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  1. Article ; Online: Vascularites cryoglobulinémiques.

    Mirouse, Adrien / Saadoun, David / Cacoub, Patrice

    La Revue du praticien

    2023  Volume 72, Issue 10, Page(s) 1122–1128

    Abstract: Cryoglobulins are immunoglobulins that precipitate in vitro when serum is incubated at temperatures lower than 37°C. Cryoglobulins are classified under three subgroups according to their components. Cryoglobulinemic vasculitis corresponds to ... ...

    Title translation Cryoglobulinemic vasculitis.
    Abstract Cryoglobulins are immunoglobulins that precipitate in vitro when serum is incubated at temperatures lower than 37°C. Cryoglobulins are classified under three subgroups according to their components. Cryoglobulinemic vasculitis corresponds to manifestations associated with vascular occlusion by cryoglobulins or inflammatory manifestations induced by the deposition of cryoglobulins containing immune complex. Main manifestations are skin lesions, including vascular purpura, necrosis, kidney involvement, and peripheral nerve involvement. Initial work-up aims at identifying the underlying disease, which may be a B-lineage hematological malignancy, a connective tissue disorder, or a chronic viral infection like hepatitis C. Treatment and prognosis are closely dependent of the underlying disease.
    MeSH term(s) Humans ; Cryoglobulins ; Hepatitis C, Chronic/complications ; Prognosis ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/therapy ; Vasculitis/diagnosis ; Vasculitis/etiology ; Vasculitis/therapy
    Chemical Substances Cryoglobulins
    Language French
    Publishing date 2023-02-22
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 205365-2
    ISSN 2101-017X ; 0035-2640
    ISSN (online) 2101-017X
    ISSN 0035-2640
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  2. Article ; Online: Regulatory T cells and systemic vasculitis.

    Mirouse, Adrien / Cacoub, Patrice / Saadoun, David

    Current opinion in rheumatology

    2022  Volume 35, Issue 1, Page(s) 25–30

    Abstract: Purpose of the review: Emerging data suggest that regulatory T-cells (Treg) alterations play a major role in systemic vasculitis pathophysiology. We performed a systematic review of recent advances in the role of Treg and interleukin (IL)-10 in the ... ...

    Abstract Purpose of the review: Emerging data suggest that regulatory T-cells (Treg) alterations play a major role in systemic vasculitis pathophysiology. We performed a systematic review of recent advances in the role of Treg and interleukin (IL)-10 in the pathogenesis and treatment of systemic vasculitis, including giant cell arteritis (GCA), Takayasu arteritis, Behçet's disease, antineutrophil cytoplasm antibodies (ANCA) associated vasculitis (AAV), and cryoglobulinemia associated vasculitis.
    Recent findings: Emerging data suggest that Treg deficiencies are disease-specific, affecting distinct pathways in distinct vasculitides. Decreased peripheral blood frequencies of Treg are described in all vasculitis when compared to healthy donors. Altered Treg functions are reported in GCA, Takayasu arteritis, AAV, and Behçet's disease with different mechanisms proposed. Treatment with biologics, and sometimes other immunosuppressants, may restore Treg frequencies and/or immune activity with significant differences in active disease or disease in remission in several systemic vasculitis. IL-10 is elevated in GCA, AAV, cryoglobulinemia associated vasculitis. In Behçet's disease, IL-10 is decreased in peripheral blood and elevated in saliva. In Takayasu arteritis, IL-10 levels were essentially elevated in patients' vessel wall. Several new therapeutic approaches targeting Treg and Il-10 (low dose IL-2, CAR Treg…) are developed to treat patients with systemic vasculitis.
    Summary: Treg and IL-10 play a central role in the regulation of inflammation in vasculitis and new targeting approaches are emerging.
    MeSH term(s) Humans ; T-Lymphocytes, Regulatory ; Interleukin-10/therapeutic use ; Behcet Syndrome ; Giant Cell Arteritis/drug therapy ; Takayasu Arteritis/drug therapy ; Systemic Vasculitis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy
    Chemical Substances Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2022-10-20
    Publishing country United States
    Document type Systematic Review ; Journal Article
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000915
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  3. Article ; Online: Ecthyma gangrenosum: An early hint for diagnosis.

    Saade, Anastasia / Mirouse, Adrien / Zafrani, Lara

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2020  Volume 97, Page(s) 19–20

    Language English
    Publishing date 2020-06-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2020.05.103
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  4. Article ; Online: Extensive cutaneous necrosis associated with cryofibrinogenemia.

    Mirouse, Adrien / Malphettes, Marion / Battistella, Maxime / Valade, Sandrine

    Intensive care medicine

    2020  Volume 46, Issue 8, Page(s) 1618–1619

    MeSH term(s) Cryoglobulinemia/complications ; Female ; Fibrinogen ; Humans ; Middle Aged ; Necrosis ; Skin ; Skin Diseases
    Chemical Substances Fibrinogen (9001-32-5)
    Language English
    Publishing date 2020-03-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-05988-6
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  5. Article ; Online: A prostatic Lemierre syndrome.

    Bonny, Vincent / Hourmant, Yannick / Mirouse, Adrien / Valade, Sandrine

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2019  Volume 84, Page(s) 73–74

    Language English
    Publishing date 2019-05-07
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2019.05.003
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  6. Article ; Online: Specific renal infiltration by aggressive lymphoma mimicking tumor lysis syndrome.

    Mirouse, Adrien / Darmon, Michael / Thieblemont, Catherine / Valade, Sandrine

    Intensive care medicine

    2019  Volume 46, Issue 1, Page(s) 123–124

    MeSH term(s) Acute Kidney Injury/diagnostic imaging ; Acute Kidney Injury/etiology ; Acute Kidney Injury/physiopathology ; Female ; Humans ; Lymphoma, Large B-Cell, Diffuse/complications ; Respiratory Insufficiency/etiology ; Tumor Lysis Syndrome/complications ; Young Adult
    Language English
    Publishing date 2019-08-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-019-05759-y
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  7. Article ; Online: Top ten tips for the management of critically ill hematopoietic stem cell transplantation recipients.

    Lengliné, Etienne / Mirouse, Adrien / Azoulay, Elie

    Intensive care medicine

    2019  Volume 45, Issue 3, Page(s) 384–387

    MeSH term(s) Critical Care/methods ; Critical Care/trends ; Critical Illness/therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/trends
    Language English
    Publishing date 2019-03-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-019-05587-0
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  8. Article ; Online: Impact of immunosuppression on mortality in critically ill COVID-19 patients.

    Mirouse, Adrien / Darmon, Michaël / Zafrani, Lara / Lengliné, Etienne / Azoulay, Elie

    British journal of haematology

    2020  Volume 191, Issue 3, Page(s) 394–395

    MeSH term(s) Aged ; Betacoronavirus ; COVID-19 ; Confounding Factors, Epidemiologic ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Coronavirus Infections/mortality ; Critical Care ; Critical Illness/mortality ; Female ; Hematologic Neoplasms/complications ; Hematologic Neoplasms/drug therapy ; Hematologic Neoplasms/immunology ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Male ; Middle Aged ; Neoplasms/complications ; Neoplasms/drug therapy ; Neoplasms/immunology ; Organ Dysfunction Scores ; Organ Transplantation ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Pneumonia, Viral/mortality ; Postoperative Complications/immunology ; Prospective Studies ; SARS-CoV-2
    Chemical Substances Immunosuppressive Agents
    Keywords covid19
    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17108
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  9. Article: Etoposide treatment in secondary hemophagocytic syndrome: impact on healthcare-associated infections and survival.

    Dupont, Thibault / Darmon, Michael / Mariotte, Eric / Lemiale, Virginie / Fadlallah, Jehane / Mirouse, Adrien / Zafrani, Lara / Azoulay, Elie / Valade, Sandrine

    Annals of intensive care

    2022  Volume 12, Issue 1, Page(s) 101

    Abstract: Background: Etoposide remains the cornerstone of symptomatic management of critically ill patients with secondary hemophagocytic syndrome (sHS). Risk of healthcare-associated infections (HAIs) in this setting with etoposide has never been assessed. We ... ...

    Abstract Background: Etoposide remains the cornerstone of symptomatic management of critically ill patients with secondary hemophagocytic syndrome (sHS). Risk of healthcare-associated infections (HAIs) in this setting with etoposide has never been assessed. We sought to evaluate the association between etoposide administration, HAIs occurrence and survival in critically ill adult patients with sHS. In this retrospective single-center study conducted in a university hospital ICU between January 2007 and March 2020, all consecutive patients with sHS were included. HAIs were defined as any microbiologically documented infection throughout ICU stay. Competing risk survival analysis was performed to determine factors associated with HAIs. Propensity score-based overlap weighting was performed to adjust for factors associated with etoposide use.
    Results: 168 patients with a median age of 49 [38, 59] were included. Forty-three (25.6%) patients presented with at least 1 microbiologically documented HAI throughout ICU stay. After adjustment, cumulative incidence of HAI was higher in patients receiving etoposide (p = 0.007), while survival was unaffected by etoposide status (p = 0.824). By multivariable analysis, etoposide treatment was associated with a higher incidence of HAIs (sHR 3.75 [1.05, 6.67]), whereas no association with survival (sHR 0.53 [0.20, 1.98]) was found. Other factors associated with increased mortality after adjustment included age, immunodepression, male sex, SOFA score > 13, and occurrence of HAI.
    Conclusions: In patients with sHS, etoposide treatment is independently associated with increased occurrence of HAIs, whereas no association with survival was found. Intensivists should be aware of increased infectious risk, to promptly detect and treat infections in this specific setting. Studies to assess benefits from prophylactic anti-infectious agents in this setting are warranted and the lack of benefit of etoposide on survival needs to be interpreted cautiously.
    Language English
    Publishing date 2022-10-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2617094-2
    ISSN 2110-5820
    ISSN 2110-5820
    DOI 10.1186/s13613-022-01075-9
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  10. Article: Vascular Behçet's disease: a comparative study from Turkey and France.

    Alibaz-Oner, Fatma / Vautier, Mathieu / Aksoy, Aysun / Mirouse, Adrien / Le Joncour, Alexandre / Cacoub, Patrice / Ilgin, Can / Saadoun, David / Direskeneli, Haner

    Clinical and experimental rheumatology

    2022  Volume 40, Issue 8, Page(s) 1491–1496

    Abstract: Objectives: Vascular Behçet's disease (VBD) is a systemic vasculitis involving both arterial and venous vessels of all sizes and occurring in up to 40% of patients with BD. VBD is the main cause of mortality in BD. Although commonly seen around the ... ...

    Abstract Objectives: Vascular Behçet's disease (VBD) is a systemic vasculitis involving both arterial and venous vessels of all sizes and occurring in up to 40% of patients with BD. VBD is the main cause of mortality in BD. Although commonly seen around the Mediterranean region, comparative studies in VBD are lacking. We aimed to compare the course and therapeutic approaches of VBD in two large cohorts from Turkey and France.
    Methods: We included 291 VBD patients (female/male:63/228, mean age: 41.2±11.3 years) who were followed up in the Department of Internal Medicine and Clinical Immunology at Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France (n=131) and Rheumatology Division of Marmara University School of Medicine, Istanbul, Turkey (n=160). All clinical and demographical data were acquired from patient charts retrospectively.
    Results: Smoking, family history for BD, HLA-B*51 presence and pathergy positivity were significantly higher in Turkish patients (TR), while neurologic involvement was more prominent in the French (FR) group. After a median follow-up of 77 months, 562 vascular events occurred including 440 venous events, 115 arterial events and 7 cardiac thrombi. In 79 (29%) patients, first vascular event developed before BD diagnosis and for 77 (28%) of them, vascular involvement was the presenting sign of the disease. First relapse developed in 130 (44.7%) patients after median 24.5 (1-276) months of follow-up (TR: 46.3% (n=74), FR: 42.7% (n=56), p=0.56). Survival graph revealed that FR cohort has 1.64 times increased recurrent event risk compared to TR cohort (HR=1.64 (1.1-2.44), p=.014) and although did not reach to statistical significance, IS treatment after the first vascular event decreased further vascular events (HR= 0.66 (0.43-1.01, p=.057).
    Conclusions: Almost half of patients relapsed of VBD within 2 years after the first vascular event. Immunosuppressants decrease VBD relapses.
    MeSH term(s) Adult ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Behcet Syndrome/epidemiology ; Female ; France/epidemiology ; Humans ; Immunosuppressive Agents/therapeutic use ; Male ; Middle Aged ; Recurrence ; Retrospective Studies ; Thrombosis ; Turkey/epidemiology
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2022-02-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/iovig5
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