LIVIVO - Search results -

Search results

Result 1 - 10 of total 49

Search options

Article ; Online: Interferome signature dynamics during the anti-dengue immune response: a systems biology characterization.

Usuda, Júlia Nakanishi / Plaça, Desirée Rodrigues / Fonseca, Dennyson Leandro M / Marques, Alexandre H C / Filgueiras, Igor Salerno / Chaves, Victor Gabriel Bastos / Adri, Anny Silva / Torrentes-Carvalho, Amanda / Hirata, Mario Hiroyuki / Freire, Paula Paccielli / Catar, Rusan / Cabral-Miranda, Gustavo / Schimke, Lena F / Moll, Guido / Cabral-Marques, Otavio

Frontiers in immunology

2023 Volume 14, Page(s) 1243516

Abstract: Dengue virus (DENV) infection manifests as a febrile illness with three distinct phases: early acute, late acute, and convalescent. Dengue can result in clinical manifestations with different degrees of severity, dengue fever, dengue hemorrhagic fever, ... ...

Abstract	Dengue virus (DENV) infection manifests as a febrile illness with three distinct phases: early acute, late acute, and convalescent. Dengue can result in clinical manifestations with different degrees of severity, dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. Interferons (IFNs) are antiviral cytokines central to the anti-DENV immune response. Notably, the distinct global signature of type I, II, and III interferon-regulated genes (the interferome) remains uncharacterized in dengue patients to date. Therefore, we performed an in-depth cross-study for the integrative analysis of transcriptome data related to DENV infection. Our systems biology analysis shows that the anti-dengue immune response is characterized by the modulation of numerous interferon-regulated genes (IRGs) enriching, for instance, cytokine-mediated signaling (e.g., type I and II IFNs) and chemotaxis, which is then followed by a transcriptional wave of genes associated with cell cycle, also regulated by the IFN cascade. The adjunct analysis of disease stratification potential, followed by a transcriptional meta-analysis of the interferome, indicated genes such as
MeSH term(s)	Humans ; Systems Biology ; Interferons/genetics ; Cytokines/genetics ; Antiviral Agents ; Cell Cycle
Chemical Substances	Interferons (9008-11-1) ; Cytokines ; Antiviral Agents
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Meta-Analysis ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1243516
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: COVID-19 Vaccination and Serological Profile of a Brazilian University Population.

Barreto, Marina Dos Santos / Silva, Beatriz Soares da / Santos, Ronaldy Santana / Silva, Deise Maria Rego Rodrigues / Silva, Eloia Emanuelly Dias / Moura, Pedro Henrique Macedo / Souza, Jessiane Bispo de / Santana, Lucas Alves da Mota / Fonseca, Dennyson Leandro M / Filgueiras, Igor Salerno / Guimarães, Adriana Gibara / Cabral-Marques, Otavio / Schimke, Lena F / Borges, Lysandro Pinto

Life (Basel, Switzerland)

2023 Volume 13, Issue 9

Abstract: Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff.: Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the ... ...

Abstract	Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants. Results: We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels. Conclusion: This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations.
Language	English
Publishing date	2023-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13091925
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Loss of balance in normal GPCR-mediated cell trafficking.

Cabral-Marques, Otavio / Carvalho-Marques, Alexandre Henrique / Schimke, Lena F / Heidecke, Harald / Riemekasten, Gabriela

Frontiers in bioscience (Landmark edition)

2019 Volume 24, Issue 1, Page(s) 18–34

Abstract: G protein-coupled receptors (GPCRs) form a most diverse family of integral membrane proteins that mediate homeostatic and pathological processes, most notably by orchestrating cell distribution throughout the body, their infiltration, and time of ... ...

Abstract	G protein-coupled receptors (GPCRs) form a most diverse family of integral membrane proteins that mediate homeostatic and pathological processes, most notably by orchestrating cell distribution throughout the body, their infiltration, and time of presence in inflamed tissues. Here we discuss loss-of-orientation-effects in GPCR-mediated cell trafficking and migration and their impact on the phenotype of autoimmune diseases. In this context, we provide a systemic and integrative view of the contribution of abnormal GPCR expression as well as the levels of natural ligands and functional autoantibodies to the phenotype of autoimmune diseases. Currently, several studies propose that functional autoantibodies (including those targeting GPCRs) constitute an exclusively pathogenic or pathognomonic phenomenon. Here we reinforce the need of revising this point of view, and suggest that functional autoantibodies primary play a role in normal human physiology, while dysregulation of their functions causes autoimmune disease. Because patients with autoimmune diseases still suffer from severe morbidity and mortality rates, we consider expanding our knowledge on (patho)physiological roles of GPCR as a prerequisite for the development of novel specific therapeutic modalities.
MeSH term(s)	Animals ; Autoantibodies/immunology ; Autoantibodies/metabolism ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; Cell Movement/immunology ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Models, Immunological ; Receptors, Chemokine/immunology ; Receptors, Chemokine/metabolism ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Autoantibodies ; Cytokines ; Inflammation Mediators ; Receptors, Chemokine ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2019-01-01
Publishing country	Singapore
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2704569-9
ISSN	2768-6698 ; 1093-9946
ISSN (online)	2768-6698
ISSN	1093-9946
DOI	10.2741/4707
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Vaccines against Emerging and Neglected Infectious Diseases: An Overview.

Vuitika, Larissa / Prates-Syed, Wasim A / Silva, Jaqueline Dinis Queiros / Crema, Karin P / Côrtes, Nelson / Lira, Aline / Lima, Julia Beatriz Menuci / Camara, Niels Olsen Saraiva / Schimke, Lena F / Cabral-Marques, Otavio / Sadraeian, Mohammad / Chaves, Lorena C S / Cabral-Miranda, Gustavo

Vaccines

2022 Volume 10, Issue 9

Abstract: Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in tropical and subtropical regions, and closely associated with poverty and marginalized populations. Infectious diseases affect over 1.6 billion people annually, and ... ...

Abstract	Neglected Tropical Diseases (NTDs) are a group of diseases that are highly prevalent in tropical and subtropical regions, and closely associated with poverty and marginalized populations. Infectious diseases affect over 1.6 billion people annually, and vaccines are the best prophylactic tool against them. Along with NTDs, emerging and reemerging infectious diseases also threaten global public health, as they can unpredictably result in pandemics. The recent advances in vaccinology allowed the development and licensing of new vaccine platforms that can target and prevent these diseases. In this work, we discuss the advances in vaccinology and some of the difficulties found in the vaccine development pipeline for selected NTDs and emerging and reemerging infectious diseases, including HIV, Dengue, Ebola, Chagas disease, malaria, leishmaniasis, zika, and chikungunya.
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines10091385
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Immunological signatures unveiled by integrative systems vaccinology characterization of dengue vaccination trials and natural infection.

Plaça, Desirée Rodrigues / Fonseca, Dennyson Leandro M / Marques, Alexandre H C / Zaki Pour, Shahab / Usuda, Júlia Nakanishi / Baiocchi, Gabriela Crispim / Prado, Caroline Aliane de Souza / Salgado, Ranieri Coelho / Filgueiras, Igor Salerno / Freire, Paula Paccielli / Rocha, Vanderson / Camara, Niels Olsen Saraiva / Catar, Rusan / Moll, Guido / Jurisica, Igor / Calich, Vera Lúcia Garcia / Giil, Lasse M / Rivino, Laura / Ochs, Hans D /

Cabral-Miranda, Gustavo / Schimke, Lena F / Cabral-Marques, Otavio

Frontiers in immunology

2024 Volume 15, Page(s) 1282754

Abstract: Introduction: Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an ... ...

Abstract	Introduction: Dengue virus infection is a global health problem lacking specific therapy, requiring an improved understanding of DENV immunity and vaccine responses. Considering the recent emerging of new dengue vaccines, here we performed an integrative systems vaccinology characterization of molecular signatures triggered by the natural DENV infection (NDI) and attenuated dengue virus infection models (DVTs). Methods and results: We analyzed 955 samples of transcriptomic datasets of patients with NDI and attenuated dengue virus infection trials (DVT1, DVT2, and DVT3) using a systems vaccinology approach. Differential expression analysis identified 237 common differentially expressed genes (DEGs) between DVTs and NDI. Among them, 28 and 60 DEGs were up or downregulated by dengue vaccination during DVT2 and DVT3, respectively, with 20 DEGs intersecting across all three DVTs. Enriched biological processes of these genes included type I/II interferon signaling, cytokine regulation, apoptosis, and T-cell differentiation. Principal component analysis based on 20 common DEGs (overlapping between DVTs and our NDI validation dataset) distinguished dengue patients by disease severity, particularly in the late acute phase. Machine learning analysis ranked the ten most critical predictors of disease severity in NDI, crucial for the anti-viral immune response. Conclusion: This work provides insights into the NDI and vaccine-induced overlapping immune response and suggests molecular markers (e.g.,
MeSH term(s)	Humans ; Vaccinology ; Vaccines ; Virus Diseases ; Vaccination ; Dengue/prevention & control
Chemical Substances	Vaccines
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1282754
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Neuroimmunology of rabies: New insights into an ancient disease.

Bastos, Victor / Pacheco, Vinicius / Rodrigues, Érika D L / Moraes, Cássia N S / Nóbile, Adriel L / Fonseca, Dennyson Leandro M / Souza, Kamilla B S / do Vale, Fernando Y N / Filgueiras, Igor S / Schimke, Lena F / Giil, Lasse M / Moll, Guido / Cabral-Miranda, Gustavo / Ochs, Hans D / Vasconcelos, Pedro F da Costa / de Melo, Guilherme D / Bourhy, Hervé / Casseb, Livia M N / Cabral-Marques, Otavio

Journal of medical virology

2023 Volume 95, Issue 10, Page(s) e29042

Abstract: Rabies is an ancient neuroinvasive viral (genus Lyssavirus, family Rhabdoviridae) disease affecting approximately 59,000 people worldwide. The central nervous system (CNS) is targeted, and rabies has a case fatality rate of almost 100% in humans and ... ...

Abstract	Rabies is an ancient neuroinvasive viral (genus Lyssavirus, family Rhabdoviridae) disease affecting approximately 59,000 people worldwide. The central nervous system (CNS) is targeted, and rabies has a case fatality rate of almost 100% in humans and animals. Rabies is entirely preventable through proper vaccination, and thus, the highest incidence is typically observed in developing countries, mainly in Africa and Asia. However, there are still cases in European countries and the United States. Recently, demographic, increasing income levels, and the coronavirus disease 2019 (COVID-19) pandemic have caused a massive raising in the animal population, enhancing the need for preventive measures (e.g., vaccination, surveillance, and animal control programs), postexposure prophylaxis, and a better understanding of rabies pathophysiology to identify therapeutic targets, since there is no effective treatment after the onset of clinical manifestations. Here, we review the neuroimmune biology and mechanisms of rabies. Its pathogenesis involves a complex and poorly understood modulation of immune and brain functions associated with metabolic, synaptic, and neuronal impairments, resulting in fatal outcomes without significant histopathological lesions in the CNS. In this context, the neuroimmunological and neurochemical aspects of excitatory/inhibitory signaling (e.g., GABA/glutamate crosstalk) are likely related to the clinical manifestations of rabies infection. Uncovering new links between immunopathological mechanisms and neurochemical imbalance will be essential to identify novel potential therapeutic targets to reduce rabies morbidity and mortality.
MeSH term(s)	Humans ; Animals ; United States ; Rabies/epidemiology ; Vaccination ; Europe ; Treatment Outcome ; Post-Exposure Prophylaxis/methods ; Rabies virus
Language	English
Publishing date	2023-10-26
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.29042
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: COVID-19 Vaccination and Serological Profile of a Brazilian University Population

Marina dos Santos Barreto / Beatriz Soares da Silva / Ronaldy Santana Santos / Deise Maria Rego Rodrigues Silva / Eloia Emanuelly Dias Silva / Pedro Henrique Macedo Moura / Jessiane Bispo de Souza / Lucas Alves da Mota Santana / Dennyson Leandro M. Fonseca / Igor Salerno Filgueiras / Adriana Gibara Guimarães / Otavio Cabral-Marques / Lena F. Schimke / Lysandro Pinto Borges

Life, Vol 13, Iss 1925, p

2023 Volume 1925

Abstract: Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to ...

Abstract	Background: COVID-19 led to the suspension academic activities worldwide, affecting millions of students and staff. Methods: In this study, we evaluated the presence of IgM and IgG anti-SARS-CoV-2 antibodies in an academic population during the return to classes after a one-year suspension. The study took place over five months at a Brazilian university and included 942 participants. Results: We found that most participants had reactive IgG and non-reactive IgM. All received at least one dose, and 940 received two or more doses, of different COVID-19 vaccines. We obtained a higher average of memory antibodies (IgG) in participants who received the CoronaVac/ChAdOx1 combination. IgG was consistently distributed for each vaccine group, but individuals who completed the vaccination schedule had higher levels. There were no differences between antibodies and gender, presence of symptoms, and previous COVID-19 infection, but older participants (>53 years) and contacts of infected individuals had higher IgM levels. Conclusion: This study makes significant contributions to the assessment of antibodies in the academic environment, allowing us to infer that most participants had memory immunity and low indications of recent infection when returning to face-to-face classes, as well as demonstrating the need to monitor immunity and update vaccinations.
Keywords	COVID-19 ; antibodies ; universities ; academic population ; vaccines ; Brazil ; Science ; Q
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach.

Fonseca, Dennyson Leandro M / Filgueiras, Igor Salerno / Marques, Alexandre H C / Vojdani, Elroy / Halpert, Gilad / Ostrinski, Yuri / Baiocchi, Gabriela Crispim / Plaça, Desirée Rodrigues / Freire, Paula P / Pour, Shahab Zaki / Moll, Guido / Catar, Rusan / Lavi, Yael Bublil / Silverberg, Jonathan I / Zimmerman, Jason / Cabral-Miranda, Gustavo / Carvalho, Robson F / Khan, Taj Ali / Heidecke, Harald /

Dalmolin, Rodrigo J S / Luchessi, Andre Ducati / Ochs, Hans D / Schimke, Lena F / Amital, Howard / Riemekasten, Gabriela / Zyskind, Israel / Rosenberg, Avi Z / Vojdani, Aristo / Shoenfeld, Yehuda / Cabral-Marques, Otavio

npj aging

2023 Volume 9, Issue 1, Page(s) 21

Abstract: Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, and chronic respiratory disease). However, despite the ... ...

Abstract	Age is a significant risk factor for the coronavirus disease 2019 (COVID-19) severity due to immunosenescence and certain age-dependent medical conditions (e.g., obesity, cardiovascular disorder, and chronic respiratory disease). However, despite the well-known influence of age on autoantibody biology in health and disease, its impact on the risk of developing severe COVID-19 remains poorly explored. Here, we performed a cross-sectional study of autoantibodies directed against 58 targets associated with autoimmune diseases in 159 individuals with different COVID-19 severity (71 mild, 61 moderate, and 27 with severe symptoms) and 73 healthy controls. We found that the natural production of autoantibodies increases with age and is exacerbated by SARS-CoV-2 infection, mostly in severe COVID-19 patients. Multiple linear regression analysis showed that severe COVID-19 patients have a significant age-associated increase of autoantibody levels against 16 targets (e.g., amyloid β peptide, β catenin, cardiolipin, claudin, enteric nerve, fibulin, insulin receptor a, and platelet glycoprotein). Principal component analysis with spectrum decomposition and hierarchical clustering analysis based on these autoantibodies indicated an age-dependent stratification of severe COVID-19 patients. Random forest analysis ranked autoantibodies targeting cardiolipin, claudin, and platelet glycoprotein as the three most crucial autoantibodies for the stratification of severe COVID-19 patients ≥50 years of age. Follow-up analysis using binomial logistic regression found that anti-cardiolipin and anti-platelet glycoprotein autoantibodies significantly increased the likelihood of developing a severe COVID-19 phenotype with aging. These findings provide key insights to explain why aging increases the chance of developing more severe COVID-19 phenotypes.
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article
ISSN	2731-6068
ISSN (online)	2731-6068
DOI	10.1038/s41514-023-00118-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Integrative systems immunology uncovers molecular networks of the cell cycle that stratify COVID-19 severity.

Prado, Caroline Aliane de Souza / Fonseca, Dennyson Leandro M / Singh, Youvika / Filgueiras, Igor Salerno / Baiocchi, Gabriela Crispim / Plaça, Desirée Rodrigues / Marques, Alexandre H C / Dantas-Komatsu, Raquel Costa Silva / Usuda, Júlia N / Freire, Paula Paccielli / Salgado, Ranieri Coelho / Napoleao, Sarah Maria da Silva / Ramos, Rodrigo Nalio / Rocha, Vanderson / Zhou, Guangyan / Catar, Rusan / Moll, Guido / Camara, Niels Olsen Saraiva / de Miranda, Gustavo Cabral /

Calich, Vera Lúcia Garcia / Giil, Lasse M / Mishra, Neha / Tran, Florian / Luchessi, Andre Ducati / Nakaya, Helder I / Ochs, Hans D / Jurisica, Igor / Schimke, Lena F / Cabral-Marques, Otavio

Journal of medical virology

2023 Volume 95, Issue 2, Page(s) e28450

Abstract: Several perturbations in the number of peripheral blood leukocytes, such as neutrophilia and lymphopenia associated with Coronavirus disease 2019 (COVID-19) severity, point to systemic molecular cell cycle alterations during severe acute respiratory ... ...

Abstract	Several perturbations in the number of peripheral blood leukocytes, such as neutrophilia and lymphopenia associated with Coronavirus disease 2019 (COVID-19) severity, point to systemic molecular cell cycle alterations during severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, the landscape of cell cycle alterations in COVID-19 remains primarily unexplored. Here, we performed an integrative systems immunology analysis of publicly available proteome and transcriptome data to characterize global changes in the cell cycle signature of COVID-19 patients. We found significantly enriched cell cycle-associated gene co-expression modules and an interconnected network of cell cycle-associated differentially expressed proteins (DEPs) and genes (DEGs) by integrating the molecular data of 1469 individuals (981 SARS-CoV-2 infected patients and 488 controls [either healthy controls or individuals with other respiratory illnesses]). Among these DEPs and DEGs are several cyclins, cell division cycles, cyclin-dependent kinases, and mini-chromosome maintenance proteins. COVID-19 patients partially shared the expression pattern of some cell cycle-associated genes with other respiratory illnesses but exhibited some specific differential features. Notably, the cell cycle signature predominated in the patients' blood leukocytes (B, T, and natural killer cells) and was associated with COVID-19 severity and disease trajectories. These results provide a unique global understanding of distinct alterations in cell cycle-associated molecules in COVID-19 patients, suggesting new putative pathways for therapeutic intervention.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Transcriptome ; Killer Cells, Natural ; Cell Cycle
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28450
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cross-sectional analysis reveals autoantibody signatures associated with COVID-19 severity.

Baiocchi, Gabriela C / Vojdani, Aristo / Rosenberg, Avi Z / Vojdani, Elroy / Halpert, Gilad / Ostrinski, Yuri / Zyskind, Israel / Filgueiras, Igor S / Schimke, Lena F / Marques, Alexandre H C / Giil, Lasse M / Lavi, Yael B / Silverberg, Jonathan I / Zimmerman, Jason / Hill, Dana A / Thornton, Amanda / Kim, Myungjin / De Vito, Roberta / Fonseca, Dennyson L M /

Plaça, Desireé R / Freire, Paula P / Camara, Niels O S / Calich, Vera L G / Scheibenbogen, Carmen / Heidecke, Harald / Lattin, Miriam T / Ochs, Hans D / Riemekasten, Gabriela / Amital, Howard / Shoenfeld, Yehuda / Cabral-Marques, Otavio

Journal of medical virology

2023 Volume 95, Issue 2, Page(s) e28538

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID-19 patients may ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with increased levels of autoantibodies targeting immunological proteins such as cytokines and chemokines. Reports further indicate that COVID-19 patients may develop a broad spectrum of autoimmune diseases due to reasons not fully understood. Even so, the landscape of autoantibodies induced by SARS-CoV-2 infection remains uncharted territory. To gain more insight, we carried out a comprehensive assessment of autoantibodies known to be linked to diverse autoimmune diseases observed in COVID-19 patients in a cohort of 231 individuals, of which 161 were COVID-19 patients (72 with mild, 61 moderate, and 28 with severe disease) and 70 were healthy controls. Dysregulated IgG and IgA autoantibody signatures, characterized mainly by elevated concentrations, occurred predominantly in patients with moderate or severe COVID-19 infection. Autoantibody levels often accompanied anti-SARS-CoV-2 antibody concentrations while stratifying COVID-19 severity as indicated by random forest and principal component analyses. Furthermore, while young versus elderly COVID-19 patients showed only slight differences in autoantibody levels, elderly patients with severe disease presented higher IgG autoantibody concentrations than young individuals with severe COVID-19. This work maps the intersection of COVID-19 and autoimmunity by demonstrating the dysregulation of multiple autoantibodies triggered during SARS-CoV-2 infection. Thus, this cross-sectional study suggests that SARS-CoV-2 infection induces autoantibody signatures associated with COVID-19 severity and several autoantibodies that can be used as biomarkers of COVID-19 severity, indicating autoantibodies as potential therapeutical targets for these patients.
MeSH term(s)	Aged ; Humans ; Autoantibodies ; COVID-19 ; Cross-Sectional Studies ; SARS-CoV-2 ; Autoimmune Diseases ; Immunoglobulin G
Chemical Substances	Autoantibodies ; Immunoglobulin G
Language	English
Publishing date	2023-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.28538
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1320: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito