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  1. Article ; Online: Expression, Purification and Preliminary Crystallographic Analysis of Bacterial Transmembrane Protein EfeU for Iron Import.

    Okumura, Kenji / Mikami, Bunzo / Oiki, Sayoko / Ogura, Kohei / Hashimoto, Wataru

    Protein expression and purification

    2024  , Page(s) 106487

    Abstract: The bacterial Efe system functions as an importer of free ... ...

    Abstract The bacterial Efe system functions as an importer of free Fe
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1055455-5
    ISSN 1096-0279 ; 1046-5928
    ISSN (online) 1096-0279
    ISSN 1046-5928
    DOI 10.1016/j.pep.2024.106487
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3084: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: 4-Deoxy-l-

    Kawai, Shigeyuki / Hashimoto, Wataru

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 2

    Abstract: 4-Deoxy-l- ...

    Abstract 4-Deoxy-l-
    MeSH term(s) Alginates/metabolism ; Hexuronic Acids/metabolism ; Oxidoreductases/metabolism
    Chemical Substances Alginates ; Hexuronic Acids ; Oxidoreductases (EC 1.-)
    Language English
    Publishing date 2022-01-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27020338
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    Zs.MO 81: Show issues

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  3. Article ; Online: Adaptation of yeast Saccharomyces cerevisiae to grape-skin environment.

    Watanabe, Daisuke / Hashimoto, Wataru

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 9279

    Abstract: Saccharomyces cerevisiae, an essential player in alcoholic fermentation during winemaking, is rarely found in intact grapes. Although grape-skin environment is unsuitable for S. cerevisiae's stable residence, Saccharomycetaceae-family fermentative yeasts ...

    Abstract Saccharomyces cerevisiae, an essential player in alcoholic fermentation during winemaking, is rarely found in intact grapes. Although grape-skin environment is unsuitable for S. cerevisiae's stable residence, Saccharomycetaceae-family fermentative yeasts can increase population on grape berries after colonization during raisin production. Here, we addressed adaptation of S. cerevisiae to grape-skin ecosystem. The yeast-like fungus Aureobasidium pullulans, a major grape-skin resident, exhibited broad spectrum assimilation of plant-derived carbon sources, including ω-hydroxy fatty acid, arising from degradation of plant cuticles. In fact, A. pullulans encoded and secreted possible cutinase-like esterase for cuticle degradation. When intact grape berries were used as a sole carbon source, such grape-skin associated fungi increased the accessibility to fermentable sugars by degrading and assimilating the plant cell wall and cuticle compounds. Their ability seems also helpful for S. cerevisiae to obtain energy through alcoholic fermentation. Thus, degradation and utilization of grape-skin materials by resident microbiota may account for their residence on grape-skin and S. cerevisiae's possible commensal behaviors. Conclusively, this study focused on the symbiosis between grape-skin microbiota and S. cerevisiae from the perspective of winemaking origin. Such plant-microbe symbiotic interaction may be a prerequisite for triggering spontaneous food fermentation.
    MeSH term(s) Saccharomyces cerevisiae/metabolism ; Vitis/microbiology ; Ecosystem ; Wine/analysis ; Fungi
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-35734-z
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  4. Article ; Online: [Altered antibody titers in patients with neuromuscular diseases after high-dose intravenous immunoglobulin therapy].

    Shiraishi, Wataru / Inamori, Yukiko / Matsuyoshi, Ayano / Hashimoto, Tetsuya

    Rinsho shinkeigaku = Clinical neurology

    2024  Volume 64, Issue 3, Page(s) 157–162

    Abstract: We investigated the changes in antibody titers after intravenous immunoglobulin (IVIg) administration in patients with neuromuscular diseases. Among patients who received IVIg from April 1, 2020, to August 31, 2022, we retrospectively evaluated 15 ... ...

    Abstract We investigated the changes in antibody titers after intravenous immunoglobulin (IVIg) administration in patients with neuromuscular diseases. Among patients who received IVIg from April 1, 2020, to August 31, 2022, we retrospectively evaluated 15 patients with antibody measurements before and after IVIg administration for any rise in the following antibody levels and examined the data for subsequent changes of false positive results to negative ones. The levels of anti SS-A, anti-thyroglobulin, anti-thyroid peroxidase, anti-glutamic acid decarboxylase, HBs, and HBc antibodies transiently increased after IVIg administration and showed false-positive results. However, levels of rheumatoid factor and anti-nuclear and antineutrophil cytoplasmic antibodies were not elevated. The false-positive results became negative after 3 months. Here, we report on the changes in antibody levels before and after IVIg administration and note that levels of hepatitis B virus-related antibodies and various autoantibodies transiently rise after IVIg administration.
    MeSH term(s) Humans ; Immunoglobulins, Intravenous ; Retrospective Studies ; Rheumatoid Factor ; Hepatitis B Antibodies ; Neuromuscular Diseases
    Chemical Substances Immunoglobulins, Intravenous ; Rheumatoid Factor (9009-79-4) ; Hepatitis B Antibodies
    Language Japanese
    Publishing date 2024-02-17
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 604200-4
    ISSN 1882-0654 ; 0009-918X
    ISSN (online) 1882-0654
    ISSN 0009-918X
    DOI 10.5692/clinicalneurol.cn-001895
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1455: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 223: Show issues

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  5. Article ; Online: Adaptation of yeast Saccharomyces cerevisiae to grape-skin environment

    Daisuke Watanabe / Wataru Hashimoto

    Scientific Reports, Vol 13, Iss 1, Pp 1-

    2023  Volume 13

    Abstract: Abstract Saccharomyces cerevisiae, an essential player in alcoholic fermentation during winemaking, is rarely found in intact grapes. Although grape-skin environment is unsuitable for S. cerevisiae’s stable residence, Saccharomycetaceae-family ... ...

    Abstract Abstract Saccharomyces cerevisiae, an essential player in alcoholic fermentation during winemaking, is rarely found in intact grapes. Although grape-skin environment is unsuitable for S. cerevisiae’s stable residence, Saccharomycetaceae-family fermentative yeasts can increase population on grape berries after colonization during raisin production. Here, we addressed adaptation of S. cerevisiae to grape-skin ecosystem. The yeast-like fungus Aureobasidium pullulans, a major grape-skin resident, exhibited broad spectrum assimilation of plant-derived carbon sources, including ω-hydroxy fatty acid, arising from degradation of plant cuticles. In fact, A. pullulans encoded and secreted possible cutinase-like esterase for cuticle degradation. When intact grape berries were used as a sole carbon source, such grape-skin associated fungi increased the accessibility to fermentable sugars by degrading and assimilating the plant cell wall and cuticle compounds. Their ability seems also helpful for S. cerevisiae to obtain energy through alcoholic fermentation. Thus, degradation and utilization of grape-skin materials by resident microbiota may account for their residence on grape-skin and S. cerevisiae’s possible commensal behaviors. Conclusively, this study focused on the symbiosis between grape-skin microbiota and S. cerevisiae from the perspective of winemaking origin. Such plant–microbe symbiotic interaction may be a prerequisite for triggering spontaneous food fermentation.
    Keywords Medicine ; R ; Science ; Q
    Subject code 571
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Migration of Vasoconstriction in Reversible Cerebral Vasoconstriction Syndrome.

    Hashimoto, Tetsuya / Matsuyoshi, Ayano / Shiraishi, Wataru

    JMA journal

    2022  Volume 6, Issue 1, Page(s) 88–89

    Language English
    Publishing date 2022-11-30
    Publishing country Japan
    Document type Case Reports
    ZDB-ID 3053329-6
    ISSN 2433-3298 ; 2433-328X
    ISSN (online) 2433-3298
    ISSN 2433-328X
    DOI 10.31662/jmaj.2022-0169
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  7. Article: Correction: Kusayanagi et al. A Smartphone Application for Personalized Tooth Shade Determination.

    Kusayanagi, Tomoya / Maegawa, Sota / Terauchi, Shuya / Hashimoto, Wataru / Kaneda, Shohei

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 13

    Abstract: In the original publication [ ... ]. ...

    Abstract In the original publication [...].
    Language English
    Publishing date 2023-07-06
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13132288
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  8. Book ; Online: Long-term Safe Reinforcement Learning with Binary Feedback

    Wachi, Akifumi / Hashimoto, Wataru / Hashimoto, Kazumune

    2024  

    Abstract: Safety is an indispensable requirement for applying reinforcement learning (RL) to real problems. Although there has been a surge of safe RL algorithms proposed in recent years, most existing work typically 1) relies on receiving numeric safety feedback; ...

    Abstract Safety is an indispensable requirement for applying reinforcement learning (RL) to real problems. Although there has been a surge of safe RL algorithms proposed in recent years, most existing work typically 1) relies on receiving numeric safety feedback; 2) does not guarantee safety during the learning process; 3) limits the problem to a priori known, deterministic transition dynamics; and/or 4) assume the existence of a known safe policy for any states. Addressing the issues mentioned above, we thus propose Long-term Binaryfeedback Safe RL (LoBiSaRL), a safe RL algorithm for constrained Markov decision processes (CMDPs) with binary safety feedback and an unknown, stochastic state transition function. LoBiSaRL optimizes a policy to maximize rewards while guaranteeing a long-term safety that an agent executes only safe state-action pairs throughout each episode with high probability. Specifically, LoBiSaRL models the binary safety function via a generalized linear model (GLM) and conservatively takes only a safe action at every time step while inferring its effect on future safety under proper assumptions. Our theoretical results show that LoBiSaRL guarantees the long-term safety constraint, with high probability. Finally, our empirical results demonstrate that our algorithm is safer than existing methods without significantly compromising performance in terms of reward.

    Comment: Accepted to AAAI-24
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; Computer Science - Robotics
    Subject code 006
    Publishing date 2024-01-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: 4-Deoxy- l - erythro -5-hexoseulose Uronate (DEH) and DEH Reductase

    Shigeyuki Kawai / Wataru Hashimoto

    Molecules, Vol 27, Iss 338, p

    Key Molecule and Enzyme for the Metabolism and Utilization of Alginate

    2022  Volume 338

    Abstract: 4-Deoxy- l - erythro -5-hexoseulose uronate (DEH), DEH reductase, and alginate lyase have key roles in the metabolism of alginate, a promising carbon source in brown macroalgae for biorefinery. In contrast to the widely reviewed alginate lyase, DEH and ... ...

    Abstract 4-Deoxy- l - erythro -5-hexoseulose uronate (DEH), DEH reductase, and alginate lyase have key roles in the metabolism of alginate, a promising carbon source in brown macroalgae for biorefinery. In contrast to the widely reviewed alginate lyase, DEH and DEH reductase have not been previously reviewed. Here, we summarize the current understanding of DEH and DEH reductase, with emphasis on (i) the non-enzymatic and enzymatic formation and structure of DEH and its reactivity to specific amino groups, (ii) the molecular identification, classification, function, and structure, as well as the structural determinants for coenzyme specificity of DEH reductase, and (iii) the significance of DEH for biorefinery. Improved understanding of this and related fields should lead to the practical utilization of alginate for biorefinery.
    Keywords alginate ; 4,5-unsaturated uronates ; 4-deoxy- l - erythro -5-hexoseulose uronate (DEH) ; Sphingomonas sp. A1 ; DEH reductase ; SDR superfamily ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Case of elderly onset possible neuro-Behçet's disease with HLA-B51 homozygosity.

    Shiraishi, Wataru / Tsujimoto, Yoshitaka / Matsuyoshi, Ayano / Hashimoto, Tetsuya

    BMJ case reports

    2023  Volume 16, Issue 6

    Abstract: Behçet's disease commonly affects 20-40-year-old men and shows ophthalmo-dermatological manifestations. Here, we report a man in his 70s with acute onset of dysarthria, dysphagia and hemiplegia showing brainstem and subcortical lesions, which responded ... ...

    Abstract Behçet's disease commonly affects 20-40-year-old men and shows ophthalmo-dermatological manifestations. Here, we report a man in his 70s with acute onset of dysarthria, dysphagia and hemiplegia showing brainstem and subcortical lesions, which responded to steroid and colchicine therapy. He had a history of uveitis and was homozygous for the human leucocyte antigen-B51 allele, and we clinically diagnosed him with acute neuro-Behçet's disease. Old-age onset neuro-Behçet's disease is uncommon, and as far as we know, this is the oldest case of the first attack of neuro-Behçet's disease. Clinicians should consider Behçet's disease even for elderly patients.
    MeSH term(s) Male ; Humans ; Aged ; Young Adult ; Adult ; HLA-B51 Antigen/genetics ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Uveitis ; Brain Stem/pathology ; Steroids ; HLA-B Antigens/genetics
    Chemical Substances HLA-B51 Antigen ; Steroids ; HLA-B Antigens
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2022-252033
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