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  1. Book ; Online ; E-Book: Metabolic diseases and gut bacteria

    Kaur, Indu Pal / Chopra, Kanwaljit / Bishnoi, Mahendra / Kondepudi, Kanthi Kiran

    (Probiotic research in therapeutics ; 5)

    2022  

    Author's details Indu Pal Kaur editor-in-chief ; Kanwaljit Chopra, Mahendra Bishnoi, Kanthi Kiran Kondepudi editors
    Series title Probiotic research in therapeutics ; 5
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xiv, 275 Seiten), Illustrationen, Diagramme
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021383424
    ISBN 978-981-16-8444-9 ; 9789811684432 ; 981-16-8444-8 ; 981168443X
    DOI 10.1007/978-981-16-8444-9
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Emerging and Transboundary Animal Viruses

    Malik, Yashpal Singh / Singh, Raj Kumar / Yadav, Mahendra Pal

    (Livestock Diseases and Management,)

    2020  

    Abstract: This book, which is the first volume of the book series-Livestock Diseases and Management, summarizes the prominence and implications of the emerging and transboundary animal viruses. Although the livestock plays an important role in the economy of many ... ...

    Author's details edited by Yashpal Singh Malik, Raj Kumar Singh, Mahendra Pal Yadav
    Series title Livestock Diseases and Management,
    Abstract This book, which is the first volume of the book series-Livestock Diseases and Management, summarizes the prominence and implications of the emerging and transboundary animal viruses. Although the livestock plays an important role in the economy of many countries, the emerging and transboundary animal viral diseases possess a serious risk to the animal-agriculture sector and food security globally. The book describes the precise and up-to-date information on animal viral diseases which have emerged in the recent past or are re-emerging due to various environmental factors and those which are not bounded in restricted national boundaries and attained the transboundary status. The chapters summarize the recent advancements in the molecular state-of-art tools towards the development of diagnostics, prophylactics, and therapeutics of these viruses. It also explicitly describes the challenges imposed by the emerging and transboundary viral infections and our preparedness to counter them. .
    Keywords Virology ; Veterinary medicine ; Infectious diseases ; Parasitology ; Veterinary Microbiology, Parasitology and Infectious Diseases ; Infectious Diseases
    Subject code 636
    Language English
    Size 1 online resource (XXIII, 377 p. 34 illus., 30 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer Singapore ; Imprint: Springer
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-15-0402-4 ; 981-15-0401-6 ; 978-981-15-0402-0 ; 978-981-15-0401-3
    DOI 10.1007/978-981-15-0402-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Level of agreement between standard broth microdilution and agar-based susceptibility tests against Candida spp. isolated from the vaginal mucosa.

    Moreira, Debora / Paula, Claudete Rodrigues / Pal, Mahendra / Ruiz, Luciana da Silva

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2023  Volume 41, Issue 9, Page(s) 584–585

    MeSH term(s) Candida ; Agar ; Antifungal Agents/pharmacology ; Microbial Sensitivity Tests ; Mucous Membrane
    Chemical Substances Agar (9002-18-0) ; Antifungal Agents
    Language English
    Publishing date 2023-06-30
    Publishing country Spain
    Document type Letter
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2023.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent advances in targeting autophagy in cancer.

    Jain, Vaibhav / Singh, Mahendra Pal / Amaravadi, Ravi K

    Trends in pharmacological sciences

    2023  Volume 44, Issue 5, Page(s) 290–302

    Abstract: Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of advanced cancers by degrading and recycling organelles and proteins. Preclinical studies have identified that within an established tumor, tumor cell autophagy and ...

    Abstract Autophagy is a cellular homeostasis mechanism that fuels the proliferation and survival of advanced cancers by degrading and recycling organelles and proteins. Preclinical studies have identified that within an established tumor, tumor cell autophagy and host cell autophagy conspire to support tumor growth. A growing body of evidence suggests that autophagy inhibition can augment the efficacy of chemotherapy, targeted therapy, or immunotherapy to enhance tumor shrinkage. First-generation autophagy inhibition trials in cancer using the lysosomal inhibitor hydroxychloroquine (HCQ) have produced mixed results but have guided the way for the development of more potent and specific autophagy inhibitors in clinical trials. In this review, we will discuss the role of autophagy in cancer, newly discovered molecular mechanisms of the autophagy pathway, the effects of autophagy modulation in cancer and host cells, and novel autophagy inhibitors that are entering clinical trials.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Hydroxychloroquine/pharmacology ; Hydroxychloroquine/therapeutic use ; Autophagy
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 282846-7
    ISSN 1873-3735 ; 0165-6147
    ISSN (online) 1873-3735
    ISSN 0165-6147
    DOI 10.1016/j.tips.2023.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Primary leiomyosarcoma of the penis: A rare penile neoplasm.

    Goyal, Neeti / Menon, Santosh / Pal, Mahendra

    Medical journal, Armed Forces India

    2022  Volume 78, Issue 3, Page(s) 365–367

    Abstract: Mesenchymal tumors arising in the penis are extremely uncommon. Sarcomas must be distinguished from sarcomatoid squamous carcinomas, owing to their treatment and prognostic implications. We report a rare case of leiomyosarcoma of the penis in a 70-year- ... ...

    Abstract Mesenchymal tumors arising in the penis are extremely uncommon. Sarcomas must be distinguished from sarcomatoid squamous carcinomas, owing to their treatment and prognostic implications. We report a rare case of leiomyosarcoma of the penis in a 70-year-old patient. Histopathology was of a high-grade spindle cell sarcoma, initially reported as sarcomatoid carcinoma on biopsy, subsequently confirmed on partial penectomy as a leiomyosarcoma.
    Language English
    Publishing date 2022-04-04
    Publishing country India
    Document type Case Reports
    ZDB-ID 196342-9
    ISSN 0377-1237
    ISSN 0377-1237
    DOI 10.1016/j.mjafi.2022.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Clear cell urothelial carcinoma of bladder: Case report of a rare and aggressive variant with review of literature.

    Sahetia, Khushboo M / Dave, Vinayak N / Pal, Mahendra / Menon, Santosh

    Indian journal of cancer

    2023  Volume 60, Issue 4, Page(s) 575–577

    Abstract: Clear cell urothelial carcinoma is a rare variant of urothelial carcinoma. It's recognition and accurate diagnosis are essential in deciding appropriate treatment protocols considering the prognosis of this variant. A 57-year-old male presented with a ... ...

    Abstract Clear cell urothelial carcinoma is a rare variant of urothelial carcinoma. It's recognition and accurate diagnosis are essential in deciding appropriate treatment protocols considering the prognosis of this variant. A 57-year-old male presented with a history of hematuria and lower urinary tract symptoms for 6 months. Microscopically, the tumor was arranged in sheets and had a nested pattern. The tumor was composed of round to polygonal cells with abundant clear cytoplasm (>90% clear cell differentiation), resembling a conventional clear renal cell carcinoma. On special stain, the tumor was positive for periodic acid-Schiff (PAS) and negative for periodic acid-Schiff with diastase (PAS-D) and mucicarmine stain. The urothelial origin of clear cells was confirmed by positivity for GATA Binding protein 3(GATA3) and High Molecular Weight Cytokeratin (HMWCK) immunohistochemistry and negativity for NK3 homeobox 1(NKX3.1), Prostate specific antigen (PSA) and Paired box gene 8 (PAX8) immunohistochemistry.
    MeSH term(s) Male ; Humans ; Middle Aged ; Carcinoma, Transitional Cell/chemistry ; Carcinoma, Transitional Cell/diagnosis ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/pathology ; Urinary Bladder/pathology ; Periodic Acid ; Biomarkers, Tumor/genetics ; Carcinoma, Renal Cell/pathology ; Kidney Neoplasms/pathology
    Chemical Substances Periodic Acid (10450-60-9) ; Biomarkers, Tumor
    Language English
    Publishing date 2023-12-21
    Publishing country India
    Document type Review ; Case Reports ; Journal Article
    ZDB-ID 410194-7
    ISSN 1998-4774 ; 0019-509X
    ISSN (online) 1998-4774
    ISSN 0019-509X
    DOI 10.4103/ijc.ijc_564_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Synergistic Antibacterial Activity of Gallic Acid Based Chalcone Indl 2 by Inhibiting Efflux Pump Transporters.

    Dwivedi, Gaurav Raj / Pathak, Nandini / Tiwari, Nimisha / Negi, Arvind Singh / Kumar, Akhil / Pal, Anirban / Sharma, Ashok / Darokar, Mahendra P

    Chemistry & biodiversity

    2024  Volume 21, Issue 4, Page(s) e202301820

    Abstract: As a part of novel discovery of drugs from natural resources, present study was undertaken to explore the antibacterial potential of chalcone Indl-2 in combination with different group of antibiotics. MIC of antibiotics was reduced up to eight folds ... ...

    Abstract As a part of novel discovery of drugs from natural resources, present study was undertaken to explore the antibacterial potential of chalcone Indl-2 in combination with different group of antibiotics. MIC of antibiotics was reduced up to eight folds against the different cultures of E. coli by both chalcones. Among the two compounds, the i. e. 1-(3', 4,'5'-trimethoxyphenyl)-3-(3-Indyl)-prop-2-enone (6, Indl-2), a chalcone derivative of gallic acid (Indl-2) was better along with tetracycline (TET) worked synergistically and was found to inhibit efflux transporters as obvious by ethidium bromide efflux confirmed by ATPase assays and docking studies. In combination, Indl-2 kills the MDREC-KG4 cells, post-antibiotic effect (PAE) of TET was prolonged and mutant prevention concentration (MPC) of TET was also decreased. In-vivo studies revealed that Indl-2 reduces the concentration of TNF-α. In acute oral toxicity study, Indl-2 was non-toxic and well tolerated up-to dose of 2000 mg/kg. Perhaps, the study is going to report gallic acid derived chalcone as synergistic agent acting via inhibiting the primary efflux pumps.
    MeSH term(s) Chalcone/pharmacology ; Chalcones/pharmacology ; Escherichia coli ; Gallic Acid/pharmacology ; Anti-Bacterial Agents/pharmacology ; Tetracycline/pharmacology ; Membrane Transport Proteins ; Microbial Sensitivity Tests ; Bacterial Proteins/metabolism
    Chemical Substances Chalcone (5S5A2Q39HX) ; Chalcones ; Gallic Acid (632XD903SP) ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Membrane Transport Proteins ; Bacterial Proteins
    Language English
    Publishing date 2024-03-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202301820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Glabridin synergy with norfloxacin induces ROS in multidrug resistant Staphylococcus aureus.

    Singh, Vigyasa / Pal, Anirban / Darokar, Mahendra P

    The Journal of general and applied microbiology

    2021  Volume 67, Issue 6, Page(s) 269–272

    Abstract: Glabridin (Glb), a polyphenolic flavonoid inhibits the growth of MDRSA (Multidrug resistant S. aureus) 4627 by inducing ROS. Glb in combination with Norfloxacin (Nor) synergistically induced oxidative stress. Increased ROS/RNS levels, in particular, ... ...

    Abstract Glabridin (Glb), a polyphenolic flavonoid inhibits the growth of MDRSA (Multidrug resistant S. aureus) 4627 by inducing ROS. Glb in combination with Norfloxacin (Nor) synergistically induced oxidative stress. Increased ROS/RNS levels, in particular, affected macromolecules' (DNA, lipid, protein) integrity and distorted cell morphology. We found correlation between drug-effects and up-/down-regulation of oxidative stress-related as well as MDR genes. These findings could considerably potentiate the dosing routine of Nor in combination with Glb, which holds a promising prospective as a antibacterial agent against S. aureus.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Isoflavones ; Methicillin-Resistant Staphylococcus aureus ; Microbial Sensitivity Tests ; Norfloxacin/pharmacology ; Phenols ; Prospective Studies ; Reactive Oxygen Species ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Isoflavones ; Phenols ; Reactive Oxygen Species ; glabridin (HOC5567T41) ; Norfloxacin (N0F8P22L1P)
    Language English
    Publishing date 2021-10-23
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 218355-9
    ISSN 1349-8037 ; 0022-1260
    ISSN (online) 1349-8037
    ISSN 0022-1260
    DOI 10.2323/jgam.2021.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Pre- and post-emergence herbicidal effect on weeds, fodder yield and quality of berseem in lowland region of Western Himalayas

    Pal, Mahendra Singh

    Indian journal of weed science. 2019, v. 51, no. 2

    2019  

    Abstract: A field experiment was carried out during winter seasons of 2013–14 and 2014–15 at GB. Pant University of Agriculture and Technology, Pantnagar to study the effect of pre- and post- emergence herbicides on weeds, fodder yield and quality of berseem ( ... ...

    Abstract A field experiment was carried out during winter seasons of 2013–14 and 2014–15 at GB. Pant University of Agriculture and Technology, Pantnagar to study the effect of pre- and post- emergence herbicides on weeds, fodder yield and quality of berseem (Trifolium alexandrinum L.). The experimental results indicated that pre emergence application of pendimethalin (1000 g/ha) followed by imazethapyr (100 g/ha) just after 1ˢᵗ cut produced significantly higher green and dry fodder yields, crude protein and net returns but alone application of pendimethalin at 1000 g/ha had the highest B:C ratio. The pooled values indicated that the lowest weed population was observed at application of pendimethalin + imazethapyr (1666 + 100 g/ha). The fresh and dry weight of weeds were recorded significantly lower under oxyflourfen + imazethapyr at 425 + 100 g/ha (just after 1ˢᵗ cut) in both the years, while pooled weed control efficiency was found significantly highest under oxyflourfen + imazethapyr at 425 + 100 g/ha (just after Iˢᵗ cut). It is therefore, concluded that the application of pendimethalin + imazethapyr at 1000 + 100 g/ha may be recommended for effective weed control as well as higher fodder yield, its quality and net profit in berseem growing areas of lowland (Tarai) region of Western Himalayas.
    Keywords Trifolium alexandrinum ; agricultural colleges ; crude protein ; field experimentation ; forage ; imazethapyr ; pendimethalin ; weed control ; weeds ; Himalayan region
    Language English
    Dates of publication 2019-01
    Size p. 173-177.
    Publishing place Indian Society of Weed Science
    Document type Article
    Note NAL-AP-2-clean
    ISSN 0974-8164
    DOI 10.5958/0974-8164.2019.00037.6
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Tailoring the dose of Moscow strain of intravesical bacillus Calmette-Guérin for Indian patients: A plea for urgent action.

    Arora, Amandeep / Bakshi, Ganesh / Pal, Mahendra / Addla, Sanjai / Waigankar, Santosh / Prakash, Gagan

    Indian journal of urology : IJU : journal of the Urological Society of India

    2022  Volume 38, Issue 3, Page(s) 165–169

    Language English
    Publishing date 2022-07-01
    Publishing country India
    Document type Editorial
    ZDB-ID 639268-4
    ISSN 1998-3824 ; 0970-1591
    ISSN (online) 1998-3824
    ISSN 0970-1591
    DOI 10.4103/iju.iju_69_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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