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  1. Article ; Online: Nigrostriatal loop - from basics and beyond.

    Monje, Mariana H G / Blesa, J

    Neurobiology of disease

    2024  Volume 195, Page(s) 106503

    MeSH term(s) Humans ; Animals ; Substantia Nigra ; Corpus Striatum ; Neural Pathways/physiology
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2024.106503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4444: Show issues Location:
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  2. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2, Olfactory Mucosa, and the Entrance in the Central Nervous System: Expanding the Evidence?

    Monje, Mariana H G

    Movement disorders clinical practice

    2021  Volume 8, Issue 3, Page(s) 350–351

    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A GNAI1 Pathogenic Variant in a Case with GNAO1-Isolated Dystonia: A Modifier of Disease Severity?

    Monje, Mariana H G / Blackburn, Joanna Sarah / Kinsley, Lisa / Krainc, Dimitri / Mencacci, Niccolò E

    Movement disorders : official journal of the Movement Disorder Society

    2024  

    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2555: Show issues Location:
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    Zs.MO 238: Show issues

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  4. Article ; Online: Focused ultrasound therapy: Back to the future.

    Verhagen Metman, Leo / Monje, Mariana H G / Obeso, José A / Martínez-Fernández, Raúl

    Parkinsonism & related disorders

    2024  Volume 121, Page(s) 106023

    MeSH term(s) Humans ; Essential Tremor/therapy ; Parkinson Disease ; Ultrasonic Therapy ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106023
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    Zs.A 4553: Show issues Location:
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    Zs.MO 420: Show issues

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  5. Article ; Online: The Apparent Impunity of the Basal Ganglia to Therapeutic Lesioning: Clinical and Scientific Lessons.

    Monje, Mariana H G / Mañez-Miró, Jorge U / Obeso, José A

    Movement disorders clinical practice

    2023  Volume 10, Issue Suppl 2, Page(s) S42–S46

    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13787
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  6. Article ; Online: Major advances in Parkinson's disease over the past two decades and future research directions.

    Obeso, Jose A / Monje, Mariana H G / Matarazzo, Michele

    The Lancet. Neurology

    2022  Volume 21, Issue 12, Page(s) 1076–1079

    MeSH term(s) Humans ; Parkinson Disease/therapy ; Forecasting
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(22)00448-3
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    Zs.A 5955: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  7. Article ; Online: Video-based analysis of the blink reflex in Parkinson's disease patients.

    Jansen, Talisa S / Güney, Gökhan / Ganse, Bergita / Monje, Mariana H G / Schulz, Jörg B / Dafotakis, Manuel / Hoog Antink, Christoph / Braczynski, Anne K

    Biomedical engineering online

    2024  Volume 23, Issue 1, Page(s) 43

    Abstract: ... and non-reflex blinks. The Glabellar Tap Reflex is a clinical sign seen in patients e.g. suffering ...

    Abstract We developed a video-based tool to quantitatively assess the Glabellar Tap Reflex (GTR) in patients with idiopathic Parkinson's disease (iPD) as well as healthy age-matched participants. We also video-graphically assessed the effect of dopaminergic medication on the GTR in iPD patients, as well as the frequency and blinking duration of reflex and non-reflex blinks. The Glabellar Tap Reflex is a clinical sign seen in patients e.g. suffering from iPD. Reliable tools to quantify this sign are lacking.
    Methods: We recorded the GTR in 11 iPD patients and 12 healthy controls (HC) with a consumer-grade camera at a framerate of at least 180 images/s. In these videos, reflex and non-reflex blinks were analyzed for blink count and blinking duration in an automated fashion.
    Results: With our setup, the GTR can be extracted from high-framerate cameras using landmarks of the MediaPipe face algorithm. iPD patients did not habituate to the GTR; dopaminergic medication did not alter that response. iPD patients' non-reflex blinks were higher in frequency and higher in blinking duration (width at half prominence); dopaminergic medication decreased the median frequency (Before medication-HC: p < 0.001, After medication-HC: p = 0.0026) and decreased the median blinking duration (Before medication-HC: p = 0.8594, After medication-HC: p = 0.6943)-both in the direction of HC.
    Conclusion: We developed a quantitative, video-based tool to assess the GTR and other blinking-specific parameters in HC and iPD patients. Further studies could compare the video data to electromyogram (EMG) data for accuracy and comparability, as well as evaluate the specificity of the GTR in patients with other neurodegenerative disorders, in whom the GTR can also be present.
    Significance: The video-based detection of the blinking parameters allows for unobtrusive measurement in patients, a safer and more comfortable option.
    MeSH term(s) Humans ; Parkinson Disease/physiopathology ; Parkinson Disease/drug therapy ; Blinking ; Video Recording ; Male ; Female ; Aged ; Middle Aged ; Image Processing, Computer-Assisted/methods ; Case-Control Studies
    Language English
    Publishing date 2024-04-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2084374-4
    ISSN 1475-925X ; 1475-925X
    ISSN (online) 1475-925X
    ISSN 1475-925X
    DOI 10.1186/s12938-024-01236-w
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  8. Article ; Online: Rest tremor in Parkinson's disease: the theta and beta sides of the coin.

    Foffani, Guglielmo / Monje, Mariana H G / Obeso, Jose A

    Brain communications

    2020  Volume 2, Issue 2, Page(s) fcaa128

    Abstract: This scientific commentary refers to 'Independently together: subthalamic theta and beta opposite roles in predicting Parkinson's tremor', by ... ...

    Abstract This scientific commentary refers to 'Independently together: subthalamic theta and beta opposite roles in predicting Parkinson's tremor', by Asch
    Language English
    Publishing date 2020-08-18
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcaa128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Parkinsonism: Is There Evidence for Concern?

    Monje, Mariana H G / Martínez-Fernández, Raul

    Movement disorders : official journal of the Movement Disorder Society

    2020  Volume 35, Issue 10, Page(s) 1725

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/virology ; Humans ; Pandemics ; Parkinsonian Disorders/complications ; Parkinsonian Disorders/virology ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/virology
    Chemical Substances Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-10-17
    Publishing country United States
    Document type Letter
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.28247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2555: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 238: Show issues

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  10. Article ; Online: Understanding motor control in health and disease: classic single (n = 1) observations.

    Bloem, Bastiaan R / Monje, Mariana H G / Obeso, Jose A

    Experimental brain research

    2020  Volume 238, Issue 7-8, Page(s) 1593–1600

    Abstract: The field of neuroscience is increasingly dominated by a preferred use of big data, where analysis of large numbers has become an essential area of development. We here draw attention to the importance of smaller numbers, and more specifically, to the ... ...

    Abstract The field of neuroscience is increasingly dominated by a preferred use of big data, where analysis of large numbers has become an essential area of development. We here draw attention to the importance of smaller numbers, and more specifically, to the historical and continued importance of detailed and judiciously performed studies in single healthy volunteers or single patients with a unique clinical presentation, as an important approach to study normal functions of the nervous system, and to understand the pathophysiology underlying neurological movement disorders. We illustrate this by discussing several historical examples and by summarising Professor John Rothwell's impressive body of work in single-patient studies, highlighting some of his seminal n = 1 studies that have had a great impact on the field. In doing so, we hope to provide a powerful incentive for the next generation of neuroscientists to keep appreciating the value of detailed analyses of single observations.
    MeSH term(s) Adult ; Aged ; Female ; Fingers ; Humans ; Male ; Middle Aged ; Motor Skills ; Movement Disorders ; Young Adult
    Language English
    Publishing date 2020-03-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1201-4
    ISSN 1432-1106 ; 0014-4819
    ISSN (online) 1432-1106
    ISSN 0014-4819
    DOI 10.1007/s00221-020-05763-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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