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  1. Book: Festschrift für Robert Wildhaber

    Escher, Walter / Wildhaber, Robert

    zum 70. Geburtstag am 3. Aug. 1972

    1973  

    Author's details hrsg. von Walter Escher
    Language German ; English ; French ; Italian
    Size XI, 820 S., Ill., Kt, 24 cm
    Publisher Krebs ; Habelt in Komm.
    Publishing place Basel ; Bonn
    Document type Book
    Note Erscheint gleichzeitig als: Schweizerisches Archiv für Volkskunde, Jg.1968/69 (1972/73), Hefte 1-6 ; Literaturangaben
    ISBN 3774909377 ; 9783774909373
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  2. Article ; Online: D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?

    Breakey, Neal / Escher, Robert

    Swiss medical weekly

    2020  Volume 150, Page(s) w20293

    Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global phenomenon has presented clinicians around the world with multiple challenges. Thromboembolic events are recognised complications of viral infection, but the ... ...

    Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global phenomenon has presented clinicians around the world with multiple challenges. Thromboembolic events are recognised complications of viral infection, but the diagnosis of an acute pulmonary thrombotic complication in the context of coronavirus disease 2019 (COVID-19) can be challenging because of the similarities of presentation, logistical considerations of diagnosis in a patient isolated for infection control reasons and the effects of cognitive errors in diagnostic reasoning. We present the case of a patient who was diagnosed with a pulmonary thrombotic complication during inpatient care for COVID-19. The haemostasis parameters we observed, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19. We suggest that it is possible to hypothesise a spectrum of secondarily acquired, prothrombotic coagulopathy mediated by the endothelial interaction with SARS-CoV-2 as a cause of mortality in a subset of patients with a complicated clinical course of COVID-19. We support the recommendation of thromboembolic chemoprophylaxis for inpatients with COVID-19 as a very minimum in the absence of strict contraindications, while recognising that pulmonary thrombotic complications can occur under standard thromboprophylaxis. We suggest that higher, possibly therapeutic levels of anticoagulation might be mandatory for a further subset of patients with COVID-19 where a discrepant evolution of C-reactive protein and D-dimer is observed. Therapeutic levels of anticoagulation are obligatory where new evidence of a macrovascular thrombotic complication has been documented. More research to delineate the macro- and microvascular thrombotic complications of COVID-19, and the therapeutic implications for this patient group is required.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/physiopathology ; Fibrin Fibrinogen Degradation Products/metabolism ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/physiopathology ; Pulmonary Embolism/mortality ; Pulmonary Embolism/physiopathology ; Pulmonary Embolism/therapy ; Pulmonary Embolism/virology ; SARS-CoV-2
    Chemical Substances Fibrin Fibrinogen Degradation Products ; fibrin fragment D
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country Switzerland
    Document type Case Reports ; Journal Article
    ZDB-ID 2036179-8
    ISSN 1424-3997 ; 1424-7860
    ISSN (online) 1424-3997
    ISSN 1424-7860
    DOI 10.4414/smw.2020.20293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.152: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Fever of Unknown Origin, a Vascular Event, and Immunosuppression in Tick-Endemic Areas: Think About Neoehrlichiosis.

    Margini, Cristina / Maldonado, Rafaela / Keller, Peter / Banz, Yara / Escher, Robert / Waldegg, Gabriel

    Cureus

    2023  Volume 15, Issue 6, Page(s) e40617

    Abstract: Three patients were referred to our hospital because of fever of unknown origin (FUO) and thrombosis or thrombophlebitis. All of them had been under immunosuppression (IS) with rituximab. Intensive diagnostics for FUO and blood cultures remained negative. ...

    Abstract Three patients were referred to our hospital because of fever of unknown origin (FUO) and thrombosis or thrombophlebitis. All of them had been under immunosuppression (IS) with rituximab. Intensive diagnostics for FUO and blood cultures remained negative. Finally, the association of fever, immunosuppression, and a vascular event led to the suspicion of
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.40617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: D-dimer and mortality in COVID-19

    Breakey, Neal / Escher, Robert

    Swiss Medical Weekly ; ISSN 1424-3997

    a self-fulfilling prophecy or a pathophysiological clue?

    2020  

    Keywords General Medicine ; covid19
    Language English
    Publisher EMH Swiss Medical Publishers, Ltd.
    Publishing country ch
    Document type Article ; Online
    DOI 10.4414/smw.2020.20293
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: Severe COVID-19 infection associated with endothelial activation.

    Escher, Robert / Breakey, Neal / Lämmle, Bernhard

    Thrombosis research

    2020  Volume 190, Page(s) 62

    MeSH term(s) Aged ; Antibodies, Antiphospholipid/blood ; Anticoagulants/therapeutic use ; Betacoronavirus/isolation & purification ; Blood Coagulation/drug effects ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Coronavirus Infections/therapy ; Dalteparin/therapeutic use ; Endothelium/drug effects ; Endothelium/pathology ; Factor VIII/analysis ; Fibrin Fibrinogen Degradation Products/analysis ; Heparin/therapeutic use ; Humans ; Immunoglobulin M/blood ; Intensive Care Units ; Male ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; von Willebrand Factor/analysis
    Chemical Substances Antibodies, Antiphospholipid ; Anticoagulants ; Fibrin Fibrinogen Degradation Products ; Immunoglobulin M ; fibrin fragment D ; von Willebrand Factor ; Factor VIII (9001-27-8) ; Heparin (9005-49-6) ; Dalteparin (S79O08V79F)
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: D-dimer and mortality in COVID-19: a self-fulfilling prophecy or a pathophysiological clue?

    Breakey, Neal / Escher, Robert

    Swiss Med Wkly

    Abstract: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global phenomenon has presented clinicians around the world with multiple challenges. Thromboembolic events are recognised complications of viral infection, but the ... ...

    Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a global phenomenon has presented clinicians around the world with multiple challenges. Thromboembolic events are recognised complications of viral infection, but the diagnosis of an acute pulmonary thrombotic complication in the context of coronavirus disease 2019 (COVID-19) can be challenging because of the similarities of presentation, logistical considerations of diagnosis in a patient isolated for infection control reasons and the effects of cognitive errors in diagnostic reasoning. We present the case of a patient who was diagnosed with a pulmonary thrombotic complication during inpatient care for COVID-19. The haemostasis parameters we observed, including increased levels of von Willebrand factor and factor VIII, point towards a relevant involvement of endothelial cells in patients with severe COVID-19. We suggest that it is possible to hypothesise a spectrum of secondarily acquired, prothrombotic coagulopathy mediated by the endothelial interaction with SARS-CoV-2 as a cause of mortality in a subset of patients with a complicated clinical course of COVID-19. We support the recommendation of thromboembolic chemoprophylaxis for inpatients with COVID-19 as a very minimum in the absence of strict contraindications, while recognising that pulmonary thrombotic complications can occur under standard thromboprophylaxis. We suggest that higher, possibly therapeutic levels of anticoagulation might be mandatory for a further subset of patients with COVID-19 where a discrepant evolution of C-reactive protein and D-dimer is observed. Therapeutic levels of anticoagulation are obligatory where new evidence of a macrovascular thrombotic complication has been documented. More research to delineate the macro- and microvascular thrombotic complications of COVID-19, and the therapeutic implications for this patient group is required.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #381831
    Database COVID19

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  7. Article: Septic arthritis of the knee due to

    Koester, Tobias / Kusano, Taro / Eijer, Henk / Escher, Robert / Waldegg, Gabriel

    Journal of bone and joint infection

    2020  Volume 6, Issue 3, Page(s) 51–55

    Abstract: We report on a patient with septic arthritis of the knee ... ...

    Abstract We report on a patient with septic arthritis of the knee with
    Language English
    Publishing date 2020-12-15
    Publishing country Germany
    Document type Case Reports
    ISSN 2206-3552
    ISSN 2206-3552
    DOI 10.5194/jbji-6-51-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Reply to: Steinbok P (2019) Letter to the Editor Re: Escher PJ, Tu A, Kearney S, Wheelwright M, Petronio J, Kebriaei M, Chinnadurai S, Tibesar RJ (2019) Minimizing transfusion in sagittal craniosynostosis surgery: the Children's Hospital of Minnesota Protocol. Childs Nerv Syst. 2019 Aug;35(8):1357-1362.

    Escher, Paul J / Tu, Albert / Tibesar, Robert J

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2019  Volume 36, Issue 1, Page(s) 5

    MeSH term(s) Blood Transfusion ; Child ; Craniosynostoses ; Facial Bones ; Hospitals, Pediatric ; Humans ; Minnesota
    Language English
    Publishing date 2019-11-26
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0302-2803 ; 0256-7040
    ISSN (online) 1433-0350
    ISSN 0302-2803 ; 0256-7040
    DOI 10.1007/s00381-019-04424-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2036: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Thrombophlebitis hiding under a KILT - case report on 40 years long-term follow-up of neonatal renal vein thrombosis.

    Lauener, Stefan / Bütikofer, Anne / Eigenheer, Sandra / Escher, Robert

    BMC pediatrics

    2019  Volume 19, Issue 1, Page(s) 183

    Abstract: Background: Neonatal renal vein thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. ...

    Abstract Background: Neonatal renal vein thrombosis is a recognised cause of renal and inferior caval vein atresia (IVCA). However, the long-term impact of the condition is underrecognized with a high burden of morbidity for the patient, especially in adulthood. IVCA has been shown to be an independent risk factor for deep venous thrombosis (DVT) with a high risk of recurrence. The acronym KILT for kidney and inferior vena cava anomaly with leg thrombosis summarizes the pathological situation.
    Case presentation: We present the case of a 40-year-old patient with pain in the right lower limb resulting from acute thrombophlebitis. No risk factors could be identified. His history was remarkable with two episodes of deep venous thrombosis first of the left, then the right leg 22 years earlier; at that time also, no risk factor was identified. Because of the idiopathic character of that thrombosis, the patient remained on long-term anticoagulation with phenprocoumon. The present thrombophlebitis occurred while the INR was not therapeutic in the preceding weeks. A CT with contrast showed atresia of the inferior vena cava and of the right kidney, and presence of numerous collaterals. A thorough medical history revealed a renal vein thrombosis as a neonate. Anticoagulation was intensified, and stent placement became necessary after a further 2 years.
    Discussion and conclusions: KILT syndrome is a rare but underrecognized condition. Complications may arise in young adulthood only, and it is of prime importance to instruct parents of the pediatric patient of the possible consequences of renal vein thrombosis and to assure guidance from the treating physicians throughout adulthood. Diagnosis of IVCA is by CT with contrast or by MRI, and lifelong anticoagulation may be necessary. Since the KILT syndrome is widely underdiagnosed, we challenge the clinicians to keep it in mind when confronted with thrombophlebitis or thrombosis of the young, male and with no other identifiable risk factors for deep vein thrombosis.
    MeSH term(s) Abbreviations as Topic ; Adult ; Anticoagulants/therapeutic use ; Follow-Up Studies ; Humans ; Infant, Newborn ; Kidney/abnormalities ; Leg/blood supply ; Male ; Pain/etiology ; Phenprocoumon/therapeutic use ; Renal Veins/diagnostic imaging ; Syndrome ; Thrombophlebitis/complications ; Time Factors ; Tomography, X-Ray Computed ; Vascular Malformations/diagnostic imaging ; Vascular Malformations/etiology ; Vena Cava, Inferior/abnormalities ; Vena Cava, Inferior/diagnostic imaging ; Venous Thrombosis/complications ; Venous Thrombosis/drug therapy
    Chemical Substances Anticoagulants ; Phenprocoumon (Q08SIO485D)
    Language English
    Publishing date 2019-06-06
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-019-1567-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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