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Article ; Online: The use of the directed acyclic graph to disentangle confounding variables from causal factors in observational studies.

Pérez-López, Faustino R / Rodríguez, Ignacio / García-Alfaro, Pascual

2024 , Page(s) 107936

Language	English
Publishing date	2024-02-03
Publishing country	Ireland
Document type	Editorial
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2024.107936
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Zs.A 1432: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 575: Show issues

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Article ; Online: Telomere Length in Patients with Gestational Diabetes Mellitus and Normoglycemic Pregnant Women: a Systematic Review and Meta-analysis.

Pérez-López, Faustino R / López-Baena, María T / Ulloque-Badaracco, Juan R / Benites-Zapata, Vicente A

Reproductive sciences (Thousand Oaks, Calif.)

2023 Volume 31, Issue 1, Page(s) 45–55

Abstract: We performed a systematic review and meta-analysis of studies assessing telomere length in blood leukocytes or mononuclear cells in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The review ... ...

Abstract	We performed a systematic review and meta-analysis of studies assessing telomere length in blood leukocytes or mononuclear cells in women with gestational diabetes mellitus (GDM) and normoglycemic pregnant women (NPW) and their infants. The review protocol was registered in PROSPERO (CRD42022300950). Searches were conducted in PubMed, Embase, LILACS, CNKI, and Wang Fang, from inception through November 2022. The primary outcomes were maternal and offspring telomere length. The Newcastle-Ottawa Scale was used to assess the quality of included studies. Random-effect meta-analyses were applied to estimate standardized mean differences (SMDs) and their 95% confidence interval (CI). The meta-analysis of four studies showed no significant maternal telomere length difference (SMD = -0.80, 95% CI: -1.66, 0.05) in women with GDM compared to NPW. In the sensibility analysis omitting one study with a small sample of women, the telomere length becomes significantly reduced in women with GDM (SMD = -1.10, 95% CI: -2.18, -0.02). GDM patients had increased glucose (SMD = 0.28, 95% CI: 0.09, 0.46) and glycosylated hemoglobin than NPW (SMD = 0.62, 95% CI: 0.23, 1.01) while total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides did not display differences between women with and without GDM. There was no significant difference in cord blood telomere length in offspring from women with GDM and NPW (SMD = 0.11, 95% CI: -0.52, 0.30). Cord blood insulin levels (SMD = 0.59, 95% CI: 0.33, 0.85) and birthweight (SMD = 0.59, 95% CI: 0.39, 0.79) were higher in offspring from pregnant women with GDM than in those from NPW. There were no significant differences in maternal and offspring telomere length between pregnancies with and without GDM.
MeSH term(s)	Infant ; Humans ; Pregnancy ; Female ; Diabetes, Gestational/diagnosis ; Pregnant Women ; Birth Weight ; Cholesterol ; Telomere
Chemical Substances	Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-023-01306-9
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Zs.A 4113: Show issues

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Article ; Online: Preeclampsia negatively affects future maternal metabolic and endocrine outcomes.

Alonso-Ventura, Vanesa / Pérez-López, Faustino R

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

2021 Volume 37, Issue 9, Page(s) 773–774

MeSH term(s)	Adult ; Diabetes, Gestational/epidemiology ; Endocrine System Diseases/epidemiology ; Endocrine System Diseases/etiology ; Female ; Humans ; Infant, Newborn ; Metabolic Diseases/epidemiology ; Metabolic Diseases/etiology ; Mothers/statistics & numerical data ; Pre-Eclampsia/epidemiology ; Pregnancy ; Risk Factors ; Women's Health
Language	English
Publishing date	2021-07-06
Publishing country	England
Document type	Editorial
ZDB-ID	639237-4
ISSN	1473-0766 ; 0951-3590
ISSN (online)	1473-0766
ISSN	0951-3590
DOI	10.1080/09513590.2021.1948996
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Zs.A 2284: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Weight management strategies in Middle-Aged Women (MAW): Development and validation of a questionnaire based on the Oxford Food and Activity Behaviors Taxonomy (OxFAB-MAW) in a Portuguese sample.

Leitão, Mafalda / Hartmann-Boyce, Jamie / Pérez-López, Faustino R / Marôco, João / Pimenta, Filipa

Frontiers in psychology

2023 Volume 13, Page(s) 1069775

Abstract: Background: The Oxford Food and Activity Behaviors (OxFAB) taxonomy systematize the cognitive-behavioral strategies adopted by individuals who are attempting to manage their weight. The present study aimed to (1) develop a questionnaire based on the ... ...

Abstract	Background: The Oxford Food and Activity Behaviors (OxFAB) taxonomy systematize the cognitive-behavioral strategies adopted by individuals who are attempting to manage their weight. The present study aimed to (1) develop a questionnaire based on the OxFAB taxonomy, specifically adapted for middle-aged women-the OxFAB-MAW-stage of life and sex, which present a high incidence of obesity, (2) assess the psychometric properties of this tool, and (3) evaluate the discriminative power of the OxFAB-MAW (normal weight vs. obesity). Methods: Overall, 1,367 Portuguese middle-aged women between 45 and 65 years ( Results: Confirmatory factor analysis demonstrated an acceptable model fit (comparative fit index = 0.928, Tucker-Lewis index = 0.913, root mean square error of approximation = 0.072, and standardized root mean square residual = 0.054). Five domains with one item were grouped into other domains, and the Weight Management Aids domain was also removed. The OxFAB-MAW showed factorial, convergent, discriminant, and external validity, as well as composite reliability. Conclusion: The OxFAB-MAW questionnaire is a valid, reliable, and theory-driven tool for assessing weight management strategies in middle-aged women, being able to discriminate between clinical and non-clinical groups (normal weight vs. obesity) in several domains. This instrument can be used to gather valid and reliable data, useful in both research and clinical settings (especially focused on structuring interventions and preventive obesity programs within this specific life cycle stage).
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.1069775
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Article: Association of Endogenous Hormones and Bone Mineral Density in Postmenopausal Women.

García-Alfaro, Pascual / García, Sandra / Rodriguez, Ignacio / Pascual, Maria Angela / Pérez-López, Faustino R

Journal of mid-life health

2023 Volume 14, Issue 3, Page(s) 196–204

Abstract: Aim: The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women.: Materials and methods: This was a cross-sectional study of 798 postmenopausal women aged 47-85 years. Data ... ...

Abstract	Aim: The aim of this study was to examine the association between endogenous hormones and bone mineral density (BMD) in postmenopausal women. Materials and methods: This was a cross-sectional study of 798 postmenopausal women aged 47-85 years. Data were collected on age, age at menopause, years since menopause, smoking status, body mass index, adiposity, BMD, physical activity, and Vitamin D supplementation. Measured hormonal parameters were: follicle-stimulating hormone (FSH), estradiol, testosterone, dehydroepiandrosterone sulfate, ∆4-androstenedione, cortisol, insulin-like growth factor-1, 25-hydroxyvitamin D, and parathormone (PTH) levels. BMD was measured at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. A directed acyclic graph was used to select potential confounding variables. Results: Multivariable analysis showed significant associations between cortisol and femoral neck BMD (β: -0.02, 95% confidence interval [CI]: -0.03--0.00), and PTH with femoral neck BMD (β: -0.01, 95% CI: -0.02--0.01) and total hip BMD (β: -0.01, 95% CI: -0.01--0.00). Hormonal factors more likely associated with a higher risk of low BMD (osteopenia or osteoporosis) were FSH (odds ratio [OR]: 1.02, 95% CI: 1.01-1.03) and PTH (OR: 1.02, 95% CI: 1.01-1.04). Conclusions: Higher cortisol and PTH levels were inversely associated with BMD. Postmenopausal women with higher FSH or PTH levels were likely to have low BMD.
Language	English
Publishing date	2023-12-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2595412-X
ISSN	0976-7819 ; 0976-7800
ISSN (online)	0976-7819
ISSN	0976-7800
DOI	10.4103/jmh.jmh_115_23
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Article ; Online: Maternal expectations of fetal gender and risk of postpartum depression.

Rong, Xiao-Fan / Li, Ming-Qing / Pérez-López, Faustino R / Wu, Jiang-Nan / Zhang, Bin

BMC pregnancy and childbirth

2023 Volume 23, Issue 1, Page(s) 112

Abstract: Background: Female offspring was associated with a high risk of postpartum depression (PPD) during the one-child policy period in China. However, little is known about the association between maternal expectations on fetal gender and the risk of PPD in ... ...

Abstract	Background: Female offspring was associated with a high risk of postpartum depression (PPD) during the one-child policy period in China. However, little is known about the association between maternal expectations on fetal gender and the risk of PPD in the context of the new two children policy implemented in 2016. Methods: We conducted a hospital-based cohort study of women with singleton pregnancies between 2017 and 2018 (n = 991) to address this concern. Logistic regression was run to estimate the association between unexpected fetal gender and the risk of PPD. Results: A total of 127 women (12.8%) were diagnosed with PPD. Compared with women who achieved fetal gender expectations, the odds ratio (OR) for PPD among those who had an unexpected fetal gender was 2.44 (95% confidence interval (CI): 1.30-4.58) (in the backward method logistic regression model) and 2.25 (95% CI: 1.21-4.18) (in the forward method model), respectively. The disparity of the association was significant among primiparous and pluriparous women (OR, 2.52, 95% CI: 1.32-4.84, P = 0.005 vs. OR, 0.91, 95% CI: 0.09-8.75, P = 0.932). Fetal gender expectations accounted for about 15% of the risk of PPD in the structural equation models. Conclusions: These results indicated that unexpected fetal gender was associated with an increased risk of PPD among Chinese primiparous women.
MeSH term(s)	Pregnancy ; Female ; Humans ; Depression, Postpartum/diagnosis ; Cohort Studies ; Motivation ; Prenatal Care ; Asian People ; Risk Factors
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-023-05419-6
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Article ; Online: Maternal and cord blood betatrophin (angiopoietin-like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta-analysis, and meta-regression.

Pérez-López, Faustino R / Yuan, Junhua / Sánchez-Prieto, Manuel / López-Baena, María T / Pérez-Roncero, Gonzalo R / Varikasuvu, Seshadri Reddy

Diabetes/metabolism research and reviews

2023 Volume 39, Issue 4, Page(s) e3612

Abstract: Aims: This systematic review and meta-analysis examined maternal and cord blood betatrophin levels in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls.: Material and methods: PubMed, Cochrane Library, Embase, LILACS, ...

Abstract	Aims: This systematic review and meta-analysis examined maternal and cord blood betatrophin levels in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls. Material and methods: PubMed, Cochrane Library, Embase, LILACS, WangFang, and China National Knowledge Infrastructure were searched for literature from inception until May 2022. The primary outcomes were maternal and cord blood betatrophin levels. A random-effect meta-analysis was used to estimate the pooled results. The mean differences (MDs) or standardised MDs (SMD) and their 95% confidence intervals (CIs) were calculated. I Results: Betatrophin levels were reported in 22 studies with a total of 3034 pregnant women, and in seven studies including cord blood from 456 infants. Women with GDM display higher betatrophin levels than the normoglycemic controls (SMD = 0.85, 95% CI: 0.38-1.31) during the second half of the pregnancy. The sensitivity analysis indicated that no single study had significantly influenced the betatrophin overall outcomes. There was heterogeneity between the studies as evidenced by high I Conclusions: Maternal betatrophin levels were higher in women with GDM than in the normoglycemic controls. There was no difference in cord blood betatrophin. Systematic review registration: PROSPERO CRD42022311372.
MeSH term(s)	Pregnancy ; Female ; Humans ; Diabetes, Gestational ; Angiopoietin-Like Protein 8 ; Pregnant Women ; Fetal Blood/metabolism ; Angiopoietin-like Proteins ; Insulin/metabolism
Chemical Substances	Angiopoietin-Like Protein 8 ; Angiopoietin-like Proteins ; Insulin
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	1470192-3
ISSN	1520-7560 ; 1520-7552
ISSN (online)	1520-7560
ISSN	1520-7552
DOI	10.1002/dmrr.3612
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Article: Etiopathogenesis of ovarian cancer. An inflamm-aging entity?

Sánchez-Prieto, Manuel / Sánchez-Borrego, Rafael / Lubián-López, Daniel Maria / Pérez-López, Faustino R

Gynecologic oncology reports

2022 Volume 42, Page(s) 101018

Abstract: Ovarian cancer is one of the most common gynecologic cancers and has the highest mortality rate. The risk/protective factors of ovarian cancer suggest that its etiology is multifactorial. Several factors are involved in age-related increases in ... ...

Abstract	Ovarian cancer is one of the most common gynecologic cancers and has the highest mortality rate. The risk/protective factors of ovarian cancer suggest that its etiology is multifactorial. Several factors are involved in age-related increases in carcinogenesis, including the accumulation of senescent cells, inflammaging (a chronic inflammatory state that persists in the elderly), and immunosenescence (aging of the immune system) changes associated with poor immune surveillance. At sites of inflammation, exposure to high levels of inflammatory mediators, such as reactive oxygen species, cytokines, prostaglandins, and growth factors, contributes to increased cell division and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the proinflammatory tumor microenvironment contributes to ovarian cancer metastasis and chemoresistance. This narrative review of the literature was carried out to delineate the possible role of inflammaging in the etiopathogenesis of ovarian cancer development. We discuss the current carcinogenic hypotheses, sites of origin, and etiological factors of ovarian cancer. Treatment of inflammation may represent an attractive strategy for both the prevention and therapy of ovarian cancer.
Language	English
Publishing date	2022-06-11
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2022.101018
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Article ; Online: Endometrial telomerase activity in women with either endometrial cancer or hyperplasia: A systematic review and meta-analysis.

Pérez-López, Faustino R / Ulloque-Badaracco, Juan R / López-Baena, María T / Yuan, Junhua / Alarcón-Braga, Esteban A / Benites-Zapata, Vicente A

Maturitas

2023 Volume 174, Page(s) 57–66

Abstract: Aim: We performed a systematic review and meta-analysis to assess whether endometrial telomerase activity is associated with endometrial cancer or hyperplasia.: Methods: PubMed, Web of Science, Embase, Scielo, LILAC, and CNKI databases were searched ... ...

Abstract	Aim: We performed a systematic review and meta-analysis to assess whether endometrial telomerase activity is associated with endometrial cancer or hyperplasia. Methods: PubMed, Web of Science, Embase, Scielo, LILAC, and CNKI databases were searched to obtain relevant literature for articles published through June 2022, following PRISMA guidelines and a registered PROSPERO protocol. We included observational studies reporting endometrial telomerase activity in patients with either endometrial cancer or hyperplasia compared with benign endometrial tissue (control women). The Newcastle-Ottawa Scale was used to evaluate the quality of studies. Data were expressed as the odds ratios (OR) and 95 % confidence intervals (CI). Random effects and inverse variance methods were used to meta-analyze associations. The I Results: There were significant associations between endometrial telomerase activity and either endometrial cancer (20 studies, OR = 10.65, 95 % CI 6.39, 17.75, p = 0.00001, I Conclusion: Endometrial telomerase activity is higher in women with either endometrial cancer or endometrial hyperplasia compared to control women without those lesions.
MeSH term(s)	Female ; Humans ; Endometrial Hyperplasia/genetics ; Endometrial Neoplasms/genetics ; Endometrium ; Hyperplasia ; Telomerase
Chemical Substances	Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2023-05-22
Publishing country	Ireland
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	80460-5
ISSN	1873-4111 ; 0378-5122
ISSN (online)	1873-4111
ISSN	0378-5122
DOI	10.1016/j.maturitas.2023.05.003
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Zs.MO 575: Show issues

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Article: Vitamin D supplementation after the menopause.

Pérez-López, Faustino R / Chedraui, Peter / Pilz, Stefan

Therapeutic advances in endocrinology and metabolism

2020 Volume 11, Page(s) 2042018820931291

Abstract: The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions ...

Abstract	The purpose of this review was to assess recent evidence regarding the effects of low vitamin D levels on some highly prevalent clinical conditions of postmenopausal women. We reviewed and selected recent literature regarding menopause-related conditions associated with vitamin D deficiency and interventions to manage them. Low circulating 25-hydroxyvitamin D (25(OH)D) levels related to menopause are linked to diet, lifestyle, changes in body composition, insulin sensitivity, and reduced physical activity. Vitamin D supplementation increases serum 25(OH)D levels while normalizing parathyroid hormone and bone markers, and in women with serum 25(OH)D levels below 10 ng/ml supplementation may improve bone mineral density. Low vitamin D status has been associated with the metabolic syndrome, high triglyceride levels, and low high-density lipoprotein cholesterol levels. When compared with placebo, vitamin D supplementation may lower the risk of the metabolic syndrome, hypertriglyceridemia, and hyperglycemia. There is an inverse relationship between fat mass and serum 25(OH)D levels and, therefore, the dosage of supplementation should be adjusted according to the body mass index. Although vitamin D supplementation may improve glucose metabolism in prediabetic subjects, data regarding muscle strength are conflictive. There is evidence that vitamin D over-treatment, to reach extremely high circulating 25(OH)D levels, does not result in better clinical outcomes. The identification and treatment of vitamin D deficiency in postmenopausal women may improve their general health and health outcomes. Vitamin D supplementation should preferably be based on the use of either cholecalciferol or calcifediol.
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2554822-0
ISSN	2042-0196 ; 2042-0188
ISSN (online)	2042-0196
ISSN	2042-0188
DOI	10.1177/2042018820931291
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