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  1. Book ; Thesis: Kinetik der S100B-Serumkonzentration bei akuter Ischämie im Versorgungsgebiet der A. cerebri media

    Förch, Christian

    Prädiktivität in Bezug auf Infarktvolumen und Gefässrekanalisation

    2003  

    Author's details vorgelegt von Christian Förch
    Language German
    Size VI, 85 S. : graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 2003
    HBZ-ID HT013942671
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 D 2444 order for loan Magazin

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  2. Article ; Online: Comment: Carotid artery stenting: Is the gut making the decision?

    Foerch, Christian

    Neurology

    2018  Volume 90, Issue 15, Page(s) 681

    MeSH term(s) Brain ; Carotid Arteries ; Methylamines ; Stents
    Chemical Substances Methylamines ; trimethyloxamine (FLD0K1SJ1A)
    Language English
    Publishing date 2018-03-14
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000005293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui II Zs.153: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 18: Show issues
    Zs.MO 374: Show issues

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  3. Book ; Online ; Thesis: Lebensqualität, kognitive Leistung und multisensorische Integrationsleistung bei NMOSD Patienten

    Soydas, Dilara [Verfasser] / Förch, Christian [Akademischer Betreuer] / Yalachkov, Yavor Vasilev [Akademischer Betreuer] / Förch, Christian [Gutachter] / Kaiser, Jochen [Gutachter]

    2023  

    Author's details Dilara Soydas ; Gutachter: Christian Förch, Jochen Kaiser ; Christian Förch, Yavor Vasilev Yalachkov
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
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  4. Article ; Online: Difficulty in identification of patients with active secondary progressive multiple sclerosis by clinical classification tools.

    Klinsing, Svenja / Yalachkov, Yavor / Foerch, Christian

    European journal of neurology

    2022  Volume 29, Issue 4, Page(s) 1100–1105

    Abstract: Background and purpose: The transition from relapsing-remitting to secondary progressive multiple sclerosis (SPMS) is not well defined. Different definitions and tools to identify SPMS have been proposed. Meanwhile, early diagnosis of "active" SPMS is ... ...

    Abstract Background and purpose: The transition from relapsing-remitting to secondary progressive multiple sclerosis (SPMS) is not well defined. Different definitions and tools to identify SPMS have been proposed. Meanwhile, early diagnosis of "active" SPMS is getting progressively more important as pharmaceutical treatment options are developed. In this study, we compared different classification methods regarding their accuracy to reliably identify "active SPMS."
    Methods: Independent from previous diagnostic classification, we descriptively analyzed the disease course (regarding relapses, progression, and magnetic resonance imaging activity) in 208 consecutive multiple sclerosis (MS) patients treated in our MS outpatient clinic in 2018. Patients were reclassified according to different SPMS criteria and tools. Diagnostic accuracy in identifying patients with "active SPMS" was determined.
    Results: Comparing the tools to each other, significant variability in the number of patients identified as having SPMS as well as in the proportion of these patients having "active SPMS" was noted. Applying both diagnostic criteria "SPMS" and "active disease" reduced the sensitivity in identifying patients with active progressive disease in all approaches.
    Conclusions: We propose lessening the emphasis on the label "SPMS" in favor of the more open term "active progressive disease" to simplify the process of identifying patients who may benefit from immune therapy.
    MeSH term(s) Delivery of Health Care ; Disease Progression ; Humans ; Multiple Sclerosis ; Multiple Sclerosis, Chronic Progressive/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/diagnostic imaging ; Multiple Sclerosis, Relapsing-Remitting/therapy ; Recurrence
    Language English
    Publishing date 2022-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.15227
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    Zs.A 4738: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 592: Show issues

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  5. Article: Proteomics-Based Approach to Identify Novel Blood Biomarker Candidates for Differentiating Intracerebral Hemorrhage From Ischemic Stroke-A Pilot Study.

    Malicek, David / Wittig, Ilka / Luger, Sebastian / Foerch, Christian

    Frontiers in neurology

    2021  Volume 12, Page(s) 713124

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.713124
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  6. Article ; Online: Prevalence, recovery and phenotype of dysphagia in patients with ischaemic cerebellar stroke.

    Schaefer, Jan Hendrik / Luft, Felix / Seiler, Alexander / Harborth, Elena / Kaffenberger, Sara / Polkowski, Christoph / Foerch, Christian / Lapa, Sriramya

    European journal of neurology

    2024  , Page(s) e16303

    Abstract: Background and purpose: Swallowing is a complex task, moderated by a sophisticated bilateral network including multiple supratentorial regions, the brainstem and the cerebellum. To date, conflicting data exist about whether focal lesions to the ... ...

    Abstract Background and purpose: Swallowing is a complex task, moderated by a sophisticated bilateral network including multiple supratentorial regions, the brainstem and the cerebellum. To date, conflicting data exist about whether focal lesions to the cerebellum are associated with dysphagia. Therefore, the aim of the study was to evaluate dysphagia prevalence, recovery and dysphagia pattern in patients with ischaemic cerebellar stroke.
    Methods: A retrospective analysis of patients consecutively admitted to an academic stroke centre with ischaemic stroke found only in the cerebellum was performed. The presence of dysphagia was the primary end-point and was assessed by a speech-language pathologist, according to defined criteria. Dysphagia pattern was evaluated by analysing the videos of the flexible endoscopic evaluation of swallowing. Brain imaging was used to identify lesion size and location associated with dysphagia.
    Results: Between January 2016 and December 2021, 102 patients (35.3% female) with a mean age of 52.8 ± 17.3 years were included. Thirteen (12.7%) patients presented with dysphagia. The most frequently observed flexible endoscopic evaluation of swallowing phenotype was premature spillage (n = 7; 58.3%), whilst significant residues or aspiration did not occur. One patient died (7.7%); the other patients showed improvement of dysphagia and one patient (7.7%) was discharged with dietary restrictions.
    Conclusions: Although the involvement of the cerebellum in deglutition has become increasingly evident, isolated lesions to the cerebellum are less likely to cause clinically relevant and persisting dysphagia compared to other brain regions. The observed dysphagia pattern shows a lack of coordination and control, resulting in premature spillage or fragmented bolus transfer in some patients.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4738: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 592: Show issues

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  7. Article: Cerclage Wiring Improves Biomechanical Stability in Distal Tibia Spiral Fractures Treated by Intramedullary Nailing.

    Förch, Stefan / Sandriesser, Sabrina / von Rüden, Christian / Mayr, Edgar / Augat, Peter

    Journal of clinical medicine

    2023  Volume 12, Issue 5

    Abstract: Background: Partial weight-bearing after operatively treated fractures has been the standard of care over the past decades. Recent studies report on better rehabilitation and faster return to daily life in case of immediate weight-bearing as tolerated. ... ...

    Abstract Background: Partial weight-bearing after operatively treated fractures has been the standard of care over the past decades. Recent studies report on better rehabilitation and faster return to daily life in case of immediate weight-bearing as tolerated. To allow early weight-bearing, osteosynthesis needs to provide sufficient mechanical stability. The purpose of this study was to investigate the stabilizing benefits of additive cerclage wiring in combination with intramedullary nailing of distal tibia fractures.
    Methods: In 14 synthetic tibiae, a reproducible distal spiral fracture was treated by intramedullary nailing. In half of the samples, the fracture was further stabilized by additional cerclage wiring. Under clinically relevant partial and full weight-bearing loads the samples were biomechanically tested and axial construct stiffness as well as interfragmentary movements were assessed. Subsequently, a 5 mm fracture gap was created to simulate insufficient reduction, and tests were repeated.
    Results: Intramedullary nails offer already high axial stability. Thus, axial construct stiffness cannot be significantly enhanced by an additive cerclage (2858 ± 958 N/mm NailOnly vs. 3727 ± 793 N/mm Nail + Cable;
    Conclusions: In well-reduced spiral fractures of the distal tibia, the construct stability of intramedullary nailing can be further increased by additional cerclage wiring. From a biomechanical point of view, augmentation of the primary implant reduced shear movement sufficiently to allow immediate weight-bearing as tolerated. Especially, elderly patients would benefit from early post-operative mobilization, which allows for accelerated rehabilitation and a faster return to daily activities.
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12051770
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  8. Article ; Online: Lateralization bias for autoimmune optic neuritis.

    Yalachkov, Yavor / Klinsing, Svenja / Foerch, Christian

    Multiple sclerosis and related disorders

    2021  Volume 52, Page(s) 102980

    Abstract: The asymmetrical structure of the human brain is reflected not only by innate interhemispheric differences but also by lateralization in neurological disease. We tested if unilateral autoimmune optic neuritis (aON) manifests more frequently on the left ... ...

    Abstract The asymmetrical structure of the human brain is reflected not only by innate interhemispheric differences but also by lateralization in neurological disease. We tested if unilateral autoimmune optic neuritis (aON) manifests more frequently on the left than the right eye in clinical and neuroimaging terms and whether Google searches for aON symptoms reflect this bias, too. We employed a retrospective analysis of a patient cohort from 2009 to 2019 with 552 unilateral aONs and 374 corresponding MRI imaging data sets. Searchmetrics Suite keywords tool was applied for the analysis of Google searches on aON-symptoms in Germany, the US and the UK for the last 12 months. Left eye aON manifestations were more frequent than right aON manifestations (55.3% vs. 44.7%, p = 0.015) and 1.9 times more likely to be associated with a pathological MRI finding in the affected optic nerve (p = 0.013). Keywords describing aON-typical but not other ocular symptoms were more frequently associated with Google searches for the left in comparison to the right eye (p < 0.001). Autoimmune optic neuritis more frequently affects the left than the right eye and people search on the Internet more often for left-sided aON symptoms. Although a reporting bias due to an increased perception of left eye symptoms is one possible explanation, MRI evidence of more frequent optic nerve affection for the left in comparison to the right side suggests a leftward lateralization bias similar to the one previously shown for cerebral neuroinflammatory lesions.
    MeSH term(s) Germany ; Humans ; Magnetic Resonance Imaging ; Neuromyelitis Optica ; Optic Nerve ; Optic Neuritis ; Retrospective Studies
    Language English
    Publishing date 2021-04-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2645330-7
    ISSN 2211-0356 ; 2211-0348
    ISSN (online) 2211-0356
    ISSN 2211-0348
    DOI 10.1016/j.msard.2021.102980
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  9. Article ; Online: Decoding the iceman's death?

    Foerch, Christian

    Cellular and molecular life sciences : CMLS

    2013  Volume 71, Issue 3, Page(s) 539–540

    MeSH term(s) Brain/metabolism ; Cause of Death ; Glial Fibrillary Acidic Protein/blood ; Glial Fibrillary Acidic Protein/metabolism ; Hematoma/metabolism ; Humans ; Mummies/pathology ; Nerve Tissue Proteins/blood ; Nerve Tissue Proteins/metabolism
    Chemical Substances Glial Fibrillary Acidic Protein ; Nerve Tissue Proteins
    Language English
    Publishing date 2013-12-11
    Publishing country Switzerland
    Document type Letter
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-013-1536-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Book ; Online ; Thesis: Multisensorische Integration und visuelle Suchaufgaben als Screening-Verfahren für kognitive Beeinträchtigungen bei Patienten mit Multipler Sklerose

    Bergmann, Heinrich Johannes [Verfasser] / Förch, Christian [Akademischer Betreuer] / Yalachkov, Yavor [Akademischer Betreuer] / Förch, Christian [Gutachter] / Kaiser, Jochen [Gutachter]

    ein Pilotprojekt

    2021  

    Author's details Heinrich Johannes Bergmann ; Gutachter: Christian Förch, Jochen Kaiser ; Christian Förch, Yavor Yalachkov
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Johann Christian Senckenberg
    Publishing place Frankfurt am Main
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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