LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 212

Search options

  1. Article ; Online: GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.

    De Giovanni, Marco / Chen, Hongwen / Li, Xiaochun / Cyster, Jason G

    Immunological reviews

    2023  Volume 317, Issue 1, Page(s) 187–202

    Abstract: ... of one G-protein coupled receptor, GPR35, in neutrophil recruitment. GPR35 has been challenging to study ... due the description of multiple ligands and G-protein couplings. Recently, we found that GPR35 ...

    Abstract Neutrophil recruitment from circulation to sites of inflammation is guided by multiple chemoattractant cues emanating from tissue cells, immune cells, and platelets. Here, we focus on the function of one G-protein coupled receptor, GPR35, in neutrophil recruitment. GPR35 has been challenging to study due the description of multiple ligands and G-protein couplings. Recently, we found that GPR35-expressing hematopoietic cells respond to the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA). We discuss distinct response profiles of GPR35 to 5-HIAA compared to other ligands. To place the functions of 5-HIAA in context, we summarize the actions of serotonin in vascular biology and leukocyte recruitment. Important sources of serotonin and 5-HIAA are platelets and mast cells. We discuss the dynamics of cell migration into inflamed tissues and how multiple platelet and mast cell-derived mediators, including 5-HIAA, cooperate to promote neutrophil recruitment. Additional actions of GPR35 in tissue physiology are reviewed. Finally, we discuss how clinically approved drugs that modulate serotonin uptake and metabolism may influence 5-HIAA-GPR35 function, and we speculate about broader influences of the GPR35 ligand-receptor system in immunity and disease.
    MeSH term(s) Humans ; Mast Cells ; Neutrophils ; Blood Platelets ; Ligands ; Serotonin/metabolism ; Hydroxyindoleacetic Acid/metabolism ; Inflammation ; Cell Movement ; Neutrophil Infiltration ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Ligands ; Serotonin (333DO1RDJY) ; Hydroxyindoleacetic Acid (54-16-0) ; GPR35 protein, human ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-03-16
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13194
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Chemo- and mechanosensing by dendritic cells facilitate antigen surveillance in the spleen.

    Liu, Dan / Duan, Lihui / Cyster, Jason G

    Immunological reviews

    2022  Volume 306, Issue 1, Page(s) 25–42

    Abstract: ... for adhesion G-protein coupled receptor E5 (Adgre5 or CD97) and its ligand CD55, detailing how ...

    Abstract Spleen dendritic cells (DC) are critical for initiation of adaptive immune responses against blood-borne invaders. Key to DC function is their positioning at sites of pathogen entry, and their abilities to selectively capture foreign antigens and promptly engage T cells. Focusing on conventional DC2 (cDC2), we discuss the contribution of chemoattractant receptors (EBI2 or GPR183, S1PR1, and CCR7) and integrins to cDC2 positioning and function. We give particular attention to a newly identified role in cDC2 for adhesion G-protein coupled receptor E5 (Adgre5 or CD97) and its ligand CD55, detailing how this mechanosensing system contributes to splenic cDC2 positioning and homeostasis. Additional roles of CD97 in the immune system are reviewed. The ability of cDC2 to be activated by circulating missing self-CD47 cells and to integrate multiple red blood cell (RBC)-derived inputs is discussed. Finally, we describe the process of activated cDC2 migration to engage and prime helper T cells. Throughout the review, we consider the insights into cDC function in the spleen that have emerged from imaging studies.
    MeSH term(s) Antigens ; Dendritic Cells ; Homeostasis ; Humans ; Ligands ; Spleen
    Chemical Substances Antigens ; Ligands
    Language English
    Publishing date 2022-02-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.13055
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: T follicular helper cells in germinal center B cell selection and lymphomagenesis.

    Mintz, Michelle A / Cyster, Jason G

    Immunological reviews

    2020  Volume 296, Issue 1, Page(s) 48–61

    Abstract: Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long-lived plasma cells. GCs are also the origin of malignancy, namely ... ...

    Abstract Germinal centers (GCs) are confined anatomic regions where rapidly proliferating B cells undergo somatic mutation and selection and eventual differentiation into memory B cells or long-lived plasma cells. GCs are also the origin of malignancy, namely follicular lymphoma (FL), GC B cell-diffuse large B cell lymphoma (GCB-DLBCL), and Burkitt lymphoma (BL). GC B cell lymphomas maintain their GC transcriptional signatures and sustain many features of the GC microenvironment, including CD4
    MeSH term(s) Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Biomarkers, Tumor ; Cell Differentiation ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/immunology ; Cell Transformation, Neoplastic/metabolism ; Clonal Selection, Antigen-Mediated ; Disease Management ; Disease Susceptibility ; Genetic Predisposition to Disease ; Germinal Center/immunology ; Germinal Center/metabolism ; Humans ; Lymphoma/diagnosis ; Lymphoma/etiology ; Lymphoma/metabolism ; Lymphoma/therapy ; Mutation ; T Follicular Helper Cells/immunology ; T Follicular Helper Cells/metabolism
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2020-05-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 391796-4
    ISSN 1600-065X ; 0105-2896
    ISSN (online) 1600-065X
    ISSN 0105-2896
    DOI 10.1111/imr.12860
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Se 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Transcriptional regulation of memory B cell differentiation.

    Laidlaw, Brian J / Cyster, Jason G

    Nature reviews. Immunology

    2020  Volume 21, Issue 4, Page(s) 209–220

    Abstract: Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to ... ...

    Abstract Memory B cells (MBCs) are critical for the rapid development of protective immunity following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such as influenza and HIV, have been identified in humans. However, efforts to develop vaccines that induce broadly protective MBCs to rapidly mutating pathogens have not yet been successful. Better understanding of the signals regulating MBC development and function are essential to overcome current challenges hindering successful vaccine development. Here, we discuss recent advancements regarding the signals and transcription factors regulating germinal centre-derived MBC development and function.
    MeSH term(s) B-Lymphocyte Subsets/immunology ; B-Lymphocytes/immunology ; CD40 Antigens ; Cell Differentiation/genetics ; Gene Expression Regulation ; Germinal Center/cytology ; Humans ; Immunologic Memory/genetics ; Immunologic Memory/immunology ; Precursor Cells, B-Lymphoid/immunology ; Proto-Oncogene Proteins c-bcl-6 ; Proto-Oncogene Proteins c-myc ; Receptors, Antigen, B-Cell ; STAT3 Transcription Factor ; STAT6 Transcription Factor ; Signal Transduction ; Toll-Like Receptors
    Chemical Substances CD40 Antigens ; Proto-Oncogene Proteins c-bcl-6 ; Proto-Oncogene Proteins c-myc ; Receptors, Antigen, B-Cell ; STAT3 Transcription Factor ; STAT6 Transcription Factor ; Toll-Like Receptors
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-00446-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5565: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 34: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Transmembrane protein CD69 acts as an S1PR1 agonist.

    Chen, Hongwen / Qin, Yu / Chou, Marissa / Cyster, Jason G / Li, Xiaochun

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector ... ...

    Abstract The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector activity
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.02.13.528406
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Transmembrane protein CD69 acts as an S1PR1 agonist.

    Chen, Hongwen / Qin, Yu / Chou, Marissa / Cyster, Jason G / Li, Xiaochun

    eLife

    2023  Volume 12

    Abstract: ... coupled to the heterotrimeric G ...

    Abstract The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector activity. Multiple drugs that inhibit S1PR1 function are in use clinically for the treatment of autoimmune diseases. Cluster of Differentiation 69 (CD69) is an endogenous negative regulator of lymphocyte egress that interacts with S1PR1 in cis to facilitate internalization and degradation of the receptor. The mechanism by which CD69 causes S1PR1 internalization has been unclear. Moreover, although there are numerous class A GPCR structures determined with different small molecule agonists bound, it remains unknown whether a transmembrane protein per se can act as a class A GPCR agonist. Here, we present the cryo-EM structure of CD69-bound S1PR1 coupled to the heterotrimeric G
    MeSH term(s) Immunologic Factors ; Lymphocytes/metabolism ; Membrane Proteins ; Receptors, Lysosphingolipid/genetics ; Receptors, Lysosphingolipid/metabolism ; T-Lymphocytes/metabolism
    Chemical Substances Immunologic Factors ; Membrane Proteins ; Receptors, Lysosphingolipid ; CD69 antigen
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88204
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Getting close to the action elicits better memories.

    Cyster, Jason G

    The Journal of experimental medicine

    2015  Volume 212, Issue 10, Page(s) 1484

    MeSH term(s) Animals ; B-Lymphocytes/immunology ; Germinal Center/immunology ; Immunologic Memory ; Orthomyxoviridae Infections/immunology
    Language English
    Publishing date 2015-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.21210insight3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.107: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 45: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: B cell peripheral tolerance is promoted by cathepsin B protease.

    Chou, Marissa Y / Liu, Dan / An, Jinping / Xu, Ying / Cyster, Jason G

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 16, Page(s) e2300099120

    Abstract: B cells that bind soluble autoantigens receive chronic signaling via the B cell receptor (signal-1) in the absence of strong costimulatory signals (signal-2), and this leads to their elimination in peripheral tissues. The factors determining the extent ... ...

    Abstract B cells that bind soluble autoantigens receive chronic signaling via the B cell receptor (signal-1) in the absence of strong costimulatory signals (signal-2), and this leads to their elimination in peripheral tissues. The factors determining the extent of soluble autoantigen-binding B cell elimination are not fully understood. Here we demonstrate that the elimination of B cells chronically exposed to signal-1 is promoted by cathepsin B (Ctsb). Using hen egg lysozyme-specific (HEL-specific) immunoglobulin transgenic (MD4) B cells and mice harboring circulating HEL, we found improved survival and increased proliferation of HEL-binding B cells in Ctsb-deficient mice. Bone marrow chimera experiments established that both hematopoietic and nonhematopoietic sources of Ctsb were sufficient to promote peripheral B cell deletion. The depletion of CD4
    MeSH term(s) Mice ; Animals ; Mice, Transgenic ; Peptide Hydrolases ; Peripheral Tolerance ; CD40 Ligand ; Cathepsin B ; Mice, Inbred C57BL ; Autoantigens
    Chemical Substances Peptide Hydrolases (EC 3.4.-) ; CD40 Ligand (147205-72-9) ; Cathepsin B (EC 3.4.22.1) ; Autoantigens
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2300099120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: LTβR overexpression promotes plasma cell accumulation.

    Kotov, Jessica A / Xu, Ying / Carey, Nicholas D / Cyster, Jason G

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0270907

    Abstract: Multiple myeloma (MM), a malignancy of plasma cells (PCs), has diverse genetic underpinnings and in rare cases these include amplification of the lymphotoxin b receptor (Ltbr) locus. LTβR has well defined roles in supporting lymphoid tissue development ... ...

    Abstract Multiple myeloma (MM), a malignancy of plasma cells (PCs), has diverse genetic underpinnings and in rare cases these include amplification of the lymphotoxin b receptor (Ltbr) locus. LTβR has well defined roles in supporting lymphoid tissue development and function through actions in stromal and myeloid cells, but whether it is functional in PCs is unknown. Here we showed that Ltbr mRNA was upregulated in mouse PCs compared to follicular B cells, but deficiency in the receptor did not cause a reduction in PC responses to a T-dependent or T-independent immunogen. However, LTβR overexpression (OE) enhanced PC formation in vitro after LPS or anti-CD40 stimulation. In vivo, LTβR OE led to increased antigen-specific splenic and bone marrow (BM) plasma cells responses. LTβR OE PCs had increased expression of Nfkb2 and of the NF-kB target genes Bcl2 and Mcl1, factors involved in the formation of long-lived BM PCs. Our findings suggest a pathway by which Ltbr gene amplifications may contribute to MM development through increased NF-kB activity and induction of an anti-apoptotic transcriptional program.
    MeSH term(s) Animals ; B-Lymphocytes/metabolism ; Lymphotoxin beta Receptor/genetics ; Lymphotoxin beta Receptor/metabolism ; Mice ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Plasma Cells/metabolism ; Spleen/metabolism
    Chemical Substances Ltbr protein, mouse ; Lymphotoxin beta Receptor ; NF-kappa B
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0270907
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Germinal Centers: Gaining Strength from the Dark Side.

    Cyster, Jason G

    Immunity

    2015  Volume 43, Issue 6, Page(s) 1026–1028

    Abstract: Germinal center B cells exist in two conditions, a dark zone state and a light zone state. Two studies in this issue (Dominguez-Sola et al., 2015; Sander et al., 2015) report that Foxo1 deficiency causes an almost complete loss of dark zone cells and an ... ...

    Abstract Germinal center B cells exist in two conditions, a dark zone state and a light zone state. Two studies in this issue (Dominguez-Sola et al., 2015; Sander et al., 2015) report that Foxo1 deficiency causes an almost complete loss of dark zone cells and an inability to undergo robust antibody affinity maturation.
    Language English
    Publishing date 2015-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2015.11.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 69: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top