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  1. Book ; Thesis: Initiation, progression and remission of diabetic nephropathy

    Hovind, Peter

    2005  

    Author's details Peter Hovind
    Keywords Nephropathia diabetica
    Subject Diabetische Nephropathie
    Language English ; Danish
    Size 85 S. : graph. Darst.
    Publisher Lægeforeningens Forl
    Publishing place København
    Publishing country Denmark
    Document type Book ; Thesis
    Thesis / German Habilitation thesis København, Univ., Diss., 2005
    Note Zsfassung in dän. Sprache
    HBZ-ID HT014705110
    ISBN 87-7891-111-7 ; 978-87-7891-111-7
    Database Catalogue ZB MED Medicine, Health

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    2005 D 61 order for loan Magazin

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  2. Article ; Online: [No title information]

    Lønnee, Mads Fich / Carlsen, Esben Andreas / Hovind, Peter

    Ugeskrift for laeger

    2023  Volume 185, Issue 13

    Title translation Spondylitis kompliceret med septiske embolier i lunger og muskulatur.
    MeSH term(s) Humans ; Spondylitis ; Muscles ; Sepsis ; Lung
    Language Danish
    Publishing date 2023-03-31
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  3. Article ; Online: The GLP-1-mediated gut-kidney cross talk in humans: mechanistic insight.

    Hinrichs, Gitte R / Hovind, Peter / Asmar, Ali

    American journal of physiology. Cell physiology

    2023  Volume 326, Issue 2, Page(s) C567–C572

    Abstract: Incretin-based therapy is an antidiabetic and antiobesity approach mimicking glucagon-like peptide-1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies, investigating the renal ... ...

    Abstract Incretin-based therapy is an antidiabetic and antiobesity approach mimicking glucagon-like peptide-1 (GLP-1) with additional end-organ protection. This review solely focuses on randomized, controlled mechanistic human studies, investigating the renal effects of GLP-1. There is no consensus about the localization of GLP-1 receptors (GLP-1Rs) in human kidneys. Rodent and primate data suggest GLP-1R distribution in smooth muscle cells in the preglomerular vasculature. Native GLP-1 and GLP-1R agonists elicit renal effects. Independently of renal plasma flow and glomerular filtration rate, GLP-1 has a natriuretic effect but only during volume expansion. This is associated with high renal extraction of GLP-1, suppression of angiotensin II, and increased medullary as well as cortical perfusion. These observations may potentially indicate that impaired GLP-1 sensing could establish a connection between salt sensitivity and insulin resistance. It is concluded that a functional GLP-1 kidney axis exists in humans, which may play a role in renoprotection.
    MeSH term(s) Animals ; Humans ; Glucagon-Like Peptide 1/pharmacology ; Kidney ; Hypoglycemic Agents/pharmacology ; Signal Transduction ; Glucagon-Like Peptide-1 Receptor
    Chemical Substances Glucagon-Like Peptide 1 (89750-14-1) ; Hypoglycemic Agents ; Glucagon-Like Peptide-1 Receptor
    Language English
    Publishing date 2023-12-18
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00476.2023
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  4. Article ; Online: [Aksillør lymfeknudesvulst efter vaccination mod COVID-19].

    Falkentoft, Rikke Bannebjerg Baarts / Jensen, Mads Radmar / Hovind, Peter

    Ugeskrift for laeger

    2022  Volume 184, Issue 5

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2 ; Vaccination
    Language Danish
    Publishing date 2022-02-17
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
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  5. Article ; Online: Sertraline treatment influences [18F]FE-PE2I PET imaging for Parkinsonism

    Thomas E. H. Justesen / Per Borghammer / Joel Aanerud / Peter Hovind / Lisbeth Marner

    EJNMMI Research, Vol 13, Iss 1, Pp 1-

    2023  Volume 6

    Abstract: Abstract Background The dopamine transporter (DaT) PET ligand [18F]FE-PE2I is used to aid ... who all showed atypical findings on [18F]FE-PE2I PET, we suspected ... with [18F]FE-PE2I PET after a 5-day sertraline pause. Sertraline plasma concentration was estimated based ...

    Abstract Abstract Background The dopamine transporter (DaT) PET ligand [18F]FE-PE2I is used to aid the diagnosis of Parkinson’s disease. After encountering four patients with a history of daily sertraline use, who all showed atypical findings on [18F]FE-PE2I PET, we suspected that the selective serotonin reuptake inhibitor (SSRI), sertraline, might interfere with the results and lead to globally reduced striatal [18F]FE-PE2I binding due to sertraline’s high affinity for DaT. Methods We rescanned the four patients with [18F]FE-PE2I PET after a 5-day sertraline pause. Sertraline plasma concentration was estimated based on body weight and dose, and specific binding ratios (SBR) in caudate nucleus, known to be more preserved in Parkinson’s, were used to estimate the effect on tracer binding. Comparison was made to a patient with [18F]FE-PE2I PET before and after a 7-day Modafinil pause. Results We found a significant effect of sertraline on caudate nucleus SBR (p = 0.029). The effect showed a linear dose-dependent relationship that corresponds to a reduction in SBR by 0.32 or 0.44 for a 75 kg male or a 65 kg female, respectively, taking a daily dose of 50 mg sertraline. Conclusion Sertraline is one of the most commonly used antidepressants and in contrast to other SSRI’s, sertraline show high affinity for DaT. We recommend that sertraline treatment is taken into account when patients are undergoing [18F]FE-PE2I PET especially in patients showing apparent globally reduced PE2I binding. If tolerable, pausing of the sertraline treatment should be considered, especially for doses above 50 mg/day.
    Keywords Dopamine transporter ; SSRI ; Blocking ; DAT ; Positron emission tomography ; Parkinson’s disease ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Sertraline treatment influences [

    Justesen, Thomas E H / Borghammer, Per / Aanerud, Joel / Hovind, Peter / Marner, Lisbeth

    EJNMMI research

    2023  Volume 13, Issue 1, Page(s) 46

    Abstract: Background: The dopamine transporter (DaT) PET ligand [: Methods: We rescanned the four ...

    Abstract Background: The dopamine transporter (DaT) PET ligand [
    Methods: We rescanned the four patients with [
    Results: We found a significant effect of sertraline on caudate nucleus SBR (p = 0.029). The effect showed a linear dose-dependent relationship that corresponds to a reduction in SBR by 0.32 or 0.44 for a 75 kg male or a 65 kg female, respectively, taking a daily dose of 50 mg sertraline.
    Conclusion: Sertraline is one of the most commonly used antidepressants and in contrast to other SSRI's, sertraline show high affinity for DaT. We recommend that sertraline treatment is taken into account when patients are undergoing [
    Language English
    Publishing date 2023-05-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-023-01000-6
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  7. Article ; Online: Age- and sex-specific changes in visceral fat mass throughout the life-span.

    Baarts, Rikke Bannebjerg / Jensen, Mads Radmer / Hansen, Ole Michael / Haddock, Bryan / Prescott, Eva / Hovind, Peter / Simonsen, Lene / Bülow, Jens / Suetta, Charlotte

    Obesity (Silver Spring, Md.)

    2023  Volume 31, Issue 7, Page(s) 1953–1961

    Abstract: Objective: Visceral fat mass (VFM) is a risk factor for cardiovascular diseases, type 2 diabetes mellitus, and malignancy; however, normative data are limited. The aim of this study was to provide reference data for VFM from a large, apparently healthy ... ...

    Abstract Objective: Visceral fat mass (VFM) is a risk factor for cardiovascular diseases, type 2 diabetes mellitus, and malignancy; however, normative data are limited. The aim of this study was to provide reference data for VFM from a large, apparently healthy Caucasian adult population.
    Methods: Volunteers aged 20 to 93 years from the Copenhagen City Heart Study had a standardized whole-body dual-energy x-ray absorptiometry scan performed using the iDXA (GE Lunar). Total and regional fat mass was measured. VFM was quantified using the CoreScan application.
    Results: A total of 1277 participants were included (708 women, mean [SD], age: 56  [19] years, height: 1.66 [0.07] m, BMI: 24.64 [4.31] kg/m
    Conclusions: Normative data of VFM from a large, healthy Danish cohort aged 20 to 93 years are presented. VFM increased with age in both sexes, but men had significantly higher VFM compared with women with the same BMI, body fat percentage, and fat mass index.
    MeSH term(s) Adult ; Male ; Humans ; Female ; Middle Aged ; Diabetes Mellitus, Type 2/metabolism ; Intra-Abdominal Fat/diagnostic imaging ; Intra-Abdominal Fat/metabolism ; Body Mass Index ; Longevity ; Risk Factors ; Absorptiometry, Photon ; Body Composition
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.23779
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    Zs.MG 87: Show issues

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  8. Article ; Online: 82

    Krakauer, Martin / Ismail, Afefah / Talleruphuus, Ulrik / Henriksen, Alexander Cuculiza / Lonsdale, Markus N / Rasmussen, Inge Lise / Fuglsang, Stefan / Prescott, Eva / Hovind, Peter / Marner, Lisbeth

    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

    2023  Volume 30, Issue 6, Page(s) 2790–2802

    Abstract: Background: 82: Methods: A total of 37 patients referred for perfusion imaging due to suspicion of coronary stenosis were examined with both : Results: [: Conclusions: In clinical transition ... ...

    Abstract Background: 82
    Methods: A total of 37 patients referred for perfusion imaging due to suspicion of coronary stenosis were examined with both
    Results: [
    Conclusions: In clinical transition from
    MeSH term(s) Humans ; Prospective Studies ; Myocardial Ischemia/diagnostic imaging ; Positron-Emission Tomography/methods ; Ischemia ; Perfusion ; Myocardial Perfusion Imaging/methods ; Coronary Artery Disease/diagnostic imaging ; Coronary Circulation
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212505-2
    ISSN 1532-6551 ; 1071-3581
    ISSN (online) 1532-6551
    ISSN 1071-3581
    DOI 10.1007/s12350-023-03372-7
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  9. Article ; Online: Erratum to: determinants of vitamin D status in young adults: influence of lifestyle, sociodemographic and anthropometric factors.

    Tønnesen, Rune / Hovind, Peter Hambak / Jensen, Lars Thorbjørn / Schwarz, Peter

    BMC public health

    2017  Volume 18, Issue 1, Page(s) 14

    Language English
    Publishing date 2017-07-12
    Publishing country England
    Document type Published Erratum
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-017-4559-2
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  10. Article ; Online: Modulation of the sympathetic nervous system in youngsters by vitamin-D supplementation.

    Tønnesen, Rune / Schwarz, Peter / Hovind, Peter / Jensen, Lars Thorbjørn

    Physiological reports

    2018  Volume 6, Issue 7, Page(s) e13635

    Abstract: The level of circulating vitamin D is known to be associated with the ejection fraction in heart failure patients and studies in rats have shown that vitamin D depletion leads to increased levels of circulating norepinephrine and decreased atrial ... ...

    Abstract The level of circulating vitamin D is known to be associated with the ejection fraction in heart failure patients and studies in rats have shown that vitamin D depletion leads to increased levels of circulating norepinephrine and decreased atrial contractility. We elucidated the effects of vitamin D supplementation on the autonomous nervous system in healthy youngsters. Thirty healthy subjects aged 18-25 years were recruited based on their serum 25-hydroxyvitamin D (25[OH]D): 15 vitamin D insufficient (25[OH]D < 50 nmol/L) and 15 vitamin D sufficient (25[OH]D > 80 nmol/L) subjects. Both groups had vitamin D supplementation (30 microg/day) and were tested at baseline and after 30, 90, and 180 days. At each visit the serum 25-hydroxyvitamin D was measured and the head-up tilt test performed. Serum 25[OH]D remained stable in the vitamin D sufficient group, while the insufficient group had a significant increase (32.0-64.5 nmol/L), P < 0.0001. Despite the increase, the insufficient group did not reach the level of the vitamin D sufficient group within the 6 months observational period (96.1 vs 64.5 nmol/L), P < 0.01. Serum norepinephrine at baseline was higher in the insufficient group (mean = 1.61 nmol/L) than in the vitamin D sufficient group (mean = 0.94 nmol/L), P < 0.01, whereas the response to tilt was lower in the insufficient group (mean = 0.69 nmol/L) compared to the sufficient group (mean = 1.17 nmol/L), P < 0.01. The heart rate at rest was higher in the insufficient group (mean = 67.7 bpm) than in the vitamin D sufficient group (mean = 56.6 bpm), P < 0.01, for the three first visits. At the last visit no difference was found. The systolic and diastolic blood pressure differed between the groups after a month, with higher pressures in the insufficient group than in the sufficient group. Vitamin D supplementation modulates the sympathetic nervous system in healthy youngsters with low serum vitamin D. The observation might lead to a greater focus on possible prevention of cardiac disease later on in life by vitamin D supplementation early in life.
    MeSH term(s) Adolescent ; Adult ; Blood Pressure/physiology ; Dietary Supplements ; Heart Rate/physiology ; Humans ; Sympathetic Nervous System/physiology ; Tilt-Table Test ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D/pharmacology ; Vitamin D Deficiency/physiopathology ; Young Adult
    Chemical Substances Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
    Language English
    Publishing date 2018-04-03
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.13635
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