patients with lung fibrosis. In Asia this biomarker is used for diagnosis and prognosis in interstitial lung diseases (ILD). There is a lack of information regarding KL-6 cut-off point for diagnosis and prognosis in European population. The aim of this study was to establish the cut-off point for serum KL-6 associated with the presence of ILD in the Spanish population.
    Methods: Prospective study including subjects who underwent chest HRCT, PFTs and autoimmune blood analysis. Two groups were created: non-ILD subjects and ILD patients. Serum KL-6 concentrations were measured using a Lumipulse KL-6 reagent assay and the optimal cut-off value was evaluated by a ROC analysis. Data on demographics and smoking history was also collected.
    Results: One hundred seventy-nine patients were included, 102 with ILD. Median serum KL-6 values overall were 762U/mL, 1080 (±787)U/mL for the ILD group vs 340 (±152)U/mL for the non-ILD group (p<0.0001). The main radiological pattern was NSIP (43%). ROC analysis showed greater specificity (86%) and sensitivity (82%) for KL-6 465U/mL for detecting ILD patients. The multivariate logistic regression model pointed to the male sex, higher KL-6 values, lower FVC and low DLCO values as independent factors associated with ILD.
    Conclusion: Serum KL-6 values greater than 465U/mL have excellent sensitivity and specificity for detecting ILD in our Spanish cohort. Multicentre studies are needed to validate our results.
    Language Spanish
    Publishing date 2024-04-06
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2024.03.028
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    Zs.B 2655: Show issues Location:
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  8. Article: Role of BAL and Serum Krebs von den Lungen-6 (KL-6) in Patients with Pulmonary Fibrosis.

    Soccio, Piera / Moriondo, Giorgia / d'Alessandro, Miriana / Scioscia, Giulia / Bergantini, Laura / Gangi, Sara / Tondo, Pasquale / Foschino Barbaro, Maria Pia / Cameli, Paolo / Bargagli, Elena / Lacedonia, Donato

    Biomedicines

    2024  Volume 12, Issue 2

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12020269
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  9. Article ; Online: High-dose steroids for the treatment of severe COVID-19: a new therapeutic tool?

    Cameli, Paolo / Bergantini, Laura / d'Alessandro, Miriana / Bargagli, Elena

    Internal and emergency medicine

    2021  Volume 16, Issue 5, Page(s) 1329–1330

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Steroids/therapeutic use
    Chemical Substances Steroids
    Language English
    Publishing date 2021-04-19
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02722-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6673: Show issues Location:
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  10. Article: Effect of Ambulatory Oxygen on the Respiratory Pattern during the 6 Min Walking Test in Patients with Interstitial Lung Diseases.

    Ventura, Vittoria / Viani, Magda / Bianchi, Francesco / d'Alessandro, Miriana / Sestini, Piersante / Bargagli, Elena

    Biomedicines

    2023  Volume 11, Issue 7

    Abstract: Introduction: Patients with pulmonary fibrosis experience early oxyhemoglobin desaturation under effort, which limits their ability to exercise and their quality of life. Recent studies have shown that in resting normoxaemic patients who become ... ...

    Abstract Introduction: Patients with pulmonary fibrosis experience early oxyhemoglobin desaturation under effort, which limits their ability to exercise and their quality of life. Recent studies have shown that in resting normoxaemic patients who become hypoxemic under exertion, administration of outpatient oxygen significantly improves stress dyspnoea and quality of life. It is unclear how this happens, since oxygen administration does not act directly on dyspnoea, and does not appear to have much effect on the heart rate and pulmonary artery pressure. We tested the hypothesis that correcting the hypoxaemia could reduce the increase in respiratory effort during the 6 min walking test, recording the breathing pattern during administration of oxygen or placebo.
    Methods: We evaluated 20 patients with fibrotic interstitial lung diseases (17 males and 3 females; mean age 72 ± 2 years; M ± SE) with a resting SpO
    Results: Oxygen saturation during the 6MWT decreased to a minimum value of 82.3% (95% CI 80.1-84.5%) during placebo and to 92% (90.3-93.7%) during oxygen with an average difference of 9.7% (7.8-11.6%,
    Conclusion: In our ILD patients, administration of outpatient oxygen during walking was related to a reduced increase in heart rate, respiratory rate, tidal volume and minute ventilation necessary to meet increased oxygen requirements, resulting in a lower workload on the cardiovascular system and on respiratory muscles and a consequent reduction in dyspnoea.
    Language English
    Publishing date 2023-06-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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