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Article ; Online: An Open-Label Study to Assess Monthly Risperidone Injections (180 mg) Following Switch from Daily Oral Risperidone (6 mg) in Stable Schizophrenic Patients.

Walling, David P / Shinde, Sunita N / Pogoda, Janice M / Kharidia, Jahnavi / Laffont, Celine M

2024 Volume 44, Issue 4, Page(s) 251–260

Abstract: Background and objective: Long-acting injectable antipsychotics have shown benefits over oral medications with reduced hospitalization rates and improved health-related quality of life. RBP-7000 (PERSERIS: Methods: Following stabilization on 6 mg/day ...

Abstract	Background and objective: Long-acting injectable antipsychotics have shown benefits over oral medications with reduced hospitalization rates and improved health-related quality of life. RBP-7000 (PERSERIS Methods: Following stabilization on 6 mg/day (3 mg twice daily) oral risperidone, clinically stable schizophrenic participants received 3 monthly doses of 180 mg RBP-7000 in the abdomen followed by a fourth monthly dose of 180 mg RBP-7000 in the upper arm (each dose administered as two 90-mg injections). The primary endpoint was the steady-state average plasma concentration (C Results: In all, 23 participants received at least one dose of RBP-7000, 16 received all four doses, and 15 completed the study. Monthly doses of 180 mg RBP-7000 provided similar C Conclusions: The results support the use of 180 mg RBP-7000 in schizophrenic patients stable on 6 mg/day oral risperidone and a second injection site in the upper arm. Trial registration: ClinicalTrials.gov identifier: NCT03978832.
MeSH term(s)	Humans ; Antipsychotic Agents ; Delayed-Action Preparations ; Injections, Subcutaneous ; Quality of Life ; Risperidone ; Schizophrenia/drug therapy ; Treatment Outcome
Chemical Substances	Antipsychotic Agents ; Delayed-Action Preparations ; Risperidone (L6UH7ZF8HC)
Language	English
Publishing date	2024-02-22
Publishing country	New Zealand
Document type	Clinical Trial ; Journal Article
ZDB-ID	1220136-4
ISSN	1179-1918 ; 0114-2402 ; 1173-2563
ISSN (online)	1179-1918
ISSN	0114-2402 ; 1173-2563
DOI	10.1007/s40261-024-01347-1
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Article: Association between Caffeine Consumption and Depression in NHANES 2009-2010.

Pogoda, Janice M / Patricio, Galilea / McEligot, Archana J

Californian journal of health promotion

2019 Volume 16, Issue 1, Page(s) 16–23

Abstract: Background and purpose: Caffeine is ubiquitous in foods, supplements, and medications and has been hypothesized to be associated with several health-related outcomes, including mental health disorders such as anxiety. We explored a possible relationship ...

Abstract	Background and purpose: Caffeine is ubiquitous in foods, supplements, and medications and has been hypothesized to be associated with several health-related outcomes, including mental health disorders such as anxiety. We explored a possible relationship between caffeine consumption and depression using data from the National Health and Nutrition Examination Survey (NHANES). Methods: Data from 1,342 adult NHANES participants were included. Statistical software for complex survey sample designs was used to perform two multivariable logistic regressions with a binary indicator of depression as the dependent variable: one using dietary caffeine consumption and one using the caffeine metabolite AAMU as the independent variable. Both analyses were adjusted for gender, race/ethnicity, smoking status, and use of anti-depressants. Results: We observed a descriptive, albeit non-significant ( Conclusion: Our finding of a possible association between caffeine metabolite level and depression is compelling because it is independent of self-reported caffeine consumption. Prospective studies are warranted to further explore the temporal relationship.
Language	English
Publishing date	2019-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2434589-1
ISSN	1545-8725
ISSN	1545-8725
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Article ; Online: Rapid Capsular Antigen Immunoassay for Diagnosis of Inhalational Anthrax: Preclinical Studies and Evaluation in a Nonhuman Primate Model.

Gates-Hollingsworth, Marcellene A / Kolton, Cari B / Hoffmaster, Alex R / Meister, Gabriel T / Moore, Addie E / Green, Heather R / Pogoda, Janice M / Pillai, Segaran P / Kozel, Thomas R

mBio

2022 Volume 13, Issue 3, Page(s) e0093122

Abstract: Inhalational anthrax is a fatal infectious disease. Rapid and effective treatment is critically dependent on early and accurate diagnosis. Blood culture followed by identification and confirmation may take days to provide clinically relevant information. ...

Abstract	Inhalational anthrax is a fatal infectious disease. Rapid and effective treatment is critically dependent on early and accurate diagnosis. Blood culture followed by identification and confirmation may take days to provide clinically relevant information. In contrast, immunoassay for a shed antigen, the capsular polypeptide gamma-d-polyglutamate (γDPGA), can provide rapid results at the point of care. In this study, a lateral flow immunoassay for γDPGA was evaluated in a robust nonhuman primate model of inhalational anthrax. The results showed that the time to a positive result with the rapid test using either serum or blood as a clinical specimen was similar to the time after infection when a blood culture became positive.
MeSH term(s)	Animals ; Anthrax/diagnosis ; Antigens, Bacterial ; Bacillus anthracis ; Humans ; Immunoassay/methods ; Macaca fascicularis ; Respiratory Tract Infections
Chemical Substances	Antigens, Bacterial
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00931-22
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Article: The Association between Total Folate Intakes and Depression amongst Three Racial/Ethnic Groups.

McEligot, Archana J / Cruz, Shaina Sta / Gonzalez, Stephen / Pogoda, Janice M

Californian journal of health promotion

2019 Volume 16, Issue 1, Page(s) 6–15

Abstract: Background and purpose: Low dietary folate intake has been associated with depression outcomes, but few studies have been reported on the association in diverse populations. Using data from the National Health and Nutrition Examination Survey (NHANES), ... ...

Abstract	Background and purpose: Low dietary folate intake has been associated with depression outcomes, but few studies have been reported on the association in diverse populations. Using data from the National Health and Nutrition Examination Survey (NHANES), we examined the relationship between depression and folate intake from diet and supplementation in non-Hispanic whites, Hispanics and African Americans. Methods: 3,687 adult respondents from the 2009-2010 NHANES cycle were included. Statistical methods for analyzing data from complex survey sample designs were used to assess differences by race/ethnicity in demographic, behavioral, dietary and depression variables and to assess the relationship between depression and folate, adjusting for confounding variables using multivariable logistic regression. Results: We observed significant ( Conclusion: These data suggest that a diet high in folate, such as from dark green leafy vegetables, may be associated with a reduced odds for depression, and specifically, Hispanics may benefit from nutrition education to potentially reduce depression in the population.
Language	English
Publishing date	2019-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2434589-1
ISSN	1545-8725
ISSN	1545-8725
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Article ; Online: Intranasal Surfactant for Acute Otitis Media: A Randomized Trial.

Muniz, Gysella B / Shope, Timothy R / Bhatnagar, Sonika / Shaikh, Nader / Haralam, Mary Ann / Liu, Hui / Martin, Judith M / Pogoda, Janice M / Hoberman, Alejandro

Pediatrics

2021 Volume 148, Issue 6

Abstract: Background: Acute otitis media (AOM) is the most frequent reason for children to be prescribed antimicrobial treatment. Surfactants are naturally occurring substances that may restore the eustachian tube's function and potentially enhance resolution of ... ...

Abstract	Background: Acute otitis media (AOM) is the most frequent reason for children to be prescribed antimicrobial treatment. Surfactants are naturally occurring substances that may restore the eustachian tube's function and potentially enhance resolution of AOM. Methods: This was a phase 2a, single-center, double-blind, randomized, placebo-controlled, parallel group clinical trial to assess safety, tolerability, and efficacy of 20 mg per day intranasal OP0201 as an adjunct therapy to oral antimicrobial agents for treating AOM in young children. We randomly assigned 103 children aged 6 to 24 months with AOM to receive either OP0201 or placebo twice daily for 10 days. All children received amoxicillin-clavulanate 90/6.4 mg/kg per day in 2 divided doses for 10 days. Participants were managed for up to 1 month. Postrandomization visits occurred between days 4 and 6 (visit 2), days 12 and 14 (visit 3), and days 26 and 30 (visit 4). Primary efficacy endpoints were resolution of a bulging tympanic membrane at visit 2 and resolution of middle-ear effusion at visit 3. Results: No clinically meaningful differences between treatment groups were apparent for primary or secondary endpoints. There were no safety concerns identified. Conclusions: In young children with AOM, intranasally administered surfactant (OP0201) did not improve clinical outcomes. Further research may be warranted among children with persistent middle-ear effusion.
MeSH term(s)	Acute Disease ; Administration, Intranasal ; Amoxicillin-Potassium Clavulanate Combination/administration & dosage ; Anti-Bacterial Agents/administration & dosage ; Double-Blind Method ; Drug Therapy, Combination/methods ; Female ; Humans ; Infant ; Male ; Otitis Media/drug therapy ; Otitis Media with Effusion/drug therapy ; Surface-Active Agents/administration & dosage ; Surface-Active Agents/adverse effects
Chemical Substances	Anti-Bacterial Agents ; Surface-Active Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4)
Language	English
Publishing date	2021-11-30
Publishing country	United States
Document type	Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	207677-9
ISSN	1098-4275 ; 0031-4005
ISSN (online)	1098-4275
ISSN	0031-4005
DOI	10.1542/peds.2021-051703
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Um IV Zs.131: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 357: Show issues

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Article ; Online: Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen.

Cowan, Robert P / Gross, Noah B / Sweeney, Melanie D / Sagare, Abhay P / Montagne, Axel / Arakaki, Xianghong / Fonteh, Alfred N / Zlokovic, Berislav V / Pogoda, Janice M / Harrington, Michael G

Headache

2021 Volume 61, Issue 3, Page(s) 536–545

Abstract: Objective: Our objective is to explore whether blood-cerebrospinal fluid (CSF) barrier biomarkers differ in episodic migraine (EM) or chronic migraine (CM) from controls.: Background: Reports of blood-brain barrier and blood-cerebrospinal fluid ... ...

Abstract	Objective: Our objective is to explore whether blood-cerebrospinal fluid (CSF) barrier biomarkers differ in episodic migraine (EM) or chronic migraine (CM) from controls. Background: Reports of blood-brain barrier and blood-cerebrospinal fluid barrier (BCSFB) disruption in migraine vary. Our hypothesis is that investigation of biomarkers associated with blood, CSF, brain, cell adhesion, and inflammation will help elucidate migraine pathophysiology. Methods: We recruited 14 control volunteers without headache disorders and 42 individuals with EM or CM as classified using the International Classification of Headache Disorders, 3rd edition, criteria in a cross-sectional study located at our Pasadena and Stanford headache research centers in California. Blood and lumbar CSF samples were collected once from those diagnosed with CM or those with EM during two states: during a typical migraine, before rescue therapy, with at least 6/10 level of pain (ictal); and when migraine free for at least 48 h (interictal). The average number of headaches per month over the previous year was estimated by those with EM; this enabled comparison of biomarker changes between controls and three headache frequency groups: <2 per month, 2-14 per month, and CM. Blood and CSF biomarkers were determined using antibody-based methods. Results: Antimigraine medication was only taken by the EM and CM groups. Compared to controls, the migraine group had significantly higher mean CSF-blood quotients of albumin (Q Conclusions: The higher Q
MeSH term(s)	Adult ; Biomarkers/blood ; Biomarkers/cerebrospinal fluid ; Blood-Brain Barrier ; Cross-Sectional Studies ; Female ; Fibrinogen/cerebrospinal fluid ; Humans ; Inflammation/blood ; Inflammation/cerebrospinal fluid ; Inflammation/immunology ; Male ; Middle Aged ; Migraine Disorders/blood ; Migraine Disorders/cerebrospinal fluid ; Migraine Disorders/physiopathology ; Vascular Cell Adhesion Molecule-1/cerebrospinal fluid
Chemical Substances	Biomarkers ; Vascular Cell Adhesion Molecule-1 ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.14088
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Article ; Online: Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline.

Asanad, Samuel / Fantini, Michele / Sultan, William / Nassisi, Marco / Felix, Christian M / Wu, Jessica / Karanjia, Rustum / Ross-Cisneros, Fred N / Sagare, Abhay P / Zlokovic, Berislav V / Chui, Helena C / Pogoda, Janice M / Arakaki, Xianghong / Fonteh, Alfred N / Sadun, Alfredo A / Harrington, Michael G

PloS one

2020 Volume 15, Issue 7, Page(s) e0236379

Abstract: This corrects the article DOI: 10.1371/journal.pone.0232785.]. ...

Abstract	[This corrects the article DOI: 10.1371/journal.pone.0232785.].
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article ; Published Erratum
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0236379
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Article ; Online: Allogeneic cardiosphere-derived cells for the treatment of heart failure with reduced ejection fraction: the Dilated cardiomYopathy iNtervention with Allogeneic MyocardIally-regenerative Cells (DYNAMIC) trial.

Chakravarty, Tarun / Henry, Timothy D / Kittleson, Michelle / Lima, Joao / Siegel, Robert J / Slipczuk, Leandro / Pogoda, Janice M / Smith, Rachel R / Malliaras, Konstantinos / Marbán, Linda / Ascheim, Deborah D / Marbán, Eduardo / Makkar, Raj R

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2020 Volume 16, Issue 4, Page(s) e293–e300

Abstract: Aims: The DYNAMIC trial assessed the safety and explored the efficacy of multivessel intracoronary infusion of allogeneic cardiosphere-derived cells (CDCs) in patients with heart failure and reduced ejection fraction (HFrEF). Here we report the results ... ...

Abstract	Aims: The DYNAMIC trial assessed the safety and explored the efficacy of multivessel intracoronary infusion of allogeneic cardiosphere-derived cells (CDCs) in patients with heart failure and reduced ejection fraction (HFrEF). Here we report the results of the DYNAMIC trial. Methods and results: We enrolled 14 patients with EF ≤35% and NYHA Class III-IV despite maximal medical and device-based therapy in this single-centre, open-label trial. Intracoronary catheterisation delivered four escalating doses (totalling 37.5-75 million cells) by sequential non-occlusive technique to all three major coronary arteries. The primary safety endpoint was a composite of post-infusion TIMI flow, ventricular tachycardia/fibrillation, sudden death, major adverse cardiac events or acute myocarditis within 72 hours. Twelve patients were male and EF averaged 23.0% (±4.5%). No primary safety endpoints were observed. Two patients died of HFrEF progression nine and 12 months following infusion. Compared to baseline, there was an improvement in EF (26.8% vs 22.9%, p=0.023) and left ventricular end-systolic volume (139.5 vs 177.8 cm3, p=0.03) at six months. Quality of life (QoL) scores and NYHA class (p=0.006) improved at six months. At 12 months, the improvement in EF and QoL remained significant. Conclusions: Global intracoronary infusion of allogeneic CDCs is safe and feasible. The efficacy of allogeneic CDCs in HFrEF needs to be tested in larger randomised trials.
MeSH term(s)	Cardiomyopathy, Dilated/therapy ; Heart Failure/therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Quality of Life ; Stem Cell Transplantation/methods ; Stroke Volume ; Transplantation, Autologous ; Treatment Outcome
Language	English
Publishing date	2020-07-17
Publishing country	France
Document type	Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJ-D-19-00035
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Zs.A 6680: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 571: Show issues

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Article ; Online: Severe Headache or Migraine History Is Inversely Correlated With Dietary Sodium Intake: NHANES 1999-2004: A Response.

Pogoda, Janice M / Gross, Noah B / Arakaki, Xianghong / Fonteh, Alfred N / Cowan, Robert P / Harrington, Michael G

Headache

2016 Volume 56, Issue 7, Page(s) 1216–1218

MeSH term(s)	Headache ; Humans ; Migraine Disorders ; Nutrition Surveys ; Sodium, Dietary
Chemical Substances	Sodium, Dietary
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	410130-3
ISSN	1526-4610 ; 0017-8748
ISSN (online)	1526-4610
ISSN	0017-8748
DOI	10.1111/head.12868
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Article ; Online: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline.

PloS one

2020 Volume 15, Issue 5, Page(s) e0232785

Abstract: Background: Alzheimer's disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment. Since the retinal nerve fiber layer (RNFL) is depleted in established AD, we tested whether its ... ...

Abstract	Background: Alzheimer's disease (AD) pathology precedes symptoms and its detection can identify at-risk individuals who may benefit from early treatment. Since the retinal nerve fiber layer (RNFL) is depleted in established AD, we tested whether its thickness can predict whether cognitively healthy (CH) individuals have a normal or pathological cerebrospinal fluid (CSF) Aß42 (A) and tau (T) ratio. Methods: As part of an ongoing longitudinal study, we enrolled CH individuals, excluding those with cognitive impairment and significant ocular pathology. We classified the CH group into two sub-groups, normal (CH-NAT, n = 16) or pathological (CH-PAT, n = 27), using a logistic regression model from the CSF AT ratio that identified >85% of patients with a clinically probable AD diagnosis. Spectral-domain optical coherence tomography (OCT) was acquired for RNFL, ganglion cell-inner plexiform layer (GC-IPL), and macular thickness. Group differences were tested using mixed model repeated measures and a classification model derived using multiple logistic regression. Results: Mean age (± standard deviation) in the CH-PAT group (n = 27; 75.2 ± 8.4 years) was similar (p = 0.50) to the CH-NAT group (n = 16; 74.1 ± 7.9 years). Mean RNFL (standard error) was thinner in the CH-PAT group by 9.8 (2.7) μm; p < 0.001. RNFL thickness classified CH-NAT vs. CH-PAT with 87% sensitivity and 56.3% specificity. Conclusions: Our retinal data predict which individuals have CSF biomarkers of AD pathology before cognitive deficits are detectable with 87% sensitivity. Such results from easy-to-acquire, objective and non-invasive measurements of the RNFL merit further study of OCT technology to monitor or screen for early AD pathology.
MeSH term(s)	Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloid beta-Peptides/genetics ; Amyloidosis/cerebrospinal fluid ; Amyloidosis/diagnostic imaging ; Amyloidosis/genetics ; Amyloidosis/pathology ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction/cerebrospinal fluid ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/genetics ; Cognitive Dysfunction/pathology ; Female ; Humans ; Male ; Middle Aged ; Nerve Fibers/metabolism ; Nerve Fibers/pathology ; Optic Disk/diagnostic imaging ; Optic Disk/metabolism ; Optic Disk/pathology ; Retina/diagnostic imaging ; Retina/metabolism ; Retina/pathology ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/pathology ; Tomography, Optical Coherence ; tau Proteins/cerebrospinal fluid ; tau Proteins/genetics
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins
Language	English
Publishing date	2020-05-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0232785
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