LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 14

Search options

  1. Article ; Online: HIV Pre-Exposure Prophylaxis: What Do Pediatricians Need to Know?

    Ungar, Stephanie P / Paret, Michal / Shust, Gail F

    Pediatric annals

    2022  Volume 51, Issue 5, Page(s) e191–e195

    Abstract: Pediatricians and adolescent providers play an important role in the health and well-being of adolescents and young adults, including their sexual health. HIV remains an ongoing concern for young people, with 21% of new HIV diagnoses occurring in this ... ...

    Abstract Pediatricians and adolescent providers play an important role in the health and well-being of adolescents and young adults, including their sexual health. HIV remains an ongoing concern for young people, with 21% of new HIV diagnoses occurring in this age group. The use of antiretroviral therapy for pre-exposure prophylaxis (PrEP) to prevent transmission of HIV to people who are not infected has been proven safe and effective. PrEP can be considered as part of a comprehensive risk mitigation strategy for adolescents and young adults, with clear guidelines for baseline evaluation and ongoing management.
    MeSH term(s) Adolescent ; Anti-HIV Agents/therapeutic use ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; Humans ; Pediatricians ; Pre-Exposure Prophylaxis ; Sexual Health ; Young Adult
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2022-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20220314-07
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: 50 Years Ago in TheJournalofPediatrics: Neonatal HSV: Many Advances and the Elusive Promise of an Effective Vaccine.

    Paret, Michal / Madan, Rebecca Pellett

    The Journal of pediatrics

    2020  Volume 218, Page(s) 177

    MeSH term(s) Acyclovir/administration & dosage ; Administration, Oral ; Antiviral Agents/administration & dosage ; Female ; Herpes Simplex/congenital ; Herpes Simplex/history ; Herpes Simplex/prevention & control ; Herpes Simplex Virus Vaccines/therapeutic use ; History, 20th Century ; Humans ; Idoxuridine/pharmacology ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Pediatrics/history ; Polymerase Chain Reaction ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Risk ; Virus Shedding
    Chemical Substances Antiviral Agents ; Herpes Simplex Virus Vaccines ; Idoxuridine (LGP81V5245) ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2020-02-23
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2019.10.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Poor Uptake of MMR Vaccine 1-year Post-Measles Outbreak: New York City and Israel.

    Paret, Michal / Trillo, Rebecca / Lighter, Jennifer / Youngster, Ilan / Ratner, Adam J / Pellett Madan, Rebecca

    Journal of the Pediatric Infectious Diseases Society

    2022  Volume 11, Issue 7, Page(s) 322–328

    Abstract: Background: In 2018-2019, large outbreaks of measles occurred in Israel and in New York City, driven in part by travel of unimmunized children between the 2 communities.: Methods: A retrospective chart review was conducted for children tested for ... ...

    Abstract Background: In 2018-2019, large outbreaks of measles occurred in Israel and in New York City, driven in part by travel of unimmunized children between the 2 communities.
    Methods: A retrospective chart review was conducted for children tested for measles (March 2018-September 2019) at NYU Langone Health in New York, NY, and in Ramla subdistrict, Israel. Vaccination records were reviewed to determine vaccination status for measles, mumps, and rubella (MMR) at the time of measles testing and 1-year post-testing.
    Results: A total of 264 children were tested for measles, and 102 (38.6%) had confirmed measles. Only 20 (19.6%) of measles-positive cases received a full 2-dose course of vitamin A. 82.4% of children with measles were ≥1 year at the time of diagnosis and fully eligible for MMR vaccine. Of the 100 measles-positive cases with available vaccine records, 63 were unvaccinated at testing, and 27 remained unimmunized against MMR 1 year later. At testing, measles-negative children were significantly more likely to have received MMR than measles-positive children (65.4% vs 37%, P < .01). One year later, 70.4% of measles-negative cases and only 57.1% of measles-positive cases had received MMR vaccine (P = .18).
    Conclusions: The majority of measles cases occurred in unimmunized children eligible for vaccination, and >25% of children in both measles-positive and -negative groups remained unimmunized for MMR 1-year post-outbreak. Our results suggest the need for novel, longitudinal vaccination strategies and increased awareness of the role of vitamin A.
    MeSH term(s) Child ; Disease Outbreaks ; Humans ; Infant ; Israel/epidemiology ; Measles/epidemiology ; Measles/prevention & control ; Measles-Mumps-Rubella Vaccine ; Mumps/epidemiology ; Mumps/prevention & control ; New York City/epidemiology ; Retrospective Studies ; Rubella/prevention & control ; Vaccination ; Vitamin A
    Chemical Substances Measles-Mumps-Rubella Vaccine ; Vitamin A (11103-57-4)
    Language English
    Publishing date 2022-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piac026
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: "Out of the box" solution for skin problems due to glucose-monitoring technology in youth with type 1 diabetes: real-life experience with fluticasone spray.

    Paret, Michal / Barash, Galia / Rachmiel, Marianna

    Acta diabetologica

    2019  Volume 57, Issue 4, Page(s) 419–424

    Abstract: Background: Use of a continuous glucose-monitoring system (CGMS) in the management of type 1 diabetes (T1D) may cause local skin irritation.: Objective: To examine the effects of fluticasone propionate aqueous nasal solution (nsFP), sprayed topically ...

    Abstract Background: Use of a continuous glucose-monitoring system (CGMS) in the management of type 1 diabetes (T1D) may cause local skin irritation.
    Objective: To examine the effects of fluticasone propionate aqueous nasal solution (nsFP), sprayed topically prior to CGMS insertion among youth with T1D.
    Methods: This is a case series observational report, including real-life 6-month follow-up data from one pediatric diabetes center. All patients suffering from local skin irritation due to CGMS adhesives were offered prevention form skin irritation by spraying 2 puffs of nsFP on the skin area prior to adhesion of CGMS. Data were collected from their charts after 6 months. Outcome measures included the difference in degree of skin irritation, number of days of CGMS use, BMI SDS, mean glucose, and HbA1c, prior to use and during 6 months after use.
    Results: Twelve patients used nsFP prior to CGMS insertion, mean age 8.6 ± 4.9 years and 66.7% males. Ten patients, median age 6.1 years (5.3-9.5) and 56% males, continued using nsFP for a mean of 0.56 ± 0.11 years, with no recurrence of local irritation nor dermatitis to same adhesive material. No differences were found before and after use of nsFP in CGMS mean glucose 180 mg/dl (153-202) versus 165 mg/dl (150-192). BMI SDS was slightly higher 0.44 (- 0.9-1.2) versus 0.25 (- 0.47-1.06), P = 0.05.
    Conclusions: This small-scale, single-site description of a simple intervention by nsFP and favorable outcome provides valuable insight for a simple solution for skin irritation and dermatitis in the pediatric population with T1D.
    MeSH term(s) Administration, Topical ; Adolescent ; Aerosol Propellants ; Blood Glucose/analysis ; Blood Glucose Self-Monitoring/adverse effects ; Blood Glucose Self-Monitoring/instrumentation ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/blood ; Equipment and Supplies/adverse effects ; Female ; Fluticasone/administration & dosage ; Follow-Up Studies ; Humans ; Infant ; Male ; Skin Diseases/drug therapy ; Skin Diseases/etiology ; Treatment Outcome ; Young Adult
    Chemical Substances Aerosol Propellants ; Blood Glucose ; Fluticasone (CUT2W21N7U)
    Language English
    Publishing date 2019-11-08
    Publishing country Germany
    Document type Journal Article ; Observational Study
    ZDB-ID 1097676-0
    ISSN 1432-5233 ; 0940-5429
    ISSN (online) 1432-5233
    ISSN 0940-5429
    DOI 10.1007/s00592-019-01446-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article ; Online: Invasive Group A Streptococcus Infection in Children in Central Israel in 2012-2019.

    Canetti, Michal / Carmi, Amit / Paret, Gideon / Goldberg, Lior / Adler, Amos / Amit, Sharon / Rokney, Assaf / Ron, Merav / Grisaru-Soen, Galia

    The Pediatric infectious disease journal

    2021  Volume 40, Issue 7, Page(s) 612–616

    Abstract: Background: Group A Streptococcus can cause serious and sometimes life-threatening disease in children. The past few years have witnessed a rise in invasive group A Streptococcus infection (iGASi) for unclear reasons. This study attempted to describe ... ...

    Abstract Background: Group A Streptococcus can cause serious and sometimes life-threatening disease in children. The past few years have witnessed a rise in invasive group A Streptococcus infection (iGASi) for unclear reasons. This study attempted to describe the epidemiology, the clinical and demographic characteristics and the outcomes associated with iGASi in hospitalized children in central Israel.
    Methods: We retrospectively analyzed the medical records of children <18 years old discharged with a diagnosis of iGASi between January 2012 and December 2019. Clinical, laboratory and microbiologic data, and immunization status were retrieved. The patients were divided into severe and nonsevere groups based on their clinical presentation. The emm type was determined at the national reference center.
    Results: A total of 167 patients with 206 positive cultures for group A Streptococcus were identified. Hospitalizations for iGASi increased from 701 to 958 per 100,000 admissions between 2012-2015 and 2016-2019, respectively, representing an increase of 37%. The majority of the isolates were from the otolaryngologic system followed by blood, deep soft tissue and respiratory sites. Uncomplicated mastoiditis was the most common diagnosis, followed by bacteremia. Pneumonia was the main diagnosis in the severe group (39.4%).
    Conclusions: The admissions because of iGASi in children <18 years old increased during the last 8 years. Surveillance systems and prospective studies should be conducted to expend our understanding of the epidemiology of iGASi in children, better assess the pathogenesis and specific risk factors and monitor changes in emm-type distribution.
    MeSH term(s) Adolescent ; Age Distribution ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/epidemiology ; Child ; Child, Preschool ; Female ; Hospitalization/statistics & numerical data ; Humans ; Incidence ; Infant ; Israel/epidemiology ; Male ; Mastoiditis/epidemiology ; Mastoiditis/microbiology ; Pneumonia, Bacterial/epidemiology ; Prospective Studies ; Retrospective Studies ; Risk Factors ; Streptococcal Infections/blood ; Streptococcal Infections/complications ; Streptococcal Infections/drug therapy ; Streptococcal Infections/epidemiology ; Streptococcus pyogenes/pathogenicity ; Tertiary Care Centers/statistics & numerical data
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003087
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Febrile Infants Without Respiratory Distress.

    Paret, Michal / Lighter, Jennifer / Pellett Madan, Rebecca / Raabe, Vanessa N / Shust, Gail F / Ratner, Adam J

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 71, Issue 16, Page(s) 2243–2245

    Abstract: We report 2 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial ... ...

    Abstract We report 2 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial infections. The diagnoses resulted from routine isolation and real-time reverse-transcription polymerase chain reaction-based testing for SARS-CoV-2 for febrile infants in an outbreak setting.
    MeSH term(s) COVID-19/diagnosis ; Dyspnea/virology ; Fever/virology ; Hospitalization/statistics & numerical data ; Humans ; Infant ; Infant, Newborn ; Male ; Nasopharynx/virology ; Respiratory Distress Syndrome, Newborn ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-17
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa452
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: SARS-CoV-2 Among Infants <90 Days of Age Admitted for Serious Bacterial Infection Evaluation.

    Paret, Michal / Lalani, Karim / Hedari, Carine / Jaffer, Annum / Narayanan, Nisha / Noor, Asif / Lighter, Jennifer / Madan, Rebecca Pellett / Shust, Gail F / Ratner, Adam J / Raabe, Vanessa N

    Pediatrics

    2021  Volume 148, Issue 4

    Abstract: Objectives: To determine the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants hospitalized for a serious bacterial infection (SBI) evaluation and clinically characterize young infants with SARS-CoV-2 infection.: ... ...

    Abstract Objectives: To determine the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in infants hospitalized for a serious bacterial infection (SBI) evaluation and clinically characterize young infants with SARS-CoV-2 infection.
    Methods: A retrospective chart review was conducted on infants <90 days of age hospitalized for an SBI evaluation. The study was conducted at 4 inpatient facilities in New York City from March 15, 2020, to December 15, 2020.
    Results: We identified 148 SBI evaluation infants who met inclusion criteria. A total of 22 infants (15%) tested positive for SARS-CoV-2 by nasopharyngeal reverse transcription polymerase chain reaction; 31% of infants admitted during periods of high community SARS-CoV-2 circulation tested positive for SARS-CoV-2, compared with 3% when community SARS-CoV-2 circulation was low (
    Conclusions: SARS-CoV-2 was common among young infants hospitalized for an SBI evaluation during periods of high but not low community SARS-CoV-2 circulation in New York City, although most infants did not require intensive care admission.
    MeSH term(s) Age of Onset ; Bacterial Infections/complications ; Bacterial Infections/diagnosis ; Bacterial Infections/epidemiology ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Nucleic Acid Testing ; Comorbidity ; Female ; Fever/microbiology ; Fever/virology ; Humans ; Infant ; Infant, Newborn ; Male ; New York City/epidemiology ; Prevalence ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-06-30
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-044685
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Predictors for plication performance following diaphragmatic paralysis in children.

    Goldberg, Lior / Krauthammer, Alexander / Ashkenazi, Moshe / Soudack, Michal / Tokatly Latzer, Itay / Vardi, Amir / Paret, Gideon

    Pediatric pulmonology

    2019  Volume 55, Issue 2, Page(s) 449–454

    Abstract: Introduction and objectives: Diaphragmatic paralysis (DP) in children can result from various etiologies. Guidelines for patient selection for diaphragmatic plication (DPL) are lacking. Our objectives were to describe the etiologies of DP and to ... ...

    Abstract Introduction and objectives: Diaphragmatic paralysis (DP) in children can result from various etiologies. Guidelines for patient selection for diaphragmatic plication (DPL) are lacking. Our objectives were to describe the etiologies of DP and to determine the risk factors and predictors for DPL in the pediatric population.
    Methods: Retrospective data were retrieved from departmental databases on patients with DP from the pediatric, cardiac, and neonatal intensive care departments of Safra Children's Hospital from 2010 to 2017.
    Results: DP was diagnosed in 88 patients, 29 with noncardiac surgery-related etiologies, for example, congenital, surgery, trauma, and shock and 59 with cardiac surgery-related etiologies. In total, 27 (31%) patients underwent DPL, and they had significant comorbidities involving respiratory, central nervous, and cardiovascular systems, higher lung injury scores, and lower weight compared with the patients who did not undergo DPL (P = .002, P = .002, P < .001, P = .012, and P = .013, respectively). A multivariate regression model revealed significant independent predictors for DPL, including morbidities of central nervous (odds ratio [OR = 9.651, P = .005), respiratory (OR = 4.875, P = .039), and cardiovascular systems (OR = 23.938, P = .001).
    Conclusions: Etiologies of DP are very diverse in the pediatric population. Comorbidities of respiratory, central nervous, and cardiovascular systems are risk factors for plication requirement in respiratory support-dependent pediatric patients with DP. Early DPL should be considered in these patients.
    MeSH term(s) Child ; Child, Preschool ; Comorbidity ; Diaphragm ; Female ; Humans ; Male ; Respiratory Paralysis/diagnosis ; Retrospective Studies ; Risk Factors
    Language English
    Publishing date 2019-10-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632784-9
    ISSN 1099-0496 ; 8755-6863
    ISSN (online) 1099-0496
    ISSN 8755-6863
    DOI 10.1002/ppul.24539
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article: SARS-CoV-2 infection (COVID-19) in febrile infants without respiratory distress

    Paret, Michal / Lighter, Jennifer / Pellett Madan, Rebecca / Raabe, Vanessa N / Shust, Gail F / Ratner, Adam J

    Clin. infect. dis

    Abstract: We report two cases of SARS-CoV-2 infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial infections. The diagnoses resulted from routine ... ...

    Abstract We report two cases of SARS-CoV-2 infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial infections. The diagnoses resulted from routine isolation and real-time RT-PCR-based testing for SARS-CoV-2 for febrile infants in an outbreak setting.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #72345
    Database COVID19

    Kategorien

  10. Article ; Online: Severe Acute Respiratory Syndrome Coronavirus 2 Infection (COVID-19) in Febrile Infants Without Respiratory Distress

    Paret, Michal / Lighter, Jennifer / Pellett Madan, Rebecca / Raabe, Vanessa N / Shust, Gail F / Ratner, Adam J

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    2020  

    Abstract: Abstract We report 2 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive ... ...

    Abstract Abstract We report 2 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (COVID-19) in infants presenting with fever in the absence of respiratory distress who required hospitalization for evaluation of possible invasive bacterial infections. The diagnoses resulted from routine isolation and real-time reverse-transcription polymerase chain reaction–based testing for SARS-CoV-2 for febrile infants in an outbreak setting.
    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa452
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

To top