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Article ; Online: Haematological sequelae in the post-acute phase of symptomatic SARS-CoV-2 infection.

Bergamaschi, Gaetano / Barteselli, Chiara / Calabretta, Francesca / Lenti, Marco Vincenzo / Merli, Stefania / Rossi, Carlo Maria / Di Sabatino, Antonio

Internal and emergency medicine

2023 Volume 19, Issue 1, Page(s) 125–133

Abstract: Many patients surviving SARS-CoV-2 infection suffer from long-term symptoms (long COVID or post COVID) such as shortness of breath, fatigue, loss of taste or smell and cognitive deterioration. However, few data are available concerning blood cell counts ... ...

Abstract	Many patients surviving SARS-CoV-2 infection suffer from long-term symptoms (long COVID or post COVID) such as shortness of breath, fatigue, loss of taste or smell and cognitive deterioration. However, few data are available concerning blood cell counts and haematological parameters during the post-COVID period. We analysed haematological data from 83 patients previously admitted to the internal medicine unit of our institution because of symptomatic SARS-CoV-2 infection; all data were obtained within 1-12 months from disease onset. A control group of 70 apparently healthy, age- and sex-matched COVID-19 negative individuals was assessed for comparison. Blood cell counts improved in the post-COVID period, but 81% of patients had persistent abnormalities, compared with 50% in the control group, p < 0.001. Most common haematological findings included anaemia (40%), reduced lymphocyte (43%) or eosinophil counts (38%) and low IgM memory B cells and correlated with advanced age, number of chronic comorbidities, female gender, altered renal function, reduced baseline Hb and procalcitonin concentrations and increased RDW. Data on lymphocytes and IgM memory B cells show that impaired immune responses may persist for up to one year in the post-COVID period, possibly contributing to long-term symptoms, especially in female patients.
MeSH term(s)	Humans ; Female ; COVID-19/complications ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Internal Medicine ; Disease Progression ; Immunoglobulin M
Chemical Substances	Immunoglobulin M
Language	English
Publishing date	2023-11-24
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2454173-4
ISSN	1970-9366 ; 1828-0447
ISSN (online)	1970-9366
ISSN	1828-0447
DOI	10.1007/s11739-023-03459-6
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Article ; Online: Pathogenesis, diagnosis and treatment of anaemia in immune-mediated gastrointestinal disorders.

Bergamaschi, Gaetano / Di Sabatino, Antonio / Corazza, Gino R

British journal of haematology

2018 Volume 182, Issue 3, Page(s) 319–329

Abstract: Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most ... ...

Abstract	Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most prevalent extra-intestinal manifestation of immune-mediated GI disorders. Anaemia is most commonly due to iron deficiency and/or inflammation, but vitamin deficiencies and, more infrequently, autoimmune haemolysis or drug-induced myelosuppression can be involved. Here we address several issues related to the differential diagnosis and treatment of anaemia in immune-mediated GI disorders, giving particular relevance to the problem of iron deficiency anaemia associated with inflammation. It is emphasized how, in most cases, anaemias due to iron or vitamin deficiencies are best treated by parenteral administration of the deficient factor(s), and how the available high dose intravenous (IV) iron formulations can reduce ambulatory and social costs of IV iron supplementation, while improving patient's compliance to treatment. Actual and future treatment possibilities for anaemia of inflammation, involving the use of erythropoiesis stimulating agents, biologicals and hepcidin inhibitors are discussed.
MeSH term(s)	Anemia/diagnosis ; Anemia/etiology ; Anemia/therapy ; Autoimmune Diseases/complications ; Celiac Disease/complications ; Diagnosis, Differential ; Gastritis, Atrophic/complications ; Gastrointestinal Diseases/complications ; Humans ; Inflammatory Bowel Diseases/complications
Language	English
Publishing date	2018-05-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.15254
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Article ; Online: Clinical outcomes of patients with coronary microvascular dysfunction in absence of obstructive coronary atherosclerosis.

De Vita, Antonio / Pizzi, Carmine / Tritto, Isabella / Morrone, Doralisa / Villano, Angelo / Bergamaschi, Luca / Lanza, Gaetano A

Journal of cardiovascular medicine (Hagerstown, Md.)

2022 Volume 23, Issue 7, Page(s) 421–426

Abstract: Up to 50% of patients presenting with stable, mainly exercise-induced, chest pain and 10-20% of those admitted to hospital with chest pain suggesting an acute coronary syndrome show normal or near-normal coronary arteries at angiography. Coronary ... ...

Abstract	Up to 50% of patients presenting with stable, mainly exercise-induced, chest pain and 10-20% of those admitted to hospital with chest pain suggesting an acute coronary syndrome show normal or near-normal coronary arteries at angiography. Coronary microvascular dysfunction (CMD) is a major cause of symptoms in these patients. However, controversial data exist about their prognosis. In this article, we critically review characteristics and results of the main studies that assessed clinical outcome of patients with angina chest pain and nonobstructive coronary artery disease presenting with either a stable angina pattern or an acute coronary syndrome. Published data indicate that the patients included in most studies are heterogeneous and a major determinant of clinical outcome is the presence of atherosclerotic, albeit not obstructive, coronary artery disease. Long-term prognosis seems instead excellent in patients with totally normal coronary arteries and a syndrome of CMD-related stable angina (microvascular angina). On the other hand, the prognostic impact of CMD in patients presenting with an acute coronary syndrome needs to be better assessed in future studies.
MeSH term(s)	Acute Coronary Syndrome/complications ; Acute Coronary Syndrome/diagnostic imaging ; Angina, Stable/diagnostic imaging ; Chest Pain/etiology ; Coronary Artery Disease/complications ; Humans ; Myocardial Ischemia/complications
Language	English
Publishing date	2022-06-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001305
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article: Ultrasound Patterns of Hepatocellular Carcinoma and Their Prognostic Impact: A Retrospective Study.

Barteselli, Chiara / Mazza, Stefano / Ravetta, Valentina / Viera, Francesca Torello / Veronese, Letizia / Frigerio, Chiara / Gori, Giulia / Bergamaschi, Gaetano / Sgarlata, Carmelo / Facciorusso, Antonio / Maestri, Marcello / Di Sabatino, Antonio / Anderloni, Andrea

Cancers

2023 Volume 15, Issue 22

Abstract: Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Abdominal ultrasound (US) is by far the most widely used first-level exam for the diagnosis of HCC. We aimed to assess whether different ultrasound patterns were ... ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. Abdominal ultrasound (US) is by far the most widely used first-level exam for the diagnosis of HCC. We aimed to assess whether different ultrasound patterns were related to tumor prognosis. Methods: We retrospectively reviewed all patients with a new diagnosis of HCC (single nodule) and undergoing radiofrequency thermal ablation (RFTA) at our clinic between January 2009 and December 2021. Patients were classified according to four HCC ultrasound patterns: 1A, single capsulated nodule; 1B, well capsulated intra-node nodule; 1C, cluster consisting of capsulated nodules; and 2, non-capsulated nodule. Results: 149 patients were analysed; median follow-up time was 43 months. US patterns 1A (32.9%) and 1B (61.1%) were the most commonly seen. Median overall survival (OS) and recurrence-free survival (RFS) from RFTA were 54 months (95% CI, 42-66) and 22 months (95% CI, 12-32), respectively. Pattern 1A showed the best OS. Compared to pattern 1A, 1B was independently associated with worse OS (51 months (95% CI, 34-68) vs. 46 months (95% CI, 18-62)) and RFS (34 months (95% CI, 27-41) vs. 18 months (95% CI, 12-24)). Patterns 1C and 2 were associated with worse RFS compared to 1A, while no difference was seen for OS. Among baseline clinical variables, pattern 1B exhibited higher histological grade ( Conclusions: Our findings demonstrate that different US patterns correlate with different survival outcomes and tumor behavior in patients with HCC. Prospective studies are needed to confirm these results.
Language	English
Publishing date	2023-11-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15225396
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Article ; Online: Impaired respiratory function reduces haemoglobin oxygen affinity in COVID-19.

Bergamaschi, Gaetano / Barteselli, Chiara / Del Rio, Virginia / Borrelli de Andreis, Federica / Pellegrino, Ivan / Mengoli, Caterina / Miceli, Emanuela / Colaneri, Marta / Zuccaro, Valentina / Di Stefano, Michele / Bruno, Raffaele / Di Sabatino, Antonio

British journal of haematology

2022 Volume 200, Issue 5, Page(s) e44–e47

MeSH term(s)	Humans ; COVID-19 ; Respiratory Insufficiency ; Hemoglobins ; Oxygen
Chemical Substances	Hemoglobins ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-12-26
Publishing country	England
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18620
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Article ; Online: Myocardial infarction with nonobstructive coronary arteries: from pathophysiology to therapeutic strategies.

Foà, Alberto / Canton, Lisa / Bodega, Francesca / Bergamaschi, Luca / Paolisso, Pasquale / De Vita, Antonio / Villano, Angelo / Mattioli, Anna Vittoria / Tritto, Isabella / Morrone, Doralisa / Lanza, Gaetano Antonio / Pizzi, Carmine

Journal of cardiovascular medicine (Hagerstown, Md.)

2023 Volume 24, Issue Suppl 2, Page(s) e134–e146

Abstract: Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a heterogeneous group of clinical entities characterized by clinical evidence of acute myocardial infarction (AMI) with normal or near-normal coronary arteries on coronary ... ...

Abstract	Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a heterogeneous group of clinical entities characterized by clinical evidence of acute myocardial infarction (AMI) with normal or near-normal coronary arteries on coronary angiography (stenosis < 50%) and without an over the alternative diagnosis for the acute presentation. Its prevalence ranges from 6% to 11% among all patients with AMI, with a predominance of young, nonwhite females with fewer traditional risks than those with an obstructive coronary artery disease (MI-CAD). MINOCA can be due to either epicardial causes such as rupture or fissuring of unstable nonobstructive atherosclerotic plaque, coronary artery spasm, spontaneous coronary dissection and cardioembolism in-situ or microvascular causes. Besides, also type-2 AMI due to supply-demand mismatch and Takotsubo syndrome must be considered as a possible MINOCA cause. Because of the complex etiology and a limited amount of evidence, there is still some confusion around the management and treatment of these patients. Therefore, the key focus of this condition is to identify the underlying individual mechanisms to achieve patient-specific treatments. Clinical history, electrocardiogram, echocardiography, and coronary angiography represent the first-level diagnostic investigations, but coronary imaging with intravascular ultrasound and optical coherent tomography, coronary physiology testing, and cardiac magnetic resonance imaging offer additional information to understand the underlying cause of MINOCA. Although the prognosis is slightly better compared with MI-CAD patients, MINOCA is not always benign and depends on the etiopathology. This review analyzes all possible pathophysiological mechanisms that could lead to MINOCA and provides the most specific and appropriate therapeutic approach in each scenario.
MeSH term(s)	Female ; Humans ; MINOCA ; Risk Factors ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/therapy ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/etiology ; Myocardial Infarction/therapy ; Coronary Angiography/adverse effects ; Coronary Vessels/diagnostic imaging
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2223461-5
ISSN	1558-2035 ; 1558-2027
ISSN (online)	1558-2035
ISSN	1558-2027
DOI	10.2459/JCM.0000000000001439
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Zs.A 5210: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 559: Show issues

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Article ; Online: Renal function evaluation in liver cirrhosis: Preliminary report on the effect of the Royal Free Hospital Cirrhosis Glomerular Filtration Rate on the Model for End-Stage Liver Disease (MELD).

Bergamaschi, Gaetano / Masotti, Michela / Corazza, Gino Roberto

European journal of internal medicine

2017 Volume 48, Page(s) e18–e20

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Creatinine/blood ; Female ; Glomerular Filtration Rate ; Humans ; Italy ; Liver Cirrhosis/complications ; Liver Cirrhosis/physiopathology ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Renal Insufficiency, Chronic/physiopathology ; Severity of Illness Index
Chemical Substances	Creatinine (AYI8EX34EU)
Language	English
Publishing date	2017-12-16
Publishing country	Netherlands
Document type	Letter ; Multicenter Study ; Observational Study
ZDB-ID	1038679-8
ISSN	1879-0828 ; 0953-6205
ISSN (online)	1879-0828
ISSN	0953-6205
DOI	10.1016/j.ejim.2017.12.003
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Article ; Online: Altered erythropoiesis in genetic hemochromatosisis.

Bergamaschi, Gaetano

Haematologica

2005 Volume 90, Issue 2, Page(s) 146

MeSH term(s)	Erythrocyte Indices ; Erythroid Precursor Cells/cytology ; Erythroid Precursor Cells/metabolism ; Erythropoiesis/physiology ; Ferritins/metabolism ; Hemochromatosis/genetics ; Hepatocytes/metabolism ; Homozygote ; Humans ; Mutation
Chemical Substances	Ferritins (9007-73-2)
Language	English
Publishing date	2005-02
Publishing country	Italy
Document type	Comment ; Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
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Article ; Online: Mutations on the von-Hippel-Lindau tumor suppressor gene.

Bergamaschi, Gaetano

Haematologica

2005 Volume 90, Issue 1, Page(s) 1

MeSH term(s)	Chromosome Aberrations ; Erythropoietin/biosynthesis ; Genes, Recessive ; Genes, Tumor Suppressor ; Humans ; Point Mutation ; Polycythemia/congenital ; Polycythemia/etiology ; Polycythemia/genetics ; von Hippel-Lindau Disease/genetics
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2005-01
Publishing country	Italy
Document type	Comment ; Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
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Article ; Online: Two novel mutations, L490R and V561X, in transferrin receptor 2 in Japanese patients with hemochromatosis.

Bergamaschi, Gaetano

Haematologica

2005 Volume 90, Issue 3, Page(s) 289A

MeSH term(s)	Adult ; Female ; Hemochromatosis/epidemiology ; Hemochromatosis/genetics ; Humans ; Japan/epidemiology ; Male ; Molecular Epidemiology ; Mutation, Missense ; Receptors, Transferrin/genetics
Chemical Substances	Receptors, Transferrin ; TFR2 protein, human
Language	English
Publishing date	2005-03
Publishing country	Italy
Document type	Comment ; Journal Article
ZDB-ID	2333-4
ISSN	1592-8721 ; 0017-6567 ; 0390-6078
ISSN (online)	1592-8721
ISSN	0017-6567 ; 0390-6078
Database	MEDical Literature Analysis and Retrieval System OnLINE

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