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Article ; Online: Gli ebrei in costa d’Amalfi al tempo di Ferdinando I d’Aragona

Giuseppe Lucibello Ferrigno

Sefer Yuḥasin, Vol 2, Pp 239-

il caso di Maiori

2018 Volume 262

Abstract: ... alla corte di Ferdinando I d’Aragona alla fine del XV secolo. Si presentano inoltre due documenti poco noti ...

Abstract	Nel maggio del 1942 il villaggio costiero di Maiori, nel ducato di Amalfi, fu colpito da un alto numero di decessi che portarono all sospensione delle attività commerciali e al rinvio di una delle più importanti fiere medioevali nel sud Italia: la fiera di Salerno. Pochi mesi dopo, gli ebrei Moyse de Gannectao e Gabriele de Salomone lasciarono Maiori per continuare la loro attività di prestatori in un luogo più sicuro del regno di Napoli. Presentando documenti noti e meno noti, l’articolo mostra come il caso di Maiori possa essere considerato come un microcosmo che permette di scoprire l’importanza della presenza dei prestatori nel regno di Napoli, come pure di comprendere le condizioni sociali, politiche ed economiche alla corte di Ferdinando I d’Aragona alla fine del XV secolo. Si presentano inoltre due documenti poco noti provenienti dall’Archivio Capitolare della Chiesa Collegiata di Santa Maria a Mare di Maiori; il primo riporta un ordine del re di perquisire i registri dei prestiti e i pegni di tutti i banchieri e prestatori ebrei del ducato di Amalfi; il secondo identifica con precisione il luogo dove si riuniva la comunità ebraica di Maiori: una piccola stanza nel cuore del paese, dove sorge l’attuale Chiesa della Madonna della Libera. The Jews on the Coast of Amalfi in the Days of Ferdinand I of Aragon: The Case of Maiori In May of 1494 the coastal village of Maiori in the Duchy of Amalfi was struck by a huge number of death cases, that brought on the suspension of customs’ activities and tohe postponement of one of the most important fairs of the Middle Ages in Southern Italy: the Salerno fair. A few months later the Jews Moyse de Gannectao and Gabriele de Salomone left Maiori to continue their activity as money-lenders in some safer place in the Kingdom of Naples. Discussing known and less known documents, the paper shows how the case of Maiori can be regarded as a microcosm which allows one to discover the importance of the presence of Jewish lenders in the Kingdom, and moreover to comprehend the social, economic and political conditions at the court of Ferdinand I of Aragon at the end of the 15th century. The article presents also two interesting documents from the Archivio Capitolare in the church Collegiata di Santa Maria a Mare of Maiori; the first one reports a royal order for the requisition of the registers of all loans and of all the pawns left as collateral to the Jewish bankers and lenders of the Duchy of Amalfi; the second document identifies the exact place where the Jewish community of Maiori used to meet: a room in the front part of the church of Madonna della Libera, still in the heart of the town.
Keywords	History (General) and history of Europe ; D ; Judaism ; BM1-990
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	UniorPress
Document type	Article ; Online
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Article ; Online: Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit.

Provvisiero, Donatella Paola / Negri, Mariarosaria / de Angelis, Cristina / Di Gennaro, Gilda / Patalano, Roberta / Simeoli, Chiara / Papa, Fortuna / Ferrigno, Rosario / Auriemma, Renata Simona / De Martino, Maria Cristina / Colao, Annamaria / Pivonello, Rosario / Pivonello, Claudia

Scientific reports

2019 Volume 9, Issue 1, Page(s) 11695

Abstract: Primary or acquired resistant mechanisms prevent the employment of individualized therapy with target drugs like the mTOR inhibitor everolimus (EVE) in hepatocellular carcinoma (HCC). The current study evaluated the effect of 1,25(OH) ...

Abstract	Primary or acquired resistant mechanisms prevent the employment of individualized therapy with target drugs like the mTOR inhibitor everolimus (EVE) in hepatocellular carcinoma (HCC). The current study evaluated the effect of 1,25(OH)
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition/drug effects ; Epithelial-Mesenchymal Transition/genetics ; Everolimus/pharmacology ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; MicroRNAs/agonists ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Proto-Oncogene Proteins c-myc/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Vitamin D/pharmacology
Chemical Substances	Adaptor Proteins, Signal Transducing ; Antineoplastic Agents ; MIRN375 microRNA, human ; MTDH protein, human ; MYC protein, human ; Membrane Proteins ; MicroRNAs ; Proto-Oncogene Proteins c-myc ; RNA-Binding Proteins ; Transcription Factors ; YAP1 protein, human ; Vitamin D (1406-16-2) ; Everolimus (9HW64Q8G6G) ; MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
Language	English
Publishing date	2019-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-019-48081-9
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Article ; Online: Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit

Donatella Paola Provvisiero / Mariarosaria Negri / Cristina de Angelis / Gilda Di Gennaro / Roberta Patalano / Chiara Simeoli / Fortuna Papa / Rosario Ferrigno / Renata Simona Auriemma / Maria Cristina De Martino / Annamaria Colao / Rosario Pivonello / Claudia Pivonello

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 13

Abstract: ... evaluated the effect of 1,25(OH)2Vitamin D (VitD) treatment on EVE sensitivity in established models of HCC ...

Abstract	Abstract Primary or acquired resistant mechanisms prevent the employment of individualized therapy with target drugs like the mTOR inhibitor everolimus (EVE) in hepatocellular carcinoma (HCC). The current study evaluated the effect of 1,25(OH)2Vitamin D (VitD) treatment on EVE sensitivity in established models of HCC cell lines resistant to everolimus (EveR). DNA content and colony formation assays, which measure the proliferative index, revealed that VitD pre-treatment re-sensitizes EveR cells to EVE treatment. The evaluation of epithelial and mesenchymal markers by western blot and immunofluorescence showed that VitD restored an epithelial phenotype in EveR cells, in which prolonged EVE treatment induced transition to mesenchymal phenotype. Moreover, VitD treatment prompted hepatic miRNAs regulation, evaluated by liver miRNA finder qPCR array. In particular, miR-375 expression was up-regulated by VitD in EveR cells, in which miR-375 was down-regulated compared to parental cells, with consequent inhibition of oncogenes involved in drug resistance and epithelial-mesenchymal transition (EMT) such as MTDH, YAP-1 and c-MYC. In conclusion, the results of the current study demonstrated that VitD can re-sensitize HCC cells resistant to EVE treatment triggering miR-375 up-regulation and consequently down-regulating several oncogenes responsible of EMT and drug resistance.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
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Article: Plasma levels of D-dimer in lung carcinoma: clinical and prognostic significance.

Buccheri, Gianfranco / Torchio, Pierfederico / Ferrigno, Domenico

Cancer

2003 Volume 97, Issue 12, Page(s) 3044–3052

Abstract: ... represents an unfavorable clinical sign. D-dimer (DD) is a sensitive marker of fibrinolysis.: Methods ... respectively). The D-dimer distinguished patients with different prognoses. The median survival periods were ...

Abstract	Background: The activation of the clotting-fibrinolytic system in cancer patients is common and represents an unfavorable clinical sign. D-dimer (DD) is a sensitive marker of fibrinolysis. Methods: The current study comprised 826 new lung carcinoma patients seen consecutively in a single institution over a 10-year period (1992-2001). For each patient, 31 variables, including DD and survival duration, were available for analysis. Results: Only weak relationships between DD and the other variables were found. The DD variable correlated best with the level of lactate dehydrogenase, performance status, tissue polypeptide antigen, stage of disease, and the number of metastases (rho = 0.33, -0.25, 0.18, 0.18, and 0.15, respectively). The D-dimer distinguished patients with different prognoses. The median survival periods were 154 days (95% confidence interval [CI], 122-189 days) and 308 days (95% CI, 227-409 days; log rank statistic, 26.56; P < 0.01), respectively, for abnormally elevated and normal values. The difference was greater in patients with adenocarcinoma and in patients presenting with a less advanced disease, especially in patients with pathologic Stage Ia disease. The best multivariate survival model selected 10 significant covariates, including DD. Conclusions: The authors recommend measuring the plasma level of DD in all new lung carcinoma patients. This measurement may help to formulate individual prognoses and can be used to indicate adjuvant treatment for surgical patients.
MeSH term(s)	Adult ; Aged ; Carcinoma, Bronchogenic/blood ; Female ; Fibrin Fibrinogen Degradation Products/analysis ; Fibrinolysis ; Humans ; Lung Neoplasms/blood ; Male ; Middle Aged ; Prognosis ; Survival Analysis ; Time Factors
Chemical Substances	Fibrin Fibrinogen Degradation Products ; fibrin fragment D
Language	English
Publishing date	2003-06-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/cncr.11432
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Article ; Online: To Diet or Not to Diet This Is the Question in Food-Protein-Induced Allergic Proctocolitis (FPIAP)-A Comprehensive Review of Current Recommendations.

Salvatore, Silvia / Folegatti, Alice / Ferrigno, Cristina / Pensabene, Licia / Agosti, Massimo / D'Auria, Enza

Nutrients

2024 Volume 16, Issue 5

Abstract: Food-protein-induced allergic proctocolitis (FPIAP) is an increasingly reported transient and benign form of colitis that occurs commonly in the first weeks of life in healthy breastfed or formula-fed infants. Distal colon mucosal inflammation is caused ... ...

Abstract	Food-protein-induced allergic proctocolitis (FPIAP) is an increasingly reported transient and benign form of colitis that occurs commonly in the first weeks of life in healthy breastfed or formula-fed infants. Distal colon mucosal inflammation is caused by a non-IgE immune reaction to food allergens, more commonly to cow's milk protein. Rectal bleeding possibly associated with mucus and loose stools is the clinical hallmark of FPIAP. To date, no specific biomarker is available, and investigations are reserved for severe cases. Disappearance of blood in the stool may occur within days or weeks from starting the maternal or infant elimination diet, and tolerance to the food allergen is typically acquired before one year of life in most patients. In some infants, no relapse of bleeding occurs when the presumed offending food is reassumed after a few weeks of the elimination diet. Many guidelines and expert consensus on cow's milk allergy have recently been published. However, the role of diet is still debated, and recommendations on the appropriateness and duration of allergen elimination in FPIAP are heterogeneous. This review summarizes and compares the different proposed nutritional management of infants suffering from FPIAP, highlighting the pros and cons according to the most recent literature data.
MeSH term(s)	Infant ; Female ; Animals ; Cattle ; Humans ; Proctocolitis ; Diet ; Food Hypersensitivity ; Milk Hypersensitivity/complications ; Colitis/complications ; Allergens
Chemical Substances	Allergens
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu16050589
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Article ; Online: Auxological and metabolic effects of long-term treatment with recombinant growth hormone in children born small for gestational age: a retrospective study.

Ferrigno, Rosario / Savanelli, Maria Cristina / Cioffi, Daniela / Pellino, Valeria / Klain, Antonella

Endocrine

2024 Volume 84, Issue 1, Page(s) 213–222

Abstract: Rationale: Children born small for gestational age (SGA) not showing catch-up during the first two years of life reportedly show an impaired growth rate and adult height, as well as a worse metabolic outcome, mainly in terms of glycemic and lipid ... ...

Abstract	Rationale: Children born small for gestational age (SGA) not showing catch-up during the first two years of life reportedly show an impaired growth rate and adult height, as well as a worse metabolic outcome, mainly in terms of glycemic and lipid profile, compared to general population. In SGA children with short stature, treatment with recombinant growth hormone (GH) is currently recommended until adolescence; therefore, it may last long-term. Study methods: The aim of the current study was to evaluate the auxological and metabolic effects and the safety of long-term recombinant GH treatment in SGA children. The study included 15 SGA children (5 F, 10 M; mean age: 6.78 yrs) treated with GH for at least 48 months. Growth and metabolic parameters, including glycemic and lipid profile, transaminases, and urycemia, were collected every six months. Results: Compared to baseline, SGA children showed a significant improvement in height, weight, and growth rate after four yaers of treatment with GH (p ≤ 0.002), being already evident after six months of treatment (p < 0.001). Noteworthy, patients showed a constant, significant improvement in height throughout the treatment, as it was significantly higher at each follow-up compared to the previous one, until 42 months of treatment, except at 30 months of treatment (p < 0.001 T6VST12; p < 0.01 T12VST18, T18VST24; p < 0.05 T30VST36, T36VST42). Considering metabolic parameters, compared to baseline, a recurring increase in glycemia (p ≤ 0.028 vs T30, T36, and T48) and decrease in AST (p ≤ 0.035 vs T36, T42, and T48) and an occasional decrease in LDL cholesterol (p ≤ 0.04 vs T24 and T42) and triglycerides (p = 0.008 vs T18) and increase in urycemia (p = 0.034 vs T42). Considering safety profile, treatment was well tolerated, as the most frequently reported adverse event was poor compliance (20%); no hyperglycemia, hypercholesterolemia or hyperstransaminasemia occurred throughout the treatment, CONCLUSIONS: Long-term GH treatment showed to be effective in improving height and growth rate in SGA children, with a positive impact of metabolic profile and a safety profile, although glycemia should be carefully monitored over time.
MeSH term(s)	Child ; Humans ; Body Height ; Gestational Age ; Growth Hormone ; Human Growth Hormone ; Infant, Small for Gestational Age ; Lipids ; Retrospective Studies
Chemical Substances	Growth Hormone (9002-72-6) ; Human Growth Hormone (12629-01-5) ; Lipids
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03665-4
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Article ; Online: Anatomy's missing faces: An assessment of representation gaps in atlas and textbook imagery.

Beresheim, Amy / Zepeda, David / Pharel, Marissa / Soy, Tyler / Wilson, Adam B / Ferrigno, Christopher

Anatomical sciences education

2024

Abstract: Previous research suggests that underrepresentation in medical curricula perpetuates inequities in healthcare. This study aimed to quantify the prevalence of human phenotypic diversity (e.g., skin tone, sex, body size, and age) across 11 commonly used ... ...

Abstract	Previous research suggests that underrepresentation in medical curricula perpetuates inequities in healthcare. This study aimed to quantify the prevalence of human phenotypic diversity (e.g., skin tone, sex, body size, and age) across 11 commonly used anatomy atlases and textbooks in pre-clerkship medical education, published from 2015 to 2020. A systematic visual content analysis was conducted on 5001 images in which at least one phenotypic attribute was quantifiable. Anatomy images most prevalently portrayed light skin tones, males, persons with intermediate body sizes, and young to middle-aged adults. Of the 3883 images in which there was a codable skin tone, 81.2% (n = 3154) depicted light, 14.3% (n = 554) depicted intermediate, and 4.5% (n = 175) depicted dark skin tones. Of the 2384 images that could be categorized into a sex binary, 38.4% (n = 915) depicted females and 61.6% (n = 1469) depicted males. A male bias persisted across all whole-body and regional-body images, including those showing sex organs or those showing characteristics commonly associated with a specific sex (e.g. for males, facial hair and/or muscle hypertrophy). Within sex-specific contexts, darker skin was underrepresented, but male depictions displayed greater overall skin tone variation. Although most images could not be assigned to a body size or age category, when codable, these images overwhelmingly depicted adults (85.0%; 482 of 567) with smaller (34.7%; 93 of 268) or intermediate (64.6%; 173 of 268) body sizes. Ultimately, these outcomes provide reference metrics for monitoring ongoing and future efforts to address representation inequalities portrayed in anatomical imagery.
Language	English
Publishing date	2024-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2483491-9
ISSN	1935-9780 ; 1935-9772
ISSN (online)	1935-9780
ISSN	1935-9772
DOI	10.1002/ase.2432
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Article: Evaluation of diagnostic and therapeutic delay in patients with rheumatoid arthritis and psoriatic arthritis.

Iacovantuono, M / Ferrigno, S / Conigliaro, P / Triggianese, P / D'Antonio, A / Spinelli, F R / Bergamini, A / Chimenti, M S

Reumatismo

2024 Volume 76, Issue 1

Abstract: Objective: A monocentric cross-sectional study recruiting rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients residing in the Lazio region, Italy, to assess factors related to diagnostic delay and treatment accessibility.: Methods: ... ...

Abstract	Objective: A monocentric cross-sectional study recruiting rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients residing in the Lazio region, Italy, to assess factors related to diagnostic delay and treatment accessibility. Methods: Clinical/serological data, including the time between symptom onset, diagnosis, and the beginning of treatment, were collected. Residence, referral to a rheumatologic center, physician who made the diagnosis, and previous misdiagnosis were also evaluated. Results: A higher diagnostic delay (p=0.003), and time between symptom onset and the start of I-line therapy (p=0.006) were observed in PsA compared to RA. A delayed start of II-line therapy was observed in RA compared to PsA (p=0.0007). Higher diagnostic delay (p=0.02), and time between symptom onset and the start of conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) (p=0.02) were observed among residents of small-medium cities for both groups. Patients who have been diagnosed by another physician rather than a rheumatologist had a longer diagnostic delay (p=0.034) and a delayed start of I-line therapy (p=0.019). Patients who received a different previous diagnosis experienced greater diagnostic delay (p=0.03 and p=0.003) and time of start of csDMARDs (p=0.05 and p=0.01) compared with those receiving RA or PsA as the first diagnosis. PsA had a delay in starting targeted synthetic disease-modifying anti-rheumatic drugs (p=0.0004) compared to RA. Seronegative RA had delayed diagnosis (p=0.02) and beginning of therapies (p=0.03; p=0.04) compared to seropositive ones. Conclusions: According to our results, greater diagnostic delay was found in PsA compared to RA, in patients living in small-medium cities, in those who did not receive the diagnosis from a rheumatologist, in those who were previously misdiagnosed, and in seronegative RA.
MeSH term(s)	Humans ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Delayed Diagnosis ; Cross-Sectional Studies ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Antirheumatic Agents/therapeutic use
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	2024-03-22
Publishing country	Italy
Document type	Journal Article
ZDB-ID	414816-2
ISSN	2240-2683 ; 0048-7449
ISSN (online)	2240-2683
ISSN	0048-7449
DOI	10.4081/reumatismo.2024.1607
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Article: An algorithm for 3-D automatic movement detection by means of standard TV cameras.

Borghese, N A / Ferrigno, G

IEEE transactions on bio-medical engineering

1990 Volume 37, Issue 12, Page(s) 1221–1225

Abstract: An algorithm for the computation of 3-D coordinates (space intersection) of marked points ... to meet the requirements of routinary analysis in biomechanic laboratories. 3-D geometrical arrangement ... squares estimation and requires little time for calibration operations; 3-D coordinates are computed ...

Abstract	An algorithm for the computation of 3-D coordinates (space intersection) of marked points on a moving subject surveyed by a couple of TV cameras is presented herein. It has been designed in order to meet the requirements of routinary analysis in biomechanic laboratories. 3-D geometrical arrangement of the TV cameras (space resection) is obtained by means of a method which is based on an iterative least-squares estimation and requires little time for calibration operations; 3-D coordinates are computed by means of a fast geometrical intersection algorithm. The whole algorithm has been extensively used in different laboratories and results on its reliability and accuracy are reported.
MeSH term(s)	Algorithms ; Biomechanical Phenomena ; Humans ; Image Processing, Computer-Assisted ; Movement/physiology ; Television/instrumentation
Language	English
Publishing date	1990-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	160429-6
ISSN	1558-2531 ; 0018-9294
ISSN (online)	1558-2531
ISSN	0018-9294
DOI	10.1109/10.64466
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Article ; Online: Pharmacological Therapy of Pruritus in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.

Medina-Morales, Esli / Barba Bernal, Romelia / Gerger, Heike / Goyes, Daniela / Trivedi, Hirsh D / Ferrigno, Bryan / Patwardhan, Vilas / Bonder, Alan

Journal of clinical gastroenterology

2023 Volume 57, Issue 2, Page(s) 143–152

Abstract: Goals: We aim to summarize the current management of pruritus in primary biliary cholangitis (PBC) by evaluating the efficacy and safety of pharmacological therapies.: Background: Pruritus is a common symptom of PBC, and evidence regarding the most ... ...

Abstract	Goals: We aim to summarize the current management of pruritus in primary biliary cholangitis (PBC) by evaluating the efficacy and safety of pharmacological therapies. Background: Pruritus is a common symptom of PBC, and evidence regarding the most effective antipruritic agents available is lacking. New pharmacotherapy for PBC has shown promising antipruritic effects. Study: We performed a systematic literature review and meta-analysis including all available double-blind, randomized, placebo-controlled clinical trials that evaluated the efficacy of pharmacotherapy for the symptomatic management of pruritus in PBC. Pruritus was assessed as either a change from baseline or a postintervention score. Results: We included 33 studies and 20 medications. Using the visual analog scale, cholestyramine did not significantly improve pruritus compared with placebo [standardized mean differences (SMD): -0.94, 95% CI: -2.05 to 0.17], whereas rifampin and nalfurafine hydrochloride both significantly improved pruritus (SMD: -3.29, 95% CI: -5.78 to -0.80; n=23 and SMD: -0.58, 95% CI: -1.04 to -0.12). In addition, Bezafibrate and linerixibat significantly improved pruritus (SMD: -1.05, 95% CI: -1.41 to -0.68; n=110 and SMD: -0.31, 95% CI: -0.62 to -0.04, respectively). This effect was also present within the subgroup analysis by pruritus scale, where both bezafibrate and linerixibat significantly improved pruritus compared with placebo (SMD: -1.09, 95% CI: -1.54 to -0.65; P <0.001; visual analog scale; as postintervention score and SMD: -0.31, 95% CI: -0.62 to -0.01; P =0.04; numeric rating scale; as a change from baseline score, respectively). Conclusions: Bezafibrate and Linerixibat are potential second-line antipruritic medications for PBC, particularly those with moderate to severe pruritus.
MeSH term(s)	Humans ; Liver Cirrhosis, Biliary/complications ; Liver Cirrhosis, Biliary/drug therapy ; Antipruritics/therapeutic use ; Treatment Outcome ; Bezafibrate/therapeutic use ; Randomized Controlled Trials as Topic ; Pruritus/drug therapy ; Pruritus/etiology
Chemical Substances	Antipruritics ; Bezafibrate (Y9449Q51XH)
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	448460-5
ISSN	1539-2031 ; 0192-0790
ISSN (online)	1539-2031
ISSN	0192-0790
DOI	10.1097/MCG.0000000000001797
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In stock of ZB MED Cologne/Königswinter

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More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito