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  1. Article ; Online: Combination of chemotherapy and immunotherapy may overcome the resistance to immunotherapy alone in pulmonary lymphoepithelial carcinoma.

    Hung, Huei-Yang / Lai, Wei-An / Chuang, Cheng-Hao / Yang, Chih-Jen

    The Kaohsiung journal of medical sciences

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country China (Republic : 1949- )
    Document type Letter
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 3187: Show issues Location:
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  2. Article: Respiratory Distress After Wisdom Tooth Extraction.

    Cheng, Sheng-Yao / Lin, Tien-Yun / Yang, Chih-Jen

    The Journal of emergency medicine

    2023  Volume 65, Issue 2, Page(s) e144–e145

    MeSH term(s) Humans ; Tooth Extraction/adverse effects ; Dyspnea ; Respiratory Distress Syndrome/etiology
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2023.04.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1895: Show issues Location:
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  3. Article ; Online: De novo exon 18 G724S point mutation may be sensitive to Gefitinib.

    Lee, Tai-Huang / Yang, Chih-Jen

    The Kaohsiung journal of medical sciences

    2021  Volume 37, Issue 10, Page(s) 918–919

    MeSH term(s) Aged ; Antineoplastic Agents/therapeutic use ; Exons ; Female ; Gefitinib/therapeutic use ; Humans ; Lung Neoplasms/drug therapy ; Male ; Middle Aged ; Point Mutation
    Chemical Substances Antineoplastic Agents ; Gefitinib (S65743JHBS)
    Language English
    Publishing date 2021-06-29
    Publishing country China (Republic : 1949- )
    Document type Letter
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Study of the Relationship between Phthalate Exposure and the Occurrence of Adult Asthma in Taiwan.

    Duh, Tsai-Hui / Yang, Chih-Jen / Lee, Chien-Hung / Ko, Ying-Chin

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 13

    Abstract: Although phthalate esters contribute to airway remodeling by increasing bronchial cells' migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and ...

    Abstract Although phthalate esters contribute to airway remodeling by increasing bronchial cells' migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and evaluated its effect on asthma. Asthma (
    MeSH term(s) Humans ; Male ; Adult ; Female ; Taiwan/epidemiology ; Phthalic Acids/toxicity ; Diethylhexyl Phthalate ; Asthma/chemically induced ; Asthma/epidemiology ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Environmental Pollutants/analysis
    Chemical Substances phthalic acid (6O7F7IX66E) ; mono-(2-ethylhexyl)phthalate (FU2EWB60RT) ; monobutyl phthalate (ZI46LWZ45G) ; Phthalic Acids ; Diethylhexyl Phthalate (C42K0PH13C) ; Environmental Pollutants
    Language English
    Publishing date 2023-07-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28135230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  5. Article ; Online: Next-Generation Sequencing in Lung Cancers-A Single-Center Experience in Taiwan.

    Lai, Wei-An / Huang, Yen-Shuo / Chang, Kung-Chao / Yang, Sheau-Fang / Yang, Chih-Jen / Liu, Yu-Wei / Chen, Huan-Da

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 2

    Abstract: Background and ... ...

    Abstract Background and Objectives
    MeSH term(s) Humans ; Lung Neoplasms/drug therapy ; Taiwan/epidemiology ; ErbB Receptors/genetics ; Mutation ; High-Throughput Nucleotide Sequencing ; Biomarkers ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances ErbB Receptors (EC 2.7.10.1) ; Biomarkers ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6270: Show issues Location:
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  6. Article ; Online: De novo exon 18 G724S point mutation may be sensitive to Gefitinib

    Tai‐Huang Lee / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 37, Iss 10, Pp 918-

    2021  Volume 919

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Comment on: Acquired low immunoglobulin levels and risk of clinically relevant infection in adult patients with systemic lupus erythematosus.

    Yang, Wen-Kang / Tseng, Chih-Jen / Wei, James Cheng-Chung

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue 9, Page(s) e347

    MeSH term(s) Adult ; Humans ; Immunoglobulin G ; Lupus Erythematosus, Systemic/complications
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 240: Show issues Location:
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    Zs.MO 497: Show issues

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  8. Article ; Online: Parameter Selection for Linear Support Vector Regression.

    Hsia, Jui-Yang / Lin, Chih-Jen

    IEEE transactions on neural networks and learning systems

    2020  Volume 31, Issue 12, Page(s) 5639–5644

    Abstract: In linear support vector regression (SVR), the regularization and error sensitivity parameters are used to avoid overfitting the training data. A proper selection of parameters is very essential for obtaining a good model, but the search process may be ... ...

    Abstract In linear support vector regression (SVR), the regularization and error sensitivity parameters are used to avoid overfitting the training data. A proper selection of parameters is very essential for obtaining a good model, but the search process may be complicated and time-consuming. In an earlier work by Chu et al. (2015), an effective parameter-selection procedure by using warm-start techniques to solve a sequence of optimization problems has been proposed for linear classification. We extend their techniques to linear SVR, but address some new and challenging issues. In particular, linear classification involves only the regularization parameter, but linear SVR has an extra error sensitivity parameter. We investigate the effective range of each parameter and the sequence in checking the two parameters. Based on this work, an effective tool for the selection of parameters for linear SVR has been available for public use.
    Language English
    Publishing date 2020-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2020.2967637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Study of the Relationship between Phthalate Exposure and the Occurrence of Adult Asthma in Taiwan

    Tsai-Hui Duh / Chih-Jen Yang / Chien-Hung Lee / Ying-Chin Ko

    Molecules, Vol 28, Iss 5230, p

    2023  Volume 5230

    Abstract: Although phthalate esters contribute to airway remodeling by increasing bronchial cells’ migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and ...

    Abstract Although phthalate esters contribute to airway remodeling by increasing bronchial cells’ migration and proliferation, the relationship between human exposure to phthalates and asthma is not understood. We measured phthalate exposure in the human body and evaluated its effect on asthma. Asthma ( n = 123) and asthma-free ( n = 139) participants were, respectively, recruited from an asthma clinic and the community in Taiwan. The urine levels of six phthalate metabolites were determined by liquid chromatography tandem mass spectrometry. Compared with the controls, male asthma patients had higher means of mono-(2-ethylhexyl) phthalate (MEHP) (116.3 nmol/g), monobutyl phthalate (MBP) (850.3 nmol/g) and monoethyl phthalate (MEP) (965.8 nmol/g), and female patients had greater MBP (2902.4 nmol/g). Each 10-fold increase in the level of these phthalate metabolites was correspondingly associated with a 5.0-, 5.8-, 4.2- and 5.3-fold risk of contracting asthma. Male asthma patients were identified to have a higher proportion of MEHP exposure (32.5%) than the controls (25.3%). In asthma patients, an increase in urine MEHP levels and the total phthalate metabolite concentration were notably linked to increased risks of emergency room visits and being hospitalized. For the occurrence and acute clinical events of adult asthma, phthalate exposures and MEHP retention may contribute to higher risks of contracting this respiratory disorder.
    Keywords adult asthma ; phthalate exposure ; phthalate metabolites ; Organic chemistry ; QD241-441
    Subject code 610
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: EGFR-TKI plus antiangiogenic agent combination therapy may reduce the incidence of EGFR-TKI-associated interstitial lung disease in Asian.

    Lee, Tai-Huang / Chen, Hsiao-Ling / Tsai, Ming-Ju / Yang, Chih-Jen

    The Kaohsiung journal of medical sciences

    2022  Volume 38, Issue 11, Page(s) 1133–1134

    MeSH term(s) Humans ; Angiogenesis Inhibitors/adverse effects ; Incidence ; ErbB Receptors/genetics ; Lung Neoplasms/drug therapy ; Lung Diseases, Interstitial/chemically induced ; Lung Diseases, Interstitial/drug therapy ; Protein Kinase Inhibitors/adverse effects ; Mutation
    Chemical Substances Angiogenesis Inhibitors ; ErbB Receptors (EC 2.7.10.1) ; Protein Kinase Inhibitors ; EGFR protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2022-08-26
    Publishing country China (Republic : 1949- )
    Document type Letter
    ZDB-ID 639302-0
    ISSN 2410-8650 ; 0257-5655
    ISSN (online) 2410-8650
    ISSN 0257-5655
    DOI 10.1002/kjm2.12584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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