LIVIVO - Search results -

Search results

Result 1 - 10 of total 101507

Book ; Online: QI-TTS

Tang, Haobin / Zhang, Xulong / Wang, Jianzong / Cheng, Ning / Xiao, Jing

Questioning Intonation Control for Emotional Speech Synthesis

2023

Abstract: ... grained styles such as intonation are neglected. In this paper, we propose QI-TTS which aims to better ... at the syllable level.Experiments have validated the effectiveness of QI-TTS for improving intonation ...

Abstract	Recent expressive text to speech (TTS) models focus on synthesizing emotional speech, but some fine-grained styles such as intonation are neglected. In this paper, we propose QI-TTS which aims to better transfer and control intonation to further deliver the speaker's questioning intention while transferring emotion from reference speech. We propose a multi-style extractor to extract style embedding from two different levels. While the sentence level represents emotion, the final syllable level represents intonation. For fine-grained intonation control, we use relative attributes to represent intonation intensity at the syllable level.Experiments have validated the effectiveness of QI-TTS for improving intonation expressiveness in emotional speech synthesis. Comment: Accepted by ICASSP 2023
Keywords	Computer Science - Sound ; Computer Science - Computation and Language ; Electrical Engineering and Systems Science - Audio and Speech Processing
Subject code	430
Publishing date	2023-03-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Correction: Qi, W

Qi, Wanchen / Lu, Changpeng / Huang, Huiliang / Zhang, Weinan / Song, Shaofei / Liu, Bing

International journal of molecular sciences

2020 Volume 21, Issue 8

Abstract: The authors wish to make the following corrections to this paper [1]:[ ... ]. ...

Abstract	The authors wish to make the following corrections to this paper [1]:[...].
Language	English
Publishing date	2020-04-21
Publishing country	Switzerland
Document type	Journal Article ; Published Erratum
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21082915
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: [Observation of effect of Wu Yun Liu Qi on reproductive hormones in varicocele patients].

Shi, Qing-Jing / Pan, Lian-Jun / Pan, Feng / Zhao, Dan / Zhang, Xing-Yuan / Li, Hai-Bo / Liao, Kai / Zhang, Feng-Lei

Zhonghua nan ke xue = National journal of andrology

2024 Volume 29, Issue 12, Page(s) 1018–1021

Abstract: ... of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods ... Qi had effect on roproductive hormone levels in varicocele patients, showing by higher E2 level ...

Abstract	Objective： To observe roproductive hormone levels in varicocele patients during a cycle (6 years) of Wu Yun Liu Qi, and explore whether the cycle had effect on the roproductive hormone levels. Methods： Data of roproductive hormone levels in varicocele patients from 2015 to 2020 were analyzed retrospectively. FSH、LH、T、PRL、E2 levels and T/E2 ratio were compared among the six years. According to Chinese sexagenary cycle heavenly stems and earthly branches of each year from 2015 to 2020 its yunqi characteristics were determined. Results: Totally data of 848 cases of varicocele patients were collected from 2015 to 2020. Among which, in 2015 (Yiwei year) there were 57 cases, in 2016 (Bingshen year) 83 cases, in 2017 (Dingyou year ) 133 cases, in 2018(Wuxu year) 156 cases, in 2019(Sihai year) 274 cases, and in 2020(Gengzi year) 145 cases. The levels of FSH、LH、PRL、T were not diferrent statistically from the six years except individual year. However, the level of E2 in 2016 when the Yunqi was Shao Yang Xiang Huo Si Tian and Jue Yin Feng Mu Zai Quan obviously higher than other years excpet 2018( All P< 0.05). And T/E2 ratio was lower in 2016 than other years except 2018 and 2020( All P< 0.05). Conclusions: Shi Xiang factors of Wu Yun Liu Qi had effect on roproductive hormone levels in varicocele patients, showing by higher E2 level in Yinshen year when the Shi Xiang factors may have bad effect on human fertility.
MeSH term(s)	Male ; Humans ; Qi ; Varicocele ; Retrospective Studies ; Follicle Stimulating Hormone
Chemical Substances	Follicle Stimulating Hormone (9002-68-0)
Language	Chinese
Publishing date	2024-04-19
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2267480-9
ISSN	1009-3591
ISSN	1009-3591
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6577: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The San-Qi-Xue-Shang-Ning formula protects against ulcerative colitis by restoring the homeostasis of gut immunity and microbiota.

Yu, Wei / Kang, Cai / Zhang, Yijia / Li, Qi / Zhang, Zhiqiang / Zheng, Yang / Liu, Xincheng / Yan, Jing

Journal of ethnopharmacology

2023 Volume 305, Page(s) 116125

Abstract: ... associated cancer (CAC). The San-Qi-Xue-Shang-Ning (SQ) formula has been utilized in clinical practice ...

Abstract	Ethnopharmacological relevance: Ulcerative colitis (UC) is a major cause of morbidity and mortality due to repetitive remissions and relapses, and many severe complications, including colitis-associated cancer (CAC). The San-Qi-Xue-Shang-Ning (SQ) formula has been utilized in clinical practice to treat gut diseases, but its pharmacological evidence is limited and awaits elucidation. Aim of the study: Here, we elucidated the molecular mechanisms of the SQ formula. Materials and methods: Its therapeutic value in combating UC and CAC was predicted from network pharmacology and weighted gene co-expression network analysis (WGCNA). Experimental colitis models were established by feeding dextran sodium sulfate (DSS) to C57BL/6N mice for 7 days, and they were subjected to the SQ formula for 14 days. High-throughput technologies and biochemical investigations were executed to corroborate the anti-colitis effect. Results: Network pharmacology and WGCNA demonstrated that the targets of the SQ formula were associated with interleukin-17 (IL-17), tumor necrosis factor (TNF), IL-1b and peroxisome proliferators-activated receptor (PPAR) signaling pathways, and correlated with the survival in patients with colorectal cancer. In mice with colitis, the SQ treatment hindered colitis progression in a dose-dependent manner, as evidenced by the rescued colon length and weight loss, improved colonic epithelial integrity, and abolished crypt loss. In addition to the suppressed serum IL-17, TNFα, and IL-1b levels, the SQ-treated colitis mice exhibited decreased colonic protein abundance of hypoxia-inducible factor-1α (HIF-1 α), PPARα, and Caspase3 (Casp3) with an increased PPARγ expression. Concurrently, the high dose of SQ promoted the alternative activation of peritoneal macrophages by increasing Arg1 and inhibiting iNOS2, thereby facilitating the migration of NCM460 cells and controlling TNF-induced reactive oxygen species production and apoptosis in intestinal organoids. In colitis-accompanied dysbiosis, the SQ formula reversed the decreased microbiota diversity indexes and restored the microbiome profile in the murine colitis models. Conclusion: The SQ formula is a potent anti-colitis drug that facilitates inflammation resolution and restores gut microbiota homeostasis.
MeSH term(s)	Mice ; Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Interleukin-17/metabolism ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colon ; Microbiota ; Homeostasis ; Dextran Sulfate/toxicity ; Disease Models, Animal
Chemical Substances	Interleukin-17 ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2023-01-02
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.116125
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1494: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Luteolin in the Qi Bi Anshen decoction improves propionic acid-induced autism-like behavior in rats by inhibiting LRP1/MMP9.

Zhang, Mengjia / Yu, Jiaoyan / Liu, An / Liu, Qing-Qing / Sun, Ting / Li, Xi / Du, Yaya / Li, Jiamin / Wang, Bin / Yang, Qi

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154965

Abstract: ... can eliminate the symptoms of autism by precisely regulating human physiology. The Qi Bi Anshen decoction (QAT ...

Abstract	Background: A neurodevelopmental illness with a high frequency and unidentified pathophysiology is known as autism spectrum disorder (ASD). A research hotspot in this field is the identification of disease-specific biomarkers and drug intervention targets. Traditional Chinese medicine (TCM) can eliminate the symptoms of autism by precisely regulating human physiology. The Qi Bi Anshen decoction (QAT) is a commonly used TCM clinical drug commonly-used to treat for treating ASD. However, the primary active ingredients and underlying mechanisms of action of this decoction remain unknown. Purpose: This study aimed to investigate the active ingredients and pharmacodynamics of QAT in the treatment of ASD using a Sprague-Dawley rat model that resembled autism. Methods: Autism-like rat models were established through intracerebroventricular injections of propionic acid (PPA). Subsequently, the rats were treated with QAT, and their efficacy was evaluated using the three-chamber method to analyze social interactions and grooming behavior. Additionally, open-field tests, elevated cross-maze tests, hematoxylin and eosin staining, Nissl staining, and enzyme-linked immunosorbent assays were performed; Western blot analysis was employed to determine the expression of synaptic plasticity-related proteins. Utilizing ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS), the effectiveness of active QAT components was assessed, and potential QAT targets were screened through molecular docking, surface plasmon resonance, and thermal migration experiments. To better understand the precise processes involved in treating ASD with active QAT components, in vivo and in vitro knockdown tests were also performed. Results: QATexhibited a significant improvement in autism-like behavior and a notable increase in the production of proteins associated with synaptic plasticity. Furthermore, luteolin (LUT), identified as a potentially important active ingredient in QAT for treating ASD, reduced matrix metallopeptidase-9 (MMP9) expression. However, this effect was attenuated by the knockdown of low-density lipoprotein receptor-associated protein 1 (LRP1), which is the target binding site for LUT. Conclusions: LUT emerges as a potentially crucial active component of QAT in the treatment of ASD, with the ability to antagonize LRP1 and subsequently reduce MMP9 expression.
MeSH term(s)	Rats ; Animals ; Humans ; Autistic Disorder/chemically induced ; Autistic Disorder/drug therapy ; Autism Spectrum Disorder/chemically induced ; Autism Spectrum Disorder/drug therapy ; Autism Spectrum Disorder/diagnosis ; Luteolin/therapeutic use ; Matrix Metalloproteinase 9 ; Receptors, Lipoprotein ; Chromatography, Liquid ; Molecular Docking Simulation ; Qi ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Low Density Lipoprotein Receptor-Related Protein-1/therapeutic use
Chemical Substances	propionic acid (JHU490RVYR) ; Luteolin (KUX1ZNC9J2) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) ; Receptors, Lipoprotein ; Drugs, Chinese Herbal ; LRP1 protein, human ; Low Density Lipoprotein Receptor-Related Protein-1 ; MMP9 protein, human (EC 3.4.24.35)
Language	English
Publishing date	2023-07-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154965
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Clinical Value of Heart Qi in the Treatment of Chronic Heart Failure With Depression.

Wang, Ying / Lv, Wang / Chen, Hu / Yang, Qian / Zhang, Yang

Alternative therapies in health and medicine

2023 Volume 30, Issue 2, Page(s) 36–41

Abstract: ... studied the effects of tonic heart qi soup for patients with CHF and depression.: Objective: The study ... intended to evaluate the clinical efficacy of tonic heart qi soup in the treatment of chronic heart failure ... which received conventional Western medical treatment combined with treatment with a commercial tonic heart qi ...

Abstract	Context: Chronic heart failure (CHF) is a form of persistent heart failure. If a patient develops depression, it can worsen the severity of heart failure and can lead to adverse outcomes. No researchers have studied the effects of tonic heart qi soup for patients with CHF and depression. Objective: The study intended to evaluate the clinical efficacy of tonic heart qi soup in the treatment of chronic heart failure (CHF) for patients with comorbid depression. Design: The research team performed a prospective randomized controlled trial. Setting: The study took place in the Department of Chinese Medicine at Cangzhou Central Hospital in Cangzhou, Hebei Province, China. Participants: Participants were 120 patients with CHF at the hospital as inpatients or outpatients between January 2016 and January 2019. Intervention: The research team divided participants into two groups, with 60 patients each: (1) an intervention group, which received conventional Western medical treatment combined with treatment with a commercial tonic heart qi soup and (2) a control group, which received conventional Western medical treatment only. Outcome measures: The research team measured: (1) treatment efficacy, (2) cardiac function, (3) adverse reactions, (4) B-type natriuretic peptide (BNP) and Ghrelin, and (5) depression. Results: In the intervention group, 55 participants showed significant improvement in the degree of heart failure, for a total effectiveness rate of 91.67%, which was significantly higher than that of the control group (P = .000). The intervention group had 10 participants in class II, 18 in class III, and 22 in class IV. Among them, 28 participants improved, indicating significantly better outcomes than those of the control group. The intervention group's BNP levels, at 1031.58 ± 118.83 pg/ml, and ghrelin levels, at 481.46 ± 57.53%, were significantly lower than those of the control group. No liver- or renal-function damage, insomnia, or significant adverse reactions occurred for either group. The intervention group's total incidence rate for adverse reactions, at 1.67%, was significantly lower than that of the control group, at 11.67% (P = .000) and also had a higher total effective rate in reducing depression, at 86.67%, compared to that of the control group, at 43.33%. Conclusions: Heart Qi Tonic Tang, as an adjunctive therapy, significantly improved outcomes for CHF patients with depression. It effectively reduced heart failure symptoms, with minimal adverse reactions and increased patient comfort and compliance.
MeSH term(s)	Humans ; Ghrelin/therapeutic use ; Qi ; Depression/therapy ; Prospective Studies ; Heart Failure/therapy ; Heart Failure/drug therapy
Chemical Substances	Ghrelin
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4504: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Qi-Po-Sheng-Mai granule ameliorates Ach-CaCl

Shi, Shuqing / Mao, Xinxin / Lv, Jiayu / Wang, Yajiao / Zhang, Xuesong / Shou, Xintian / Zhang, Bingxuan / Li, Yumeng / Wu, Huaqin / Song, Qingqiao / Hu, Yuanhui

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 119, Page(s) 155017

Abstract: ... safety of medical therapies. The Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) has been widely ...

Abstract	Background: Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical settings. Currently, the pathophysiology of AF remains unclear, which severely limits the effectiveness and safety of medical therapies. The Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) has been widely used in China to treat AF. However, its pharmacological and molecular mechanisms remain unknown. Purpose: The purpose of this study was to investigate the molecular mechanisms and potential targets of QPSM for AF. Study design and methods: The AF model was induced by Ach (66 μg/ml) and CaCl Results: Based on an Ach-CaCl Conclusion: The present study has systematically elucidated the role of QPSM in maintaining calcium homeostasis in cardiomyocytes through the regulation of calcium transporters, which could lead to new drug development ideas for AF.
MeSH term(s)	Humans ; Atrial Fibrillation/chemically induced ; Atrial Fibrillation/drug therapy ; Myocytes, Cardiac ; Calcium ; Calcium Chloride ; Molecular Docking Simulation ; Qi ; Bone Density Conservation Agents ; Amino Acids ; Homeostasis
Chemical Substances	Calcium (SY7Q814VUP) ; Calcium Chloride (M4I0D6VV5M) ; Bone Density Conservation Agents ; Amino Acids
Language	English
Publishing date	2023-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155017
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4115: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Shen Qi Wan attenuates renal interstitial fibrosis through upregulating AQP1.

Lin, Yiyou / Wei, Jiale / Zhang, Yehui / Huang, Junhao / Wang, Sichen / Luo, Qihan / Yu, Hongxia / Ji, Liting / Zhou, Xiaojie / Li, Changyu

Chinese journal of natural medicines

2023 Volume 21, Issue 5, Page(s) 359–370

Abstract: ... to the end-stage renal failure. However, the underlying mechanism of Shen Qi Wan (SQW) on RIF is not fully understood ...

Abstract	Renal interstitial fibrosis (RIF) is the crucial pathway in chronic kidney disease (CKD) leading to the end-stage renal failure. However, the underlying mechanism of Shen Qi Wan (SQW) on RIF is not fully understood. In the current study, we investigated the role of Aquaporin 1 (AQP1) in SQW on tubular epithelial-to-mesenchymal transition (EMT). A RIF mouse model induced by adenine and a TGF-β1-stimulated HK-2 cell model were etablished to explore the involvement of AQP 1 in the protective effect of SQW on EMT in vitro and in vivo. Subsequently, the molecular mechanism of SQW on EMT was explored in HK-2 cells with AQP1 knockdown. The results indicated that SQW alleviated kidney injury and renal collagen deposition in the kidneys of mice induced by adenine, increased the protein expression of E-cadherin and AQP1 expression, and decreased the expression of vimentin and α-smooth muscle actin (α-SMA). Similarly, treatmement with SQW-containing serum significantly halted EMT process in TGF-β1 stimulated HK-2 cells. The expression of snail and slug was significantly upregulated in HK-2 cells after knockdown of AQP1. AQP1 knockdown also increased the mRNA expression of vimentin and α-SMA, and decreased the expression of E-cadherin. The protein expression of vimentin increased, while the expression of E-cadherin and CK-18 significantly decreased after AQP1 knockdown in HK-2 cells. These results revealed that AQP1 knockdown promoted EMT. Furthermore, AQP1 knockdown abolished the protective effect of SQW-containing serum on EMT in HK-2 cells. In sum, SQW attentuates EMT process in RIF through upregulation of the expression of AQP1.
MeSH term(s)	Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Humans ; Animals ; Mice ; Male ; Cell Line ; Rats ; Kidney/pathology ; Kidney/physiology ; Fibrosis/drug therapy ; Renal Insufficiency, Chronic/drug therapy ; Adenine ; Epithelial-Mesenchymal Transition ; Aquaporin 1/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Adenine (JAC85A2161) ; Aqp1 protein, mouse ; Aquaporin 1 (146410-94-8)
Language	English
Publishing date	2023-05-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(23)60453-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 6113: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cultivation and morphology of jujube (Ziziphus Jujuba Mill.) in the Qi River Basin of Northern China during the Neolithic Period.

Li, Yanpeng / Zhou, Xinying / Zhao, Keliang / Liu, Junchi / Chen, Guanhan / Zhang, Yaping / Ma, Jiacheng / Sun, Nan / Li, Xiaoqiang

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2305

Abstract: ... China's Qi River basin, Zhujia, Wangzhuang, and Dalaidian. The measurements of these jujube kernels are ... Therefore, this study suggests that jujube was selected and cultivated as an important food supplement in the Qi ...

Abstract	This transition from gathering to cultivation is a significant aspect of studying early agricultural practices. Fruit trees are an essential component of food resources and have played a vital role in both ancient and modern agricultural production systems. The jujube (Ziziphus jujuba Mill.), with its long history of cultivation in northern China, holds great importance in uncovering the diet of prehistoric humans and understanding the origins of Chinese agricultural civilization. This paper focuses on the domestication of jujube by analyzing the morphology of jujube stones found in three Neolithic sites in northern China's Qi River basin, Zhujia, Wangzhuang, and Dalaidian. The measurements of these jujube kernels are compared with those found in other areas of northern China, as well as modern jujube kernels that were collected. The measurements revealed that the length-to-diameter (L/D) ratio of sour jujube kernels ranged from 1.36 to 1.78, whereas the L/D ratio of cultivated jujube stones varied between 1.96 and 4.23. Furthermore, jujube stones obtained from Zhujia and Wangzhuang sites exhibit pointed ends and possess an elongated oval or narrow oval shape overall, which is indicative of clearly artificial domestication traits. Therefore, this study suggests that jujube was selected and cultivated as an important food supplement in the Qi River basin no later than around 6200 BP.
MeSH term(s)	Humans ; Ziziphus ; Qi ; Rivers ; Fruit ; China
Language	English
Publishing date	2024-01-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52260-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Roles of β-catenin in innate immune process and regulating intestinal flora in Qi river crucian carp (Carassius auratus).

Wu, Limin / Lv, Xixi / Zhang, Jingjing / Wu, Mengfan / Zhao, Xianliang / Shi, Xi / Ma, Wenge / Li, Xuejun / Zou, Yuanchao

Fish & shellfish immunology

2024 Volume 148, Page(s) 109521

Abstract: ... the function of β-catenin in the natural defense mechanism of Qi river crucian carp (Carassius auratus). β ... catenin plays a vital role in combating pathogen invasion and regulating intestinal flora in Qi river ...

Abstract	In mammals, β-catenin participates in innate immune process through interaction with NF-κB signaling pathway. However, its role in teleost immune processes remains largely unknown. We aimed to clarify the function of β-catenin in the natural defense mechanism of Qi river crucian carp (Carassius auratus). β-catenin exhibited a ubiquitous expression pattern in adult fish, as indicated by real-time PCR analysis. Following lipopolysaccharide (LPS), Polyinosinic-polycytidylic acid (polyI: C) and Aeromonas hydrophila (A. hydrophila) challenges, β-catenin increased in gill, intestine, liver and kidney, indicating that β-catenin likely plays a pivotal role in the immune response against pathogen infiltration. Inhibition of the β-catenin pathway using FH535, an inhibitor of Wnt/β-catenin pathway, resulting in pathological damage of the gill, intestine, liver and kidney, significant decrease of innate immune factors (C3, defb3, LYZ-C, INF-γ), upregulation of inflammatory factors (NF-κB, TNF-α, IL-1, IL-8), and downregulation of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities, increase of Malondialdehyde (MDA) content. Following A. hydrophila invasion, the mortality rate in the FH535 treatment group exceeded that of the control group. In addition, the diversity of intestinal microflora decreased and the community structure was uneven after FH535 treatment. In summary, our findings strongly suggest that β-catenin plays a vital role in combating pathogen invasion and regulating intestinal flora in Qi river crucian carp.
MeSH term(s)	Animals ; Goldfish/genetics ; Goldfish/metabolism ; Carps/genetics ; Carps/metabolism ; Gastrointestinal Microbiome ; NF-kappa B ; Rivers ; beta Catenin/genetics ; Qi ; Immunity, Innate/genetics ; Antioxidants ; Aeromonas hydrophila/physiology ; Fish Diseases ; Fish Proteins ; Gram-Negative Bacterial Infections/veterinary ; Mammals/metabolism ; Sulfonamides
Chemical Substances	FH535 ; NF-kappa B ; beta Catenin ; Antioxidants ; Fish Proteins ; Sulfonamides
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1067738-0
ISSN	1095-9947 ; 1050-4648
ISSN (online)	1095-9947
ISSN	1050-4648
DOI	10.1016/j.fsi.2024.109521
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 5917: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED