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Article ; Online: OCCUPATIONAL ALLERGY.

Anderson, Stacey E / Long, Carrie / Dotson, G Scott

European Medical Journal (Chelmsford, England)

2019 Volume 2, Issue 2, Page(s) 65–71

Abstract: ... which can adversely affect health and well-being. Hundreds of chemicals (e.g. metals, epoxy and acrylic resins, rubber ... additives, and chemical intermediates) and proteins (e.g. natural rubber latex, plant proteins, mould ...

Abstract	An estimated 11 million workers in the USA are potentially exposed to agents that can become a cause of allergic diseases such as occupational asthma and allergic contact dermatitis, which can adversely affect health and well-being. Hundreds of chemicals (e.g. metals, epoxy and acrylic resins, rubber additives, and chemical intermediates) and proteins (e.g. natural rubber latex, plant proteins, mould, animal dander) present in virtually every industry have been identified as causes of allergic disease. In general, allergens can be classified as low molecular weight (chemical) allergens and high molecular weight (protein) allergens. These agents are capable of inducing immunological responses that are both immunoglobulin E and non-immunoglobulin E-mediated. Interestingly, the same chemical can induce diverse immune responses in different individuals. As new hazards continue to emerge, it is critical to understand the immunological mechanisms of occupational allergic disease. Specific understanding of these mechanisms has direct implications in hazard identification, hazard communication, and risk assessment. Such efforts will ultimately assist in the development of risk management strategies capable of controlling workplace exposures to allergens to prevent the induction of sensitisation in naïve individuals and inhibit elicitation of allergic responses. The purpose of this short review is to give a brief synopsis of the incidence, agents, mechanisms, and research needs related to occupational allergy.
Language	English
Publishing date	2019-03-29
Publishing country	England
Document type	Journal Article
ISSN	2397-6764
ISSN (online)	2397-6764
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Risk Assessment's New Era, Part 3: Vision of the AIHA

Rossner, Alan / Dotson, G Scott

Synergist (Akron, Ohio)

2015 Volume 23, Page(s) 30–31

Language	English
Publishing date	2015-06-25
Publishing country	United States
Document type	Journal Article
ISSN	1066-7660
ISSN	1066-7660
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Challenges and Opportunities for Communication about the Role of Genomics in Public Health.

Allen, Caitlin G / Green, Ridgely Fisk / Bowen, Scott / Dotson, W David / Yu, Wei / Khoury, Muin J

Public health genomics

2021 Volume 24, Issue 1-2, Page(s) 67–74

Abstract: Despite growing awareness about the potential for genomic information to improve population health, lingering communication challenges remain in describing the role of genomics in public health programs. Identifying and addressing these challenges ... ...

Abstract	Despite growing awareness about the potential for genomic information to improve population health, lingering communication challenges remain in describing the role of genomics in public health programs. Identifying and addressing these challenges provide an important opportunity for appropriate communication to ensure the translation of genomic discoveries for public health benefits. In this commentary, we describe 5 common communication challenges encountered by the Centers for Disease Control and Prevention's Office of Genomics and Precision Public Health based on over 20 years of experience in the field. These include (1) communicating that using genomics to assess rare diseases can have an impact on public health; (2) providing evidence that genetic factors can add important information to environmental, behavioral, and social determinants of health; (3) communicating that although genetic factors are nonmodifiable, they can increase the impact of public health programs and communication strategies; (4) addressing the concern that genomics is not ready for clinical practice; and (5) communicating that genomics is valuable beyond the domain of health care and can be integrated as part of public health programs. We discuss opportunities for addressing these communication challenges and provide examples of ongoing approaches to communication about the role of genomics in public health to the public, researchers, and practitioners.
MeSH term(s)	Centers for Disease Control and Prevention, U.S. ; Communication ; Delivery of Health Care ; Genomics ; Humans ; Public Health ; Social Determinants of Health ; United States
Language	English
Publishing date	2021-01-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2457023-0
ISSN	1662-8063 ; 1662-4246
ISSN (online)	1662-8063
ISSN	1662-4246
DOI	10.1159/000512485
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4908: Show issues

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Article ; Online: Carcinogenicity of Poorly Soluble Low Toxicity Particles: Commentary on Epidemiology as a Risk Assessment "Reality Check".

Mundt, Kenneth A / Santamaria, Annette B / Thompson, William J / Bates, Christopher A / Boles, Corey / Dotson, G Scott / Yong, Mei

Frontiers in public health

2022 Volume 10, Page(s) 920032

Abstract: Inhaled particles that are poorly soluble or insoluble and of low toxicity ("poorly soluble low toxicity" or "PSLT" particles), can accumulate in the lung and at lung overload levels induce lung cancers in rats. The question of whether PSLT particles ... ...

Abstract	Inhaled particles that are poorly soluble or insoluble and of low toxicity ("poorly soluble low toxicity" or "PSLT" particles), can accumulate in the lung and at lung overload levels induce lung cancers in rats. The question of whether PSLT particles increase lung cancer risk in humans is complicated by large differences between rats and humans and the relatively large particle doses administered in animal studies even when compared with heavy human occupational exposures. We review the findings of epidemiological studies on occupational exposure to each of three different PSLT particles (carbon black, talc and taconite). The epidemiological evidence indicates that at even very high occupational exposure levels at which non-malignant respiratory diseases including pneumoconiosis and even talcosis are observed, lung cancer risks appear not to be elevated. Although positive human cancer risks might be predicted based on extrapolation from overload doses in rats to relevant exposures in humans, the epidemiological "reality check" based on the three examples indicates that these PSLT particles are unlikely to increase lung cancer risk in humans even at high occupational levels of exposure. Therefore, we propose that careful evaluation of the epidemiological evidence can serve as a "reality check" for human risk assessment and help balance the risk evaluation process.
MeSH term(s)	Animals ; Humans ; Lung Neoplasms/chemically induced ; Lung Neoplasms/epidemiology ; Occupational Exposure/adverse effects ; Rats ; Risk Assessment ; Soot/toxicity ; Talc/toxicity
Chemical Substances	Soot ; Talc (14807-96-6)
Language	English
Publishing date	2022-07-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.920032
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Dermal Exposure Risk Management and Logic eTookit: Characterizing and managing dermal exposure during emergency management operations.

Hudson, Naomi L / Dotson, G Scott / Maier, A

Journal of emergency management (Weston, Mass.)

2018 Volume 16, Issue 3, Page(s) 159–172

Abstract: Objective: Emergency management and operations (EMO) personnel require up-to-date information to make informed decisions during natural and man-made disasters. However, information gaps present challenges for accessing human health risk assessment and ... ...

Abstract	Objective: Emergency management and operations (EMO) personnel require up-to-date information to make informed decisions during natural and man-made disasters. However, information gaps present challenges for accessing human health risk assessment and risk management strategies for dermal exposure. This article describes the development of a decision support system, the Dermal Exposure Risk Management and Logic (DERMaL) eToolkit. Design: The DERMaL eToolkit provides information on key resources used in emergency incidents. Resources were classified according to response phase, resource categories, and information category and evaluated on reliability, accessibility, and preference by subject matter experts in emergency management fields. These rankings were used to generate a value of information score, unique for each resource, which aids in developing reference lists for users during each incident phase. Results: This tool will identify and prioritize information resources on dermal risks, and can readily find the most relevant information to suit EMO needs. Conclusion: The DERMaL eToolkit can be used as an aid in finding information resources targeted to scenario-driven needs by providing well-vetted and prioritized resources related to dermal hazards, exposure, and risk assessments for EMO.
MeSH term(s)	Chemical Hazard Release ; Decision Support Techniques ; Disaster Planning ; Environmental Exposure/analysis ; Humans ; Risk Assessment ; Risk Management ; Skin Diseases/chemically induced ; User-Computer Interface
Language	English
Publishing date	2018-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ISSN	1543-5865
ISSN	1543-5865
DOI	10.5055/jem.2018.0365
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Setting occupational exposure limits for antimicrobial agents: A case study based on a quaternary ammonium compound-based disinfectant.

Dotson, G Scott / Lotter, Jason T / Zisook, Rachel E / Gaffney, Shannon H / Maier, Andrew / Colvin, Jonathan

Toxicology and industrial health

2020 Volume 36, Issue 9, Page(s) 619–633

Abstract: Antimicrobial agents have become an essential tool in controlling the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and guidelines on their use have been issued by various public health agencies. Through ... ...

Abstract	Antimicrobial agents have become an essential tool in controlling the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and guidelines on their use have been issued by various public health agencies. Through its
MeSH term(s)	Anti-Infective Agents/standards ; Anti-Infective Agents/therapeutic use ; COVID-19/prevention & control ; Disinfectants/standards ; Disinfectants/therapeutic use ; Humans ; Occupational Exposure/prevention & control ; Occupational Exposure/standards ; Occupational Health ; Organizational Case Studies ; Pandemics ; Quaternary Ammonium Compounds/standards ; Quaternary Ammonium Compounds/therapeutic use ; Risk Assessment ; SARS-CoV-2
Chemical Substances	Anti-Infective Agents ; Disinfectants ; Quaternary Ammonium Compounds
Language	English
Publishing date	2020-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	56831-4
ISSN	1477-0393 ; 0748-2337
ISSN (online)	1477-0393
ISSN	0748-2337
DOI	10.1177/0748233720970438
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2268: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Risk Assessment's New Era: part 2: Evolving Methods and Future Directions.

Williams, Pamela R D / Dotson, G Scott / Maier, Andrew

Synergist (Akron, Ohio)

2015 Volume 25, Issue 5, Page(s) 46–48

Language	English
Publishing date	2015-09-01
Publishing country	United States
Document type	Journal Article
ISSN	1066-7660
ISSN	1066-7660
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evaluation of the Safety and Efficacy of Hand Sanitizer Products Marketed to Children Available during the COVID-19 Pandemic.

Gloekler, Lauren E / de Gandiaga, Elise J / Binczewski, Natalie R / Steimel, Katie G / Massarsky, Andrey / Kozal, Jordan / Vincent, Melissa / Zisook, Rachel / LaGuardia, Mark J / Dotson, Scott / Gaffney, Shannon

International journal of environmental research and public health

2022 Volume 19, Issue 21

Abstract: Hand sanitizer use in the United States (U.S.) increased after the SARS-CoV-2 outbreak. The U.S. Food and Drug Administration (FDA) released temporary manufacturer guidance, changing impurity level limits for alcohol-based hand sanitizers (ABHSs). Since ... ...

Abstract	Hand sanitizer use in the United States (U.S.) increased after the SARS-CoV-2 outbreak. The U.S. Food and Drug Administration (FDA) released temporary manufacturer guidance, changing impurity level limits for alcohol-based hand sanitizers (ABHSs). Since the guidance took effect, the FDA has recommended against using these hand sanitizers due to concerns over safety, efficacy, and/or risk of incidental ingestion. To address current gaps in exposure characterization, this study describes a survey of ABHSs marketed to children available in the U.S., as defined by several inclusion criteria. A subset of ABHSs (
MeSH term(s)	Child ; Humans ; United States ; Hand Sanitizers ; COVID-19/epidemiology ; Pandemics ; SARS-CoV-2 ; Ethanol
Chemical Substances	Hand Sanitizers ; Ethanol (3K9958V90M)
Language	English
Publishing date	2022-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192114424
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Article ; Online: Occupational Allergy

Stacey E. Anderson / Carrie Long / G. Scott Dotson

European Medical Journal, Vol 2, Iss 2, Pp 65-

2017 Volume 71

Abstract	An estimated 11 million workers in the USA are potentially exposed to agents that can become a cause of allergic diseases such as occupational asthma and allergic contact dermatitis, which can adversely affect health and well-being. Hundreds of chemicals (e.g. metals, epoxy and acrylic resins, rubber additives, and chemical intermediates) and proteins (e.g. natural rubber latex, plant proteins, mould, animal dander) present in virtually every industry have been identified as causes of allergic disease. In general, allergens can be classified as low molecular weight (chemical) allergens and high molecular weight (protein) allergens. These agents are capable of inducing immunological responses that are both immunoglobulin E and non-immunoglobulin E-mediated. Interestingly, the same chemical can induce diverse immune responses in different individuals. As new hazards continue to emerge, it is critical to understand the immunological mechanisms of occupational allergic disease. Specific understanding of these mechanisms has direct implications in hazard identification, hazard communication, and risk assessment. Such efforts will ultimately assist in the development of risk management strategies capable of controlling workplace exposures to allergens to prevent the induction of sensitisation in naïve individuals and inhibit elicitation of allergic responses. The purpose of this short review is to give a brief synopsis of the incidence, agents, mechanisms, and research needs related to occupational allergy.
Keywords	allergic contact dermatitis (acd) ; occupational allergy ; asthma ; Medicine ; R
Subject code	610
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	European Medical Journal
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: TCF7L2 silencing results in altered gene expression patterns accompanied by local genomic reorganization.

Brown, Markus A / Dotson, Gabrielle A / Ronquist, Scott / Emons, Georg / Rajapakse, Indika / Ried, Thomas

Neoplasia (New York, N.Y.)

2021 Volume 23, Issue 2, Page(s) 257–269

Abstract: Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling effector in the intestines, is required for stem cell maintenance. The capability of TCF4 to maintain the stem cell phenotype is contingent upon β-catenin, a ... ...

Abstract	Canonical Wnt signaling is crucial for intestinal homeostasis as TCF4, the major Wnt signaling effector in the intestines, is required for stem cell maintenance. The capability of TCF4 to maintain the stem cell phenotype is contingent upon β-catenin, a potent transcriptional activator, which interacts with histone acetyltransferases and chromatin remodeling complexes. We used RNAi to explore the influence of TCF4 on chromatin structure (Hi-C) and gene expression (RNA sequencing) across a 72-hour time series in colon cancer. We found that TCF4 reduction results in a disproportionate up-regulation of gene expression, including a powerful induction of SOX2. Integration of RNA sequencing and Hi-C data revealed a TAD boundary loss, which occurred concomitantly with the over-expression of a cluster of CEACAM genes on chromosome 19. We identified EMT and E2F as the 2 most deregulated pathways upon TCF4 depletion and LUM, TMPO, and AURKA as highly influential genes in these networks using measures of centrality. Results from gene expression, chromatin structure, and centrality analyses were integrated to generate a list of candidate transcription factors crucial for colon cancer cell homeostasis. The top ranked factor was c-JUN, an oncoprotein known to interact with TCF4 and β-catenin, confirming the usefulness of this approach.
MeSH term(s)	3' Untranslated Regions ; Cell Line, Tumor ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin Immunoprecipitation Sequencing ; Colonic Neoplasms/genetics ; Computational Biology/methods ; Gene Expression Profiling ; Gene Expression Regulation ; Gene Silencing ; Humans ; Multigene Family ; RNA Interference ; RNA, Small Interfering/genetics ; Transcription Factor 7-Like 2 Protein/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Wnt Signaling Pathway
Chemical Substances	3' Untranslated Regions ; Chromatin ; RNA, Small Interfering ; TCF7L2 protein, human ; Transcription Factor 7-Like 2 Protein ; Transcription Factors
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	1483840-0
ISSN	1476-5586 ; 1522-8002
ISSN (online)	1476-5586
ISSN	1522-8002
DOI	10.1016/j.neo.2020.12.010
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