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  1. Article ; Online: Clinical Impact of

    Yönal-Hindilerden, İpek / Şahin, Ezgi / Hindilerden, Fehmi / Dağlar-Aday, Aynur / Nalçacı, Meliha

    Turkish journal of haematology : official journal of Turkish Society of Haematology

    2023  Volume 40, Issue 3, Page(s) 174–182

    Abstract: Objective: The impact of : Materials and methods: A total of 228 patients with Ph-negative MPNs, including 118 with essential thrombocythemia (ET), 84 with primary myelofibrosis (PMF), and 26 with polycythemia vera (PV), were analyzed. The JAK2 ... ...

    Abstract Objective: The impact of
    Materials and methods: A total of 228 patients with Ph-negative MPNs, including 118 with essential thrombocythemia (ET), 84 with primary myelofibrosis (PMF), and 26 with polycythemia vera (PV), were analyzed. The JAK2 MutaScreen assay was used to quantify
    Results: In PV cases, high
    Conclusion: Our results suggest that high
    MeSH term(s) Humans ; Alleles ; Primary Myelofibrosis/genetics ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/genetics ; Polycythemia Vera/genetics ; Thrombocythemia, Essential/diagnosis ; Thrombocythemia, Essential/genetics ; Splenomegaly ; Janus Kinase 2/genetics ; Mutation
    Chemical Substances Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2023-08-16
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2185903-6
    ISSN 1308-5263 ; 1300-7777
    ISSN (online) 1308-5263
    ISSN 1300-7777
    DOI 10.4274/tjh.galenos.2023.2023.0169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rapid progression after ibrutinib discontinuation in a patient with mantle cell lymphoma who has severe coronavirus disease 2019 infection

    Fehmi Hindilerden / İpek Yönal Hindilerden / Reyhan Diz Küçükkaya

    Balkan Medical Journal, Vol 38, Iss 2, Pp 141-

    2021  Volume 142

    Keywords Medicine ; R
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Galenos Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Comparison of Response to Rituximab Therapy in Adults with Refractory Symptomatic Immune Thrombocytopenia According to the Presence of Accessory Spleen.

    Hindilerden, Fehmi / Yonal-Hindilerden, Ipek / Yenerel, Mustafa Nuri / Nalcaci, Meliha / Diz-Kucukkaya, Reyhan

    Hematology reports

    2022  Volume 14, Issue 3, Page(s) 222–227

    Abstract: No data exist for the association between the presence of accessory spleen after splenectomy and response to rituximab in immune thrombocytopenia (ITP). We investigated the relationship between accessory spleen presence and rituximab response in ... ...

    Abstract No data exist for the association between the presence of accessory spleen after splenectomy and response to rituximab in immune thrombocytopenia (ITP). We investigated the relationship between accessory spleen presence and rituximab response in splenectomized ITP patients. Fifteen chronic refractory ITP patients were included. Four weekly doses of rituximab 375 mg/m
    Language English
    Publishing date 2022-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2586645-X
    ISSN 2038-8330 ; 2038-8322
    ISSN (online) 2038-8330
    ISSN 2038-8322
    DOI 10.3390/hematolrep14030030
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  4. Article ; Online: Rapid progression after ibrutinib discontinuation in a patient with mantle cell lymphoma who has severe coronavirus disease 2019 infection.

    Hindilerden, Fehmi / Yönal Hindilerden, İpek / Diz Küçükkaya, Reyhan

    Balkan medical journal

    2020  Volume 38, Issue 2, Page(s) 141–142

    MeSH term(s) Adenine/analogs & derivatives ; Adenine/therapeutic use ; Aged ; Antineoplastic Agents/therapeutic use ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/drug therapy ; Follow-Up Studies ; Humans ; Lymphoma, Mantle-Cell/complications ; Lymphoma, Mantle-Cell/drug therapy ; Lymphoma, Mantle-Cell/pathology ; Male ; Piperidines/therapeutic use ; Recurrence ; Retreatment ; Treatment Outcome
    Chemical Substances Antineoplastic Agents ; Piperidines ; ibrutinib (1X70OSD4VX) ; Adenine (JAC85A2161)
    Keywords covid19
    Language English
    Publishing date 2020-10-12
    Publishing country Turkey
    Document type Case Reports ; Letter
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2020.2020.9.106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The impact of JAK2V617F mutation on Philadelphia-negative myeloproliferative neoplasms.

    Şahin, Ezgi / Yönal-Hindilerden, İpek / Hindilerden, Fehmi / Aday, Aynur / Nalçacı, Meliha

    Turkish journal of medical sciences

    2022  Volume 52, Issue 1, Page(s) 150–165

    Abstract: Background: JAK2V617F mutation is expressed in almost all polycthemia vera (PV), 55% of essential thrombocythemia (ET), and 65% of primary myelofibrosis (PMF) patients. Studies investigating phenotypic effects of JAK2V617F mutation on ... ...

    Abstract Background: JAK2V617F mutation is expressed in almost all polycthemia vera (PV), 55% of essential thrombocythemia (ET), and 65% of primary myelofibrosis (PMF) patients. Studies investigating phenotypic effects of JAK2V617F mutation on Philadelphianegative myeloproliferative neoplasms (Ph-negative MPNs) have reported controversial results. This study aims to determine the impact of JAK2V617F mutation on clinical phenotype and outcome in Ph-negative MPNs.
    Methods: Clinical correlates and long-term prognostic relevance of the JAK2V617F mutation were analyzed in 410 Phnegative MPNs-170 ET, 135 PV, 105 PMF- from two institutions and followed for a mean of 76.7 months (SD 62.1) (mean 87 months (SD 67.8), 70.4 months (SD 56.4), 68 months (SD 57.4), respectively for ET, PV, and PMF). Two hundred and twenty-eight patients were genotyped for JAK2V617F mutation using the JAK2 Ipsogen MutaScreen assay, which involves allele-specific polymerase chain reaction (PCR), and 182 patients were genotyped using melting curve analysis.
    Results: In PV patients, JAK2V617F mutation was associated with higher rate in females, lower hemoglobin (Hgb) level, higher leukocyte and platelet count and higher prevalence of thrombosis (p = 0.008, p = 0.018, p = 0.001, p = 0.001, and p = 0.035, respectively). In ET patients, JAK2V617F mutation was associated with higher Hgb and hematocrit (Hct) levels and lower platelet count (p = 0.001, p = 0.001, and p = 0.001, respectively). JAK2V617F-negative ET patients showed a trend towards higher rate of leukemic transformation (p = 0.061). JAK2V617F mutation-positive PMF patients had higher leukocyte count, greater spleen size and showed a trend towards higher Hgb level (p = 0.019, p = 0.042, and p = 0.056, respectively). Among PMF patients with JAK2V617F mutation, the rate of female patients was lower (p = 0.001). Overall survival (OS) in Dynamic International Prognostic Scoring System (DIPSS) - plus high risk PMF patients was shorter compared to the other risk groups (p = 0.001). Leukemia-free survival (LFS) was shorter in DIPSS - plus high risk PMF patients than the other risk groups (p = 0.005). In the entire cohort of Ph-negative MPN patients, JAK2V617F mutation was associated with higher leukocyte count, higher Hgb and Hct levels and lower platelet count, higher frequency of phlebotomies, a trend towards older age, a trend towards greater spleen size, a trend towards a higher prevalence of risk factors for cardiovascular diseases and thrombosis (p = 0.001, p = 0.005, p = 0.001, p = 0.003, p = 0.004, p =0.052, p = 0.056, p = 0.052, and p = 0.059, respectively).
    MeSH term(s) Female ; Humans ; Mutation/genetics ; Myeloproliferative Disorders/genetics ; Neoplasms ; Primary Myelofibrosis/genetics ; Thrombocythemia, Essential ; Thrombosis ; Male
    Language English
    Publishing date 2022-02-22
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 1183461-4
    ISSN 1303-6165 ; 1300-0144
    ISSN (online) 1303-6165
    ISSN 1300-0144
    DOI 10.3906/sag-2103-247
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  6. Article: Immune Thrombocytopenia in a Very Elderly Patient With Covid-19.

    Hindilerden, Fehmi / Yonal-Hindilerden, Ipek / Sevtap, Senoglu / Kart-Yasar, Kadriye

    Frontiers in medicine

    2020  Volume 7, Page(s) 404

    Abstract: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a decreased number of platelets and mucocutaneous bleeding. Many viruses have been identified as triggers of the autoimmune process, including human immunodeficiency virus (HIV), ... ...

    Abstract Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by a decreased number of platelets and mucocutaneous bleeding. Many viruses have been identified as triggers of the autoimmune process, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), parvovirus, rubella, and measles. Association with the new severe acute respiratory syndrome coronavirus, SARS-CoV-2 infection (Covid-19 infection) has been rarely reported. Here, we report the oldest case of ITP patient triggered by the novel coronavirus infection. He showed inadequate response to IVIG but responded to corticosteroids with no severe adverse events. Further studies are warranted to determine the optimal therapeutic strategies for ITP with the Covid-19 infection.
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00404
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  7. Article ; Online: Covid-19 associated autoimmune thrombotic thrombocytopenic purpura: Report of a case.

    Hindilerden, Fehmi / Yonal-Hindilerden, Ipek / Akar, Emre / Kart-Yasar, Kadriye

    Thrombosis research

    2020  Volume 195, Page(s) 136–138

    MeSH term(s) ADAMTS13 Protein/blood ; Aged ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Female ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; Purpura, Thrombocytopenic, Idiopathic/blood ; Purpura, Thrombocytopenic, Idiopathic/etiology ; Purpura, Thrombocytopenic, Idiopathic/pathology ; Purpura, Thrombocytopenic, Idiopathic/therapy ; SARS-CoV-2
    Chemical Substances ADAMTS13 Protein (EC 3.4.24.87) ; ADAMTS13 protein, human (EC 3.4.24.87)
    Keywords covid19
    Language English
    Publishing date 2020-07-05
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.07.005
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  8. Article: Rapid Progression after Ibrutinib Discontinuation in a Mantle Cell Lymphoma Patient with Severe COVID-19 Infection

    Hindilerden, Fehmi / Yönal Hindilerden, Ipek / Diz Küçükkaya, Reyhan

    Balkan Med. J. (Online)

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #854423
    Database COVID19

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  9. Article ; Online: IgG4 producing POEMS syndrome: A rarely recognized subtype.

    Hindilerden, Fehmi / Yonal-Hindilerden, Ipek / Gulturk, Emine / Yuksel, Mahmut / Ozturkmen, Asli Yuksel / Sakız, Damlanur

    Indian journal of pathology & microbiology

    2021  Volume 64, Issue 3, Page(s) 584–586

    Abstract: Serum IgG4 is typically measured for Immunoglobulin G4-related Disease (IgG4-RD), a fibroinflammatory condition associated with polyclonal increase in serum IgG4. Yet, increased IgG4 may still be monoclonal, and little is known about IgG4 POEMS syndrome. ...

    Abstract Serum IgG4 is typically measured for Immunoglobulin G4-related Disease (IgG4-RD), a fibroinflammatory condition associated with polyclonal increase in serum IgG4. Yet, increased IgG4 may still be monoclonal, and little is known about IgG4 POEMS syndrome. We present a case of 40-year-old male with a mass lesion in the left sacral ala. The mass was composed of non-neoplastic fibrous tissue and dense infiltrate of mature plasmacytes with dense eosinophilic cytoplasm and eccentrically placed nuclei that express monoclonal Lambda free light chains and show diffuse positivity for IgG and IgG4. We discuss clinical manifestations and challenges encountered in the diagnosis and treatment of this rare coexistence.
    MeSH term(s) Adult ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G4-Related Disease/blood ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin lambda-Chains/immunology ; Immunologic Tests ; Male ; POEMS Syndrome/classification ; POEMS Syndrome/diagnosis ; POEMS Syndrome/immunology ; Plasma Cells ; Spinal Cord/cytology ; Spinal Cord/pathology
    Chemical Substances Immunoglobulin G ; Immunoglobulin lambda-Chains
    Language English
    Publishing date 2021-07-23
    Publishing country India
    Document type Case Reports
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/IJPM.IJPM_995_20
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  10. Article: Severe Autoimmune Hemolytic Anemia in COVID-19 İnfection, Safely Treated with Steroids.

    Hindilerden, Fehmi / Yonal-Hindilerden, Ipek / Akar, Emre / Yesilbag, Zuhal / Kart-Yasar, Kadriye

    Mediterranean journal of hematology and infectious diseases

    2020  Volume 12, Issue 1, Page(s) e2020053

    Keywords covid19
    Language English
    Publishing date 2020-07-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2020.053
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