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  1. Article ; Online: Simulation study on 3D convolutional neural networks for time-of-flight prediction in monolithic PET detectors using digitized waveforms.

    Maebe, Jens / Vandenberghe, Stefaan

    Physics in medicine and biology

    2022  Volume 67, Issue 12

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Monte Carlo Method ; Neural Networks, Computer ; Photons ; Positron-Emission Tomography/methods ; Scintillation Counting/methods
    Language English
    Publishing date 2022-06-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ac73d3
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    Zs.A 199: Show issues Location:
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  2. Book ; Thesis: Studies on the costimulatory signal in the activation of human T-lymphocytes

    Vandenberghe, Peter

    1993  

    Author's details Peter Vandenberghe
    Language English
    Size X, 112 S. : graph. Darst.
    Publishing country Belgium
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Leuven, Univ., Diss., 1993
    HBZ-ID HT009715655
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Discrepant high-sensitivity cardiac troponin I concentrations when measured on the Abbott Alinity ci versus the Abbott Architect system.

    Brinc, Davor / Vandenberghe, Hilde / Kulasingam, Vathany / Kavsak, Peter A

    Clinica chimica acta; international journal of clinical chemistry

    2022  Volume 537, Page(s) 105–106

    MeSH term(s) Humans ; Troponin I
    Chemical Substances Troponin I
    Language English
    Publishing date 2022-10-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2022.10.002
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  4. Article ; Online: In vivo PET of synaptic density as potential diagnostic marker for cognitive disorders: prospective comparison with current imaging markers for neuronal dysfunction and relation to symptomatology - study protocol.

    Vanderlinden, Greet / Carron, Charles / Vandenberghe, Rik / Vandenbulcke, Mathieu / Van Laere, Koen

    BMC medical imaging

    2024  Volume 24, Issue 1, Page(s) 41

    Abstract: Background: 18: Methods: In this prospective, multimodal imaging study, 110 patients with uncertain diagnosis of cognitive impairment who are referred for : Discussion: The main endpoint of the study will be the comparison of the diagnostic ... ...

    Abstract Background: 18
    Methods: In this prospective, multimodal imaging study, 110 patients with uncertain diagnosis of cognitive impairment who are referred for
    Discussion: The main endpoint of the study will be the comparison of the diagnostic accuracy between
    MeSH term(s) Humans ; Fluorodeoxyglucose F18 ; Prospective Studies ; Fluorine Radioisotopes ; Cognitive Dysfunction/diagnostic imaging ; Positron-Emission Tomography/methods ; Magnetic Resonance Imaging/methods ; Pyridines ; Pyrrolidines
    Chemical Substances SynVesT-1 (9HJJ2N3UU8) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Fluorine Radioisotopes ; Pyridines ; Pyrrolidines
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2061975-3
    ISSN 1471-2342 ; 1471-2342
    ISSN (online) 1471-2342
    ISSN 1471-2342
    DOI 10.1186/s12880-024-01224-5
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  5. Article ; Online: Revisiting a case of idiopathic hypereosinophilic syndrome with novel molecular techniques identifies a second case of a myeloid/lymphoid neoplasm with a SART3::PDGFRB fusion.

    Van Thillo, Quentin / Dewaele, Barbara / De Bie, Jolien / Michaux, Lucienne / Devos, Timothy / Vandenberghe, Peter

    British journal of haematology

    2023  Volume 202, Issue 1, Page(s) e7–e10

    MeSH term(s) Humans ; Receptor, Platelet-Derived Growth Factor beta ; Myeloproliferative Disorders ; Hypereosinophilic Syndrome/diagnosis ; Hypereosinophilic Syndrome/genetics ; Lymphoma ; Oncogene Proteins, Fusion/genetics ; Antigens, Neoplasm ; RNA-Binding Proteins
    Chemical Substances Receptor, Platelet-Derived Growth Factor beta (EC 2.7.10.1) ; Oncogene Proteins, Fusion ; SART3 protein, human ; Antigens, Neoplasm ; RNA-Binding Proteins ; PDGFRB protein, human (EC 2.7.10.1)
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18849
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  6. Article ; Online: t(1;7;22)(p13;q21;q13) is a novel 3-way variant of t(1;22)(p13;q13) neonatal acute megakaryoblastic leukemia: A case report.

    Messiaen, Julie / Uyttebroeck, Anne / Michaux, Lucienne / Vandenberghe, Peter / Boeckx, Nancy / Jacobs, Sandra A

    Molecular and clinical oncology

    2023  Volume 18, Issue 3, Page(s) 18

    Abstract: Acute megakaryoblastic leukemia (AMKL) is a rare disease, occurring mostly in infants and young children. The chromosomal translocation t(1;22)(p13;q13), resulting in the RBM15-MKL1 fusion gene, is a recurrent and diagnostic translocation in infants with ...

    Abstract Acute megakaryoblastic leukemia (AMKL) is a rare disease, occurring mostly in infants and young children. The chromosomal translocation t(1;22)(p13;q13), resulting in the RBM15-MKL1 fusion gene, is a recurrent and diagnostic translocation in infants with AMKL. The present case report describes a case of a newborn girl, without Down's syndrome, with congenital AMKL. At birth, the infant had hepatosplenomegaly and the peripheral blood count revealed anemia, thrombopenia and leukocytosis, with 28% blasts. Immunophenotyping demonstrated blasts positive for CD34, CD61 and CD42b. Karyotyping of these blasts (R-banding) showed a hitherto unreported chromosomal translocation, t(1;7;22)(p13;q21;q13), a 3-way variant of the t(1;22)(p13;q13) variant. Fluorescent
    Language English
    Publishing date 2023-01-31
    Publishing country England
    Document type Case Reports
    ZDB-ID 2796865-0
    ISSN 2049-9469 ; 2049-9450
    ISSN (online) 2049-9469
    ISSN 2049-9450
    DOI 10.3892/mco.2023.2614
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  7. Article ; Online: Shallow whole-genome sequencing of bone marrow aspirates in myelodysplastic neoplasms: A retrospective comparison with cytogenetics.

    Rengifo, Laura Y / Smits, Sanne / Boeckx, Nancy / Michaux, Lucienne / Vandenberghe, Peter / Dewaele, Barbara

    Genes, chromosomes & cancer

    2023  Volume 62, Issue 11, Page(s) 663–671

    Abstract: Copy number alterations (CNA) are powerful prognostic markers in myelodysplastic neoplasms (MDS) and are routinely analyzed by conventional cytogenetic analysis (CCA) on bone marrow (BM). Although CCA is still the gold standard, it requires extensive ... ...

    Abstract Copy number alterations (CNA) are powerful prognostic markers in myelodysplastic neoplasms (MDS) and are routinely analyzed by conventional cytogenetic analysis (CCA) on bone marrow (BM). Although CCA is still the gold standard, it requires extensive hands-on time and highly trained staff for the analysis, making it a laborious technique. To reduce turn-around-time per case, shallow whole genome sequencing (sWGS) technologies offer new perspectives for the diagnostic work-up of this disorder. We compared sWGS with CCA for the detection of CNAs in 33 retrospective BM samples of patients with MDS. Using sWGS, CNAs were detected in all cases and additionally allowed the analysis of three cases for which CCA failed. The prognostic stratification (IPSS-R score) of 27 out of 30 patients was the same with both techniques. In the remaining cases, discrepancies were caused by the presence of balanced translocations escaping sWGS detection in two cases, a subclonal aberration reported with CCA that could not be confirmed by FISH or sWGS, and the presence of an isodicentric chromosome idic(17)(p11) missed by CCA. Since sWGS can almost entirely be automated, our findings indicate that sWGS is valuable in a routine setting validating it as a cost-efficient tool.
    MeSH term(s) Humans ; Bone Marrow ; Retrospective Studies ; Neoplasms ; Cytogenetic Analysis/methods ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/diagnosis ; Whole Genome Sequencing
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1018988-9
    ISSN 1098-2264 ; 1045-2257
    ISSN (online) 1098-2264
    ISSN 1045-2257
    DOI 10.1002/gcc.23183
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    Zs.A 2966: Show issues Location:
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  8. Article ; Online: Combined lenalidomide/bortezomib for multiple myeloma complicated by fulminant myocarditis: a rare case report of widely used chemotherapy.

    Verbesselt, Matthias / Meekers, Evelyne / Vandenberghe, Peter / Delforge, Michel / Vandenbriele, Christophe

    European heart journal. Case reports

    2022  Volume 6, Issue 3, Page(s) ytac093

    Abstract: Background: Drug-induced myocarditis is a rare complication of certain cancer treatments, characterized by the development of myocardial inflammation shortly after initiation of treatment, potentially leading to heart failure and/or malignant ... ...

    Abstract Background: Drug-induced myocarditis is a rare complication of certain cancer treatments, characterized by the development of myocardial inflammation shortly after initiation of treatment, potentially leading to heart failure and/or malignant arrhythmias. The development of eosinophilic myocarditis after administration of lenalidomide has been described and bortezomib has been associated with the development of cardiomyopathies and atherosclerosis.
    Case summary: A 69-year-old woman, recently diagnosed with multiple myeloma underwent local radiotherapy for a pathological fracture of the 4th lumbar vertebra and was treated with bortezomib-lenalidomide-dexamethasone. Within 19 days after therapy initiation, she presented with gastrointestinal symptoms, an erythematous pruritic rash, and general fatigue. Surprisingly, routine electrocardiogram (ECG) showed upwardly concave ST-elevation in I and aVL and ST-depressions in II, III, and aVF. Troponin levels were markedly elevated to 5470 ng/L. Complete blood count revealed eosinophilia. Based on further cardiac work-up, including echocardiography, coronary angiography, and cardiac magnetic resonance imaging (MRI) showing positive T2 imaging and patchy subepicardial late gadolinium enhancement, she was diagnosed with hypersensitivity myocarditis. Additional endomyocardial heart biopsy did not reveal any abnormalities, probably due to sampling error. After discontinuation of chemotherapy and prompt treatment with high doses of corticosteroids, the patient recovered.
    Discussion: Diagnosis of drug-induced myocarditis can be challenging and even long known widely used (chemo)therapy should be considered a potential trigger. Early diagnosis and treatment are crucial, warranting alertness for suggestive symptoms. Cardiac biomarkers, ECG monitoring, and cardiac MRI are key to confirm the diagnosis. In patients with preserved left ventricular systolic function, two-dimensional speckle tracking echocardiography can provide additional diagnostic information. Every patient presenting with eosinophilia and/or acute onset of auto-immune symptoms after initiation of therapy with lenalidomide/bortezomib deserves prompt cardiac screening. The gold standard remains an endomyocardial biopsy, although sampling error may occur.
    Language English
    Publishing date 2022-02-22
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac093
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  9. Article ; Online: Longitudinal Imaging of Regional Brain Volumes, SV2A, and Glucose Metabolism In Huntington's Disease.

    Delva, Aline / Van Laere, Koen / Vandenberghe, Wim

    Movement disorders : official journal of the Movement Disorder Society

    2023  Volume 38, Issue 8, Page(s) 1515–1526

    Abstract: ... aided by the use of imaging biomarkers of disease progression. Positron emission tomography (PET ...

    Abstract Background: Development of disease-modifying treatments for Huntington's disease (HD) could be aided by the use of imaging biomarkers of disease progression. Positron emission tomography (PET) with
    Methods: Seventeen HD mutation carriers (six premanifest and 11 early manifest) and 13 healthy controls underwent
    Results: The HD group showed significant 2-year worsening of Unified Huntington's Disease Rating Scale motor scores. There was significant longitudinal volume loss within the HD group in caudate (-4.5% ± 3.8%), putamen (-3.6% ± 3.5%), pallidum (-3.0% ± 2.7%), and frontal cortex (-2.0% ± 2.1%) (all P < 0.001). Within the HD group there was longitudinal loss of putaminal SV2A binding (6.4% ± 8.8%, P = 0.01) and putaminal glucose metabolism (-2.8% ± 4.4%, P = 0.008), but these changes were not significant after correction for multiple comparisons. Premanifest subjects at BL only had significantly lower SV2A binding than controls in basal ganglia structures, but at Y2 additionally had significant SV2A loss in frontal and parietal cortex, indicating spread of SV2A loss from subcortical to cortical regions.
    Conclusions: Volumetric MRI may be more sensitive than
    MeSH term(s) Humans ; Huntington Disease/metabolism ; Fluorodeoxyglucose F18 ; Positron-Emission Tomography ; Brain/pathology ; Movement Disorders ; Glucose ; Membrane Glycoproteins ; Nerve Tissue Proteins/metabolism
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2) ; SV2A protein, human (148845-93-6) ; Membrane Glycoproteins ; Nerve Tissue Proteins
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29501
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    Zs.A 2555: Show issues Location:
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  10. Article ; Online: The different faces of Janus kinase inhibition.

    Vandenberghe, Peter

    Haematologica

    2012  Volume 97, Issue 4, Page(s) 475

    MeSH term(s) Humans ; Janus Kinase 2/antagonists & inhibitors ; Mutation ; Primary Myelofibrosis/drug therapy ; Primary Myelofibrosis/enzymology ; Primary Myelofibrosis/genetics ; Protein Kinase Inhibitors/therapeutic use ; Pyrazoles/therapeutic use
    Chemical Substances Protein Kinase Inhibitors ; Pyrazoles ; ruxolitinib (82S8X8XX8H) ; Janus Kinase 2 (EC 2.7.10.2)
    Language English
    Publishing date 2012-04-02
    Publishing country Italy
    Document type News
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2012.066449
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