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  1. Article ; Online: Optimizing hospital antibiotic stewardship programs; should human resources or digital tools be prioritized?

    Diamantis, Sylvain / Meyssonnier, Vanina

    Infectious diseases now

    2023  Volume 53, Issue 8, Page(s) 104791

    MeSH term(s) Humans ; Antimicrobial Stewardship ; Anti-Bacterial Agents/therapeutic use ; Workforce ; Hospitals
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-09-28
    Publishing country France
    Document type Letter
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.104791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Identifying General Practitioners' Antibiotic Prescribing Profiles Based on National Health Reimbursement Data.

    Arias, Pauline / Matta, Matta / Strazzulla, Alessio / Le Mener, Christine / Gallien, Sébastien / Diamantis, Sylvain

    Open forum infectious diseases

    2024  Volume 11, Issue 4, Page(s) ofae172

    Abstract: Background: Antibiotic selection pressure in human medicine is a significant driver of antibiotic resistance in humans. The primary aspect of antibiotic consumption is associated with general practitioner (GP) prescriptions. We aimed to identify ... ...

    Abstract Background: Antibiotic selection pressure in human medicine is a significant driver of antibiotic resistance in humans. The primary aspect of antibiotic consumption is associated with general practitioner (GP) prescriptions. We aimed to identify prescriber profiles for targeted antimicrobial stewardship programs using novel indicators.
    Methods: A cross-sectional study was conducted in 2018 investigating GPs' antibiotic prescriptions in a French department, utilizing the reimbursement database of the national health service. Three antibiotic prescribing indicators were used. Specific targets were established for each indicator to identify the antibiotic prescribers most likely contributing to the emergence of resistance.
    Results: Over 2018, we had 2,908,977 visits to 784 GPs, leading to 431,549 antibiotic prescriptions. Variations between GPs were shown by the 3 indicators. The median antibiotic prescription rate per visit was 13.6% (interquartile range [IQR], 9.8%-17.7%). Median ratios of the prescriptions of low-impact antibiotics to the prescriptions of high-impact antibiotics and of amoxicillin prescriptions to amoxicillin-clavulanic acid prescriptions were 2.5 (IQR, 1.7-3.7) and 2.94 (IQR, 1.7-5), respectively. We found 163 (21%) high prescribers of antibiotics with 3 distinct patterns: The first group overuses broad-spectrum antibiotics but without an overprescription rate per visit, the second group displays an overprescription rate but no excessive use of broad-spectrum antibiotics, and the third group shows both an overprescription rate and excessive use of broad-spectrum antibiotics.
    Conclusions: Prescription-based indicators enable the identification of distinct profiles of antibiotic prescribers. This identification may allow for targeted implementation of stewardship programs focused on the specific prescribing patterns of each profile.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae172
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  3. Article: Optimizing Betalactam Clinical Response by Using a Continuous Infusion: A Comprehensive Review.

    Diamantis, Sylvain / Chakvetadze, Catherine / de Pontfarcy, Astrid / Matta, Matta

    Antibiotics (Basel, Switzerland)

    2023  Volume 12, Issue 6

    Abstract: Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to ...

    Abstract Introduction: Antimicrobial resistance is a major healthcare issue responsible for a large number of deaths. Many reviews identified that PKPD data are in favor of the use of continuous infusion, and we wanted to review clinical data results in order to optimize our clinical practice.
    Methodology: We reviewed Medline for existing literature comparing continuous or extended infusion to intermittent infusion of betalactams.
    Results: In clinical studies, continuous infusion is as good as intermittent infusion. In the subset group of critically ill patients or those with an infection due to an organism with high MIC, a continuous infusion was associated with better clinical response.
    Conclusions: Clinical data appear to confirm those of PK/PD to use a continuous infusion in severely ill patients or those infected by an organism with an elevated MIC, as it is associated with higher survival rates. In other cases, it may allow for a decrease in antibiotic daily dosage, thereby contributing to a decrease in overall costs.
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics12061052
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  4. Article ; Online: Streptococcal and enterococcal endocarditis: time for individualized antibiotherapy?-authors' response.

    Flateau, Clara / Riazi, Adélie / Cassard, Bruno / Camus, Maryse / Diamantis, Sylvain

    The Journal of antimicrobial chemotherapy

    2022  Volume 77, Issue 7, Page(s) 2045–2046

    MeSH term(s) Bacterial Infections ; Endocarditis ; Endocarditis, Bacterial/drug therapy ; Enterococcus faecalis ; Humans ; Streptococcal Infections/drug therapy ; Streptococcus
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkac140
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
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  5. Article: Coexistence of Acquired Hemophilia and Antiphospholipid Serology in Monoclonal Gammopathy Patient.

    Belfeki, Nabil / Hamrouni, Sarra / Strazzulla, Alessio / Diamantis, Sylvain

    International medical case reports journal

    2021  Volume 14, Page(s) 261–264

    Abstract: Acquired hemophilia is a rare coagulopathy with hemorrhage into the skin, muscle, or soft tissues and mucous membranes and caused by inhibitor antibodies, mainly against FVIII. We report a case of acquired hemophilia presenting with diffuse cutaneous ... ...

    Abstract Acquired hemophilia is a rare coagulopathy with hemorrhage into the skin, muscle, or soft tissues and mucous membranes and caused by inhibitor antibodies, mainly against FVIII. We report a case of acquired hemophilia presenting with diffuse cutaneous hemorrhage and hemothorax. The patient was found to have acquired an FVIII inhibitor and a high titer of anti β2 glycoprotein 1 IgG and IgM, and anticardiolipin IgM in the context of IgA kappa-type monoclonal gammopathy. He received 3 injections of recombinant factor VII (rFVIIa) and blood transfusion. He was started on steroids and oral cyclophosphamide for 6 weeks. Thromboprophylaxis with aspirin at 100 mg/day was started 3 months after discharge. Antiphospholipid antibodies remained positive after 3 months as well as prolonged aPTT, factor VIII raised at 100%, and the inhibitor was not detected. The association between acquired hemophilia and antiphospholipid antibodies is rare and its distinction is mandatory because clinical presentation ranges from massive hemorrhage to thrombosis.
    Language English
    Publishing date 2021-04-28
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2495077-4
    ISSN 1179-142X
    ISSN 1179-142X
    DOI 10.2147/IMCRJ.S293931
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  6. Article: Advocacy for Responsible Antibiotic Production and Use.

    Mondain, Véronique / Retur, Nicolas / Bertrand, Benjamin / Lieutier-Colas, Florence / Carenco, Philippe / Diamantis, Sylvain

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 7

    Abstract: Antibiotic-resistant bacteria have become one of humankind's major challenges, as testified by the UN's Call to Action on Antimicrobial Resistance in 2021. Our knowledge of the underlying processes of antibiotic resistance is steadily improving. Beyond ... ...

    Abstract Antibiotic-resistant bacteria have become one of humankind's major challenges, as testified by the UN's Call to Action on Antimicrobial Resistance in 2021. Our knowledge of the underlying processes of antibiotic resistance is steadily improving. Beyond the inappropriate use of antimicrobials in human medicine, other causes have been identified, raising ethical issues and requiring an approach to the problem from a "One Health" perspective. Indeed, it is now clear that the two main issues regarding the subject of antibiotics are their misuse in the global food industry and their method of production, both leading to the emergence and spread of bacterial resistance.
    Language English
    Publishing date 2022-07-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11070980
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  7. Article ; Online: Extreme gonococcal susceptibility associated with acquired complement deficiency secondary to hypocomplementemic urticarial vasculitis and systemic lupus erythematosus.

    Belfeki, Nabil / Zayet, Souheil / Hamrouni, Sarra / Diamantis, Sylvain / Boutboul, David

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2021  Volume 28, Issue 2, Page(s) 308–310

    Abstract: Gonococcal infection is rarely associated with septic shock. We describe a recurrent case of septic shock related to disseminated gonococcemia in a patient with systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, and discuss the ... ...

    Abstract Gonococcal infection is rarely associated with septic shock. We describe a recurrent case of septic shock related to disseminated gonococcemia in a patient with systemic lupus erythematosus and hypocomplementemic urticarial vasculitis, and discuss the implication of profound acquired complement deficiency secondary to these auto-immune diseases. This case raises the question of systematic antibioprophylaxis in patients with acquired complement deficiency.
    MeSH term(s) Complement System Proteins ; Hereditary Complement Deficiency Diseases ; Humans ; Lupus Erythematosus, Systemic/complications ; Urticaria/etiology ; Vasculitis
    Chemical Substances Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2021-11-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2021.10.020
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
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  8. Article ; Online: Scleroderma skin disease with megaesophagus and intense nephrotic syndrome

    Marion Larue / Tracie Joyner Youbong / Franck Pourcine / Sylvain Diamantis / Catherine Chakvetadze

    Medicina Clínica Práctica, Vol 5, Iss 4, Pp 100338- (2022)

    an unusual hypothyroidism

    2022  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-10-01T00:00:00Z
    Publisher Elsevier España
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Tuberculosis in the Elderly.

    Caraux-Paz, Pauline / Diamantis, Sylvain / de Wazières, Benoit / Gallien, Sébastien

    Journal of clinical medicine

    2021  Volume 10, Issue 24

    Abstract: The tuberculosis (TB) epidemic is most prevalent in the elderly, and there is a progressive increase in the notification rate with age. Most cases of TB in the elderly are linked to the reactivation of lesions that have remained dormant. The awakening of ...

    Abstract The tuberculosis (TB) epidemic is most prevalent in the elderly, and there is a progressive increase in the notification rate with age. Most cases of TB in the elderly are linked to the reactivation of lesions that have remained dormant. The awakening of these lesions is attributable to changes in the immune system related to senescence. The mortality rate from tuberculosis remains higher in elderly patients. Symptoms of active TB are nonspecific and less pronounced in the elderly. Diagnostic difficulties in the elderly are common in many diseases but it is important to use all possible techniques to make a microbiological diagnosis. Recognising frailty to prevent loss of independence is a major challenge in dealing with the therapeutic aspects of elderly patients. Several studies report contrasting data about poorer tolerance of TB drugs in this population. Adherence to antituberculosis treatment is a fundamental issue for the outcome of treatment. Decreased completeness of treatment was shown in older people as well as a higher risk of treatment failure.
    Language English
    Publishing date 2021-12-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10245888
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  10. Article ; Online: Streptococcal and enterococcal endocarditis: time for individualized antibiotherapy?

    Flateau, Clara / Riazi, Adélie / Cassard, Bruno / Camus, Maryse / Diamantis, Sylvain

    The Journal of antimicrobial chemotherapy

    2021  Volume 76, Issue 12, Page(s) 3073–3076

    Abstract: Recommendations for the treatment of streptococcal and enterococcal endocarditis are based on old efficacy studies, but the starting doses have never been reassessed and are associated with significant adverse events. Based on data from other serious ... ...

    Abstract Recommendations for the treatment of streptococcal and enterococcal endocarditis are based on old efficacy studies, but the starting doses have never been reassessed and are associated with significant adverse events. Based on data from other serious infections, we suggest that maintaining a concentration of β-lactams higher than 4-6 times the responsible bacteria MIC 100% of the time in the heart of the vegetation would be a pertinent therapeutic objective. The data point to a diffusion gradient of β-lactams in the vegetation. Yet, so far as is known, the ratio of antibiotic concentration at steady state between plasma and vegetation cannot be completely determined. Answering this crucial question would make it possible for each patient to have a targeted β-lactam plasma concentration, according to the MIC for the responsible bacteria. This would lead the way to personalized antibiotherapy and allow a safe switch to oral medication.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Endocarditis, Bacterial/drug therapy ; Humans ; Streptococcal Infections/drug therapy ; Streptococcus ; beta-Lactams
    Chemical Substances Anti-Bacterial Agents ; beta-Lactams
    Language English
    Publishing date 2021-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkab333
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1197: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 124: Show issues

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