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  1. Article ; Online: Sex Differences in Respiratory Viral Pathogenesis and Treatments.

    Ursin, Rebecca L / Klein, Sabra L

    Annual review of virology

    2021  Volume 8, Issue 1, Page(s) 393–414

    Abstract: Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 ... ...

    Abstract Biological sex affects the outcome of diverse respiratory viral infections. The pathogenesis of respiratory infections caused by viruses ranging from respiratory syncytial virus to influenza viruses and severe acute respiratory syndrome coronavirus 2 differs between the sexes across the life course. Generally, males are more susceptible to severe outcomes from respiratory viral infections at younger and older ages. During reproductive years (i.e., after puberty and prior to menopause), females are often at greater risk than males for severe outcomes. Pregnancy and biological sex affect the pathogenesis of respiratory viral infections. In addition to sex differences in the pathogenesis of disease, there are consistent sex differences in responses to treatments, with females often developing greater immune responses but experiencing more adverse reactions than males. Animal models provide mechanistic insights into the causes of sex differences in respiratory virus pathogenesis and treatment outcomes, where available.
    MeSH term(s) Age Factors ; Animals ; Female ; Humans ; Male ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/immunology ; Respiratory Tract Infections/therapy ; Respiratory Tract Infections/virology ; Severity of Illness Index ; Sex Characteristics ; Sex Factors ; Virus Physiological Phenomena ; Viruses/classification
    Language English
    Publishing date 2021-06-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2764224-0
    ISSN 2327-0578 ; 2327-056X
    ISSN (online) 2327-0578
    ISSN 2327-056X
    DOI 10.1146/annurev-virology-091919-092720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sex-biased Immune Responses Following SARS-CoV-2 Infection.

    Ursin, Rebecca L / Shapiro, Janna R / Klein, Sabra L

    Trends in microbiology

    2020  Volume 28, Issue 12, Page(s) 952–954

    Abstract: Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the ... ...

    Abstract Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucidating the mechanisms that underlie the male bias in severe disease and death from coronavirus disease 2019 (COVID-19).
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Male ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-10-10
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2020.10.002
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  3. Article ; Online: Single cell RNA-sequencing profiling to improve the translation between human IBD and

    Karmele, Erik P / Moldoveanu, Ana Laura / Kaymak, Irem / Jugder, Bat-Erdene / Ursin, Rebecca L / Bednar, Kyle J / Corridoni, Daniele / Ort, Tatiana

    Frontiers in immunology

    2023  Volume 14, Page(s) 1291990

    Abstract: Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn's Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract. The use of pre-clinical animal models has been invaluable for ... ...

    Abstract Inflammatory bowel disease (IBD) is an umbrella term for two conditions (Crohn's Disease and Ulcerative Colitis) that is characterized by chronic inflammation of the gastrointestinal tract. The use of pre-clinical animal models has been invaluable for the understanding of potential disease mechanisms. However, despite promising results of numerous therapeutics in mouse colitis models, many of these therapies did not show clinical benefits in patients with IBD. Single cell RNA-sequencing (scRNA-seq) has recently revolutionized our understanding of complex interactions between the immune system, stromal cells, and epithelial cells by mapping novel cell subpopulations and their remodeling during disease. This technology has not been widely applied to pre-clinical models of IBD. ScRNA-seq profiling of murine models may provide an opportunity to increase the translatability into the clinic, and to choose the most appropriate model to test hypotheses and novel therapeutics. In this review, we have summarized some of the key findings at the single cell transcriptomic level in IBD, how specific signatures have been functionally validated
    MeSH term(s) Humans ; Animals ; Mice ; Inflammatory Bowel Diseases/therapy ; Inflammatory Bowel Diseases/drug therapy ; Colitis ; Colitis, Ulcerative ; Crohn Disease ; RNA
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Journal Article ; Review ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1291990
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  4. Article ; Online: A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide.

    Crossnohere, Norah L / Anderson, Nicola / Baumhauer, Judith / Calvert, Melanie / Esparza, Rebecca / Gulbransen, Sandi / Haverman, Lotte / Li, Yuchen / Petersen, Carolyn / Retzer, Ameeta / Sidey-Gibbons, Christopher / Stover, Angela M / Thorner, Elissa / Ursin, Garrett / Velikova, Galina / Walker, Elliott Sparkman / Brundage, Michael / Snyder, Claire

    Nature medicine

    2024  

    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Letter
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-024-02909-8
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  5. Article ; Online: Sex-biased Immune Responses Following SARS-CoV-2 Infection

    Ursin, Rebecca L. / Shapiro, Janna R. / Klein, Sabra L.

    Trends in Microbiology

    2020  Volume 28, Issue 12, Page(s) 952–954

    Keywords Microbiology (medical) ; Microbiology ; Virology ; Infectious Diseases ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2020.10.002
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    Zs.A 3738: Show issues Location:
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  6. Article: Sex-biased Immune Responses Following SARS-CoV-2 Infection

    Ursin, Rebecca L / Shapiro, Janna R / Klein, Sabra L

    Trends Microbiol

    Abstract: Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the ... ...

    Abstract Males are disproportionately affected by severe disease and death from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In their recent article, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of disease progression. These findings contribute to elucidating the mechanisms that underlie the male bias in severe disease and death from coronavirus disease 2019 (COVID-19).
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #882775
    Database COVID19

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  7. Article ; Online: Considering how biological sex impacts immune responses and COVID-19 outcomes.

    Scully, Eileen P / Haverfield, Jenna / Ursin, Rebecca L / Tannenbaum, Cara / Klein, Sabra L

    Nature reviews. Immunology

    2020  Volume 20, Issue 7, Page(s) 442–447

    Abstract: A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral ... ...

    Abstract A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with the pathogenesis of other viral infections. Biological sex differences may manifest themselves in susceptibility to infection, early pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation and tissue repair in the resolution of infection. We discuss available sex-disaggregated epidemiological data from the COVID-19 pandemic, introduce sex-differential features of immunity and highlight potential sex differences underlying COVID-19 severity. We propose that sex differences in immunopathogenesis will inform mechanisms of COVID-19, identify points for therapeutic intervention and improve vaccine design and increase vaccine efficacy.
    MeSH term(s) Adaptive Immunity ; Age Factors ; Betacoronavirus/physiology ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/pathology ; Coronavirus Infections/physiopathology ; Female ; Humans ; Interferons/immunology ; Male ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; Severity of Illness Index ; Sex Factors ; Sociological Factors
    Chemical Substances Interferons (9008-11-1)
    Keywords covid19
    Language English
    Publishing date 2020-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-020-0348-8
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    Zs.A 5565: Show issues Location:
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  8. Article ; Online: Biological sex impacts COVID-19 outcomes.

    Klein, Sabra L / Dhakal, Santosh / Ursin, Rebecca L / Deshpande, Sharvari / Sandberg, Kathryn / Mauvais-Jarvis, Franck

    PLoS pathogens

    2020  Volume 16, Issue 6, Page(s) e1008570

    Abstract: The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in ... ...

    Abstract The current novel coronavirus disease 2019 (COVID-19) pandemic is revealing profound differences between men and women in disease outcomes worldwide. In the United States, there has been inconsistent reporting and analyses of male-female differences in COVID-19 cases, hospitalizations, and deaths. We seek to raise awareness about the male-biased severe outcomes from COVID-19, highlighting the mechanistic differences including in the expression and activity of angiotensin-converting enzyme 2 (ACE2) as well as in antiviral immunity. We also highlight how sex differences in comorbidities, which can be associated with both age and race, impact male-biased outcomes from COVID-19.
    MeSH term(s) Angiotensin-Converting Enzyme 2 ; COVID-19 ; Comorbidity ; Coronavirus Infections/epidemiology ; Coronavirus Infections/metabolism ; Coronavirus Infections/physiopathology ; Hospitalization ; Humans ; Pandemics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/physiopathology ; Receptors, Virus/metabolism ; Sex Factors ; United States/epidemiology
    Chemical Substances Receptors, Virus ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Keywords covid19
    Language English
    Publishing date 2020-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7374
    ISSN (online) 1553-7374
    ISSN 1553-7374
    DOI 10.1371/journal.ppat.1008570
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  9. Article ; Online: Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza.

    Vermillion, Meghan S / Ursin, Rebecca L / Attreed, Sarah E / Klein, Sabra L

    Endocrinology

    2018  Volume 159, Issue 9, Page(s) 3306–3320

    Abstract: Estriol (E3) is an endogenous estrogen in females with broad biological activity within diverse tissue types. In the context of certain T-cell-mediated autoimmune inflammatory diseases, E3 can ameliorate disease severity through immunomodulatory ... ...

    Abstract Estriol (E3) is an endogenous estrogen in females with broad biological activity within diverse tissue types. In the context of certain T-cell-mediated autoimmune inflammatory diseases, E3 can ameliorate disease severity through immunomodulatory mechanisms that decrease tissue inflammation. Severe disease caused by influenza A virus (IAV) infection is also characterized by aberrant inflammation and immunopathology. How E3 might affect the pathogenesis of IAV infection, however, has not been explored. Gonadally intact female C57BL/6 mice that were treated with exogenous E3 during infection with mouse-adapted 2009 H1N1 had reduced total pulmonary inflammation and improved disease outcomes compared with females that received no hormone. Furthermore, compared with no hormone treatment, E3 treatment reduced the induction of genes associated with proinflammatory cytokine and chemokine responses in the lungs, which preceded clinical disease, reductions in innate immune cell recruitment, altered pulmonary T-cell skewing, and reduced antibody titers during IAV infection. Although E3 treatment was associated with reduced local and systemic anti-influenza adaptive immune responses, there was no effect of E3 on viral replication or clearance. Together, these data suggest that exogenous E3 confers protection during IAV infection through immunomodulatory mechanisms and that E3 may have broad therapeutic potential in the context of both infectious and noninfectious inflammatory diseases.
    MeSH term(s) Animals ; Chemokines/drug effects ; Chemokines/immunology ; Cytokines/drug effects ; Cytokines/immunology ; Estriol/pharmacology ; Female ; Inflammation/immunology ; Influenza A Virus, H1N1 Subtype/drug effects ; Lung/drug effects ; Lung/immunology ; Mice ; Mice, Inbred C57BL ; Orthomyxoviridae Infections/immunology ; Pneumonia, Viral/immunology ; Severity of Illness Index ; T-Lymphocytes/drug effects ; Virus Replication/drug effects
    Chemical Substances Chemokines ; Cytokines ; Estriol (FB33469R8E)
    Language English
    Publishing date 2018-09-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 427856-2
    ISSN 1945-7170 ; 0013-7227
    ISSN (online) 1945-7170
    ISSN 0013-7227
    DOI 10.1210/en.2018-00486
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  10. Article ; Online: Biological sex affects vaccine efficacy and protection against influenza in mice.

    Fink, Ashley L / Engle, Kyrra / Ursin, Rebecca L / Tang, Wan-Yee / Klein, Sabra L

    Proceedings of the National Academy of Sciences of the United States of America

    2018  Volume 115, Issue 49, Page(s) 12477–12482

    Abstract: Biological sex affects adaptive immune responses, which could impact influenza infection and vaccine efficacy. Infection of mice with 2009 H1N1 induced antibody responses, ... ...

    Abstract Biological sex affects adaptive immune responses, which could impact influenza infection and vaccine efficacy. Infection of mice with 2009 H1N1 induced antibody responses, CD4
    MeSH term(s) Animals ; Female ; Immunity, Humoral ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H1N1 Subtype/immunology ; Influenza Vaccines/immunology ; Male ; Mice ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/prevention & control ; Sex Factors
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2018-11-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1805268115
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