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  1. Article: JOSHUA CLAPP HUBBARD 1869-1934.

    Jones, D F

    Annals of surgery

    2007  Volume 103, Issue 1, Page(s) 153–155

    Language English
    Publishing date 2007-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/00000658-193601000-00021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.35/1: Show issues Location:
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  2. Book ; Online ; E-Book: Palliative radiation oncology

    Vapiwala, Neha / Jones, Joshua A. / Dharmarajan, Kavita

    2024  

    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xx, 417 Seiten), Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030018331
    ISBN 978-0-323-87689-6 ; 9780323876889 ; 0-323-87689-7 ; 0323876889
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Heterogenous Biofilm Mass-Transport Model Replicates Periphery Sequestration of Antibiotics in

    Prince, Joshua / Jones, A-Andrew D

    bioRxiv : the preprint server for biology

    2023  

    Abstract: A spatiotemporal model for antibiotic accumulation in bacterial biofilm microcolonies which leverages heterogenous porosity and attachment site profiles replicated the periphery sequestration phenomena reported in prior experimental studies ... ...

    Abstract A spatiotemporal model for antibiotic accumulation in bacterial biofilm microcolonies which leverages heterogenous porosity and attachment site profiles replicated the periphery sequestration phenomena reported in prior experimental studies on
    Language English
    Publishing date 2023-07-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.28.551018
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  4. Article ; Online: Heterogenous biofilm mass-transport model replicates periphery sequestration of antibiotics in

    Prince, Joshua / Jones, A-Andrew D

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 47, Page(s) e2312995120

    Abstract: A model for antibiotic accumulation in bacterial biofilm microcolonies utilizing heterogenous porosity and attachment site profiles replicated the periphery sequestration reported in prior experimental studies ... ...

    Abstract A model for antibiotic accumulation in bacterial biofilm microcolonies utilizing heterogenous porosity and attachment site profiles replicated the periphery sequestration reported in prior experimental studies on
    MeSH term(s) Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Pseudomonas aeruginosa ; Biofilms ; Extracellular Polymeric Substance Matrix ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/microbiology ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-11-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2312995120
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    Zs.A 1148: Show issues Location:
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  5. Article ; Online: “The Past Dictates the Future”

    Joshua Jones

    NANO, Iss

    Epistemic Ambivalence and the Compromised Ethics of Complicity in Twin Peaks: The Return and Fire Walk with Me

    2020  Volume 15

    Abstract: In this paper I explore questions of epistemology and complicity in Twin Peaks: The Return with reference to the original series and to Twin Peaks: Fire Walk with Me. I characterize these works as auto-exegetical texts (texts that critically read ... ...

    Abstract In this paper I explore questions of epistemology and complicity in Twin Peaks: The Return with reference to the original series and to Twin Peaks: Fire Walk with Me. I characterize these works as auto-exegetical texts (texts that critically read themselves), and I introduce the notion of epistemic ambivalence to describe how they proffer the possibility of teleological resolution while deliberately failing to provide enough information to realize that possibility. I examine how epistemic ambivalence is frequently deployed around questions of complicity with and culpability for evil, with the effect that the desire for certain knowledge and meaning is problematized by its connection to a masculinized desire for mastery. I argue that epistemic ambivalence is not just an important theme but is an integral characteristic of The Return’s ambivalently complicit story of violence and objectification. I reach two main conclusions: first, that the foregrounding of Laura’s pain in both Fire Walk with Me and The Return demands that audiences address and reflect upon our own complicity with the violence inflicted upon her; and second, that while there may be value in remaining attached to the desire for certain knowledge and to the dualistic conceptions of good and evil deployed ambiguously throughout Twin Peaks, there is perhaps more ethical and critical value to be found in exploring how these works engage the ambivalence such attachment engenders.
    Keywords twin peaks ; david lynch ; laura palmer ; objectification ; epistemology ; ambivalence ; auto-exegesis ; History of scholarship and learning. The humanities ; AZ20-999 ; Language and Literature ; P ; Literature (General) ; PN1-6790
    Subject code 170
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher New York City College of Technology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Plasticity, symbionts and niche construction interact in shaping dung beetle development and evolution.

    Rohner, Patrick T / Jones, Joshua A / Moczek, Armin P

    The Journal of experimental biology

    2024  Volume 227, Issue Suppl_1

    Abstract: Developmental plasticity is an important product of evolutionary processes, allowing organisms to maintain high fitness in the face of environmental perturbations. Once evolved, plasticity also has the potential to influence subsequent evolutionary ... ...

    Abstract Developmental plasticity is an important product of evolutionary processes, allowing organisms to maintain high fitness in the face of environmental perturbations. Once evolved, plasticity also has the potential to influence subsequent evolutionary outcomes, for example, by shaping phenotypic variation visible to selection and facilitating the emergence of novel trait variants. Furthermore, organisms may not just respond to environmental conditions through plasticity but may also actively modify the abiotic and (sym)biotic environments to which they themselves respond, causing plasticity to interact in complex ways with niche construction. Here, we explore developmental mechanisms and evolutionary consequences of plasticity in horned dung beetles. First, we discuss how post-invasion evolution of plasticity in an introduced Onthophagus species facilitated rapid range expansion and concurrent local adaptation of life history and morphology to novel climatic conditions. Second, we discuss how, in addition to plastically responding to variation in nutritional conditions, dung beetles engage in behaviors that modify the environment that they themselves respond to during later development. We document that these environment-modifying behaviors mask heritable variation for life history traits within populations, thereby shielding genetic variants from selection. Such cryptic genetic variation may be released and become selectable when these behaviors are compromised. Together, this work documents the complex interactions between plasticity, symbionts and niche construction, and highlights the usefulness of an integrative Eco-Evo-Devo framework to study the varied mechanisms and consequences of plasticity in development and evolution.
    MeSH term(s) Animals ; Coleoptera/genetics ; Introduced Species ; Life History Traits ; Phenotype
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 218085-6
    ISSN 1477-9145 ; 0022-0949
    ISSN (online) 1477-9145
    ISSN 0022-0949
    DOI 10.1242/jeb.245976
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    Zs.A 2629: Show issues Location:
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  7. Article ; Online: Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking.

    Kohtz, Amy S / Zhao, Joshua / Aston-Jones, Gary

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2024  Volume 44, Issue 17

    Abstract: The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by blocking 5-HT signaling in dorsal hippocampal cornu ... ...

    Abstract The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by blocking 5-HT signaling in dorsal hippocampal cornu ammonis 1 (CA1) in both male and female rats. We hypothesized that the experience of ED1 can substantially influence later relapse behavior and that dorsal raphe (DR) serotonin (5-HT) input to CA1 may be involved. We inhibited 5-HT
    MeSH term(s) Animals ; Male ; Drug-Seeking Behavior/physiology ; Drug-Seeking Behavior/drug effects ; Rats ; Serotonin/metabolism ; Female ; Cocaine/administration & dosage ; Cocaine/pharmacology ; Hippocampus/metabolism ; Hippocampus/drug effects ; Pyridines/pharmacology ; Serotonin Antagonists/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology ; Piperazines/pharmacology ; Rats, Sprague-Dawley ; Cocaine-Related Disorders/metabolism ; Cocaine-Related Disorders/psychology ; Self Administration ; Extinction, Psychological/drug effects ; Extinction, Psychological/physiology ; Receptor, Serotonin, 5-HT1B/metabolism ; CA1 Region, Hippocampal/drug effects ; CA1 Region, Hippocampal/metabolism ; Oxadiazoles
    Chemical Substances Serotonin (333DO1RDJY) ; Cocaine (I5Y540LHVR) ; N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide (71IH826FEG) ; Pyridines ; Serotonin Antagonists ; Piperazines ; GR 127935 (2LLH6CEB40) ; Receptor, Serotonin, 5-HT1B ; Oxadiazoles
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1505-21.2024
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    Zs.A 1668: Show issues Location:
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  8. Article ; Online: A Severe Presentation of Ulcers Throughout the Limbs.

    Tsai, Joshua T / Alexander, Helen / Bailey, Clare / Wilsher, Mark / Jones, Isabel / Markeson, Daniel

    Clinical and experimental dermatology

    2024  

    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llae065
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    Zs.A 1278: Show issues Location:
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  9. Article: Fever and Increased Gastrointestinal Uptake on Positron Emission Tomography after Anti-Tumour Necrosis Factor Therapy: A Case Report of Whipple's Disease.

    Arzivian, Arteen / Jones, Brett / Joshua, Fredrick / Paul, Miriam / Lynch, Thomas / Brown, Martin / Gasiorowski, Robin

    Case reports in gastroenterology

    2024  Volume 18, Issue 1, Page(s) 221–230

    Abstract: Introduction: Whipple's disease is a rare condition that can present with atypical and non-specific features requiring a high index of suspicion for diagnosis.: Case presentation: We present a case of a man in his 40s with peripheral arthritis and ... ...

    Abstract Introduction: Whipple's disease is a rare condition that can present with atypical and non-specific features requiring a high index of suspicion for diagnosis.
    Case presentation: We present a case of a man in his 40s with peripheral arthritis and bilateral sacro-ileitis for 4-5 years that was treated with an anti-tumour necrosis factor therapy, which led to worsening of his symptoms, elevation of the inflammatory markers, and the development of fever, night sweats, anorexia, and a significant weight loss. The patient had no abdominal pain, diarrhoea, or other gastrointestinal symptoms. An FDG-PET scan showed increased uptake in the stomach and caecum. Endoscopic examination showed inflammatory changes in the stomach and normal mucosa of the duodenum, jejunum, terminal ileum, caecum, and colon. Histopathology was inconclusive, but the diagnosis was confirmed with
    Conclusion: This case presents an atypical and challenging presentation of Whipple's disease and the importance of proactive testing for neurological involvement.
    Language English
    Publishing date 2024-04-20
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2440540-1
    ISSN 1662-0631
    ISSN 1662-0631
    DOI 10.1159/000538462
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  10. Article ; Online: The Effects of Occupational Complexity on Late Life Cognition in ACTIVE: Examining the Mediating and Moderating Effects of Race.

    Owens, Joshua / Jones, Richard / Marsiske, Michael

    Journal of aging and health

    2023  Volume 35, Issue 9_suppl, Page(s) 95S–106S

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Aged ; Humans ; Cognition ; Occupations ; Aging
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1045392-1
    ISSN 1552-6887 ; 0898-2643
    ISSN (online) 1552-6887
    ISSN 0898-2643
    DOI 10.1177/08982643211038837
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    Zs.A 3012: Show issues Location:
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