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  1. Article ; Online: Systemic contact dermatitis with fever and mucosal involvement caused by Basic Blue 99 in hair color treatment.

    Iwasaki, Mariko / Mitsui, Hiroshi / Onaka, Misaki / Okamoto, Takashi / Ogawa, Youichi / Shimada, Shinji / Kawamura, Tatsuyoshi

    International journal of dermatology

    2024  Volume 63, Issue 3, Page(s) 387–389

    MeSH term(s) Humans ; Hair Color ; Dermatitis, Allergic Contact/etiology ; Naphthoquinones ; Quaternary Ammonium Compounds ; Hair Dyes
    Chemical Substances Basic Blue 99 (68123-13-7) ; Naphthoquinones ; Quaternary Ammonium Compounds ; Hair Dyes
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Letter
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.17020
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  2. Article ; Online: Post-transplant lymphoproliferative disease of two different histological types.

    Onaka, Takashi / Ohshima, Koichi / Kinoshita, Izumi / Miyakawa, Naoto / Shirae, Atsuto / Kato-Ogura, Aiko / Otsuka, Yasuyuki / Iwai, Fumie / Yonezawa, Akihito

    Annals of hematology

    2024  

    Language English
    Publishing date 2024-04-13
    Publishing country Germany
    Document type Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05722-y
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  3. Article: [HIV-negative plasmablastic lymphoma sustaining long-term response after autologous peripheral blood stem cell transplantation].

    Kitagawa, Tomoya / Onaka, Takashi / Yonezawa, Akihito

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2022  Volume 63, Issue 3, Page(s) 201–205

    Abstract: The patient is a 34-year-old HIV antibody-negative female with normal immunocompetence. The patient was referred to the hospital of the current study due to diarrhea and abdominal pain, which developed in May 2014. On conducting computed tomography (CT), ...

    Abstract The patient is a 34-year-old HIV antibody-negative female with normal immunocompetence. The patient was referred to the hospital of the current study due to diarrhea and abdominal pain, which developed in May 2014. On conducting computed tomography (CT), remarkable wall thickening was noted in the terminal ilium over the ascending colon, suggesting a malignant tumor. However, making a definite diagnosis by lower gastrointestinal endoscopic biopsy and left hemicolectomy was not possible. The dense proliferation of plasma cell-like cells and plasmablasts was noted; CD20, CD19, CD79a, CD3, CD4, and Epstein-Barr virus-encoded miRNAs (EBER) were negative and CD138 was positive on immunostaining. Based on the aforementioned data, the patient was diagnosed with plasmablastic lymphoma (PBL). High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation (PBSCT) was performed in the first remission period after the completion of four cycles of hyper CVAD/MTX-AraC alternating therapy. Remission was confirmed by FDG-PET/CT 3 months after autologous PBSCT. No signs of recurrence have been observed in 6 years after the transplantation. Although no standard treatment for PBL has been established, autologous peripheral blood stem cell transplantation combined with high-dose chemotherapy during the first remission period may be a beneficial treatment option.
    MeSH term(s) Adult ; Antineoplastic Combined Chemotherapy Protocols ; Epstein-Barr Virus Infections ; Female ; HIV Infections/complications ; Herpesvirus 4, Human ; Humans ; Peripheral Blood Stem Cell Transplantation ; Plasmablastic Lymphoma/diagnosis ; Plasmablastic Lymphoma/therapy ; Positron Emission Tomography Computed Tomography ; Transplantation, Autologous
    Language Japanese
    Publishing date 2022-04-06
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.63.201
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  4. Article ; Online: Improvement of acyclovir-resistant herpes zoster infection by amenamevir.

    Onaka, Takashi / Shiraki, Kimiyasu / Yonezawa, Akihito

    The Journal of dermatology

    2021  Volume 48, Issue 9, Page(s) e478–e479

    MeSH term(s) Acyclovir/therapeutic use ; Antiviral Agents/therapeutic use ; Herpes Zoster/diagnosis ; Herpes Zoster/drug therapy ; Humans ; Oxadiazoles/therapeutic use
    Chemical Substances ASP2151 ; Antiviral Agents ; Oxadiazoles ; Acyclovir (X4HES1O11F)
    Language English
    Publishing date 2021-06-16
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16027
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  5. Article: Herpes zoster duplex bilateralis in bortezomib-based chemotherapy.

    Onaka, Takashi / Yonezawa, Akihito

    Blood research

    2016  Volume 51, Issue 3, Page(s) 155

    Language English
    Publishing date 2016-09-23
    Publishing country Korea (South)
    Document type Case Reports
    ZDB-ID 2711910-5
    ISSN 2288-0011 ; 2287-979X
    ISSN (online) 2288-0011
    ISSN 2287-979X
    DOI 10.5045/br.2016.51.3.155
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  6. Article: Deschloroclozapine exhibits an exquisite agonistic effect at lower concentration compared to clozapine-N-oxide in hM3Dq expressing chemogenetically modified rats.

    Shimizu, Makiko / Yoshimura, Mitsuhiro / Baba, Kazuhiko / Ikeda, Naofumi / Nonaka, Yuki / Maruyama, Takashi / Onaka, Tatsushi / Ueta, Yoichi

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1301515

    Abstract: Introduction: Within the realm of chemogenetics, a particular form of agonists targeting designer receptors exclusively activated by designer drugs (DREADDs) has emerged. Deschloroclozapine (DCZ), a recently introduced DREADDs agonist, demonstrates ... ...

    Abstract Introduction: Within the realm of chemogenetics, a particular form of agonists targeting designer receptors exclusively activated by designer drugs (DREADDs) has emerged. Deschloroclozapine (DCZ), a recently introduced DREADDs agonist, demonstrates remarkable potency in activating targeted neurons at a lower dosage compared to clozapine-N-oxide (CNO).
    Methods: We conducted a comparative analysis of the effects of subcutaneously administered CNO (1 mg/kg) and DCZ (0.1 mg/kg) in our transgenic rats expressing hM3Dq and mCherry exclusively in oxytocin (OXT) neurons.
    Results and discussion: Notably, DCZ exhibited a swift and robust elevation of serum OXT, surpassing the effects of CNO, with a significant increase in the area under the curve (AUC) up to 3 hours post-administration. Comprehensive assessment of brain neuronal activity, using Fos as an indicator, revealed comparable effects between CNO and DCZ. Additionally, in a neuropathic pain model, both CNO and DCZ increased the mechanical nociceptive and thermal thresholds; however, the DCZ-treated group exhibited a significantly accelerated onset of the effects, aligning harmoniously with the observed alterations in serum OXT concentration following DCZ administration. These findings emphasize the remarkable efficacy of DCZ in rats, suggesting its equivalent or potentially superior performance to CNO at considerably lower dosages, thus positioning it as a promising contender among DREADDs agonists.
    Language English
    Publishing date 2023-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1301515
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  7. Article: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection after allogeneic stem cell transplantation.

    Onaka, Takashi / Iwai, Fumie / Kato-Ogura, Aiko / Yonezawa, Akihito

    Clinical case reports

    2020  Volume 8, Issue 9, Page(s) 1791–1792

    Abstract: This is the first report of a case of COVID-19 after allogeneic stem cell transplantation. Our case suggests that COVID-19 may exist without characteristic CT images, especially in immunocompromised hosts, such as patients after transplantation. ...

    Abstract This is the first report of a case of COVID-19 after allogeneic stem cell transplantation. Our case suggests that COVID-19 may exist without characteristic CT images, especially in immunocompromised hosts, such as patients after transplantation.
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.2984
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  8. Article ; Online: A case report of combined treatment of gilteritinib and LH-RH agonist for Fms-related tyrosine kinase 3 receptor mutation-positive acute myeloid leukemia and bone marrow metastasis of prostate cancer.

    Onaka, Takashi / Kato-Ogura, Aiko / Otsuka, Yasuyuki / Iwai, Fumie / Yonezawa, Akihito

    Annals of hematology

    2021  Volume 101, Issue 2, Page(s) 457–458

    MeSH term(s) Aniline Compounds/therapeutic use ; Bone Marrow Neoplasms/drug therapy ; Bone Marrow Neoplasms/genetics ; Bone Marrow Neoplasms/pathology ; Bone Marrow Neoplasms/secondary ; Gonadotropin-Releasing Hormone/agonists ; Humans ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/genetics ; Male ; Middle Aged ; Mutation/drug effects ; Oligopeptides/therapeutic use ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Pyrazines/therapeutic use ; fms-Like Tyrosine Kinase 3/genetics
    Chemical Substances Aniline Compounds ; Oligopeptides ; Pyrazines ; acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide ; gilteritinib ; Gonadotropin-Releasing Hormone (33515-09-2) ; FLT3 protein, human (EC 2.7.10.1) ; fms-Like Tyrosine Kinase 3 (EC 2.7.10.1)
    Language English
    Publishing date 2021-04-12
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-021-04516-w
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  9. Article: [Treatment for acute leukemia showing PCR-positivity of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) at initial diagnosis: a case report and review of literature].

    Onaka, Takashi / Otsuka, Yasuyuki / Miyakawa, Naoto / Ogura, Aiko / Iwai, Fumie / Yonezawa, Akihito

    Rinsho ketsueki] The Japanese journal of clinical hematology

    2021  Volume 62, Issue 11, Page(s) 1604–1608

    Abstract: The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading across the world. We encountered two patients with COVID-19 who underwent treatment for acute leukemia at initial ... ...

    Abstract The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading across the world. We encountered two patients with COVID-19 who underwent treatment for acute leukemia at initial diagnosis. Both the patients received conventional induction therapy without the exacerbation of COVID-19. Although the impact of SARS-CoV-2 on the treatment of leukemia is unclear, our treatment experience suggests that there is no major contraindication to standard chemotherapy for acute leukemia in patients with COVID-19. As COVID-19 continues to be a threat worldwide, further evaluations of large cohorts are needed for future treatment decisions for acute leukemia with COVID-19.
    MeSH term(s) COVID-19 ; Humans ; Leukemia ; Polymerase Chain Reaction ; SARS-CoV-2
    Language Japanese
    Publishing date 2021-12-01
    Publishing country Japan
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 390900-1
    ISSN 0485-1439
    ISSN 0485-1439
    DOI 10.11406/rinketsu.62.1604
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  10. Article ; Online: Allogeneic stem cell transplantation for trisomy 8-positive myelodysplastic syndrome or myelodysplastic/myeloproliferative disease with refractory Behçet's disease: Case report and the review of literature.

    Onaka, Takashi / Nakano, Kazuhisa / Uemoto, Yuri / Miyakawa, Naoto / Otsuka, Yasuyuki / Ogura-Kato, Aiko / Iwai, Fumie / Tanaka, Yoshiya / Yonezawa, Akihito

    Modern rheumatology case reports

    2022  Volume 6, Issue 2, Page(s) 273–277

    Abstract: We had two cases of trisomy 8-positive myelodysplastic syndrome (MDS) with incomplete Behçet's disease (BD) in which the remissions of both diseases were maintained by allogeneic stem cell transplantation (allo-SCT). Among MDS with BD patients, sometimes ...

    Abstract We had two cases of trisomy 8-positive myelodysplastic syndrome (MDS) with incomplete Behçet's disease (BD) in which the remissions of both diseases were maintained by allogeneic stem cell transplantation (allo-SCT). Among MDS with BD patients, sometimes it is difficult to control the symptoms of BD with standard therapies such as corticosteroids and tumor necrosis factor (TNF) inhibitors. Although there should be careful consideration regarding indications for transplantation, our two cases, in which refractory BD was completely controlled by allo-SCT, suggest that allo-SCT can be one of the treatment options for higher-risk MDS with BD patients.
    MeSH term(s) Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Behcet Syndrome/therapy ; Chromosomes, Human, Pair 8 ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Myelodysplastic Syndromes/complications ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy ; Trisomy
    Language English
    Publishing date 2022-04-01
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ISSN 2472-5625
    ISSN (online) 2472-5625
    DOI 10.1093/mrcr/rxac032
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