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Article: [Effect of Knocking Out

Man, Jian-Cheng / Cheng, Juan / Zhao, Li

2024 Volume 32, Issue 1, Page(s) 52–56

Abstract: Objective: To construct a acute myeloid leukemia (AML) cell line in which : Methods: The expression of HOXA5 in bone marrow mononuclear cells (BMMC) of non-tumor hematological patients and newly diagnosed AML patients was detected by quantitative ... ...

Abstract	Objective: To construct a acute myeloid leukemia (AML) cell line in which Methods: The expression of HOXA5 in bone marrow mononuclear cells (BMMC) of non-tumor hematological patients and newly diagnosed AML patients was detected by quantitative real-time PCR (qRT-PCR) and Western blot, respectively. The AML cell line KO-HOXA5-THP-1 was constructed in which Results: Compared with non-tumor hematological patients, the levels of Conclusion: HOXA5
MeSH term(s)	Humans ; Gene Editing ; CRISPR-Cas Systems ; Leukemia, Myeloid, Acute/metabolism ; Genes, Homeobox ; Cell Line, Tumor ; Cell Proliferation ; Homeodomain Proteins/genetics
Chemical Substances	HOXA5 protein, human ; Homeodomain Proteins
Language	Chinese
Publishing date	2024-02-23
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2024.01.009
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Article ; Online: Guillain-Barré syndrome characterized by cerebral infarction: A case report with literature review.

Wang, Lihui / Zhao, Zhenming / Dong, Chunyu / Man, Honghao

Asian journal of surgery

2024

Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.02.107
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Article: Secondary Phase Precipitation in Fe-22Mn-9Al-0.6C Low-Density Steel during Continuous Cooling Process.

Zhou, Yihao / Man, Tinghui / Wang, Jun / Zhao, Hongshan / Dong, Han

Materials (Basel, Switzerland)

2024 Volume 17, Issue 3

Abstract: Secondary phase precipitation in Fe-22Mn-9Al-0.6C low-density steel was investigated during a continuous cooling process with different cooling rates through a DIL805A thermal expansion dilatometer, and the changes in microstructures and hardness by ... ...

Abstract	Secondary phase precipitation in Fe-22Mn-9Al-0.6C low-density steel was investigated during a continuous cooling process with different cooling rates through a DIL805A thermal expansion dilatometer, and the changes in microstructures and hardness by different cooling rates were discussed. The results showed that the matrix of the Fe-22Mn-9Al-0.6C was composed of austenite and δ-ferrite; moreover, the secondary phases included κ-carbide, β-Mn and DO
Language	English
Publishing date	2024-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17030631
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Article: CO and HCHO Sensing by Single Au Atom-Decorated WS

Zhao, Qi / Man, Yuyan / He, Jin / Li, Songyuan / Li, Lin

Materials (Basel, Switzerland)

2024 Volume 17, Issue 5

Abstract: CO and HCHO are the main pyrolysis gases in long-term running dry-type reactors, and thus the diagnosis of thermal insulation faults inside such devices can be realized by sensing these gases. In this paper, a single Au atom-decorated ... ...

Abstract	CO and HCHO are the main pyrolysis gases in long-term running dry-type reactors, and thus the diagnosis of thermal insulation faults inside such devices can be realized by sensing these gases. In this paper, a single Au atom-decorated WS
Language	English
Publishing date	2024-03-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17051173
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Article: [Pathogenesis and Therapeutic Prospects of Chronic Graft-Versus-Host Disease --Review].

Xu, Shu-Hui / Man, Yan / Zhao, Jin-Lian / Wang, Ya-Jie

Zhongguo shi yan xue ye xue za zhi

2024 Volume 32, Issue 2, Page(s) 647–652

Abstract: Chronic graft-versus-host disease (cGVHD) is one of a major complication that affecting the long-term survival and living quality of patients after allogeneic hematopoietic stem cell transplantation, with the incidence of 30%-70%. Unlike acute GVHD, ... ...

Abstract	Chronic graft-versus-host disease (cGVHD) is one of a major complication that affecting the long-term survival and living quality of patients after allogeneic hematopoietic stem cell transplantation, with the incidence of 30%-70%. Unlike acute GVHD, cGVHD involves a large number of immune cells and cytokines in addition to T cell, which is activated abnormally by the donor, and cytokine storms, which characterized by infiltration of donor lymphocytes and damage to host target organ. Recent studies have further made progress in targeting related immune cells and cytokines. In this review, the pathogenesis and therapeutic prospects of cGVHD were summarized from the perspectives of classical innate and adaptive immunity.
MeSH term(s)	Graft vs Host Disease/therapy ; Humans ; Hematopoietic Stem Cell Transplantation/adverse effects ; Chronic Disease ; Cytokines/metabolism ; Immunity, Innate ; Transplantation, Homologous ; T-Lymphocytes/immunology ; Adaptive Immunity ; Bronchiolitis Obliterans Syndrome
Chemical Substances	Cytokines
Language	Chinese
Publishing date	2024-04-25
Publishing country	China
Document type	Journal Article ; Review ; English Abstract
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2024.02.050
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Article ; Online: RELA promotes the progression of oral squamous cell carcinoma via TFAP2A-Wnt/β-catenin signaling.

Yang, Kaicheng / Zhao, Jianguang / Liu, Shenghui / Man, Shasha

Molecular carcinogenesis

2023 Volume 62, Issue 5, Page(s) 641–651

Abstract: Oral squamous cell carcinoma (OSCC) has emerged as the most prevailing oral malignancy worldwide, characterized by cervical solid lymph node metastasis and strong local invasiveness. Overexpression of Transcription Factor AP-2 alpha (TFAP2A) is observed ... ...

Abstract	Oral squamous cell carcinoma (OSCC) has emerged as the most prevailing oral malignancy worldwide, characterized by cervical solid lymph node metastasis and strong local invasiveness. Overexpression of Transcription Factor AP-2 alpha (TFAP2A) is observed in a significant proportion of OSCC cases. In this study, we aimed to elucidate the function of TFAP2A in the progression of OSCC and the related molecular signaling pathways. The role of RELA was predicted using bioinformatics analysis. The mRNA abundances of RELA, TFAP2A, and β-catenin were assessed by Western blot and quantitative real-timePCR. The relationship between RELA, TFAP2A, and β-catenin and their correlation with clinicopathological characteristics of OSCC was evaluated. The target of RELA and TFAP2A was identified by the chromatin immunoprecipitation as well as luciferase reporter assay. The colony formation assay and MTS assay were performed to determine the proliferative level of OSCC cells. OSCC cell motility was determined by Transwell assay and wound-healing assay. The protein expressions of epithelial-mesenchymal transition-associated factors were evaluated by Western blot. The expressions of RELA and TFAP2A were elevated in OSCC, and their expressions displayed a positive correlation. The expression levels of RELA and TFAP2A were found to be associated with TNM staging and lymphatic metastasis of OSCC patients. RELA upregulation promoted OSCC progression, as manifested by increased levels of proliferation, invasion, and migration of OSCC cells. We also demonstrated that RELA was directly bound to the promoter of TFAP2A transcription, which activated multiple malignant and metastatic phenotypes. Furthermore, TFAP2A activated the Wnt/β-catenin signaling by targeting the promoter regions of β-catenin. The study found that RELA is critical for promoting the progression of OSCC via the RELA-TFAP2A-Wnt/β-catenin signaling pathway. The RELA-TFAP2A-Wnt/β-catenin signaling pathway is a potential target for reducing the aggressiveness of OSCC.
MeSH term(s)	Humans ; beta Catenin/genetics ; beta Catenin/metabolism ; Carcinoma, Squamous Cell/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Head and Neck Neoplasms/genetics ; Mouth Neoplasms/genetics ; Mouth Neoplasms/pathology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Transcription Factor AP-2/genetics ; Transcription Factor AP-2/metabolism ; Transcription Factor RelA/genetics ; Transcription Factor RelA/metabolism ; Wnt Signaling Pathway/genetics
Chemical Substances	beta Catenin ; RELA protein, human ; TFAP2A protein, human ; Transcription Factor AP-2 ; Transcription Factor RelA
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1004029-8
ISSN	1098-2744 ; 0899-1987
ISSN (online)	1098-2744
ISSN	0899-1987
DOI	10.1002/mc.23512
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Article ; Online: Urinary insulin signaling pathway related proteins may serve as potential biomarkers for monitoring diabetes mellitus without hypertension and hyperlipidemia.

Zhao, Man / Meng, Qian / Zhang, Man

Medicine

2023 Volume 102, Issue 5, Page(s) e32862

Abstract: The insulin signaling pathway plays an important role in the development of diabetes mellitus. The expression of insulin signaling pathway related proteins in the urine of diabetic patients has not been reported. The aim of this study was to analyze and ... ...

Abstract	The insulin signaling pathway plays an important role in the development of diabetes mellitus. The expression of insulin signaling pathway related proteins in the urine of diabetic patients has not been reported. The aim of this study was to analyze and verify the expression of insulin signaling pathway related proteins in the urine of diabetic patients without hypertension and hyperlipidemia, and to explore their clinical application value. Based on data-independent acquisition proteomics technology and bioinformatics, the urinary protein expression profile of diabetic patients without hypertension and hyperlipidemia was established. Western blot and enzyme-linked immunoassay were performed to verify the expression of insulin signaling pathway related proteins in the urine of diabetic patients. Sixteen proteins related to the insulin signaling pathway were screened in urine, and 7 of them were differentially expressed in the urine of diabetic patients without hypertension and hyperlipidemia. Further quantitative analysis showed that the downregulation of protein kinase CAMP-dependent type II regulatory subunit α, growth factor receptor bound protein 2, and guanine nucleotide-binding protein G(s) in the urine of diabetic patients without hyperlipidemia and hypertension was consistent with the preliminary screening results. In this exploratory study, we detected the expression of insulin signaling pathway related proteins in the urine of diabetic patients without hypertension and hyperlipidemia. protein kinase CAMP-dependent type II regulatory subunit α, growth factor receptor bound protein 2, and guanine nucleotide-binding protein G(s) in the urine of diabetic patients were downregulated, which was associated with diabetes. They may be promising noninvasive biomarkers for monitoring diabetes.
MeSH term(s)	Humans ; Insulin/metabolism ; GRB2 Adaptor Protein/metabolism ; Hyperlipidemias ; Diabetes Mellitus, Type 2 ; Hypertension ; Signal Transduction ; GTP-Binding Proteins/metabolism ; Biomarkers ; Guanine Nucleotides ; Protein Kinases
Chemical Substances	Insulin ; GRB2 Adaptor Protein ; GTP-Binding Proteins (EC 3.6.1.-) ; Biomarkers ; Guanine Nucleotides ; Protein Kinases (EC 2.7.-)
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000032862
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Article: Quantitative study of bioinformatics analysis on glioma: a bibliometric analysis.

Yang, Xiaobing / Man, Dulegeqi / Zhao, Peng / Li, Xingang

Frontiers in oncology

2023 Volume 13, Page(s) 1222797

Abstract: Background: The bioinformatics analysis on glioma has been a hot point recently. The purpose of this study was to provide an overview of the research in this field using a bibliometric method.: Methods: The Web of Science Core Collection (WOSCC) ... ...

Abstract	Background: The bioinformatics analysis on glioma has been a hot point recently. The purpose of this study was to provide an overview of the research in this field using a bibliometric method. Methods: The Web of Science Core Collection (WOSCC) database was used to search for literature related to the bioinformatics analysis of gliomas. Countries, institutions, authors, references, and keywords were analyzed using VOSviewer, CiteSpace, and Microsoft Excel software. Result: China was the most productive country, while the USA was the most cited. Capital Medical University had the largest number of publications and citations. Institutions tend to collaborate more with other institutions in their countries rather than foreign ones. The most productive and most cited author was Jiang Tao. Two citation paths were identified, with literature in basic research journals often cited in clinical journals. Immune-related vocabularies appeared frequently in recent studies. Conclusion: Glioma bioinformatics analyses spanned a wide range of fields. The international communication in this field urgently needs to be strengthened. Glioma bioinformatics approaches are developing from basic research to clinical applications. Recently, immune-related research has become a focus.
Language	English
Publishing date	2023-11-15
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1222797
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Article ; Online: Tree-Structured Data Clustering-Driven Neural Network for Intra Prediction in Video Coding.

Man, Hengyu / Fan, Xiaopeng / Xiong, Ruiqin / Zhao, Debin

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

2023 Volume 32, Page(s) 3493–3506

Abstract: Intra prediction is a crucial part of video compression, which utilizes local information in images to eliminate spatial redundancy. As the state-of-the-art video coding standard, Versatile Video Coding (H.266/VVC) employs multiple directional prediction ...

Abstract	Intra prediction is a crucial part of video compression, which utilizes local information in images to eliminate spatial redundancy. As the state-of-the-art video coding standard, Versatile Video Coding (H.266/VVC) employs multiple directional prediction modes in intra prediction to find the texture trend of local areas. Then the prediction is made based on reference samples in the selected direction. Recently, neural network-based intra prediction has achieved great success. Deep network models are trained and applied to assist the HEVC and VVC intra modes. In this paper, we propose a novel tree-structured data clustering-driven neural network (dubbed TreeNet) for intra prediction, which builds the networks and clusters the training data in a tree-structured manner. Specifically, in each network split and training process of TreeNet, every parent network on a leaf node is split into two child networks by adding or subtracting Gaussian random noise. Then data clustering-driven training is applied to train the two derived child networks using the clustered training data of their parent. On the one hand, the networks at the same level in TreeNet are trained with non-overlapping clustered datasets, and thus they can learn different prediction abilities. On the other hand, the networks at different levels are trained with hierarchically clustered datasets, and thus they will have different generalization abilities. TreeNet is integrated into VVC to assist or replace intra prediction modes to test its performance. In addition, a fast termination strategy is proposed to accelerate the search of TreeNet. The experimental results demonstrate that when TreeNet is used to assist the VVC Intra modes, TreeNet with depth = 3 can bring an average of 3.78% bitrate saving (up to 8.12%) over VTM-17.0. If TreeNet with the same depth replaces all VVC intra modes, an average of 1.59% bitrate saving can be reached.
MeSH term(s)	Cluster Analysis ; Data Compression ; Neural Networks, Computer
Language	English
Publishing date	2023-06-23
Publishing country	United States
Document type	Journal Article
ISSN	1941-0042
ISSN (online)	1941-0042
DOI	10.1109/TIP.2023.3286256
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Article ; Online: Identification of the therapeutic mechanism of the saffron crocus on glioma through network pharmacology and bioinformatics analysis.

Yang, Xiaobing / Man, Dulegeqi / Zhao, Peng / Li, Xingang

Medical oncology (Northwood, London, England)

2023 Volume 40, Issue 10, Page(s) 296

Abstract: Saffron crocus is a herbal medicine of traditional Tibetan medicine (TTM). Saffron extract has been indicated to inhibit tumor cell growth and promote tumor cell apoptosis in a variety of cancers, including glioma, but the specific mechanism is not clear. ...

Abstract	Saffron crocus is a herbal medicine of traditional Tibetan medicine (TTM). Saffron extract has been indicated to inhibit tumor cell growth and promote tumor cell apoptosis in a variety of cancers, including glioma, but the specific mechanism is not clear. To study the possible mechanism of saffron action on glioma, network pharmacology and bioinformatics analysis methods were used in this study. We used the online database to obtain the active ingredients of saffron and their targets. Glioma-related targets were also acquired from online database. We intersected drug targets with glioma-related targets and conducted PPI network analysis to obtain network core genes. Then, we obtained RNA-seq data from The Cancer Genome Atlas (TCGA) database for glioma patients. Through different expression analysis and lasso regression, further screening of core genes in the network was conducted, and a prognostic model was established. The sample was divided into two groups with high and low risk using this model. The RNA-seq data from the Chinese Glioma Genome Atlas (CGGA) database were used to further validate our prediction model. Then, we explored the difference in pathways enrichment between high-risk patients and low-risk patients and calculated the difference in immune microenvironment between the two groups. Finally, we used scRNA-seq data in the CGGA database to analyze the cell types in which the model gene is mainly enriched and predicted the cell types which saffron effected on.
MeSH term(s)	Humans ; Crocus ; Network Pharmacology ; Glioma/drug therapy ; Glioma/genetics ; Apoptosis ; Biological Products ; Computational Biology ; Tumor Microenvironment
Chemical Substances	Biological Products
Language	English
Publishing date	2023-09-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-023-02142-2
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