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  1. Article ; Online: Salivary IgA subtypes as novel disease biomarkers in systemic lupus erythematosus.

    Romero-Ramírez, Sandra / Sosa-Hernández, Víctor A / Cervantes-Díaz, Rodrigo / Carrillo-Vázquez, Daniel A / Meza-Sánchez, David E / Núñez-Álvarez, Carlos / Torres-Ruiz, Jiram / Gómez-Martín, Diana / Maravillas-Montero, José L

    Frontiers in immunology

    2023  Volume 14, Page(s) 1080154

    Abstract: Introduction: Immunoglobulin A (IgA) is the main antibody isotype in body fluids such as tears, intestinal mucous, colostrum, and saliva. There are two subtypes of IgA in humans: IgA1, mainly present in blood and mucosal sites, and IgA2, preferentially ... ...

    Abstract Introduction: Immunoglobulin A (IgA) is the main antibody isotype in body fluids such as tears, intestinal mucous, colostrum, and saliva. There are two subtypes of IgA in humans: IgA1, mainly present in blood and mucosal sites, and IgA2, preferentially expressed in mucosal sites like the colon. In clinical practice, immunoglobulins are typically measured in venous or capillary blood; however, alternative samples, including saliva, are now being considered, given their non-invasive and easy collection nature. Several autoimmune diseases have been related to diverse abnormalities in oral mucosal immunity, such as rheumatoid arthritis, Sjogren's syndrome, and systemic lupus erythematosus (SLE).
    Methods: We decided to evaluate the levels of both IgA subtypes in the saliva of SLE patients. A light chain capture-based ELISA measured specific IgA1 and IgA2 levels in a cohort of SLE patients compared with age and gender-matched healthy volunteers.
    Results: Surprisingly, our results indicated that in the saliva of SLE patients, total IgA and IgA1 subtype were significantly elevated; we also found that salivary IgA levels, particularly IgA2, positively correlate with anti-dsDNA IgG antibody titers. Strikingly, we also detected the presence of salivary anti-nucleosome IgA antibodies in SLE patients, a feature not previously reported elsewhere.
    Conclusions: According to our results and upon necessary validation, IgA characterization in saliva could represent a potentially helpful tool in the clinical care of SLE patients with the advantage of being a more straightforward, faster, and safer method than manipulating blood samples.
    MeSH term(s) Humans ; Immunoglobulin A, Secretory ; Lupus Erythematosus, Systemic ; Immunoglobulin A ; Immunoglobulin G ; Mouth Mucosa ; Biomarkers
    Chemical Substances Immunoglobulin A, Secretory ; Immunoglobulin A ; Immunoglobulin G ; Biomarkers
    Language English
    Publishing date 2023-02-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1080154
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  2. Article ; Online: Circulating B10 regulatory cells are decreased in severe and critical COVID-19.

    Cervantes-Díaz, Rodrigo / Sosa-Hernández, Víctor A / Romero-Ramírez, Sandra / Torres-Ruiz, Jiram / Pérez-Fragoso, Alfredo / Meza-Sánchez, David E / Gómez-Martín, Diana / Maravillas-Montero, José L

    Journal of leukocyte biology

    2022  Volume 112, Issue 2, Page(s) 333–337

    Abstract: The contribution of B cells in COVID-19 pathogenesis, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Since one of their most relevant functional roles includes their immune-suppressive mechanisms, we ... ...

    Abstract The contribution of B cells in COVID-19 pathogenesis, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Since one of their most relevant functional roles includes their immune-suppressive mechanisms, we decided to evaluate one of the most recognized human B regulatory subpopulations: the IL-10
    MeSH term(s) B-Lymphocytes, Regulatory ; COVID-19 ; Flow Cytometry ; Humans ; Interleukin-10 ; SARS-CoV-2
    Chemical Substances Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.5COVCRA0721-387RR
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  3. Article ; Online: Severity of SARS-CoV-2 infection is linked to double-negative (CD27

    Cervantes-Díaz, Rodrigo / Sosa-Hernández, Víctor Andrés / Torres-Ruíz, Jiram / Romero-Ramírez, Sandra / Cañez-Hernández, Mariana / Pérez-Fragoso, Alfredo / Páez-Franco, José C / Meza-Sánchez, David E / Pescador-Rojas, Miriam / Sosa-Hernández, Víctor Adrián / Gómez-Martín, Diana / Maravillas-Montero, José L

    Inflammation research : official journal of the European Histamine Research Society ... [et al.

    2021  Volume 71, Issue 1, Page(s) 131–140

    Abstract: Objectives: The role of B cells in COVID-19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27: Methods: Using multiparametric ...

    Abstract Objectives: The role of B cells in COVID-19, beyond the production of specific antibodies against SARS-CoV-2, is still not well understood. Here, we describe the novel landscape of circulating double-negative (DN) CD27
    Methods: Using multiparametric flow cytometry, we determined DN B cell subset amounts from 91 COVID-19 patients, correlated those with cytokines, clinical and laboratory parameters, and segregated them by principal components analysis.
    Results: We detected significant increments in the DN2 and DN3 B cell subsets, while we found a relevant decrease in the DN1 B cell subpopulation, according to disease severity and patient outcomes. These DN cell numbers also appeared to correlate with pro- or anti-inflammatory signatures, respectively, and contributed to the segregation of the patients into disease severity groups.
    Conclusion: This study provides insights into DN B cell subsets' potential role in immune responses against SARS-CoV-2, particularly linked to the severity of COVID-19.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; B-Lymphocytes/cytology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Cell Lineage ; Computational Biology ; Disease Progression ; Female ; Humans ; Immunoglobulin D/blood ; Male ; Middle Aged ; Principal Component Analysis ; Prognosis ; Respiration, Artificial ; SARS-CoV-2 ; Severity of Illness Index ; Tumor Necrosis Factor Receptor Superfamily, Member 7/blood ; Young Adult
    Chemical Substances Immunoglobulin D ; Tumor Necrosis Factor Receptor Superfamily, Member 7
    Language English
    Publishing date 2021-11-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1221794-3
    ISSN 1420-908X ; 1023-3830
    ISSN (online) 1420-908X
    ISSN 1023-3830
    DOI 10.1007/s00011-021-01525-3
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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: CD11c

    Sosa-Hernández, Víctor A / Romero-Ramírez, Sandra / Cervantes-Díaz, Rodrigo / Carrillo-Vázquez, Daniel A / Navarro-Hernandez, Itze C / Whittall-García, Laura P / Absalón-Aguilar, Abdiel / Vargas-Castro, Ana S / Reyes-Huerta, Raúl F / Juárez-Vega, Guillermo / Meza-Sánchez, David E / Ortiz-Navarrete, Vianney / Torres-Ruiz, Jiram / Mejía-Domínguez, Nancy R / Gómez-Martín, Diana / Maravillas-Montero, José L

    Frontiers in immunology

    2022  Volume 13, Page(s) 892241

    Abstract: Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), characterized by abnormal B cell activation and differentiation to memory or plasma effector cells. However, the role of these cells in the pathogenesis ... ...

    Abstract Lupus nephritis (LN) is one of the most common manifestations of systemic lupus erythematosus (SLE), characterized by abnormal B cell activation and differentiation to memory or plasma effector cells. However, the role of these cells in the pathogenesis of LN is not fully understood, as well as the effect of induction therapy on B cell subsets, possibly associated with this manifestation, like aged-associated B cells (ABCs). Consequently, we analyzed the molecules defining the ABCs subpopulation (CD11c, T-bet, and CD21) through flow cytometry of blood samples from patients with lupus presenting or not LN, following up a small sub-cohort after six months of induction therapy. The frequency of ABCs resulted higher in LN patients compared to healthy subjects. Unexpectedly, we identified a robust reduction of a CD21
    MeSH term(s) Aged ; B-Lymphocyte Subsets ; Biomarkers ; CD11c Antigen ; Complement System Proteins/therapeutic use ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Nephritis/diagnosis ; Renal Insufficiency
    Chemical Substances Biomarkers ; CD11c Antigen ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.892241
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  5. Article: Participación de los linfocitos B reguladores (Breg) en las enfermedades alérgicas.

    Navarro-Hernández, Itze Cecilia / Cervantes-Díaz, Rodrigo / Romero-Ramírez, Sandra / Sosa-Hernández, Víctor Andrés / Kleinberg, Ari / Meza-Sánchez, David Eduardo / Maravillas-Montero, José L

    Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

    2019  Volume 65, Issue 4, Page(s) 400–413

    Abstract: Immune tolerance, both to exogenous antigens and autoantigens, is essential for restraining undesired inflammatory responses that might result in severe damage to body tissues or cause chronic diseases. During the past few decades, different cell ... ...

    Title translation Regulatory B cells (Bregs) role in allergic diseases.
    Abstract Immune tolerance, both to exogenous antigens and autoantigens, is essential for restraining undesired inflammatory responses that might result in severe damage to body tissues or cause chronic diseases. During the past few decades, different cell populations and molecules by them secreted have been associated with suppressing and regulatory mechanisms of immune responses. Although B cells typically acquire relevance as precursors of antibody-producing cells, they can also develop potent regulatory functions through the production of soluble molecules or by establishing direct cellular interactions mediated by different surface proteins implicated in signal transduction. While most studies of regulatory B cells define the role of these lymphocytes in autoimmune diseases, evidence of their importance and mechanisms of action in allergic diseases has accumulated in recent years. As a result, regulatory B cells appear to be relevant elements for the establishment or loss of allergen tolerance in different allergic diseases, although they still have been little explored.
    MeSH term(s) Animals ; B-Lymphocytes, Regulatory/physiology ; Disease Models, Animal ; Humans ; Hypersensitivity/immunology ; Immune Tolerance
    Language Spanish
    Publishing date 2019-01-02
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 639125-4
    ISSN 0002-5151
    ISSN 0002-5151
    DOI 10.29262/ram.v65i4.529
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 488: Show issues Location:
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  6. Article ; Online: Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients.

    Páez-Franco, José C / Torres-Ruiz, Jiram / Sosa-Hernández, Víctor A / Cervantes-Díaz, Rodrigo / Romero-Ramírez, Sandra / Pérez-Fragoso, Alfredo / Meza-Sánchez, David E / Germán-Acacio, Juan Manuel / Maravillas-Montero, José L / Mejía-Domínguez, Nancy R / Ponce-de-León, Alfredo / Ulloa-Aguirre, Alfredo / Gómez-Martín, Diana / Llorente, Luis

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 6350

    Abstract: We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid ... ...

    Abstract We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.
    MeSH term(s) Adult ; Amino Acids/metabolism ; COVID-19/metabolism ; Case-Control Studies ; Female ; Homeostasis ; Humans ; Male ; Metabolomics ; Middle Aged ; Mitochondria/metabolism ; Oxygen/metabolism
    Chemical Substances Amino Acids ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-03-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85788-0
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  7. Article ; Online: Severe COVID-19 is marked by dysregulated serum levels of carboxypeptidase A3 and serotonin.

    Soria-Castro, Rodolfo / Meneses-Preza, Yatsiri G / Rodríguez-López, Gloria M / Romero-Ramírez, Sandra / Sosa-Hernández, Víctor A / Cervantes-Díaz, Rodrigo / Pérez-Fragoso, Alfredo / Torres-Ruíz, José J / Gómez-Martín, Diana / Campillo-Navarro, Marcia / Álvarez-Jiménez, Violeta D / Pérez-Tapia, Sonia M / Chávez-Blanco, Alma D / Estrada-Parra, Sergio / Maravillas-Montero, José L / Chacón-Salinas, Rommel

    Journal of leukocyte biology

    2021  Volume 110, Issue 3, Page(s) 425–431

    Abstract: The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of ... ...

    Abstract The immune response plays a critical role in the pathophysiology of SARS-CoV-2 infection ranging from protection to tissue damage and all occur in the development of acute respiratory distress syndrome (ARDS). ARDS patients display elevated levels of inflammatory cytokines and innate immune cells, and T and B cell lymphocytes have been implicated in this dysregulated immune response. Mast cells are abundant resident cells of the respiratory tract and are able to release different inflammatory mediators rapidly following stimulation. Recently, mast cells have been associated with tissue damage during viral infections, but their role in SARS-CoV-2 infection remains unclear. In this study, we examined the profile of mast cell activation markers in the serum of COVID-19 patients. We noticed that SARS-CoV-2-infected patients showed increased carboxypeptidase A3 (CPA3) and decreased serotonin levels in their serum when compared with symptomatic SARS-CoV-2-negative patients. CPA3 levels correlated with C-reactive protein, the number of circulating neutrophils, and quick SOFA. CPA3 in serum was a good biomarker for identifying severe COVID-19 patients, whereas serotonin was a good predictor of SARS-CoV-2 infection. In summary, our results show that serum CPA3 and serotonin levels are relevant biomarkers during SARS-CoV-2 infection. This suggests that mast cells and basophils are relevant players in the inflammatory response in COVID-19 and may represent targets for therapeutic intervention.
    MeSH term(s) Biomarkers/analysis ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/metabolism ; COVID-19/virology ; Carboxypeptidases A/metabolism ; Humans ; Inflammation/diagnosis ; Inflammation/etiology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Mast Cells/immunology ; Mast Cells/pathology ; SARS-CoV-2/isolation & purification ; Serotonin/metabolism ; Severity of Illness Index
    Chemical Substances Biomarkers ; Inflammation Mediators ; Serotonin (333DO1RDJY) ; CPA3 protein, human (EC 3.4.17.1) ; Carboxypeptidases A (EC 3.4.17.1)
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4HI0221-087R
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 603: Show issues Location:
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  8. Article ; Online: Redefining COVID-19 Severity and Prognosis: The Role of Clinical and Immunobiotypes.

    Torres-Ruiz, Jiram / Pérez-Fragoso, Alfredo / Maravillas-Montero, José Luis / Llorente, Luis / Mejía-Domínguez, Nancy R / Páez-Franco, José Carlos / Romero-Ramírez, Sandra / Sosa-Hernández, Victor Andrés / Cervantes-Díaz, Rodrigo / Absalón-Aguilar, Abdiel / Nuñez-Aguirre, Miroslava / Juárez-Vega, Guillermo / Meza-Sánchez, David / Kleinberg-Bid, Ari / Hernández-Gilsoul, Thierry / Ponce-de-León, Alfredo / Gómez-Martín, Diana

    Frontiers in immunology

    2021  Volume 12, Page(s) 689966

    Abstract: Background: Most of the explanatory and prognostic models of COVID-19 lack of a comprehensive assessment of the wide COVID-19 spectrum of abnormalities. The aim of this study was to unveil novel biological features to explain COVID-19 severity and ... ...

    Abstract Background: Most of the explanatory and prognostic models of COVID-19 lack of a comprehensive assessment of the wide COVID-19 spectrum of abnormalities. The aim of this study was to unveil novel biological features to explain COVID-19 severity and prognosis (death and disease progression).
    Methods: A predictive model for COVID-19 severity in 121 patients was constructed by ordinal logistic regression calculating odds ratio (OR) with 95% confidence intervals (95% CI) for a set of clinical, immunological, metabolomic, and other biological traits. The accuracy and calibration of the model was tested with the area under the curve (AUC), Somer's D, and calibration plot. Hazard ratios with 95% CI for adverse outcomes were calculated with a Cox proportional-hazards model.
    Results: The explanatory variables for COVID-19 severity were the body mass index (BMI), hemoglobin, albumin, 3-Hydroxyisovaleric acid, CD8+ effector memory T cells, Th1 cells, low-density granulocytes, monocyte chemoattractant protein-1, plasma TRIM63, and circulating neutrophil extracellular traps. The model showed an outstanding performance with an optimism-adjusted AUC of 0.999, and Somer's D of 0.999. The predictive variables for adverse outcomes in COVID-19 were severe and critical disease diagnosis, BMI, lactate dehydrogenase, Troponin I, neutrophil/lymphocyte ratio, serum levels of IP-10, malic acid, 3, 4 di-hydroxybutanoic acid, citric acid, myoinositol, and cystine.
    Conclusions: Herein, we unveil novel immunological and metabolomic features associated with COVID-19 severity and prognosis. Our models encompass the interplay among innate and adaptive immunity, inflammation-induced muscle atrophy and hypoxia as the main drivers of COVID-19 severity.
    MeSH term(s) Adult ; Blood Coagulation ; Body Mass Index ; COVID-19/blood ; COVID-19/immunology ; COVID-19/metabolism ; Cytokines/blood ; Extracellular Traps/immunology ; Female ; Hemoglobins/analysis ; Humans ; Male ; Metabolome ; Middle Aged ; Muscular Atrophy ; Neutrophils/immunology ; Phenotype ; Prognosis ; SARS-CoV-2 ; Serum Albumin, Human/analysis ; Severity of Illness Index ; T-Lymphocytes/immunology ; Valerates/blood
    Chemical Substances Cytokines ; Hemoglobins ; Valerates ; beta-hydroxyisovaleric acid (3F752311CD) ; Serum Albumin, Human (ZIF514RVZR)
    Language English
    Publishing date 2021-09-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.689966
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  9. Article ; Online: Novel clinical and immunological features associated with persistent post-acute sequelae of COVID-19 after six months of follow-up: a pilot study.

    Torres-Ruiz, Jiram / Lomelín-Gascón, Julieta / Lira Luna, Jaquelin / Vargas-Castro, Ana Sofia / Pérez-Fragoso, Alfredo / Nuñez-Aguirre, Miroslava / Alcalá-Carmona, Beatriz / Absalón-Aguilar, Abdiel / Balderas-Miranda, Jennifer T / Maravillas-Montero, José Luis / Mejía-Domínguez, Nancy R / Núñez-Álvarez, Carlos / Llorente, Luis / Romero-Ramírez, Sandra / Sosa-Hernández, Victor Andrés / Cervantes-Díaz, Rodrigo / Juárez-Vega, Guillermo / Meza-Sánchez, David / Rull-Gabayet, Marina /
    Martínez-Juárez, Luis Alberto / Morales, Linda / López-López, Lizeth Naomi / Negrete-Trujillo, José Adrián / Falcón-Lezama, Jorge Abelardo / Valdez-Vázquez, Rafael Ricardo / Gallardo-Rincón, Héctor / Tapia-Conyer, Roberto / Gómez-Martín, Diana

    Infectious diseases (London, England)

    2023  Volume 55, Issue 4, Page(s) 243–254

    Abstract: Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study.: Methods: A cohort study of 102 COVID-19 patients was conducted. The post- ... ...

    Abstract Background: Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study.
    Methods: A cohort study of 102 COVID-19 patients was conducted. The post-COVID-19 symptoms were assessed by a standardised questionnaire. Lymphocyte immunophenotyping was performed by flow cytometry and chemokines/cytokines, neutrophil extracellular traps, the tripartite motif 63, anti-cellular, and anti-SARS-CoV-2 IgG antibodies were addressed in serum. The primary outcome was the persistence of post-COVID-19 syndrome after six months follow-up.
    Results: Thirteen patients (12.7%) developed the primary outcome and had a more frequent history of post-COVID-19 syndrome 3 months after infection onset (
    Conclusion: Our data suggest an important relationship between a pro-inflammatory state mediated through metabolic pathways related to obesity and increased cellular senescence as a key element in the persistence of post-COVID-19 syndrome at six months of follow-up.
    MeSH term(s) Humans ; COVID-19/complications ; Pilot Projects ; Post-Acute COVID-19 Syndrome ; CD8-Positive T-Lymphocytes ; Cohort Studies ; Chemokine CXCL10 ; Obesity
    Chemical Substances Chemokine CXCL10
    Language English
    Publishing date 2023-01-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2839775-7
    ISSN 2374-4243 ; 2374-4235
    ISSN (online) 2374-4243
    ISSN 2374-4235
    DOI 10.1080/23744235.2022.2158217
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients.

    Sosa-Hernández, Víctor A / Torres-Ruíz, Jiram / Cervantes-Díaz, Rodrigo / Romero-Ramírez, Sandra / Páez-Franco, José C / Meza-Sánchez, David E / Juárez-Vega, Guillermo / Pérez-Fragoso, Alfredo / Ortiz-Navarrete, Vianney / Ponce-de-León, Alfredo / Llorente, Luis / Berrón-Ruiz, Laura / Mejía-Domínguez, Nancy R / Gómez-Martín, Diana / Maravillas-Montero, José L

    Frontiers in immunology

    2020  Volume 11, Page(s) 611004

    Abstract: Background: SARS-CoV-2 infection represents a global health problem that has affected millions of people. The fine host immune response and its association with the disease course have not yet been fully elucidated. Consequently, we analyze circulating ... ...

    Abstract Background: SARS-CoV-2 infection represents a global health problem that has affected millions of people. The fine host immune response and its association with the disease course have not yet been fully elucidated. Consequently, we analyze circulating B cell subsets and their possible relationship with COVID-19 features and severity.
    Methods: Using a multiparametric flow cytometric approach, we determined B cell subsets frequencies from 52 COVID-19 patients, grouped them by hierarchical cluster analysis, and correlated their values with clinical data.
    Results: The frequency of CD19
    Conclusions: The severity of COVID-19 is accompanied by changes in the B cell subpopulations, either immature or terminally differentiated. Furthermore, the existing relationship of B cell subset frequencies with clinical and laboratory parameters suggest that these lymphocytes could serve as potential biomarkers and even active participants in the adaptive antiviral response mounted against SARS-CoV-2.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocyte Subsets/pathology ; COVID-19/blood ; COVID-19/immunology ; COVID-19/pathology ; Female ; Flow Cytometry ; Humans ; Male ; Middle Aged ; SARS-CoV-2/immunology ; SARS-CoV-2/metabolism ; Severity of Illness Index
    Language English
    Publishing date 2020-12-03
    Publishing country Switzerland
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.611004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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