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Article ; Online: Genitourinary cancer neoadjuvant therapies: current and future approaches.

Nair, Sujit S / Chakravarty, Dimple / Patel, Vaibhav / Bhardwaj, Nina / Tewari, Ashutosh K

2023 Volume 9, Issue 12, Page(s) 1041–1057

Abstract: Neoadjuvant therapies can improve tolerability, reduce tumor volume to facilitate surgery, and assess subsequent treatment response. Therefore, there is much enthusiasm for expanding the benefits of cancer therapies to the neoadjuvant setting to reduce ... ...

Abstract	Neoadjuvant therapies can improve tolerability, reduce tumor volume to facilitate surgery, and assess subsequent treatment response. Therefore, there is much enthusiasm for expanding the benefits of cancer therapies to the neoadjuvant setting to reduce recurrence and improve survival in patients with localized or locally advanced genitourinary (GU) cancer. This approach is clinically pertinent because these treatments are administered primarily to treatment-naive patients and can elicit the greatest drug response. In addition, the results are not impacted by other anticancer treatments. While neoadjuvant therapies have been the standard treatment for bladder cancer in the past, they are presently restricted to clinical trials for renal and prostate cancer (PCa); however, changes are imminent. Precision neoadjuvant therapies will be ushered in by biomarker-stratified neoadjuvant trials with appropriate survival endpoints and comprehensive correlative and imaging studies. This review discusses neoadjuvant studies in GU malignancies and how they inform future study design considerations.
MeSH term(s)	Male ; Humans ; Neoadjuvant Therapy ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Chemotherapy, Adjuvant
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2852626-0
ISSN	2405-8025 ; 2405-8033 ; 2405-8033
ISSN (online)	2405-8025 ; 2405-8033
ISSN	2405-8033
DOI	10.1016/j.trecan.2023.07.011
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Article ; Online: Racial disparity in prostate cancer in the African American population with actionable ideas and novel immunotherapies.

Dovey, Zachary S / Nair, Sujit S / Chakravarty, Dimple / Tewari, Ashutosh K

Cancer reports (Hoboken, N.J.)

2021 Volume 4, Issue 5, Page(s) e1340

Abstract: Background: African Americans (AAs) in the United States are known to have a higher incidence and mortality for Prostate Cancer (PCa). The drivers of this epidemiological disparity are multifactorial, including socioeconomic factors leading to lifestyle ...

Abstract	Background: African Americans (AAs) in the United States are known to have a higher incidence and mortality for Prostate Cancer (PCa). The drivers of this epidemiological disparity are multifactorial, including socioeconomic factors leading to lifestyle and dietary issues, healthcare access problems, and potentially tumor biology. Recent findings: Although recent evidence suggests once access is equal, AA men have equal outcomes to Caucasian American (CA) men, differences in PCa incidence remain, and there is much to do to reverse disparities in mortality across the USA. A deeper understanding of these issues, both at the clinical and molecular level, can facilitate improved outcomes in the AA population. This review first discusses PCa oncogenesis in the context of its diverse hallmarks before benchmarking key molecular and genomic differences for PCa in AA men that have emerged in the recent literature. Studies have emphasized the importance of tumor microenvironment that contributes to both the unequal cancer burden and differences in clinical outcome between the races. Management of comorbidities like obesity, hypertension, and diabetes will provide an essential means of reducing prostate cancer incidence in AA men. Although requiring further AA specific research, several new treatment strategies such as immune checkpoint inhibitors used in combination PARP inhibitors and other emerging vaccines, including Sipuleucel-T, have demonstrated some proven efficacy. Conclusion: Genomic profiling to integrate clinical and genomic data for diagnosis, prognosis, and treatment will allow physicians to plan a "Precision Medicine" approach to AA men. There is a pressing need for further research for risk stratification, which may allow early identification of AA men with higher risk disease based on their unique clinical, genomic, and immunological profiles, which can then be mapped to appropriate clinical trials. Treatment options are outlined, with a concise description of recent work in AA specific populations, detailing several targeted therapies, including immunotherapy. Also, a summary of current clinical trials involving AA men is presented, and it is important that policies are adopted to ensure that AA men are actively recruited. Although it is encouraging that many of these explore the lifestyle and educational initiatives and therapeutic interventions, there is much still work to be done to reduce incidence and mortality in AA men and equalize current racial disparities.
MeSH term(s)	African Americans/statistics & numerical data ; Health Services Accessibility ; Health Status Disparities ; Healthcare Disparities ; Humans ; Immunotherapy/methods ; Male ; Prostatic Neoplasms/ethnology ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Socioeconomic Factors ; Whites/statistics & numerical data
Language	English
Publishing date	2021-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2573-8348
ISSN (online)	2573-8348
DOI	10.1002/cnr2.1340
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Article ; Online: Immunotherapy for Metastatic Prostate Cancer: Current and Emerging Treatment Options.

Chakravarty, Dimple / Huang, Li / Kahn, Matthew / Tewari, Ashutosh K

The Urologic clinics of North America

2020 Volume 47, Issue 4, Page(s) 487–510

Abstract: The advent of immunotherapy has revolutionized cancer treatment. Prostate cancer has an immunosuppressive microenvironment and a low tumor mutation burden, resulting in low neoantigen expression. The consensus was that immunotherapy would be less ... ...

Abstract	The advent of immunotherapy has revolutionized cancer treatment. Prostate cancer has an immunosuppressive microenvironment and a low tumor mutation burden, resulting in low neoantigen expression. The consensus was that immunotherapy would be less effective in prostate cancer. However, recent studies have reported that prostate cancer does have a high number of DNA damage and repair gene defects. Immunotherapies that have been tested in prostate cancer so far have been mainly vaccines and checkpoint inhibitors. A combination of genomically targeted therapies, with approaches to alleviate immune response and thereby make the tumor microenvironment immunologically hot, is promising.
MeSH term(s)	Aged ; Animals ; Antigens, Neoplasm/drug effects ; Antigens, Neoplasm/immunology ; Biological Products/administration & dosage ; Cancer Vaccines/administration & dosage ; Forecasting ; Humans ; Immunotherapy/methods ; Male ; Mice ; Middle Aged ; Molecular Targeted Therapy/methods ; Neoplasm Invasiveness/pathology ; Neoplasm Metastasis/genetics ; Neoplasm Metastasis/immunology ; Neoplasm Staging ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/therapy ; Treatment Outcome ; Tumor Microenvironment/drug effects ; Tumor Microenvironment/genetics
Chemical Substances	Antigens, Neoplasm ; Biological Products ; Cancer Vaccines
Language	English
Publishing date	2020-09-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	192293-2
ISSN	1558-318X ; 0094-0143
ISSN (online)	1558-318X
ISSN	0094-0143
DOI	10.1016/j.ucl.2020.07.010
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Article ; Online: Why do African-American men face higher risks for lethal prostate cancer?

Nair, Sujit S / Chakravarty, Dimple / Dovey, Zachary S / Zhang, Xiangfu / Tewari, Ashutosh K

Current opinion in urology

2021 Volume 32, Issue 1, Page(s) 96–101

Abstract: Purpose of review: African-American men in the USA have a higher incidence of and mortality from prostate cancer (PCa), with a longstanding debate about the cause for these worse outcomes. This review examines differences in tumour biology and ... ...

Abstract	Purpose of review: African-American men in the USA have a higher incidence of and mortality from prostate cancer (PCa), with a longstanding debate about the cause for these worse outcomes. This review examines differences in tumour biology and socioeconomics for African-American and Non-Hispanic White (NHW) men to answer the question 'why AA men face higher risks for lethal PCa' and draw a management consensus to redress the imbalance. Recent findings: Recent evidence from over the past 2 years suggests the reasons why African-American men face a higher risk of lethal PCa are multifactorial, with contributions from differences in tumour biology as well as socioeconomic and healthcare access factors. Regarding tumour biology, genomic and transcriptome profiling suggests African-American men have upregulated expression of genes related to inflammatory pathways with downregulation of DNA repair genes. In contrast, NHW men have higher DNA repair pathways and metabolic pathways involving glycolysis and cell cycle activity. In addition, epidemiological evidence suggests equal healthcare access ensures equal PCa specific outcomes, implying African-American men's disease is not inherently more lethal. However, differences in tumour biology remain, which may explain specific differences in PCa incidence and the clinical findings of African-American men's increased response to immunotherapy and radiotherapy in recent trials. Summary: Regardless of racial differences in disease outcomes and the factors causing them, African-American and NHW men seem to have diseases unique to their ancestry. This supports the exploration of personalized PCa treatment approaches, leveraging translational basic science research to uncover these differences and devise specific individualized methods therapeutic regimes to address them.
MeSH term(s)	Black or African American/genetics ; Health Services Accessibility ; Humans ; Immunotherapy ; Male ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy ; White People/genetics
Language	English
Publishing date	2021-11-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/MOU.0000000000000951
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Zs.A 3345: Show issues

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Article: Increased Hospitalization and Mortality from COVID-19 in Prostate Cancer Patients.

Chakravarty, Dimple / Ratnani, Parita / Sobotka, Stanislaw / Lundon, Dara / Wiklund, Peter / Nair, Sujit S / Tewari, Ashutosh K

Cancers

2021 Volume 13, Issue 7

Abstract: Background: Cancer patients with COVID-19 have a poor disease course. Among tumor types, prostate cancer and COVID-19 share several risk factors, and the interaction of prostate cancer and COVID-19 is purported to have an adverse outcome.: Methods: ... ...

Abstract	Background: Cancer patients with COVID-19 have a poor disease course. Among tumor types, prostate cancer and COVID-19 share several risk factors, and the interaction of prostate cancer and COVID-19 is purported to have an adverse outcome. Methods: This was a single-institution retrospective study on 286,609 patients who underwent the COVID-19 test at Mount Sinai Hospital system from March 2020 to December 2020. Chi-square/Fisher's exact tests were used to summarize baseline characteristics of categorical data, and Mann-Whitney U test was used for continuous variables. Univariable logistic regression analysis to compare the hospitalization and mortality rates and the strength of association was obtained by the odds ratio and confidence interval. Results: This study aimed to compare hospitalization and mortality rates between men with COVID-19 and prostate cancer and those who were COVID-19-positive with non-prostate genitourinary malignancy or any solid cancer, and with breast cancer patients. We also compared our studies to others that reported the incidence and severity of COVID-19 in prostate cancer patients. Our studies highlight that patients with prostate cancer had higher susceptibility to COVID-19-related pathogenesis, resulting in higher mortality and hospitalization rates. Hospitalization and mortality rates were higher in prostate cancer patients with COVID-19 when compared with COVID-19 patients with non-prostate genitourinary (GU) malignancies.
Language	English
Publishing date	2021-04-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13071630
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Article ; Online: Impact of diverticular disease on prostate cancer risk among hypertensive men.

Tomer, Nir / Chakravarty, Dimple / Ratnani, Parita / Mohamed, Nihal E / Jambor, Ivan / Dovey, Zachary / Palese, Michael A / Tewari, Ashutosh K

Prostate cancer and prostatic diseases

2021 Volume 25, Issue 4, Page(s) 700–706

Abstract: Introduction: Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk ... ...

Abstract	Introduction: Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa. Methods: Hypertensive patients with DD and hypertensive controls were identified between 1995 and 2010 from the Statewide Planning and Research Cooperative System database. Cohorts were queried for PCa incidence through 2015. Univariable and multivariable logistic regression analyses were used for determining independent predictors of PCa diagnosis. Results: A total of 51,353 patients with DD and 111,541 controls were identified. In all, 6.26% of DD developed PCa, and 3.71% of controls developed PCa (p < 0.01). DD was a significant risk factor for PCa (OR: 1.27 CI: 1.19-1.34, p < 0.01). On subgroup analysis, the patients diagnosed with DD <50 years old had an OR of 3.39 for PCa (CI: 2.52-4.56, p < 0.01), age 50-59 had an OR of 2.12 (CI: 1.86-2.15, p < 0.01), and age 60-69 had an OR of 1.20 (CI: 1.10-1.31, p < 0.01). Finally, age and race stratification showed that white patients <50 had an OR of 2.56 (CI: 1.75-3.76, p < 0.01), while black patients <50 had an OR of 3.98 (CI: 2.61-6.07, p < 0.01). The trend in differing odds between these populations was the same for age groups 50-59 and 60-69. Conclusion: Our analysis shows that DD is associated with diagnosis of PCa in hypertensive men. Importantly, the earlier the diagnosis of DD, the higher the odds for development of PCa, particularly in black men.
MeSH term(s)	Male ; Humans ; Middle Aged ; Aged ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/etiology ; Risk Factors ; Incidence ; Diverticular Diseases ; Chronic Disease
Language	English
Publishing date	2021-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1419277-9
ISSN	1476-5608 ; 1365-7852
ISSN (online)	1476-5608
ISSN	1365-7852
DOI	10.1038/s41391-021-00454-w
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Article ; Online: Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery.

Marron, Thomas U / Galsky, Matthew D / Taouli, Bachir / Fiel, Maria Isabel / Ward, Stephen / Kim, Edward / Yankelevitz, David / Doroshow, Deborah / Guttman-Yassky, Emma / Ungar, Benjamin / Mehandru, Saurabh / Golas, Benjamin J / Labow, Daniel / Sfakianos, John / Nair, Sujit S / Chakravarty, Dimple / Buckstein, Michael / Song, Xiaoyu / Kenigsberg, Effi /

Gnjatic, Sacha / Brown, Brian D / Sparano, Joseph / Tewari, Ashutosh / Schwartz, Myron / Bhardwaj, Nina / Merad, Miriam

Nature medicine

2022 Volume 28, Issue 8, Page(s) 1723

Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-022-01948-3
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Article ; Online: Paid Open Access

DIMPLE SHARMA / DR. RUPAK CHAKRAVARTY

International Journal of Digital Library Services, Vol 2, Iss 1, Pp 96-

A Comparative Study of Selected International Publishers

2012 Volume 134

Abstract: Open Access as emerged as a global movement in the academic sphere providing freeonline access to scholarly literature. Generally author submits a manuscript to the open access journals and after the peer-reviewing and editorial process is over the ... ...

Abstract	Open Access as emerged as a global movement in the academic sphere providing freeonline access to scholarly literature. Generally author submits a manuscript to the open access journals and after the peer-reviewing and editorial process is over the article is published for free access and download. Some publishers have developed a model in which either the author(s) or their parent organization has to pay the open access fee or article processing charges. This paper aims to provide an insight of selected international publishers who have adopted paid open access model. In the data analysis section the facts have been presented in tables and charts focusing on various aspects of paid open access. At the end of the paper some practical recommendations have been made for sustaining and removing the shortcomings of this model.
Keywords	Open Access ; Paid Open Access ; Article Processing Charges ; OA Fee ; Embargo. ; Bibliography. Library science. Information resources ; Z ; DOAJ:Library and Information Science ; DOAJ:Social Sciences
Subject code	306
Language	English
Publishing date	2012-01-01T00:00:00Z
Publisher	International Journal of Digital Library Services
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery.

Gnjatic, Sacha / Brown, Brian D / Sparano, Joseph / Tewari, Ashutosh / Schwartz, Myron / Bhardwaj, Nina / Merad, Miriam

Nature medicine

2022 Volume 28, Issue 4, Page(s) 626–629

MeSH term(s)	Antineoplastic Agents/therapeutic use ; Breast Neoplasms/drug therapy ; Clinical Trials as Topic ; Drug Discovery ; Female ; Humans ; Neoadjuvant Therapy ; Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220066-9
ISSN	1546-170X ; 1078-8956
ISSN (online)	1546-170X
ISSN	1078-8956
DOI	10.1038/s41591-022-01681-x
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Article ; Online: Sex differences in SARS-CoV-2 infection rates and the potential link to prostate cancer

Dimple Chakravarty / Sujit S. Nair / Nada Hammouda / Parita Ratnani / Yasmine Gharib / Vinayak Wagaskar / Nihal Mohamed / Dara Lundon / Zachary Dovey / Natasha Kyprianou / Ashutosh K. Tewari

Communications Biology, Vol 3, Iss 1, Pp 1-

2020 Volume 12

Abstract: Dimple Chakravarty et al. review the rapidly emerging data indicating a higher rate of SARS-CoV-2 ...

Abstract	Dimple Chakravarty et al. review the rapidly emerging data indicating a higher rate of SARS-CoV-2 infection in men. They note that men in the age group most at risk of infection are also at high risk of prostate cancer, and explore the potential links between these diseases and implications for COVID-19 treatment in prostate cancer patients.
Keywords	Biology (General) ; QH301-705.5 ; covid19
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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