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Article ; Online: Hepato- and reno-protective effects of thymoquinone, crocin, and carvacrol

Akbar Anaeigoudari

Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 5, Pp 185-

A comprehensive review

2022 Volume 196

Abstract: Medicinal plants are rich in nutrients and phytochemicals which prevent and treat a wide range of ailments. Accumulating experimental studies exhibit that some bioactive ingredients extracted from medicinal plants have suitable therapeutic effects on ... ...

Abstract	Medicinal plants are rich in nutrients and phytochemicals which prevent and treat a wide range of ailments. Accumulating experimental studies exhibit that some bioactive ingredients extracted from medicinal plants have suitable therapeutic effects on hepatic and renal injuries. This review focuses on the hepato- and reno-protective effects of thymoquinone, crocin, and carvacrol. The relevant literature was retrieved from PubMed, Scopus, Web of Science, and Google Scholar databases from the beginning of 2015 until the end of November 2021. According to the scientific evidence, the considered phytochemicals in this review have been applied with useful therapeutic effects on hepatic and renal damage. These therapeutic effects were mainly mediated through the amelioration of oxidative stress, suppression of inflammatory responses, and inhibition of apoptosis. Intracellular signaling pathways linked to nuclear factor kappa B (NF-κB), adenosine monophosphate-activated protein kinase, c-jun N-terminal kinase, and extracellular signal-regulated kinase 1/2 and Toll-like receptors are the most important pathways targeted by these phytochemicals. Up-regulation of transcription factor Nrf2 and down-regulation of transforming growth factor-beta 1 by these natural compounds also contribute to the alleviation of hepatic and renal injuries.
Keywords	carvacrol ; crocin ; thymoquinone ; hepatoprotective ; reno-protective ; inflammatory ; oxidative stress ; nf-κb ; nrf2 ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	306
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents.

Anaeigoudari, Fatemeh / Anaeigoudari, Akbar / Kheirkhah-Vakilabad, Aliasghar

Physiological reports

2023 Volume 11, Issue 15, Page(s) e15785

Abstract: Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The ... ...

Abstract	Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The outcomes of human and animal experiments indicate that therapeutic impacts of saffron and its constituents, crocin, crocetin, and safranal, mainly are mediated via inhibiting the inflammatory reactions and scavenging free radicals. It has been suggested that saffron and crocin extracted from it also up-regulate the expression of sirtuin 1 (SIRT1) and nuclear factor erythroid 2-related factor 2 (Nrf2), down-regulate nuclear factor kappa B (NF-κB) signaling pathway and untimely improve the body organs dysfunction. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 (COX2) also is attributed to crocin. The current review narrates the therapeutic effects of saffron and its constituents on various body systems through looking for the scientific databases including Web of Science, PubMed, Scopus, and Google Scholar from the beginning of 2010 until the end of 2022.
MeSH term(s)	Animals ; Humans ; Crocus ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Coloring Agents
Chemical Substances	crocin (877GWI46C2) ; Plant Extracts ; Coloring Agents
Language	English
Publishing date	2023-08-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15785
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Nano-selenium relieved hepatic and renal oxidative damage in hypothyroid rats.

Hosseini, Mahmoud / Behehsti, Farimah / Marefati, Narges / Anaeigoudari, Akbar

Physiological reports

2023 Volume 11, Issue 9, Page(s) e15682

Abstract: Hypothyroidism can induce oxidative stress. Nano-selenium (Nano Sel) has antioxidant effects. The current research explored Nano Sel effects on hepatic and renal oxidative damage induced by hypothyroidism in rats. Animals were grouped into (1) Control; ( ... ...

Abstract	Hypothyroidism can induce oxidative stress. Nano-selenium (Nano Sel) has antioxidant effects. The current research explored Nano Sel effects on hepatic and renal oxidative damage induced by hypothyroidism in rats. Animals were grouped into (1) Control; (2) Propylthiouracil (PTU) group which received water mixed with 0.05% of PTU; (3) PTU-Nano Sel 50; (4) PTU-Nano Sel 100; and (5) PTU-Nano Sel 150. Besides PTU, the PTU-Nano Sel groups were treated with 50, 100, or 150 μg/kg of Nano Sel intraperitoneally. Treatments were done for 6 weeks. The serum level of T4, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), albumin, total protein, creatinine, and blood urea nitrogen (BUN) was evaluated. Malondialdehyde (MDA) and total thiol concentration and the activity of catalase (CAT) and superoxide dismutase (SOD) in hepatic and renal tissues also were checked. Hypothyroidism induced by PTU significantly increased AST, ALT, ALP, creatinine, BUN, and MDA concentration and noticeably reduced albumin, total protein, total thiol level, and SOD and CAT activity. Administration of Nano Sel ameliorated the adverse effects of hypothyroidism on liver and kidney function. Nano Sel applied protective effects against hepatic and renal damage resulting from hypothyroidism via ameliorating the oxidative stress status. More cellular and molecular experiments need to be done to understand the exact mechanisms.
MeSH term(s)	Rats ; Animals ; Selenium/pharmacology ; Selenium/therapeutic use ; Creatinine ; Rats, Wistar ; Oxidative Stress ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Hypothyroidism/drug therapy ; Liver/metabolism ; Kidney/metabolism ; Superoxide Dismutase/metabolism ; Sulfhydryl Compounds
Chemical Substances	Selenium (H6241UJ22B) ; Creatinine (AYI8EX34EU) ; Antioxidants ; Superoxide Dismutase (EC 1.15.1.1) ; Sulfhydryl Compounds
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2724325-4
ISSN	2051-817X ; 2051-817X
ISSN (online)	2051-817X
ISSN	2051-817X
DOI	10.14814/phy2.15682
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Article ; Online: Methyl Jasmonate Modulates Feeding Behaviors and Hypothalamic Expression of the Orexin 1 Receptor in Rats.

Anaeigoudari, Akbar / Seyedi, Fatemeh / Kooshki, Razieh / Poran, Mohadeseh / Zamyad, Mahnaz / Abbasnejad, Mehdi

Turkish journal of pharmaceutical sciences

2024 Volume 20, Issue 6, Page(s) 374–379

Abstract: Objectives: Active plant ingredients have been successfully used in modern medicine to control appetite and energy hemostasis. This study was designed to evaluate the efficacy of the phytohormone methyl jasmonate (MJ) on food-related behaviors in rats.!# ...

Abstract	Objectives: Active plant ingredients have been successfully used in modern medicine to control appetite and energy hemostasis. This study was designed to evaluate the efficacy of the phytohormone methyl jasmonate (MJ) on food-related behaviors in rats. Materials and methods: Adult male Wistar rats were randomly divided into different groups (7 rats) and infused intracerebroventricularly ( Results: MJ (2.5, 5, and 10 μg/rat) administration significantly decreased food intake in the light and dark phases compared with the control group. Moreover, all the MJ-treated groups exhibited a decrease in visits to food containers at the light and dark times ( Conclusion: Overall, the results indicated the potential of MJ to modulate feeding-related behavior and Orx1R expression in the hypothalamus of rats.
Language	English
Publishing date	2024-01-04
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2238484-4
ISSN	2148-6247 ; 2148-6247
ISSN (online)	2148-6247
ISSN	2148-6247
DOI	10.4274/tjps.galenos.2023.63833
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Article: Effects of

Anaeigoudari, Akbar / Safari, Hamidreza / Khazdair, Mohammad Reza

Frontiers in pharmacology

2021 Volume 12, Page(s) 762182

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.762182
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Article ; Online: The Antidiabetic Drug Metformin Attenuated Depressive and Anxietylike Behaviors and Oxidative Stress in the Brain in a Rodent Model of Inflammation Induced by Lipopolysaccharide in Male Rats.

Kakhki, Faezeh Sadat Hosseini / Asghari, Amir / Bardaghi, Zahra / Anaeigoudari, Akbar / Beheshti, Farimah / Salmani, Hossein / Hosseini, Mahmoud

Endocrine, metabolic & immune disorders drug targets

2024

Abstract: Background: Inflammation is considered to be a link between diabetes and central nervous system (CNS) disorders, including depression and anxiety. Metformin is suggested to have antioxidant, anti-inflammatory, and mood-improving effects. The aim of the ... ...

Abstract	Background: Inflammation is considered to be a link between diabetes and central nervous system (CNS) disorders, including depression and anxiety. Metformin is suggested to have antioxidant, anti-inflammatory, and mood-improving effects. The aim of the current research was to investigate the effects of the antidiabetic drug metformin on depressive- and anxiety- like behaviors and oxidative stress in the brain in a rodent model of inflammation induced by lipopolysaccharide (LPS) in male rats. Materials and methods: The rats were treated as follows: (1) Vehicle instead of metformin and lipopolysaccharide, (2) Lipopolysaccharide (1 mg/ kg) + vehicle instead of metformin, (3-5) Lipopolysaccharide + 50, 100, or 150 mg/ kg of metformin. After the behavioral tests, including open field (OF), elevated pulse maze (EPM), and force swimming (FS) tests, the brains were removed, and malondialdehyde (MDA), nitric oxide (NO) metabolites, total thiol, catalase (CAT) activity, interleukin-6 (IL-6) and superoxide dismutase (SOD) activity were determined. Results: In the EPM, metformin increased the open arm time and entry and decreased closed arm time and entry. In the FS test, metformin lowered the immobility and increased active time compared to lipopolysaccharide. In the OF test, metformin increased total crossing and total distance, time spent, traveled distance, and crossing number in the central zone. As a result of metformin administration, IL-6, MDA, and NO metabolites were decreased while thiol content, SOD, and CAT activity were increased. Conclusion: The results indicated that the well-known antidiabetic drug metformin attenuated depressive- and anxiety-like behaviors induced by inflammation in rats. These beneficial effects are suggested to be due to their attenuating effects on neuroinflammation, oxidative stress, and NO in the brain.
Language	English
Publishing date	2024-01-25
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2228325-0
ISSN	2212-3873 ; 1871-5303
ISSN (online)	2212-3873
ISSN	1871-5303
DOI	10.2174/0118715303275039231228065050
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Article ; Online: Zataria multiflora and its constituent, carvacrol, counteract sepsis-induced aortic and cardiac toxicity in rat: Involvement of nitric oxide and oxidative stress.

Hosseini, Mahmoud / Arab, Zohreh / Beheshti, Farimah / Anaeigoudari, Akbar / Shakeri, Farzaneh / Rajabian, Arezoo

Animal models and experimental medicine

2023 Volume 6, Issue 3, Page(s) 221–229

Abstract: Background: Zataria multiflora and carvacrol showed various pharmacological properties including anti-inflammatory and anti-oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and ... ...

Abstract	Background: Zataria multiflora and carvacrol showed various pharmacological properties including anti-inflammatory and anti-oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis-induced aortic and cardiac injury. Thus, this study aimed to investigate the effects of Z. multiflora and carvacrol on nitric oxide (NO) and oxidative stress indicators in lipopolysaccharide (LPS)-induced aortic and cardiac injury. Methods: Adult male Wistar rats were assigned to: Control, lipopolysaccharide (LPS) (1 mg/kg, intraperitoneal (i.p.)), and Z. multiflora hydro-ethanolic extract (ZME, 50-200 mg/kg, oral)- and carvacrol (25-100 mg/kg, oral)-treated groups. LPS was injected daily for 14 days. Treatment with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS administration. At the end of the study, the levels of malondialdehyde (MDA), NO, thiols, and antioxidant enzymes were evaluated. Results: Our findings showed a significant reduction in the levels of superoxide dismutase (SOD), catalase (CAT), and thiols in the LPS group, which were restored by ZME and carvacrol. Furthermore, ZME and carvacrol decreased MDA and NO in cardiac and aortic tissues of LPS-injected rats. Conclusions: The results suggest protective effects of ZME and carvacrol on LPS-induced cardiovascular injury via improved redox hemostasis and attenuated NO production. However, additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.
MeSH term(s)	Rats ; Male ; Animals ; Nitric Oxide/pharmacology ; Lipopolysaccharides/toxicity ; Cardiotoxicity/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Rats, Wistar ; Oxidative Stress/physiology ; Antioxidants/pharmacology ; Sepsis/complications ; Sepsis/drug therapy ; Sulfhydryl Compounds/pharmacology
Chemical Substances	carvacrol (9B1J4V995Q) ; Nitric Oxide (31C4KY9ESH) ; Lipopolysaccharides ; Plant Extracts ; Antioxidants ; Sulfhydryl Compounds
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2576-2095
ISSN (online)	2576-2095
DOI	10.1002/ame2.12323
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Zataria multiflora and its constituent, carvacrol, counteract sepsis‐induced aortic and cardiac toxicity in rat

Mahmoud Hosseini / Zohreh Arab / Farimah Beheshti / Akbar Anaeigoudari / Farzaneh Shakeri / Arezoo Rajabian

Animal Models and Experimental Medicine, Vol 6, Iss 3, Pp 221-

Involvement of nitric oxide and oxidative stress

2023 Volume 229

Abstract: Abstract Background Zataria multiflora and carvacrol showed various pharmacological properties including anti‐inflammatory and anti‐oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis‐induced aortic ... ...

Abstract	Abstract Background Zataria multiflora and carvacrol showed various pharmacological properties including anti‐inflammatory and anti‐oxidant effects. However, up to now no studies have explored its potential benefits in ameliorating sepsis‐induced aortic and cardiac injury. Thus, this study aimed to investigate the effects of Z. multiflora and carvacrol on nitric oxide (NO) and oxidative stress indicators in lipopolysaccharide (LPS)‐induced aortic and cardiac injury. Methods Adult male Wistar rats were assigned to: Control, lipopolysaccharide (LPS) (1 mg/kg, intraperitoneal (i.p.)), and Z. multiflora hydro‐ethanolic extract (ZME, 50–200 mg/kg, oral)‐ and carvacrol (25–100 mg/kg, oral)‐treated groups. LPS was injected daily for 14 days. Treatment with ZME and carvacrol started 3 days before LPS administration and treatment continued during LPS administration. At the end of the study, the levels of malondialdehyde (MDA), NO, thiols, and antioxidant enzymes were evaluated. Results Our findings showed a significant reduction in the levels of superoxide dismutase (SOD), catalase (CAT), and thiols in the LPS group, which were restored by ZME and carvacrol. Furthermore, ZME and carvacrol decreased MDA and NO in cardiac and aortic tissues of LPS‐injected rats. Conclusions The results suggest protective effects of ZME and carvacrol on LPS‐induced cardiovascular injury via improved redox hemostasis and attenuated NO production. However, additional studies are needed to elucidate the effects of ZME and its constituents on inflammatory responses mediated by LPS.
Keywords	carvacrol ; lipopolysaccharide ; nitric oxide ; oxidative injury ; sepsis ; Z. multiflora ; Medicine (General) ; R5-920
Subject code	630
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effects of Medicinal Plants and Flavonoids on Parkinson's Disease: A Review on Basic and Clinical Evidences.

Khazdair, Mohammad Reza / Kianmehr, Majid / Anaeigoudari, Akbar

Advanced pharmaceutical bulletin

2020 Volume 11, Issue 2, Page(s) 224–232

Abstract: Parkinson's disease (PD) is a neurodegenerative disorder which is characterized by typical symptoms including gradual progressive muscle rigidity, tremor and loss of motor skills. Although there is no definitive cure for PD, the extract of some medicinal ...

Abstract	Parkinson's disease (PD) is a neurodegenerative disorder which is characterized by typical symptoms including gradual progressive muscle rigidity, tremor and loss of motor skills. Although there is no definitive cure for PD, the extract of some medicinal plants and their ingredients have been suggested to relieve its symptoms and to prevent disability in patients. This review is focused on therapeutic effects of some medicinal plants and their ingredients on PD. The findings presented in this review were collected from experimental and clinical studies in databases including PubMed, Web of Science and Google Scholar until the end of May 2019. The keywords "neurotoxicity " or "Parkinson's disease" or "neuroprotective" and "Medicinal plants" and "Flavonoids" were searched. Based on the results of animal and clinical studies, the extract of medicinal plants and their components which are discussed in this review have neuro-protective effects against PD. These protective properties mainly are mediated through inhibition of dopamine metabolizing enzymes, reduction oxidant markers, increase of antioxidant agents and suppression of neuro-inflammation.
Language	English
Publishing date	2020-07-01
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	3018440-X
ISSN	2251-7308 ; 2228-5881
ISSN (online)	2251-7308
ISSN	2228-5881
DOI	10.34172/apb.2021.026
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Article ; Online: Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats

Narges Marefati / Farimah Beheshti / Poorya Etemadizadeh / Mahmoud Hosseini / Akbar Anaeigoudari

Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 1, Pp 20-

2022 Volume 25

Abstract: Objective: To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide (LPS) induced inflammation and oxidative damage in hepatic and renal tissues of rats. Methods: The rats were divided into four groups: control, ...

Abstract	Objective: To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide (LPS) induced inflammation and oxidative damage in hepatic and renal tissues of rats. Methods: The rats were divided into four groups: control, LPS, LPS+Boswellia serrata extracts (100 mg/kg and 200 mg/kg). LPS (1 mg/kg) and the extract (100 and 200 mg/kg, 30 min before LPS) were administered intraperitoneally for 3 weeks. The levels of liver enzymes, albumin, total protein, creatinine, blood urea nitrogen (BUN), interleukin (IL)-6, malondialdehyde (MDA), and total thiol groups and superoxide dismutase (SOD) and catalase (CAT) activities were measured. Results: The levels of liver enzymes, creatinine, and BUN, IL-6, MDA in the LPS group were markedly increased (P<0.001) while albumin, total protein, and total thiol concentration, as well as SOD and CAT activities, were decreased compared with the control group (P<0.05 or 0.01). Boswellia serrata extracts diminished the levels of liver enzymes, creatinine, BUN, IL-6, and MDA (P<0.01 and P<0.001), and elevated the concentration of total protein and total thiol and SOD and CAT activities (P<0.05 or 0.01). Conclusions: The ethyl acetate gum resin extract of Boswellia serrata reduces LPS-induced inflammatory reactions and oxidative damage, thus ameliorating hepatic and renal function.
Keywords	boswellia serrata ; lipopolysaccharide ; inflammation ; oxidative stress ; renal function ; hepatic function ; Arctic medicine. Tropical medicine ; RC955-962 ; Biology (General) ; QH301-705.5
Subject code	630
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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