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  1. Article ; Online: Dolosigranulum pigrum: A promising nasal probiotic candidate.

    Stubbendieck, Reed M / Hurst, Jillian H / Kelly, Matthew S

    PLoS pathogens

    2024  Volume 20, Issue 2, Page(s) e1011955

    MeSH term(s) Gram-Positive Cocci ; Carnobacteriaceae
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1011955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Leveraging the human microbiota to target bacterial respiratory pathogens: new paths toward an expanded antimicrobial armamentarium.

    Hurst, Jillian H / Kelly, Matthew S

    mBio

    2023  Volume 14, Issue 4, Page(s) e0085423

    Abstract: Acute respiratory infections are the most frequent infections across the lifespan and are the leading infectious cause of death among children globally. Bacterial respiratory infections are routinely treated with antibiotics, nearly all of which are ... ...

    Abstract Acute respiratory infections are the most frequent infections across the lifespan and are the leading infectious cause of death among children globally. Bacterial respiratory infections are routinely treated with antibiotics, nearly all of which are derived from microbial natural products. Unfortunately, antibiotic-resistant bacteria are an increasingly frequent cause of respiratory infections, and there are few new antibiotics in development that target these pathogens. In the article by Stubbendieck et al., the authors identified
    MeSH term(s) Child ; Humans ; Moraxella catarrhalis/drug effects ; Anti-Infective Agents ; Respiratory Tract Infections/drug therapy ; Respiratory Tract Infections/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances peptidoglycan endopeptidase ; Anti-Infective Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00854-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Understanding the influence of the microbiome on childhood infections.

    Heston, Sarah M / Hurst, Jillian H / Kelly, Matthew S

    Expert review of anti-infective therapy

    2024  , Page(s) 1–17

    Abstract: Introduction: The microbiome is known to have a substantial impact on human health and disease. However, the impacts of the microbiome on immune system development, susceptibility to infectious diseases, and vaccine-elicited immune responses are ... ...

    Abstract Introduction: The microbiome is known to have a substantial impact on human health and disease. However, the impacts of the microbiome on immune system development, susceptibility to infectious diseases, and vaccine-elicited immune responses are emerging areas of interest.
    Areas covered: In this review, we provide an overview of development of the microbiome during childhood. We highlight available data suggesting that the microbiome is critical to maturation of the immune system and modifies susceptibility to a variety of infections during childhood and adolescence, including respiratory tract infections, Clostridioides difficile infection, and sexually transmitted infections. We discuss currently available and investigational therapeutics that have the potential to modify the microbiome to prevent or treat infections among children. Finally, we review the accumulating evidence that the gut microbiome influences vaccine-elicited immune responses among children.
    Expert opinion: Recent advances in sequencing technologies have led to an explosion of studies associating the human microbiome with the risk and severity of infectious diseases. As our knowledge of the extent to which the microbiome influences childhood infections continues to grow, microbiome-based diagnostics and therapeutics will increasingly be incorporated into clinical practice to improve the prevention, diagnosis, and treatment of infectious diseases among children.
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2024.2340664
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  4. Article ; Online: Host microbiome-pathogen interactions in pediatric infections.

    Hurst, Jillian H / Heston, Sarah M / Kelly, Matthew S

    Current opinion in infectious diseases

    2023  Volume 36, Issue 5, Page(s) 399–404

    Abstract: Purpose of review: In this review, we discuss recent research that has furthered our understanding of microbiome development during childhood, the role of the microbiome in infections during this life stage, and emerging opportunities for microbiome- ... ...

    Abstract Purpose of review: In this review, we discuss recent research that has furthered our understanding of microbiome development during childhood, the role of the microbiome in infections during this life stage, and emerging opportunities for microbiome-based therapies for infection prevention or treatment in children.
    Recent findings: The microbiome is highly dynamic during childhood and shaped by a variety of host and environmental factors. In turn, the microbiome influences risk and severity of a broad range of infections during childhood, with recent studies highlighting potential roles in respiratory, gastrointestinal, and systemic infections. The microbiome exerts this influence through both direct interactions with potential pathogens and indirectly through modulation of host immune responses. The elucidation of some of these mechanisms by recent studies and the development of effective microbiome-based therapies for adults with recurrent Clostridioides difficile infection highlight the enormous promise that targeting the microbiome has for reducing the burden of infectious diseases during childhood.
    Summary: The microbiome has emerged as a key modifier of infection susceptibility and severity among children. Further research is needed to define the roles of microbes other than bacteria and to elucidate the mechanisms underlying microbiome-host and microbiome-pathogen interactions of importance to infectious diseases in children.
    MeSH term(s) Adult ; Humans ; Child ; Gastrointestinal Microbiome ; Microbiota ; Gastrointestinal Tract ; Clostridium Infections ; Communicable Diseases
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 645085-4
    ISSN 1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
    ISSN (online) 1473-6527 ; 1535-3877
    ISSN 0951-7375 ; 1355-834X
    DOI 10.1097/QCO.0000000000000949
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  5. Article ; Online: William Kaelin, Peter Ratcliffe, and Gregg Semenza receive the 2016 Albert Lasker Basic Medical Research Award.

    Hurst, Jillian H

    The Journal of clinical investigation

    2016  Volume 126, Issue 10, Page(s) 3628–3638

    MeSH term(s) Animals ; Awards and Prizes ; Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Hypoxia/history ; Hypoxia/metabolism ; Hypoxia/pathology ; Portraits as Topic
    Language English
    Publishing date 2016-09-13
    Publishing country United States
    Document type Biography ; Historical Article ; News
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI90055
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  6. Article ; Online: Correction to: Combining adult with pediatric patient data to develop a clinical decision support tool intended for children: leveraging machine learning to model heterogeneity.

    Sabharwal, Paul / Hurst, Jillian H / Tejwani, Rohit / Hobbs, Kevin T / Routh, Jonathan C / Goldstein, Benjamin A

    BMC medical informatics and decision making

    2022  Volume 22, Issue 1, Page(s) 128

    Language English
    Publishing date 2022-05-12
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2046490-3
    ISSN 1472-6947 ; 1472-6947
    ISSN (online) 1472-6947
    ISSN 1472-6947
    DOI 10.1186/s12911-022-01846-1
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  7. Article ; Online: Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award.

    Hurst, Jillian H

    The Journal of clinical investigation

    2015  Volume 125, Issue 10, Page(s) 3732–3736

    MeSH term(s) Allergy and Immunology/history ; Animals ; Antibodies, Monoclonal/therapeutic use ; Awards and Prizes ; CTLA-4 Antigen/immunology ; Clinical Trials, Phase III as Topic ; Drug Screening Assays, Antitumor ; History, 20th Century ; History, 21st Century ; Humans ; Immunologic Surveillance ; Immunotherapy/history ; Ipilimumab ; Lymphocyte Activation ; Medical Oncology/history ; Melanoma/secondary ; Melanoma/therapy ; Mice ; Neoplasms/immunology ; Neoplasms/therapy ; New York ; Randomized Controlled Trials as Topic ; Receptors, Antigen, T-Cell/chemistry ; Receptors, Antigen, T-Cell/immunology ; T-Lymphocyte Subsets/immunology ; Texas
    Chemical Substances Antibodies, Monoclonal ; CTLA-4 Antigen ; CTLA4 protein, human ; Ipilimumab ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2015-10-01
    Publishing country United States
    Document type Biography ; Historical Article ; News
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI84236
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  8. Article ; Online: Child Sexual Abuse Documentation in Primary Care Settings.

    MacPherson, Stephanie C / Golonka, Megan / Liu, Yuerong / Terrell, Lindsay / Evans, Kelly E / Hurst, Jillian H / Gifford, Elizabeth J

    Clinical pediatrics

    2023  , Page(s) 99228231218536

    Abstract: Primary care providers (PCPs) can play an important role in the continuity of care for children who experience sexual abuse (SA). We performed a retrospective, chart-based study of children 3 to 17 years old with SA history. Primary care medical records ... ...

    Abstract Primary care providers (PCPs) can play an important role in the continuity of care for children who experience sexual abuse (SA). We performed a retrospective, chart-based study of children 3 to 17 years old with SA history. Primary care medical records were reviewed for 2 years after a subspecialty SA evaluation. Descriptive statistics and logistic regression were used to assess factors associated with documentation of SA history and mental health management by the PCP. Of 131 included patients, 43% had PCP documentation of their SA history, which was associated with care from resident providers (
    Language English
    Publishing date 2023-12-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207678-0
    ISSN 1938-2707 ; 0009-9228
    ISSN (online) 1938-2707
    ISSN 0009-9228
    DOI 10.1177/00099228231218536
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  9. Article ; Online: Pioneering geneticist Mary-Claire King receives the 2014 Lasker~Koshland Special Achievement Award in Medical Science.

    Hurst, Jillian H

    The Journal of clinical investigation

    2014  Volume 124, Issue 10, Page(s) 4148–4151

    MeSH term(s) Awards and Prizes ; BRCA1 Protein/genetics ; Biomedical Research/history ; Breast Neoplasms/genetics ; Female ; Genetic Predisposition to Disease ; Genetics/history ; Genomics/history ; History, 20th Century ; History, 21st Century ; Humans
    Chemical Substances BRCA1 Protein ; BRCA1 protein, human
    Language English
    Publishing date 2014-09-08
    Publishing country United States
    Document type Biography ; Historical Article ; News ; Portrait
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI78507
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  10. Article ; Online: An integrated genome and phenome-wide association study approach to understanding Alzheimer's disease predisposition.

    Khaire, Archita S / Wimberly, Courtney E / Semmes, Eleanor C / Hurst, Jillian H / Walsh, Kyle M

    Neurobiology of aging

    2022  Volume 118, Page(s) 117–123

    Abstract: Genome-wide association studies (GWAS) have identified common single nucleotide polymorphisms (SNPs) that increase late-onset Alzheimer's disease (LOAD) risk. To identify additional LOAD-associated variants and provide insight into underlying disease ... ...

    Abstract Genome-wide association studies (GWAS) have identified common single nucleotide polymorphisms (SNPs) that increase late-onset Alzheimer's disease (LOAD) risk. To identify additional LOAD-associated variants and provide insight into underlying disease biology, we performed a phenome-wide association study on 23 known LOAD-associated SNPs and 4:1 matched control SNPs using UK Biobank data. LOAD-associated SNPs were significantly enriched for associations with 8/778 queried traits, including 3 platelet traits. The strongest enrichment was for platelet distribution width (PDW) (p = 1.2 × 10
    MeSH term(s) Alzheimer Disease/genetics ; ErbB Receptors/genetics ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Polymorphism, Single Nucleotide/genetics
    Chemical Substances ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 604505-4
    ISSN 1558-1497 ; 0197-4580
    ISSN (online) 1558-1497
    ISSN 0197-4580
    DOI 10.1016/j.neurobiolaging.2022.05.011
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