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Article: Age-appropriate design of domestic intelligent medical products: An example of smart blood glucose detector for the elderly with AHP-QFD Joint KE.

Li, Xiaojie / Li, Hong

2024 Volume 10, Issue 5, Page(s) e27387

Abstract: ... functionalities and service design elements. Further, we employed Kansei Engineering (KE) to select sample designs ...

Abstract	Background: In response to the rise of intelligent products and the increasing prevalence of urban "empty nesters," we have developed a product specifically tailored for elderly diabetic patients. This product fulfils functional requirements and addresses stylistic preferences, contributing to the age-friendly evolution of home intelligent medical devices, particularly in intelligent blood glucose monitoring. Methods: Our approach commenced with a comprehensive user experience analysis to ascertain the needs of elderly users regarding home blood glucose meters. This involved constructing a hierarchy of user demands, followed by analysing and prioritising these needs. Utilizing Quality Function Deployment (QFD), we aligned user requirements with design specifications, identifying specific product functionalities and service design elements. Further, we employed Kansei Engineering (KE) to select sample designs that resonate with the concept of sensual imagery, leading to the derivation of specific modelling intentions. Combining these design elements, we proposed product design strategies and conducted practical case studies. The effectiveness of these designs was then assessed through fuzzy evaluation methods, allowing for user feedback. Results: Employing the Analytic Hierarchy Process for goal analysis, along with Quality Function Deployment theory and Kansei Engineering, we developed a home intelligent blood glucose meter catered to the elderly. This device not only meets its users' physiological and psychological needs but also provides an operationally convenient, health-conscious, and aesthetically pleasing experience. Conclusions: This methodology enhances the age-appropriate design of home-based smart glucose monitors for the elderly, offering innovative insights and optimization strategies for designing elderly-centric smart medical products.
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e27387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incorrect P Values in Two Articles by Ke-Xuan Liu, M.D., Ph.D., et al.

Liu, Ke-Xuan / Li, Cai / Yang, Wen-Han

Anesthesiology

2019 Volume 131, Issue 1, Page(s) 220

MeSH term(s)	Anesthetics ; Periodicals as Topic
Chemical Substances	Anesthetics
Language	English
Publishing date	2019-06-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000002792
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Article: Therapeutic mechanisms of the medicine and food homology formula Xiao-Ke-Yin on glucolipid metabolic dysfunction revealed by transcriptomics, metabolomics and microbiomics in mice.

Li, Mei / Cheng, Ding / Peng, Chuan / Huang, Yujiao / Geng, Jie / Huang, Guangrui / Wang, Ting / Xu, Anlong

Chinese medicine

2023 Volume 18, Issue 1, Page(s) 57

Abstract: ... therapeutic choice. Xiao-Ke-Yin (XKY) is a medicine and food homology TCM formula consisting of nine "medicine ...

Abstract	Background: In recent decades, the prevalence of metabolic diseases, particularly diabetes, hyperlipidemia, obesity, and non-alcoholic fatty liver disease (NAFLD), has increased dramatically, causing great public health and economic burdens worldwide. Traditional Chinese medicine (TCM) serves as an effective therapeutic choice. Xiao-Ke-Yin (XKY) is a medicine and food homology TCM formula consisting of nine "medicine and food homology" herbs and is used to ameliorate metabolic diseases, such as insulin resistance, diabetes, hyperlipidemia and NAFLD. However, despite its therapeutic potential in metabolic disorders, the underlying mechanisms of this TCM remain unclear. This study aimed to evaluate the therapeutic effectiveness of XKY on glucolipid metabolism dysfunction and explore the potential mechanisms in db/db mice. Methods: To verify the effects of XKY, db/db mice were treated with different concentrations of XKY (5.2, 2.6 and 1.3 g/kg/d) and metformin (0.2 g/kg/d, a hypoglycemic positive control) for 6 weeks, respectively. During this study, we detected the body weight (BW) and fasting blood glucose (FBG), oral glucose tolerance test (OGTT), insulin tolerance test (ITT), daily food intake and water intake. At the end of the animal experiment, blood samples, feces, liver and intestinal tissue of mice in all groups were collected. The potential mechanisms were investigated by using hepatic RNA sequencing, 16 S rRNA sequencing of the gut microbiota and metabolomics analysis. Results: XKY efficiently mitigated hyperglycemia, IR, hyperlipidemia, inflammation and hepatic pathological injury in a dose dependent manner. Mechanistically, hepatic transcriptomic analysis showed that XKY treatment significantly reversed the upregulated cholesterol biosynthesis which was further confirmed by RT-qPCR. Additionally, XKY administration maintained intestinal epithelial homeostasis, modulated gut microbiota dysbiosis, and regulated its metabolites. In particular, XKY decreased secondary bile acid producing bacteria (Clostridia and Lachnospircaeae) and lowered fecal secondary bile acid (lithocholic acid (LCA) and deoxycholic acid (DCA)) levels to promote hepatic bile acid synthesis by inhibiting the LCA/DCA-FXR-FGF15 signalling pathway. Furthermore, XKY regulated amino acid metabolism including arginine biosynthesis, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, and tryptophan metabolism likely by increasing Bacilli, Lactobacillaceae and Lactobacillus, and decreasing Clostridia, Lachnospircaeae, Tannerellaceae and Parabacteroides abundances. Conclusion: Taken together, our findings demonstrate that XKY is a promising "medicine food homology" formula for ameliorating glucolipid metabolism and reveal that the therapeutic effects of XKY may due to its downregulation of hepatic cholesterol biosynthesis and modulation of the dysbiosis of the gut microbiota and metabolites.
Language	English
Publishing date	2023-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-023-00752-6
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Article ; Online: Lu Tong Ke Li protects neurons from injury by regulating inflammation in rats with brain trauma.

Chen, Jie / Li, Ting-Ting / Chen, Ting-Bao / Niu, Rui-Ze / Chen, Ji-Lin / Chen, Yong / Huang, Jin

Ibrain

2022 Volume 8, Issue 1, Page(s) 100–108

Abstract: ... was conducted to determine the protective effect of Lu Tong Ke Li (LTKL), a Chinese medicine, for TBI ...

Abstract	Currently, there is no effective therapy for traumatic brain injury (TBI). Therefore, this study was conducted to determine the protective effect of Lu Tong Ke Li (LTKL), a Chinese medicine, for TBI in experimental animals. The TBI rat model was induced using the modified Feeney's protocol. The rats were divided into four groups: Sham group, Control group, LTKL lower-dose group (LTL, 2 g/kg/day, p.o.), and LTKL higher-dose group (LTH, 4 g/kg/day, p.o.). The Neurological Severity Score (NSS) was used to examine neurological function. Magnetic resonance imaging was performed to check the brain tissue lesions in rats. Cell apoptosis in the damaged area was evaluated using the Terminal deoxynucleotidyl transferase deoxy-UTP-nick end labeling assay. Reverse-transcription polymerase chain reaction was used to investigate the expression of inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), and interleukin 10 (IL-10). The TBI rat model was successfully constructed. Neurological function was enhanced at 14, 21, and 28 days post TBI in the LTH groups, indicated by gradually decreased NSS scores. Administration of LTH led to fewer brain defects in the damaged area, and the number of apoptosis cells in the brain injury area markedly decreased. LTKL treatment led to upregulation of IL-10 expression and downregulation of TNF-α and IL-1β expressions at the molecular level. LTKL can improve the neurobehavior of TBI. The neuroprotective effect was probably related to regulation of inflammation cytokines. Our results provide crucial evidence of the potentially useful application of LTKL in the therapy of TBI in clinic practice in the future.
Language	English
Publishing date	2022-03-11
Publishing country	United States
Document type	Journal Article
ISSN	2769-2795
ISSN (online)	2769-2795
DOI	10.1002/ibra.12029
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Article ; Online: Gu-Ben-Zhi-Ke-Zhong-Yao Alleviated PM2.5-Induced Lung Injury via HMGB1/NF-

Hou, Wenxiao / Zhang, Hongchun / Jiang, Meng / Wu, Yina / Li, Tao / Cong, Luhong / Duan, Jun

publication RETRACTED

Journal of healthcare engineering

2022 Volume 2022, Page(s) 8450673

Abstract: Background: Inhalation of particles with a diameter of less than 2.5 : Methods: We constructed a mice lung injury model through PM2.5 stimulation and simultaneously performed GBZK gavage treatment. After 4 weeks, the lung tissues of the mice were ... ...

Abstract	Background: Inhalation of particles with a diameter of less than 2.5 Methods: We constructed a mice lung injury model through PM2.5 stimulation and simultaneously performed GBZK gavage treatment. After 4 weeks, the lung tissues of the mice were collected for pathological staining to analyze the degree of damage. The activities of myeloperoxidase (MPO), malondialdehyde (MDA), and oxidative stress-related factors (superoxide dismutase, SOD; glutathione peroxidase, GSH-Px) were detected by commercial kit in lung tissue. Furthermore, the number of neutrophils and related inflammatory factors (interleukin-1, IL-1 Results: The result revealed that PM2.5 induces lung damage, and GBZK gavage treatment could reduce the degree of injury in a concentration-dependent manner in mice. After GBZK treatment, the MPO activity, MDA content, and oxidative stress level in the lung tissues of mice decreased. And after GBZK treatment, the expression levels of inflammatory cytokines in BALF and blood were decreased. GBZK treatment also improved pulmonary fibrosis in mice. In addition, we also found that GBZK prevented the up-regulation of the HMGB1/NF- Conclusion: These results indicated that GBZK might protect mice from PM2.5-induced lung injury by inhibiting the HMGB1/NF
MeSH term(s)	Animals ; HMGB1 Protein ; Humans ; Inflammation ; Lung Injury/chemically induced ; Lung Injury/drug therapy ; Mice ; NF-kappa B/metabolism ; Particulate Matter ; Pulmonary Fibrosis ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	HMGB1 Protein ; NF-kappa B ; Particulate Matter ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2545054-2
ISSN	2040-2309 ; 2040-2295
ISSN (online)	2040-2309
ISSN	2040-2295
DOI	10.1155/2022/8450673
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Article: Jie Ke versus AlphaGo

Chao, Xiangrui / Yi Peng / Kou, Gang / Li, Tie

European journal of operational research : EJOR Vol. 265, No. 1 , p. 239-247

a ranking approach using decision making method for large-scale data with incomplete information

2018 Volume 265, Issue 1, Page(s) 239–247

Author's details	Xiangrui Chao, Gang Kou, Tie Li, Yi Peng
Keywords	Multiple criteria analysis ; Incomplete fuzzy pair-wise comparison matrix ; Cosine similarity measure ; Ranking large-scale alternatives
Language	English
Publisher	Elsevier
Publishing place	Amsterdam
Document type	Article
ZDB-ID	243003-4
ISSN	0377-2217
Database	ECONomics Information System

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Article ; Online: Effects of the Chinese herbal formula San-Huang Gu-Ben Zhi-Ke treatment on stable chronic obstructive pulmonary disease

Tianyi Lyu / Demin Li / Xiang Lei / Yuteng Zhang / Shilei Cheng / Xinyang Shu / Hongchun Zhang

Frontiers in Pharmacology, Vol

a randomized, double-blind, placebo-controlled trial

2023 Volume 14

Abstract: ... formula San-Huang Gu-Ben Zhi-Ke (SHGBZK) as a treatment for patients with stable chronic ...

Abstract	Objective: The aim of this study was to evaluate the efficacy and safety of the Chinese herbal formula San-Huang Gu-Ben Zhi-Ke (SHGBZK) as a treatment for patients with stable chronic obstructive pulmonary disease (COPD) diagnosed with lung-spleen Qi deficiency.Method: A randomized, double-blind, placebo-controlled trial was designed. 98 adults aged between 40 and 80 years with stable COPD diagnosed with lung-spleen Qi deficiency were included. All participants received basic treatment for COPD. Patients in the experimental group took SHGBZK, while the control group took placebo. The primary outcome was the frequency of acute exacerbation. The secondary outcomes were lung function, symptom score, exercise capacity and quality of life.Results: Of 98 patients who underwent randomization, 50 patients in the SHGBZK group and 48 in the placebo group were included in the full analysis set. After 24-week therapy and 28-week follow-up, patients in treatment group had significant improvements in symptom, exercise capacity and quality of life. After Subgroup analysis, the frequency of acute exacerbation in patients with a COPD Assessment Test (CAT) score of at least 10 or a modified Medical Research Council (mMRC) score of at least 2 was significantly lower in the SHGBZK group than in the placebo group. Lung function in patients with frequent exacerbation was significantly higher in the SHGBZK group than in the placebo group. The incidence of adverse events was generally similar in the two groups.Conclusion: SHGBZK had beneficial effects on symptom, exercise capacity and quality of life in stable COPD patients. SHGBZK also had the potential to reduce the frequency of exacerbation and improve lung function in specific groups of COPD patients.Clinical Trial Registration:https://www.chictr.org.cn/showproj.html?proj=26933, identifier ChiCTR1800016349
Keywords	chronic obstructive pulmonary disease ; traditional Chinese medicine ; San-Huang Gu-Ben Zhi-Ke ; clinical trials ; subgroup analysis ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of the Chinese herbal formula San-Huang Gu-Ben Zhi-Ke treatment on stable chronic obstructive pulmonary disease: a randomized, double-blind, placebo-controlled trial.

Lyu, Tianyi / Li, Demin / Lei, Xiang / Zhang, Yuteng / Cheng, Shilei / Shu, Xinyang / Zhang, Hongchun

Frontiers in pharmacology

2023 Volume 14, Page(s) 1164818

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1164818
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Book: Wang zhe ke jian

Li, Honghe

Zhongguo gong chan dang ling dao wei sheng fang yi shi ye de li shi jing yan yan jiu = Lessons from history : a study on the experience of health and diseases prevention under the leadership of the Communist Party of China

2016

Title variant	Lessons from history : a study on the experience of health and diseases prevention under the leadership of the Communist Party of China
Institution	Zhongguo gong chan dang
Author's details	Li Honghe zhu
MeSH term(s)	Preventive Health Services/organization & administration ; Communism/history ; History, 20th Century ; History, 21st Century
Keywords	China
Language	Chinese
Size	2, 360 pages ;, 26 cm
Edition	Di 1 ban.
Document type	Book
ISBN	9787010160108 ; 7010160104
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Lu Tong Ke Li protects neurons from injury by regulating inflammation in rats with brain trauma

Jie Chen / Ting‐Ting Li / Ting‐Bao Chen / Rui‐Ze Niu / Ji‐Lin Chen / Yong Chen / Jin Huang

Ibrain, Vol 8, Iss 1, Pp 100-

2022 Volume 108

Abstract: ... Therefore, this study was conducted to determine the protective effect of Lu Tong Ke Li (LTKL), a Chinese medicine ...

Abstract	Abstract Currently, there is no effective therapy for traumatic brain injury (TBI). Therefore, this study was conducted to determine the protective effect of Lu Tong Ke Li (LTKL), a Chinese medicine, for TBI in experimental animals. The TBI rat model was induced using the modified Feeney's protocol. The rats were divided into four groups: Sham group, Control group, LTKL lower‐dose group (LTL, 2 g/kg/day, p.o.), and LTKL higher‐dose group (LTH, 4 g/kg/day, p.o.). The Neurological Severity Score (NSS) was used to examine neurological function. Magnetic resonance imaging was performed to check the brain tissue lesions in rats. Cell apoptosis in the damaged area was evaluated using the Terminal deoxynucleotidyl transferase deoxy‐UTP‐nick end labeling assay. Reverse‐transcription polymerase chain reaction was used to investigate the expression of inflammatory cytokines, including tumor necrosis factor‐α (TNF‐α), interleukin 1β (IL‐1β), and interleukin 10 (IL‐10). The TBI rat model was successfully constructed. Neurological function was enhanced at 14, 21, and 28 days post TBI in the LTH groups, indicated by gradually decreased NSS scores. Administration of LTH led to fewer brain defects in the damaged area, and the number of apoptosis cells in the brain injury area markedly decreased. LTKL treatment led to upregulation of IL‐10 expression and downregulation of TNF‐α and IL‐1β expressions at the molecular level. LTKL can improve the neurobehavior of TBI. The neuroprotective effect was probably related to regulation of inflammation cytokines. Our results provide crucial evidence of the potentially useful application of LTKL in the therapy of TBI in clinic practice in the future.
Keywords	Chinese medicine ; Inflammation genes ; Lu Tong Ke Li ; Neuroprotection ; Traumatic brain injury ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	610
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Wiley-VCH
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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