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Article ; Online: Prehabilitation: tertiary prevention matters.

Driessens, Heleen / Wijma, Allard G / Buis, Carlijn I / Nijkamp, Maarten W / Nieuwenhuijs-Moeke, Gertrude J / Klaase, Joost M

The British journal of surgery

2024 Volume 111, Issue 3

MeSH term(s)	Humans ; Preoperative Exercise ; Tertiary Prevention
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2985-3
ISSN	1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
ISSN (online)	1365-2168
ISSN	0263-1202 ; 0007-1323 ; 1355-7688
DOI	10.1093/bjs/znae028
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Article ; Online: Pro-Con Debate: Should All General Anesthesia Be Done Using Target-Controlled Propofol Infusion Guided by Objective Monitoring of Depth of Anesthesia?

Schnider, Thomas W / Nieuwenhuijs-Moeke, Gertrude J / Beck-Schimmer, Beatrice / Hemmerling, Thomas M

Anesthesia and analgesia

2023 Volume 137, Issue 3, Page(s) 565–575

Abstract: In this Pro-Con commentary article, we discuss whether all general anesthesia should be done using target-controlled propofol anesthesia guided by monitoring of depth of anesthesia. This is an ongoing debate since more than 25 years, representing a ... ...

Abstract	In this Pro-Con commentary article, we discuss whether all general anesthesia should be done using target-controlled propofol anesthesia guided by monitoring of depth of anesthesia. This is an ongoing debate since more than 25 years, representing a scientific, cultural as well as geographical divide in the anesthesia community. The Pro side argues that total intravenous anesthesia causes less postoperative nausea and higher patient satisfaction than anesthesia using volatile anesthetics. Target-controlled infusion (TCI) of anesthetic agents allows for better titration of intravenous anesthesia using pharmacokinetic models. Processed EEG monitors, such as bispectral index monitoring, allows for better assessing the effect of TCI anesthesia than solely assessment of clinical parameters, such as ECG or blood pressure. The combination of TCI propofol and objective depth of anesthesia monitoring allows creating a pharmacokinetic-pharmacodynamic profile for each patient. Finally, anesthesia using volatile anesthetics poses health risks for healthcare professionals and contributes to greenhouse effect. The Con side argues that for procedures accompanied with ischemia and reperfusion injury of an organ or tissue and for patients suffering from a severe inflammation' the use of volatile anesthetics might well have its advantages above propofol. In times of sudden shortage of drugs, volatile anesthetics can overcome the restriction in the operating theater or even on the intensive care unit, which is another advantage. Volatile anesthetics can be used for induction of anesthesia when IV access is impossible, end-tidal measurements of volatile anesthetic concentration allows confirmation that patients receive anesthetics. Taking environmental considerations into account, both propofol and volatile anesthetics bear certain harm to the environment, be it as waste product or as greenhouse gases. The authors therefore suggest to carefully considering advantages and disadvantages for each patient in its according environment. A well-balanced choice based on the available literature is recommended. The authors recommend careful consideration of advantages and disadvantages of each technique when tailoring an anesthetic to meet patient needs. Where appropriate, anesthesia providers are encouraged to account for unique features of anesthetic drug behavior, patient-reported and observed postoperative outcomes, and economic and environmental considerations when choosing any of the 2 described techniques.
MeSH term(s)	Humans ; Propofol/adverse effects ; Anesthesia, General/adverse effects ; Anesthesia, Intravenous/adverse effects ; Postoperative Nausea and Vomiting ; Blood Pressure
Chemical Substances	Propofol (YI7VU623SF)
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	80032-6
ISSN	1526-7598 ; 0003-2999
ISSN (online)	1526-7598
ISSN	0003-2999
DOI	10.1213/ANE.0000000000006293
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Article ; Online: Timing of renal replacement therapy in acute kidney injury: case closed?

Nieuwenhuijs-Moeke, Gertrude J / Sanders, Jan Stephan F

Lancet (London, England)

2020 Volume 395, Issue 10235, Page(s) 1465–1467

MeSH term(s)	Acute Kidney Injury ; Humans ; Renal Replacement Therapy
Language	English
Publishing date	2020-04-23
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(20)30805-9
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Article ; Online: Molecular Aspects of Volatile Anesthetic-Induced Organ Protection and Its Potential in Kidney Transplantation.

Nieuwenhuijs-Moeke, Gertrude J / Bosch, Dirk J / Leuvenink, Henri G D

International journal of molecular sciences

2021 Volume 22, Issue 5

Abstract: Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion ... ...

Abstract	Ischemia reperfusion injury (IRI) is inevitable in kidney transplantation and negatively impacts graft and patient outcome. Reperfusion takes place in the recipient and most of the injury following ischemia and reperfusion occurs during this reperfusion phase; therefore, the intra-operative period seems an attractive window of opportunity to modulate IRI and improve short- and potentially long-term graft outcome. Commonly used volatile anesthetics such as sevoflurane and isoflurane have been shown to interfere with many of the pathophysiological processes involved in the injurious cascade of IRI. Therefore, volatile anesthetic (VA) agents might be the preferred anesthetics used during the transplantation procedure. This review highlights the molecular and cellular protective points of engagement of VA shown in in vitro studies and in vivo animal experiments, and the potential translation of these results to the clinical setting of kidney transplantation.
MeSH term(s)	Anesthetics, Inhalation/therapeutic use ; Animals ; Humans ; Isoflurane/therapeutic use ; Kidney/metabolism ; Kidney Transplantation ; Reperfusion Injury/prevention & control ; Sevoflurane/therapeutic use
Chemical Substances	Anesthetics, Inhalation ; Sevoflurane (38LVP0K73A) ; Isoflurane (CYS9AKD70P)
Language	English
Publishing date	2021-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22052727
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Article ; Online: Pathophysiological Changes in the Hemostatic System and Antithrombotic Management in Kidney Transplant Recipients.

van den Berg, Tamar A J / Nieuwenhuijs-Moeke, Gertrude J / Lisman, Ton / Moers, Cyril / Bakker, Stephan J L / Pol, Robert A

Transplantation

2023 Volume 107, Issue 6, Page(s) 1248–1257

Abstract: Nowadays, the main cause for early graft loss is renal graft thrombosis because kidney transplant outcomes have improved drastically owing to advances in immunological techniques and immunosuppression. However, data regarding the efficacy of ... ...

Abstract	Nowadays, the main cause for early graft loss is renal graft thrombosis because kidney transplant outcomes have improved drastically owing to advances in immunological techniques and immunosuppression. However, data regarding the efficacy of antithrombotic therapy in the prevention of renal graft thrombosis are scarce. Adequate antithrombotic management requires a good understanding of the pathophysiological changes in the hemostatic system in patients with end-stage kidney disease (ESKD). Specifically, ESKD and dialysis disrupt the fine balance between pro- and anticoagulation in the body, and further changes in the hemostatic system occur during kidney transplantation. Consequently, kidney transplant recipients paradoxically are at risk for both thrombosis and bleeding. This overview focuses on the pathophysiological changes in hemostasis in ESKD and kidney transplantation and provides a comprehensive summary of the current evidence for antithrombotic management in (adult) kidney transplant recipients.
MeSH term(s)	Adult ; Humans ; Kidney Transplantation/adverse effects ; Fibrinolytic Agents ; Hemostatics ; Kidney Failure, Chronic/etiology ; Thrombosis/complications ; Hemostasis
Chemical Substances	Fibrinolytic Agents ; Hemostatics
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004452
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Association between anaesthesia-related factors and postoperative neurocognitive disorder: a post-hoc analysis.

Stern, Manon / Nieuwenhuijs-Moeke, Gertrude J / Absalom, Anthony / van Leeuwen, Barbara / van der Wal-Huisman, Hanneke / Plas, Matthijs / Bosch, Dirk J

BMC anesthesiology

2023 Volume 23, Issue 1, Page(s) 368

Abstract: Background: Postoperative neurocognitive disorder (pNCD) is common after surgery. Exposure to anaesthetic drugs has been implicated as a potential cause of pNCD. Although several studies have investigated risk factors for the development of cognitive ... ...

Abstract	Background: Postoperative neurocognitive disorder (pNCD) is common after surgery. Exposure to anaesthetic drugs has been implicated as a potential cause of pNCD. Although several studies have investigated risk factors for the development of cognitive impairment in the early postoperative phase, risk factors for pNCD at 3 months have been less well studied. The aim of this study was to identify potential anaesthesia-related risk factors for pNCD at 3 months after surgery. Methods: We analysed data obtained for a prospective observational study in patients aged ≥ 65 years who underwent surgery for excision of a solid tumour. Cognitive function was assessed preoperatively and at 3 months postoperatively using 5 neuropsychological tests. Postoperative NCD was defined as a postoperative decline of ≥ 25% relative to baseline in ≥ 2 tests. The association between anaesthesia-related factors (type of anaesthesia, duration of anaesthesia, agents used for induction and maintenance of anaesthesia and analgesia, the use of additional vasoactive medication, depth of anaesthesia [bispectral index] and mean arterial pressure) and pNCD was analysed using logistic regression analyses. Furthermore, the relation between anaesthesia-related factors and change in cognitive test scores expressed as a continuous variable was analysed using a z-score. Results: Of the 196 included patients, 23 (12%) fulfilled the criteria for pNCD at 3 months postoperatively. A low preoperative score on Mini-Mental State Examination (OR, 8.9 [95% CI, (2.8-27.9)], p < 0.001) and a longer duration of anaesthesia (OR, 1.003 [95% CI, (1.001-1.005)], p = 0.013) were identified as risk factors for pNCD. On average, patients scored higher on postoperative tests (mean z-score 2.35[± 3.13]). Conclusion: In this cohort, duration of anaesthesia, which is probably an expression of the complexity of the surgery, was the only anaesthesia-related predictor of pNCD. On average, patients' scores on cognitive tests improved postoperatively.
MeSH term(s)	Humans ; Postoperative Complications/etiology ; Anesthesia/adverse effects ; Neurocognitive Disorders/etiology ; Cognitive Dysfunction/chemically induced ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Neuropsychological Tests
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-023-02318-3
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Article ; Online: Mild and deep hypothermia differentially affect cerebral neuroinflammatory and cold shock response following cardiopulmonary bypass in rat.

Stern, Manon / Kok, Wendelinde F / Doorduin, Janine / Jongman, Rianne M / Jainandunsing, Jayant / Nieuwenhuijs-Moeke, Gertrude J / Absalom, Anthony R / Henning, R H / Bosch, Dirk J

Brain, behavior, and immunity

2024 Volume 119, Page(s) 96–104

Abstract: Introduction: Targeted temperature management (TTM) is considered to be a neuroprotective strategy during cardiopulmonary bypass (CPB) assisted procedures, possibly through the activation of cold shock proteins. We therefore investigated the effects of ... ...

Abstract	Introduction: Targeted temperature management (TTM) is considered to be a neuroprotective strategy during cardiopulmonary bypass (CPB) assisted procedures, possibly through the activation of cold shock proteins. We therefore investigated the effects of mild compared with deep hypothermia on the neuroinflammatory response and cold shock protein expression after CPB in rats. Methods: Wistar rats were subjected to 1 hr of mild (33 °C) or deep (18 °C) hypothermia during CPB or sham procedure. PET scan analyses using TSPO ligand [ Results: In both groups target temperature was reached within an hour. Standard uptake values (SUV) of [ Conclusions: TTM at 18 °C increased the neuroinflammatory response in amygdala and hippocampus compared to TTM at 33 °C in rats undergoing a CPB procedure. Additionally, TTM at 33 °C induced increased expression of TrkB and RBM3 in cortex and hippocampus of rats on CPB compared to TTM at 18 °C. Together, these data indicate that neuroinflammation is alleviated by TTM at 33 °C, possibly by recruiting protective mechanisms through cold shock protein induction.
Language	English
Publishing date	2024-03-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	639219-2
ISSN	1090-2139 ; 0889-1591
ISSN (online)	1090-2139
ISSN	0889-1591
DOI	10.1016/j.bbi.2024.03.046
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Zs.A 2276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 327: Show issues

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Article ; Online: Kidney Transplantation Improves Health-Related Quality of Life in Older Recipients.

de Boer, Silke E / Knobbe, Tim J / Kremer, Daan / van Munster, Barbara C / Nieuwenhuijs-Moeke, Gertrude J / Pol, Robert A / Bakker, Stephan J L / Berger, Stefan P / Sanders, Jan Stephan F

Transplant international : official journal of the European Society for Organ Transplantation

2024 Volume 37, Page(s) 12071

Abstract: Kidney transplantation is the best treatment for kidney failure in older patients. However, little is known regarding changes in health-related quality of life (HRQoL) from before to after transplantation and determinants of HRQoL in older kidney ... ...

Abstract	Kidney transplantation is the best treatment for kidney failure in older patients. However, little is known regarding changes in health-related quality of life (HRQoL) from before to after transplantation and determinants of HRQoL in older kidney transplant recipients (KTR). We studied both, using data of older (≥65 years) patients waitlisted for kidney transplantation and older KTR 1 year after transplantation from the TransplantLines Biobank and Cohort Study. HRQoL was assessed using the SF-36 questionnaire. We included 145 older waitlisted patients (68% male, age 70 ± 4 years) and 115 older KTR at 1 year after transplantation (73% male, age 70 ± 4 years). Both mental (48.5 ± 8.4 versus 51.2 ± 7.7,
MeSH term(s)	Humans ; Kidney Transplantation ; Quality of Life ; Male ; Female ; Aged ; Waiting Lists ; Surveys and Questionnaires ; Cohort Studies ; Transplant Recipients/psychology ; Kidney Failure, Chronic/surgery
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2024.12071
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Article ; Online: Sevoflurane, a sigh of relief in COVID-19?

Nieuwenhuijs-Moeke, Gertrude J / Jainandunsing, Jayant S / Struys, Michel M R F

British journal of anaesthesia

2020 Volume 125, Issue 2, Page(s) 118–121

MeSH term(s)	Anesthetics, Inhalation/administration & dosage ; COVID-19 ; Conscious Sedation/methods ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Respiration, Artificial/adverse effects ; Respiration, Artificial/methods ; Respiratory Distress Syndrome ; Sevoflurane/administration & dosage
Chemical Substances	Anesthetics, Inhalation ; Sevoflurane (38LVP0K73A)
Keywords	covid19
Language	English
Publishing date	2020-05-01
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	80074-0
ISSN	1471-6771 ; 0007-0912
ISSN (online)	1471-6771
ISSN	0007-0912
DOI	10.1016/j.bja.2020.04.076
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Article ; Online: Ex Vivo Optimization of Donor Lungs with Inhaled Sevoflurane during Normothermic Ex Vivo Lung Perfusion (VITALISE): A Pilot and Feasibility Study in Sheep.

Steinkühler, Timo / Yang, Shuqi / Hu, Michiel A / Jainandunsing, Jayant S / Jager, Neeltina M / Erasmus, Michiel E / Struys, Michel M R F / Bosch, Dirk J / van Meurs, Matijs / Jabaudon, Matthieu / Richard, Damien / Timens, Wim / Leuvenink, Henri G D / Nieuwenhuijs-Moeke, Gertrude J

International journal of molecular sciences

2024 Volume 25, Issue 4

Abstract: Volatile anesthetics have been shown in different studies to reduce ischemia reperfusion injury (IRI). Ex vivo lung perfusion (EVLP) facilitates graft evaluation, extends preservation time and potentially enables injury repair and improvement of lung ... ...

Abstract	Volatile anesthetics have been shown in different studies to reduce ischemia reperfusion injury (IRI). Ex vivo lung perfusion (EVLP) facilitates graft evaluation, extends preservation time and potentially enables injury repair and improvement of lung quality. We hypothesized that ventilating lungs with sevoflurane during EVLP would reduce lung injury and improve lung function. We performed a pilot study to test this hypothesis in a slaughterhouse sheep DCD model. Lungs were harvested, flushed and stored on ice for 3 h, after which EVLP was performed for 4 h. Lungs were ventilated with either an FiO
MeSH term(s)	Animals ; Sheep ; Sevoflurane/pharmacology ; Lung Transplantation ; Feasibility Studies ; Pilot Projects ; Organ Preservation ; Lung ; Perfusion
Chemical Substances	Sevoflurane (38LVP0K73A)
Language	English
Publishing date	2024-02-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25042413
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