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  1. Article ; Online: Looking for lights in the fog of long-term neurological COVID.

    Padovani, Alessandro / Pilotto, Andrea

    Nature reviews. Neurology

    2023  Volume 19, Issue 1, Page(s) 7–8

    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2023-03-09
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-022-00750-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identifying Subtle Motor Deficits Before Parkinson's Disease is Diagnosed: What to Look for?

    Maetzler, Walter / Mirelman, Anat / Pilotto, Andrea / Bhidayasiri, Roongroj

    Journal of Parkinson's disease

    2024  

    Abstract: Motor deficits typical of Parkinson's disease (PD), such as gait and balance disturbances, tremor, reduced arm swing and finger movement, and voice and breathing changes, are believed to manifest several years prior to clinical diagnosis. Here we ... ...

    Abstract Motor deficits typical of Parkinson's disease (PD), such as gait and balance disturbances, tremor, reduced arm swing and finger movement, and voice and breathing changes, are believed to manifest several years prior to clinical diagnosis. Here we describe the evidence for the presence and progression of motor deficits in this pre-diagnostic phase in order to provide suggestions for the design of future observational studies for an effective, quantitatively oriented investigation. On the one hand, these future studies must detect these motor deficits in as large (potentially, population-based) cohorts as possible with high sensitivity and specificity. On the other hand, they must describe the progression of these motor deficits in the pre-diagnostic phase as accurately as possible, to support the testing of the effect of pharmacological and non-pharmacological interventions. Digital technologies and artificial intelligence can substantially accelerate this process.
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2620609-2
    ISSN 1877-718X ; 1877-7171
    ISSN (online) 1877-718X
    ISSN 1877-7171
    DOI 10.3233/JPD-230350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hereditary Ataxias: From Bench to Clinic, Where Do We Stand?

    Pilotto, Federica / Del Bondio, Andrea / Puccio, Hélène

    Cells

    2024  Volume 13, Issue 4

    Abstract: Cerebellar ataxias are a wide heterogeneous group of movement disorders. Within this broad umbrella of diseases, there are both genetics and sporadic forms. The clinical presentation of these conditions can exhibit a diverse range of symptoms across ... ...

    Abstract Cerebellar ataxias are a wide heterogeneous group of movement disorders. Within this broad umbrella of diseases, there are both genetics and sporadic forms. The clinical presentation of these conditions can exhibit a diverse range of symptoms across different age groups, spanning from pure cerebellar manifestations to sensory ataxia and multisystemic diseases. Over the last few decades, advancements in our understanding of genetics and molecular pathophysiology related to both dominant and recessive ataxias have propelled the field forward, paving the way for innovative therapeutic strategies aimed at preventing and arresting the progression of these diseases. Nevertheless, the rarity of certain forms of ataxia continues to pose challenges, leading to limited insights into the etiology of the disease and the identification of target pathways. Additionally, the lack of suitable models hampers efforts to comprehensively understand the molecular foundations of disease's pathophysiology and test novel therapeutic interventions. In the following review, we describe the epidemiology, symptomatology, and pathological progression of hereditary ataxia, including both the prevalent and less common forms of these diseases. Furthermore, we illustrate the diverse molecular pathways and therapeutic approaches currently undergoing investigation in both pre-clinical studies and clinical trials. Finally, we address the existing and anticipated challenges within this field, encompassing both basic research and clinical endeavors.
    MeSH term(s) Humans ; Spinocerebellar Degenerations ; Cerebellar Ataxia/genetics ; Cerebellar Ataxia/pathology ; Ataxia/pathology ; Cerebellum/pathology
    Language English
    Publishing date 2024-02-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NIRS-Based Muscle Oxygenation Is Not Suitable to Compute Convective and Diffusive Components of O 2 Transport at V̇O 2max.

    Porcelli, Simone / Pilotto, Andrea M / Rossiter, Harry B

    Medicine and science in sports and exercise

    2023  Volume 55, Issue 11, Page(s) 2106–2109

    MeSH term(s) Humans ; Muscles ; Musculoskeletal System ; Respiratory Physiological Phenomena ; Oxygen Consumption/physiology ; Exercise Test
    Language English
    Publishing date 2023-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000003239
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: NIRS-Based Muscle Oxygenation Is Not Suitable to Compute Convective and Diffusive Components of O 2 Transport at V̇O 2max : Response to Manferdelli, Barstow, and Millet.

    Porcelli, Simone / Pilotto, Andrea M / Rossiter, Harry B

    Medicine and science in sports and exercise

    2023  Volume 55, Issue 11, Page(s) 2112–2113

    MeSH term(s) Humans ; Millets ; Muscles ; Musculoskeletal System ; Respiratory Physiological Phenomena ; Oxygen Consumption/physiology ; Exercise Test
    Language English
    Publishing date 2023-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603994-7
    ISSN 1530-0315 ; 0195-9131 ; 0025-7990
    ISSN (online) 1530-0315
    ISSN 0195-9131 ; 0025-7990
    DOI 10.1249/MSS.0000000000003240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Digital assessment at home - mPower against Parkinson disease.

    Maetzler, Walter / Pilotto, Andrea

    Nature reviews. Neurology

    2021  Volume 17, Issue 11, Page(s) 661–662

    MeSH term(s) Cell Phone ; Home Care Services ; Humans ; Mobile Applications ; Parkinson Disease/therapy ; Patient Selection ; Reproducibility of Results ; Research Design
    Language English
    Publishing date 2021-10-05
    Publishing country England
    Document type News
    ZDB-ID 2491514-2
    ISSN 1759-4766 ; 1759-4758
    ISSN (online) 1759-4766
    ISSN 1759-4758
    DOI 10.1038/s41582-021-00567-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Looking at the burden of neurological disorders in Europe.

    Padovani, Alessandro / Pilotto, Andrea

    The Lancet. Public health

    2020  Volume 5, Issue 10, Page(s) e523

    MeSH term(s) Europe/epidemiology ; Global Burden of Disease ; Humans ; Mental Disorders ; Nervous System Diseases/epidemiology
    Language English
    Publishing date 2020-10-02
    Publishing country England
    Document type Letter ; Comment
    ISSN 2468-2667
    ISSN (online) 2468-2667
    DOI 10.1016/S2468-2667(20)30205-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply to the Letter "COVID-19-Associated Encephalopathy and Cytokine-Mediated Neuroinflammation".

    Pilotto, Andrea / Padovani, Alessandro

    Annals of neurology

    2020  Volume 88, Issue 4, Page(s) 861–862

    MeSH term(s) Betacoronavirus ; Brain Diseases ; COVID-19 ; Coronavirus Infections ; Cytokines ; Humans ; Inflammation ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Chemical Substances Cytokines
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.25856
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The p.Val234Met LRP10 likely pathogenic variant associated with Parkinson's disease: Possible molecular implications.

    Pilotto, Andrea / Carini, Mattia / Lupini, Alessandro / di Fonzo, Alessio / Monti, Eugenio / Bresciani, Roberto / Padovani, Alessandro / Biasiotto, Giorgio

    Parkinsonism & related disorders

    2024  Volume 123, Page(s) 106973

    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Letter
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2024.106973
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Correction: Expert opinion of an Italian working group on the assessment of cognitive, psychological, and neurological outcomes in pediatric, adolescent, and adult patients with phenylketonuria.

    Manti, Filippo / Caviglia, Stefania / Cazzorla, Chiara / Dicintio, Annamaria / Pilotto, Andrea / Burlina, Alessandro P

    Orphanet journal of rare diseases

    2023  Volume 18, Issue 1, Page(s) 44

    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2225857-7
    ISSN 1750-1172 ; 1750-1172
    ISSN (online) 1750-1172
    ISSN 1750-1172
    DOI 10.1186/s13023-023-02644-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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