Result 1 - 5 of total 5
Gastroenterology
| Keywords | covid19 |
|---|---|
| Publisher | WHO |
| Document type | Article |
| Note | WHO #Covidence: #867606 |
| Database | COVID19 |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
Gastroenterology ; ISSN 0016-5085
2020
| Keywords | Gastroenterology ; covid19 |
|---|---|
| Language | English |
| Publisher | Elsevier BV |
| Publishing country | us |
| Document type | Article ; Online |
| DOI | 10.1053/j.gastro.2020.10.021 |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2020 Volume 160, Issue 3, Page(s) 925–928.e4
| MeSH term(s) | Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; COVID-19/enzymology ; COVID-19/virology ; Case-Control Studies ; Colitis, Ulcerative/enzymology ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/microbiology ; Crohn Disease/enzymology ; Crohn Disease/genetics ; Crohn Disease/immunology ; Crohn Disease/microbiology ; Disease Models, Animal ; Down-Regulation ; Gastrointestinal Microbiome ; Host-Pathogen Interactions ; Humans ; Ileum/enzymology ; Ileum/immunology ; Ileum/microbiology ; Inflammation Mediators/metabolism ; Mice, Knockout ; Receptors, Virus/metabolism ; SARS-CoV-2/enzymology ; SARS-CoV-2/pathogenicity ; STAT Transcription Factors/genetics ; STAT Transcription Factors/metabolism ; Serine Endopeptidases/metabolism ; Signal Transduction ; Toll-Like Receptors/genetics ; Toll-Like Receptors/metabolism ; Mice |
|---|---|
| Chemical Substances | Inflammation Mediators ; Receptors, Virus ; STAT Transcription Factors ; Toll-Like Receptors ; ACE2 protein, human (EC 3.4.17.23) ; Ace2 protein, mouse (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-10-17 |
| Publishing country | United States |
| Document type | Comparative Study ; Journal Article |
| ZDB-ID | 80112-4 |
| ISSN | 1528-0012 ; 0016-5085 |
| ISSN (online) | 1528-0012 |
| ISSN | 0016-5085 |
| DOI | 10.1053/j.gastro.2020.10.021 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui V Zs.44: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 572: Show issues |
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2022 Volume 14, Issue 6, Page(s) e14121
Abstract: The gut has a specific vascular barrier that controls trafficking of antigens and microbiota ... into the bloodstream. However, the molecular mechanisms regulating the maintenance of this vascular barrier remain ... that is required to actively maintain vascular homeostasis in the small intestine in an organ-specific ...
| Abstract | The gut has a specific vascular barrier that controls trafficking of antigens and microbiota into the bloodstream. However, the molecular mechanisms regulating the maintenance of this vascular barrier remain elusive. Here, we identified Caspase-8 as a pro-survival factor in mature intestinal endothelial cells that is required to actively maintain vascular homeostasis in the small intestine in an organ-specific manner. In particular, we find that deletion of Caspase-8 in endothelial cells results in small intestinal hemorrhages and bowel inflammation, while all other organs remained unaffected. We also show that Caspase-8 seems to be particularly needed in lymphatic endothelial cells to maintain gut homeostasis. Our work demonstrates that endothelial cell dysfunction, leading to the breakdown of the gut-vascular barrier, is an active driver of chronic small intestinal inflammation, highlighting the role of the intestinal vasculature as a safeguard of organ function. |
|---|---|
| MeSH term(s) | Animals ; Caspase 8/metabolism ; Endothelial Cells/enzymology ; Endothelial Cells/metabolism ; Endothelial Cells/pathology ; Enteritis/enzymology ; Enteritis/pathology ; Homeostasis ; Intestinal Mucosa/enzymology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Intestine, Small/enzymology ; Intestine, Small/pathology ; Mice |
| Chemical Substances | Casp8 protein, mouse (EC 3.4.22.-) ; Caspase 8 (EC 3.4.22.-) |
| Language | English |
| Publishing date | 2022-05-02 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2467145-9 |
| ISSN | 1757-4684 ; 1757-4676 |
| ISSN (online) | 1757-4684 |
| ISSN | 1757-4676 |
| DOI | 10.15252/emmm.202114121 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 6784: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
EMBO Molecular Medicine, Vol 14, Iss 6, Pp n/a-n/a (2022)
2022
Abstract: Abstract The gut has a specific vascular barrier that controls trafficking of antigens and ... of this vascular barrier remain elusive. Here, we identified Caspase‐8 as a pro‐survival factor in mature ... intestinal endothelial cells that is required to actively maintain vascular homeostasis ...
| Abstract | Abstract The gut has a specific vascular barrier that controls trafficking of antigens and microbiota into the bloodstream. However, the molecular mechanisms regulating the maintenance of this vascular barrier remain elusive. Here, we identified Caspase‐8 as a pro‐survival factor in mature intestinal endothelial cells that is required to actively maintain vascular homeostasis in the small intestine in an organ‐specific manner. In particular, we find that deletion of Caspase‐8 in endothelial cells results in small intestinal hemorrhages and bowel inflammation, while all other organs remained unaffected. We also show that Caspase‐8 seems to be particularly needed in lymphatic endothelial cells to maintain gut homeostasis. Our work demonstrates that endothelial cell dysfunction, leading to the breakdown of the gut‐vascular barrier, is an active driver of chronic small intestinal inflammation, highlighting the role of the intestinal vasculature as a safeguard of organ function. |
|---|---|
| Keywords | caspase‐8 ; chronic intestinal inflammation ; endothelium ; necroptosis ; vascular homeostasis ; Medicine (General) ; R5-920 ; Genetics ; QH426-470 |
| Subject code | 570 |
| Language | English |
| Publishing date | 2022-06-01T00:00:00Z |
| Publisher | Wiley |
| Document type | Article ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.