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Article ; Online: The Therapeutic Effect and Potential Pharmacological Mechanisms of Ding-Zhi-Xiao-Wan on Depression were Investigated by Meta-analysis, Network Pharmacology and Molecular Docking.

Lin, Li-Li / Wu, Han-Biao / Qiu, Zhi-Kun

Current computer-aided drug design

2023 Volume 20, Issue 1, Page(s) 16–32

Abstract: Introduction: Ding-Zhi-Xiao-Wan (DZXW) produces potential antidepressant-like effects ...

Abstract	Introduction: Ding-Zhi-Xiao-Wan (DZXW) produces potential antidepressant-like effects. However, its antidepressant mechanisms are still unclear. Objective: To analyze the antidepressant effects and the pharmacological mechanisms of DZXW, meta-analysis, network pharmacology, and molecular docking were selected in this study. Methods: The compounds of DZXW and genes associated with compounds or depression were obtained from databases. The genes overlapping between DZXW compounds and depression were compared by Venn diagram. A network of medicine-ingredients-targets-disease was constructed, visualized, and analyzed. Protein-protein interaction, gene ontology, pathway enrichment, and molecular docking were performed to evaluate the potential mechanisms of DZXW for the treatment of depression. Results: Meta-analysis showed that the antidepressant-like effects were produced by DZXW. The network pharmacology analysis showed that a total of 74 compound-related genes and 12607 PTSD-related genes were identified in the databases with 65 overlapping genes. The active ingredients derived from DZXW (i.e Beta-sitosterol, Stigmasterol, Fumarine, Hederagenin) elicited the antidepressant-like effects by targets, such as ACHE, HTR2A, and CHRM1. Moreover, the signaling pathways, like neuroactive ligand-receptor interaction, pathways in cancer, and cholinergic synapse, might play important roles in the treatment of depression by DZXW. Conclusion: This study provides studies analysis and molecular evidence with the beneficial effects of DZXW for the treatment of depression.
Language	English
Publishing date	2023-04-19
Publishing country	United Arab Emirates
Document type	Journal Article
ISSN	1875-6697
ISSN (online)	1875-6697
DOI	10.2174/1573409919666230417103355
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Article ; Online: Optimization of the proportions of advantageous components in the hypolipidemic "bioequivalent substance system" of Jiang-Zhi-Ning and its mechanism of action.

Li, Yumiao / Zhang, Yan / Zhang, Yu / Lin, Tianfeng / Gao, Yanyan / Cai, Yuan / Zhou, Chang / Yang, Leyi / Liu, Bin / Dong, Shifen / Jiang, Yanyan

Pharmaceutical biology

2023 Volume 61, Issue 1, Page(s) 1374–1386

Abstract: Context: Jiang-Zhi-Ning (JZN), a traditional Chinese medicinal formula, is used to treat ...

Abstract	Context: Jiang-Zhi-Ning (JZN), a traditional Chinese medicinal formula, is used to treat hyperlipidemia in clinics. Objective: To screen the hypolipidemic "bioequivalent substance system (BSS)" of JZN and elucidate the potential hypolipidemic mechanism. Materials and methods: In vitro Results: In vitro Discussion and conclusions: These findings provided new feasible ideas and methods for the elucidation of the pharmacodynamic material basis.
MeSH term(s)	Male ; Animals ; Mice ; Mice, Inbred ICR ; Cholesterol, LDL ; Administration, Oral ; Gene Expression Profiling
Chemical Substances	Jiang-Zhi-Ning ; Cholesterol, LDL
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1440131-9
ISSN	1744-5116 ; 1388-0209
ISSN (online)	1744-5116
ISSN	1388-0209
DOI	10.1080/13880209.2023.2243999
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Article: Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis

Xu, Rui / Zeng, Qinghe / Xia, Chenjie / Chen, Jiali / Wang, Pinger / Zhao, Shan / Yuan, Wenhua / Lou, Zhaohuan / Lin, Houfu / Xia, Hanting / Lv, Shuaijie / Xu, Taotao / Tong, Peijian / Gu, Mancang / Jin, Hongting

Frontiers in pharmacology

2021 Volume 12, Page(s) 711004

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.711004
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Article ; Online: Integration of gut microbiome and serum metabolome revealed the effect of Qing-Wei-Zhi-Tong Micro-pills on gastric ulcer in rats.

Wang, Chao / Jiang, Shengyu / Zheng, Haoyu / An, Yiming / Zheng, Wenxue / Zhang, Jiaqi / Liu, Jianming / Lin, Hongqiang / Wang, Guoqiang / Wang, Fang

Journal of ethnopharmacology

2023 Volume 319, Issue Pt 3, Page(s) 117294

Abstract: Ethnopharmacological relevance: Qing-Wei-Zhi-Tong Micro-pills (QWZT) is herbal compound used ...

Abstract	Ethnopharmacological relevance: Qing-Wei-Zhi-Tong Micro-pills (QWZT) is herbal compound used in the treatment of GU, whose functions include clearing the stomach and fire, softening the liver and relieving pain. However, its mechanistic profile on host intestinal microbiota and metabolism has not been determined. Aim of the study: The present study aimed to observe the healing effect of QWZT on acetic acid-induced gastric ulcer in a rat model and to preliminarily elucidate its possible therapeutic mechanism from the perspective of host intestinal microbiota and metabolism. Materials and methods: The Wistar male rats (7 weeks old; weight 180-200 g) were randomly divided into normal control group (NC), acetic acid-induced gastric ulcer group (GU), and QWZT treatment group (High dose: 1250 mg/kg/day, Middle dose: 625 mg/kg/day, Low dose: 312.5 mg/kg/day) of 6 rats each. An acetic acid-induced gastric ulcer rat model was constructed based on anatomical surgery. QWZT (High dose, Middle dose, and Low dose) was used to treat gastric ulcer rats for 7 days by gavage. At the end of treatment, the body weight, macroscopic condition of gastric tissue ulcers, pathological changes (HE staining), inflammatory factors, oxidative stress factors, and endocrine factors were assessed in each group of rats. Fresh feces and serum from each group of rats were collected for microbiome and metabolome analysis on the machine, respectively. Drug-disease common targets and functional pathways were captured based on network pharmacology. The complex network of Herbs-Targets-Pathways-Metabolites-Microbiota interactions was constructed. Ultimately, Fecal Microbiota Transplantation (FMT) evaluated the contribution of gut microbiota in disease. Results: QWZT increased the abundance of beneficial bacteria (Bacteroides, Alloprevotella, Rikenellaceae_RC9_gut_group, Lactobacillus, Lachnospiraceae_NK4A136_group, Parabacteroides, etc.), reduced the abundance of harmful bacteria (Micromonospora, Geobacter, Nocardioides, and Arenimonas, etc.), reduced the levels of inflammatory mediators (12,13-EpOME, 9,10-Epoxyoctadecenoic acid, SM(d18:1/16:0) and Leukotriene A4, etc.), restored host metabolic disorders (Linoleic acid metabolism, Glycerophospholipid metabolism, and Arachidonic acid metabolism), and regulated the level of cytokines (IL-6, TNF-a, SOD, MDA, PEG-2 and NO), ultimately exerting an anti-ulcer effect. Apart from that, FMT improved acetic acid-induced gastric ulcers in rats. Conclusion: QWZT improved acetic acid-induced gastric ulcers in rats by remodeling intestinal microbiota and regulating host metabolism. This work may promote the process of developing and utilizing clinical applications of QWZT.
MeSH term(s)	Male ; Rats ; Animals ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Gastrointestinal Microbiome ; Rats, Wistar ; Metabolome ; Acetic Acid
Chemical Substances	Acetic Acid (Q40Q9N063P)
Language	English
Publishing date	2023-10-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117294
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Article ; Online: Xie Zhuo Tiao Zhi formula modulates intestinal microbiota and liver purine metabolism to suppress hepatic steatosis and pyroptosis in NAFLD therapy.

Qiu, Jiannan / Chen, Lin / Zhang, Ling / Xu, Fangying / Zhang, Congcong / Ren, Guilin / Chang, Kaixin / He, Guonong / Du, Zhongyan / Le, Yifei / Yu, Zhiling / Li, Songtao / Liu, Qingsheng / Dou, Xiaobing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 121, Page(s) 155111

Abstract: ... inflammation. The Xie Zhuo Tiao Zhi (XZTZ) decoction has been employed in clinical practice for alleviating ...

Abstract	Background: Current evidence indicates a rising global prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), which is closely associated to conditions such as obesity, dyslipidemia, insulin resistance, and metabolic syndrome. The relationship between the gut microbiome and metabolites in NAFLD is gaining attention understanding the pathogenesis and progression of dysregulated lipid metabolism and inflammation. The Xie Zhuo Tiao Zhi (XZTZ) decoction has been employed in clinical practice for alleviating hyperlipidemia and symptoms related to metabolic disorders. However, the pharmacological mechanisms underlying the effects of XZTZ remain to be elucidated. Purpose: The objective of this study was to examine the pharmacological mechanisms underlying the hypolipidemic and anti-inflammatory effects of XZTZ decoction in a mouse model of NAFLD, as well as the effects of supplementing exogenous metabolites on PO induced cell damage and lipid accumulation in cultured hepatocytes. Methods: A high-fat diet (HFD) mouse model was established to examine the effects of XZTZ through oral gavage. The general condition of mice and the protective effect of XZTZ on liver injury were evaluated using histological and biochemical methods. Hematoxylin and eosin staining (H&E) staining and oil red O staining were performed to assess inflammatory and lipid accumulation detection, and cytokine levels were quantitatively analyzed. Additionally, the study included full-length 16S rRNA sequencing, liver transcriptome analysis, and non-targeted metabolomics analysis to investigate the relationship among intestinal microbiome, liver metabolic function, and XZTZ decoction. Results: XZTZ had a significant impact on the microbial community structure in NAFLD mice. Notably, the abundance of Ileibacterium valens, which was significantly enriched by XZTZ, exhibited a negative correlation with liver injury biomarkers such as, alanine transaminase (ALT) and aspartate transaminase (AST) activity. Moreover, treatment with XZTZ led to a significant enrichment of the purine metabolism pathway in liver tissue metabolites, with inosine, a purine metabolite, showing a significant positive correlation with the abundance of I. valens. XZTZ and inosine also significantly enhanced fatty acid β-oxidation, which led to a reduction in the expression of pro-inflammatory cytokines and the inhibition of liver pyroptosis. These effects contributed to the mitigation of liver injury and hepatocyte damage, both in vivo and vitro. Furthermore, the utilization of HPLC fingerprints and UPLC-Q-TOF-MS elucidated the principal constituents within the XZTZ decoction, including naringin, neohesperidin, atractylenolide III, 23-o-Acetylalisol B, pachymic acid, and ursolic acid which are likely responsible for its therapeutic efficacy. Further investigations are imperative to fully uncover and validate the pharmacodynamic mechanisms underlying these observations. Conclusion: The administration of XZTZ decoction demonstrates a protective effect on the livers of NAFLD mice by inhibiting lipid accumulation and reducing hepatocyte inflammatory damage. This protective effect is mediated by the upregulation of I.valens abundance in the intestine, highlighting the importance of the gut-liver axis. Furthermore, the presesnce of inosine, adenosine, and their derivatives are important in promoting the protective effects of XZTZ. Furthermore, the in vitro approaching, we provide hitherto undocumented evidence indicating that the inosine significantly improves lipid accumulation, inflammatory damage, and pyroptosis in AML12 cells incubated with free fatty acids.
MeSH term(s)	Animals ; Mice ; Non-alcoholic Fatty Liver Disease/metabolism ; Gastrointestinal Microbiome ; Pyroptosis ; RNA, Ribosomal, 16S ; Liver ; Lipid Metabolism ; Diet, High-Fat/adverse effects ; Fatty Acids, Nonesterified/metabolism ; Purines/pharmacology ; Inosine/metabolism ; Inosine/pharmacology ; Inosine/therapeutic use ; Mice, Inbred C57BL
Chemical Substances	RNA, Ribosomal, 16S ; Fatty Acids, Nonesterified ; Purines ; Inosine (5A614L51CT)
Language	English
Publishing date	2023-09-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155111
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Zs.A 4115: Show issues

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Article ; Online: Gut microbiota mediates the pharmacokinetics of Zhi-zi-chi decoction for the personalized treatment of depression.

Gao, Fang-Yuan / Chen, Xue-Feng / Cui, Li-Xun / Zhai, Yu-Jia / Liu, Jia-Lin / Gao, Cong-Cong / Fang, Yi-Chao / Huang, Tao-Hong / Wen, Jun / Zhou, Ting-Ting

Journal of ethnopharmacology

2022 Volume 302, Issue Pt B, Page(s) 115934

Abstract: Ethnopharmacological relevance: Zhi-zi-chi decoction (ZZCD), from "Treatise on Febrile Diseases ...

Abstract	Ethnopharmacological relevance: Zhi-zi-chi decoction (ZZCD), from "Treatise on Febrile Diseases", is a typical traditional Chinese medicine herb pair, which consists of Gardeniae Fructus (GF) and Semen Sojae Praeparatu (SSP). In clinical research, ZZCD was widely used to fight depression, remove annoyance. Many studies have reported that gut microbiota is critical target for the influence of depress through gut-brain axis, and our previously studies have found that ZZCD exhibiting antidepressant effect was through the gut-brain axis. However, the specific mechanism by which gut microbiota mediates the pharmacokinetics parameters of active compounds from ZZCD during the process of depression treatment has not yet been studied. Aim of the study: To explore the differences in pharmacokinetics characters of bioactive iridoids from ZZCD and study the changes of gut microbiota at different stages of depression with the personalized medicine of ZZCD. Materials and methods: A new strategy exploring the relationship among disease phenotypes (D), intestinal microbiota (I), enzymes (E) and traits of metabolism (T) named as "DIET" was established. Firstly, a fast, selective and sensitive ultra-performance liquid chromatography coupled with tandem mass spectrometer (UPLC-MS/MS) was established and validated to quality the main bioactive compounds from ZZCD and compare the pharmacokinetics and bioavailability of different iridoids prototypes and metabolites from ZZCD between normal and chronic unpredictable mild stress rats. Subsequently, the activity of corresponding metabolic enzymes of anti-depressive compounds, β-glucosidases and sulfotransferases, were analyzed by ρ-nitrophenyl-β -D-glucopyranoside and sulfotransferases ELISA kits, respectively. Finally, 16S rRNA gene sequencing was adopt to analyze intestinal bacteria composition for the treatment of depression by ZZCD. Results: The antidepressant effect of ZZCD was promoted due to the increased exposures and reduced eliminations of anti-depressive compounds, especially geniposide and genipin 1-gentiobioside, under the depression state. With the ZZCD treatment, the depression was improved, but the exposures of anti-depressive compounds from ZZCD gradually decreased. Meanwhile, there were the corresponding decreased trends on the activity of β-glucosidases and sulfotransferases. With the consumption of ZZDC and the improvement of depression, the exposures of anti-depressive iridoid glycosides decreased and the activity of metabolism enzymes restored. Meanwhile, the dysbiosis of pathogenic bacteria (Bacteroidota) induced by depression was ameliorated and the probiotics (Firmicutes) at the phylum and genus level raised, the two phyla are closely related to the production of β-glucosidase and sulfotransferases. Conclusions: It is the first proposed that ZZCD could personalized to treat depression at different stages targeting gut microbiota and gut microbiome could emerged as a potential diagnostic and therapeutic biomarker in depression.
MeSH term(s)	Animals ; Rats ; Cellulases ; Chromatography, Liquid ; Depression/drug therapy ; Gastrointestinal Microbiome ; Iridoids ; Precision Medicine ; RNA, Ribosomal, 16S ; Tandem Mass Spectrometry ; Drugs, Chinese Herbal/pharmacology
Chemical Substances	Cellulases (EC 3.2.1.-) ; Iridoids ; RNA, Ribosomal, 16S ; Drugs, Chinese Herbal
Language	English
Publishing date	2022-11-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115934
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Article: Exploring the Possible Mechanism and Drug Targets of Huang-Qi-Gui-Zhi-Wu-Wu Decoction for the Treatment of Chemotherapy-Induced Peripheral Neuropathy on Network Pharmacology.

Gu, Jia-Lin / Wei, Guo-Li / Ma, Yu-Zhu / Zhang, Jin-Zhi / Ji, Yi / Li, Ling-Chang / Yu, Jia-Lin / Hu, Can-Hong / Huo, Jie-Ge

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 2363262

Abstract: ... which may influence its successful completion. The Huang-Qi-Gui-Zhi-Wu-Wu decoction (HQGZWWD) has been widely used ...

Abstract	Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of anticancer treatment, which may influence its successful completion. The Huang-Qi-Gui-Zhi-Wu-Wu decoction (HQGZWWD) has been widely used to treat CIPN in China although the pharmacological mechanisms involved have not been clarified. Using the network pharmacology approach, this study investigated the potential pathogenesis of CIPN and the therapeutic mechanisms exerted by the HQGZWWD herbal formula in CIPN. The targets of HQGZWWD were identified using traditional Chinese medicine (TCM) databases (TCMSP and ETCM) and prediction platforms (PharmMapper and TargetNet), and the genes of CIPN were collected by DisGeNET, GeneCards, and literature search. The common target interaction network between herbal formula and diseases was constructed by using Cytoscape. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were used to reveal the mechanism and efficacy of HQGZWWD in the treatment of CIPN. A total of 153 CIPN-related genes were screened, and a protein-protein interaction (PPI) network with 96 nodes and 424 edges was constructed. Sixty-three active components were retrieved from HQGZWWD, with a herb-composite compound-target network including 748 nodes and 5448 edges. Forty-one targets belong to the above two networks. The analysis of network results and literature review shows that the main pathological processes of CIPN may be the inflammatory response and nerve injury, and HQGZWWD plays a therapeutic role in CIPN by regulating inflammatory response and repairing nerve injury, thus verifying the reliable efficacy of this herbal formula. In addition, we found two new potential therapeutic targets (CDK7 and GSTM2) warranting further investigation. This study fully illustrates that TCM has the characteristics of a multicompound, multitarget, and multipathway treatment, which is of great significance to study the curative effect of herbal formulations.
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/2363262
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Zs.A 5995: Show issues

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Article ; Online: Screening of hypolipidemic active components in Jiang-Zhi-Ning and its preliminary mechanism research based on "active contribution value" study.

Zhang, Yu / Li, Lihua / Zhang, Jinhua / Lin, Tianfeng / Jiang, Yanyan / Liu, Bin

Journal of ethnopharmacology

2021 Volume 272, Page(s) 113926

Abstract: Ethnopharmacological relevance: Jiang-Zhi-Ning (JZN) is a traditional Chinese medicine formula ...

Abstract	Ethnopharmacological relevance: Jiang-Zhi-Ning (JZN) is a traditional Chinese medicine formula, which has the effect of lowering blood lipid level and softening blood vessels. It is clinically used in the treatment of hyperlipidemia with significant curative effect. Aim of the study: This study aims to screen the active components of JZN that are responsible for its blood lipids lowering effect and lay the foundation for elucidating pharmacodynamic material basis of the hypolipidemic effect of the formula. Materials and methods: The hyperlipidemia model was used to evaluate the efficacy of the JZN effective extraction with the TC and TG of rat plasma as evaluation index. Then the established ultra-high performance liquid chromatography coupled with electrospray ionization-quadrupole-time of flight-mass spectrometry (UPLC-ESI-Q-TOF-MS Results: The pharmacodynamics results showed that JZN effective extraction has displayed a good hypolipidemic effect. 45 components were identified in vitro, 108 components were identified from rat plasma, and 17 potential active components were screened out. The content determination result showed that the ratio of each potential active components in PACC as following: cassiaside C: rubrofusarin-6-O-gentiobioside: aurantio-obtusin-6-O-glucoside: hyperoside: isoquercitrin: quercetin-3-O-glucuronide: (E)-2,3,5,4'-tetrahydroxystilbene-2-O-glucoside: rutin: emodin-8-O-glucoside: astragalin: armepavine: N-nornuciferine: coclaurine: O-nornuciferine: nuciferine: N-norarmepavine: higenamine = 3.30: 16.06: 9.15: 23.94: 98.40: 417.45: 189.68: 8.62: 1.28: 5: 3.51: 14.57: 1.06: 1.35: 1: 5.64: 6.06, and the activity study results showed that it has displayed a good hypolipidemic activity. Finally, the hypolipidemic active components screened out by the "activity contribution study" were: quercetin-3-O-glucuronide, (E)-2,3,5,4'-tetrahydroxystilbene-2-O-glucoside, isoquercitrin, O-nornuciferine, hyperoside and rubrofusarin-6-O-gentiobioside. Conclusions: A scientific and rational approach of screening the hypolipidemic active ingredients of JZN has been developed in the current study. In addition, the research revealed the blood lipid lowering mechanism of those ingredients, which provide a solid basis for further elucidating the hypolipidemic pharmacodynamic material basis and action mechanism of JZN.
MeSH term(s)	Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Hep G2 Cells ; Humans ; Hyperlipidemias/blood ; Hyperlipidemias/drug therapy ; Hypolipidemic Agents/administration & dosage ; Hypolipidemic Agents/analysis ; Hypolipidemic Agents/chemistry ; Hypolipidemic Agents/pharmacology ; Lipids/blood ; Oleic Acid/toxicity ; Phytochemicals/administration & dosage ; Phytochemicals/analysis ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Rats, Wistar ; Spectrometry, Mass, Electrospray Ionization ; Tandem Mass Spectrometry ; Therapeutic Equivalency ; Rats
Chemical Substances	Drugs, Chinese Herbal ; Hypolipidemic Agents ; Jiang-Zhi-Ning ; Jiangzhining extract ; Lipids ; Phytochemicals ; Oleic Acid (2UMI9U37CP) ; osteum (399SL044HN)
Language	English
Publishing date	2021-02-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.113926
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Article ; Online: Prevention of dextran sulfate sodium-induced mouse colitis by the fungal protein Ling Zhi-8

Chen, Yu-Huan / Shin, Jenn-Yeu / Wei, Hsiu-Mei / Lin, Chi-Chien / Yu, Linda C H / Liao, Wei-Ting / Chen, Dz-Chi / Chu, Ching-Liang

Food & function

2021 Volume 12, Issue 4, Page(s) 1639–1650

Abstract: The fungal immunomodulatory protein Ling Zhi-8 (LZ-8) isolated from Ganoderma lucidum (GL ...

Abstract	The fungal immunomodulatory protein Ling Zhi-8 (LZ-8) isolated from Ganoderma lucidum (GL) regulates immune cells and inhibits tumor growth; however, the role of LZ-8 in protecting intestinal epithelial cells (IECs) is unknown. In this study, we aim to investigate the functional effect of LZ-8 on IECs. LZ-8 effectively rescued the pro-inflammatory cytokine-induced loss of tight junctions (TJs) by enhancing transepithelial electrical resistance (TEER), reducing permeability, and maintaining the distribution of TJ proteins, in Caco-2 cells. Mechanistically, LZ-8 blocked the upregulation of myosin light chain kinase (MLCK) and NF-kB activation by TLR2-mediated suppression of cytokine signaling (SOCS)-1 expression. Furthermore, LZ-8 pre-treatment reduced the pathological scores of dextran sulfate sodium (DSS)-induced colitis in mice. These results indicated that LZ-8 protected the barrier function of IECs against inflammation. Thus, LZ-8 may potentially be a novel candidate for treating inflammatory bowel disease (IBD).
MeSH term(s)	Animals ; Caco-2 Cells ; Cell Survival/drug effects ; Colitis/chemically induced ; Colitis/metabolism ; Dextran Sulfate/adverse effects ; Epithelial Cells/drug effects ; Fungal Proteins/pharmacology ; Humans ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Mice ; Mice, Inbred C57BL ; Protective Agents/pharmacology ; Tight Junctions/drug effects
Chemical Substances	Fungal Proteins ; Protective Agents ; LZ-8 protein, Ganoderma lucidum (127187-71-7) ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d0fo02604b
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Article ; Online: Compound Dan Zhi tablet attenuates experimental ischemic stroke via inhibiting platelet activation and thrombus formation.

Cheng, Tao-Fang / Zhao, Jing / Wu, Qiu-Lin / Zeng, Hua-Wu / Sun, Yu-Ting / Zhang, Yu-Hao / Mi, Rui / Qi, Xiao-Po / Zou, Jing-Tao / Liu, Ai-Jun / Jin, Hui-Zi / Zhang, Wei-Dong

Phytomedicine : international journal of phytotherapy and phytopharmacology

2020 Volume 79, Page(s) 153330

Abstract: Background: Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula ...

Abstract	Background: Compound Dan Zhi tablet (DZT) is a commonly used traditional Chinese medicine formula. It has been used for the treatment of ischemic stroke for many years in clinical. However, its pharmacological mechanism is unclear. Purpose: The aim of the current study was to understand the protective effects and underlying mechanisms of DZT on ischemic stroke. Methods: Fifteen representative chemical markers in DZT were determined by ultra-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS). The protective effect of DZT against ischemic stroke was studied in a rat model of middle cerebral artery occlusion (MCAO), and the mechanism was further explored through a combination of network pharmacology and experimental verification. Results: Quantitative analysis showed that the contents of phenolic acids, furan sulfonic acids, tanshinones, flavonoids, saponins and phthalides in DZT were calculated as 7.47, 0.788, 0.627, 0.531 and 0.256 mg/g, respectively. Phenolic acids were the most abundant constituents. Orally administered DZT (1.701 g kg Conclusion: DZT protected against cerebral ischemic injury. The inhibition of TXA
MeSH term(s)	Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/pathology ; Disease Models, Animal ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/pharmacology ; Infarction, Middle Cerebral Artery/drug therapy ; Ischemic Stroke/drug therapy ; Male ; Mice, Inbred ICR ; Platelet Activation/drug effects ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/pharmacology ; Pulmonary Embolism/drug therapy ; Rabbits ; Rats, Sprague-Dawley ; Tablets ; Thrombosis/chemically induced ; Thrombosis/drug therapy ; Thromboxane A2/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Platelet Aggregation Inhibitors ; Tablets ; Thromboxane A2 (57576-52-0)
Language	English
Publishing date	2020-09-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2020.153330
Database	MEDical Literature Analysis and Retrieval System OnLINE

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