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  1. Article ; Online: Eosinophilic annular erythema successfully treated with dupilumab: A case report.

    Okazaki, Toshiki / Takahashi, Takehiro / Asano, Yoshihide

    The Journal of dermatology

    2024  

    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17158
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Sex differences in immune responses.

    Takahashi, Takehiro / Iwasaki, Akiko

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6527, Page(s) 347–348

    MeSH term(s) COVID-19/blood ; COVID-19/immunology ; Cytokines/blood ; Female ; Humans ; Immunity ; Male ; Sex Characteristics ; Sex Factors
    Chemical Substances Cytokines
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abe7199
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  3. Article ; Online: Author's reply.

    Takahashi, Wataru / Morita, Takehiro / Tanaka, Kiu / Ide, Shougo / Fujimori, Kouki

    Journal of cardiology cases

    2022  Volume 26, Issue 2, Page(s) 166–167

    Language English
    Publishing date 2022-04-07
    Publishing country Japan
    Document type Journal Article
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2022.03.004
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  4. Article ; Online: Serum levels of AGGF1: Potential association with cutaneous and cardiopulmonary involvements in systemic sclerosis.

    Takahashi, Takuya / Takahashi, Takehiro / Ikawa, Tetsuya / Terui, Hitoshi / Takahashi, Toshiya / Segawa, Yuichiro / Sumida, Hayakazu / Yoshizaki, Ayumi / Sato, Shinichi / Asano, Yoshihide

    The Journal of dermatology

    2024  

    Abstract: Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms ... ...

    Abstract Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, aberrant immune activation, and extensive tissue fibrosis of the skin and internal organs. Because of the complicated nature of its pathogenesis, the underlying mechanisms of SSc remain incompletely understood. Angiogenic factor with a G-patch domain and a Forkhead-associated domain 1 (AGGF1) is a critical factor in angiogenesis expressed on vascular endothelial cells, associated with inflammatory and fibrotic responses. To elucidate the possible implication of AGGF1 in SSc pathogenesis, we investigated the association between serum AGGF1 levels and clinical manifestations in SSc patients. We conducted a cross-sectional analysis of AGGF1 levels in sera from 60 SSc patients and 19 healthy controls with enzyme-linked immunosorbent assay. Serum AGGF1 levels in SSc patients were significantly higher than those in healthy individuals. In particular, diffuse cutaneous SSc patients with shorter disease duration had higher levels compared to those with longer disease duration and limited cutaneous SSc patients. Patients with higher serum AGGF1 levels had a higher incidence of digital ulcers, higher modified Rodnan Skin Scores (mRSS), elevated serum Krebs von den Lungen-6 (KL-6) levels, C-reactive protein levels, and right ventricular systolic pressures (RVSP) on the echocardiogram, whereas they had reduced percentage of vital capacity (%VC) and percentage of diffusing capacity of the lungs for carbon monoxide (%DLCO) in pulmonary functional tests. In line, serum AGGF1 levels were significantly correlated with mRSS, serum KL-6 and surfactant protein D levels, RVSP, and %DLCO. These results uncovered notable correlations between serum AGGF1 levels and key cutaneous and vascular involvements in SSc, suggesting potential roles of AGGF1 in SSc pathogenesis.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.17233
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  5. Article ; Online: 2,5-Dimethyl-celecoxib induces early termination of inflammatory responses by transient macrophage accumulation and inhibits the progression of cardiac remodeling in a mouse model of cryoinjury-induced myocardial infarction.

    Kishigami, Takehiro / Ishikane, Shin / Arioka, Masaki / Igawa, Kazunobu / Nishimura, Yosuke / Takahashi-Yanaga, Fumi

    Journal of pharmacological sciences

    2024  Volume 154, Issue 2, Page(s) 97–107

    Abstract: In our previous study, we reported that 2, 5-dimethyl-celecoxib (DM-C), a derivative of celecoxib, prevents cardiac remodeling in different mouse models of heart failure, including myocardial infarction (MI). The inflammatory response after MI affects ... ...

    Abstract In our previous study, we reported that 2, 5-dimethyl-celecoxib (DM-C), a derivative of celecoxib, prevents cardiac remodeling in different mouse models of heart failure, including myocardial infarction (MI). The inflammatory response after MI affects the progression of cardiac remodeling, wherein the immune cells, mainly macrophages, play crucial roles. Therefore, we evaluated the effect of DM-C on macrophages in a cryoinjury-induced myocardial infarction (CMI) mouse model. We observed that DM-C attenuated the deterioration of left ventricular ejection fraction and cardiac fibrosis 14 d after CMI. Gene expression of pro-inflammatory cytokines at the infarct site was reduced by DM-C treatment. Analysis of macrophage surface antigens revealed that DM-C induced transient accumulation of macrophages at the infarct site without affecting their polarization. In vitro experiments using peritoneal monocytes/macrophages revealed that DM-C did not directly increase the phagocytic ability of the macrophages but increased their number, thereby upregulating the clearance capacity. Moreover, DM-C rapidly excluded the cells expressing necrotic cell marker from the infarct site. These results suggested that DM-C enhanced the clearance capacity of macrophages by transiently increasing their number at the infarct site, and terminated the escape from the inflammatory phase earlier, thereby suppressing excessive cardiac remodeling and ameliorating cardiac dysfunction.
    MeSH term(s) Animals ; Mice ; Celecoxib/pharmacology ; Celecoxib/therapeutic use ; Stroke Volume ; Ventricular Remodeling ; Ventricular Function, Left ; Myocardial Infarction/drug therapy ; Macrophages ; Disease Models, Animal ; Pyrazoles ; Sulfonamides
    Chemical Substances Celecoxib (JCX84Q7J1L) ; 2,5-dimethylcelecoxib ; Pyrazoles ; Sulfonamides
    Language English
    Publishing date 2024-01-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2104264-0
    ISSN 1347-8648 ; 1347-8613
    ISSN (online) 1347-8648
    ISSN 1347-8613
    DOI 10.1016/j.jphs.2024.01.001
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    Zs.A 237: Show issues Location:
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  6. Article ; Online: Ultralinear 140-GHz FMCW signal generation with optical parametric wideband frequency modulation enabling 1-mm range resolution.

    Ishimura, Shota / Kan, Takashi / Takahashi, Hidenori / Tsuritani, Takehiro / Suzuki, Masatoshi

    Optics express

    2023  Volume 31, Issue 8, Page(s) 13384–13392

    Abstract: We demonstrate ultralinear and ultrawideband frequency-modulated continuous-wave (FMCW) signal generation using an optical parametric wideband frequency modulation (OPWBFM) method. The OPWBFM method optically expands the bandwidths of FMCW signals beyond ...

    Abstract We demonstrate ultralinear and ultrawideband frequency-modulated continuous-wave (FMCW) signal generation using an optical parametric wideband frequency modulation (OPWBFM) method. The OPWBFM method optically expands the bandwidths of FMCW signals beyond the electrical bandwidths of optical modulators via a cascaded four-wave mixing (FWM) process. Compared to the conventional direct modulation approach, the OPWBFM method simultaneously achieves high linearity and a short measurement time of the frequency sweep. On the other hand, it is also known that the OPWBFM method expands the phase noise of idlers as well as their bandwidths if an input conjugate pair has different phase noise. To avoid this phase noise expansion, it is crucial to synchronize the phase of an input complex conjugate pair of an FMCW signal using an optical frequency comb. For demonstration, we successfully generated an ultralinear 140-GHz FMCW signal by using the OPWBFM method. Moreover, we employ a frequency comb in the conjugate pair generation process, leading to the mitigation of phase noise expansion. By using a 140-GHz FMCW signal, we achieve a range resolution of ∼1 mm through fiber-based distance measurement. The results show the feasibility of an ultralinear and ultrawideband FMCW system with a sufficiently short measurement time.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.485140
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  7. Article ; Online: Psychosis treatment in a patient with Parkinsonian type multiple system atrophy using modified electroconvulsive therapy: a case report.

    Yawata, Takumi / Takagi, Shunsuke / Tamura, Takehiro / Sugihara, Genichi / Takahashi, Hidehiko

    Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society

    2022  Volume 23, Issue 2, Page(s) 364–367

    MeSH term(s) Humans ; Multiple System Atrophy ; Electroconvulsive Therapy ; Psychotic Disorders ; Parkinson Disease ; Patients
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Case Reports
    ZDB-ID 2213105-X
    ISSN 1479-8301 ; 1346-3500
    ISSN (online) 1479-8301
    ISSN 1346-3500
    DOI 10.1111/psyg.12923
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  8. Article: Atezolizumab-related sclerosing cholangitis with multiple liver abscesses in a patient with lung squamous cell carcinoma: A case report.

    Jingu, Daisuke / Horii, Akira / Yajima, Takehiro / Ohira, Ryuta / Ubukata, Satoshi / Satou, Kosuke / Takahashi, Hiroshi / Watanabe, Hiroshi / Funayama, Hiroyuki

    Respirology case reports

    2024  Volume 12, Issue 3, Page(s) e01324

    Abstract: A 76-year-old man underwent an operation for lung squamous cell carcinoma in the right lower lobe, followed by initial adjuvant therapy with atezolizumab, an antibody against anti-programmed death-ligand 1 (PD-L1). On day 4 after atezolizumab treatment, ... ...

    Abstract A 76-year-old man underwent an operation for lung squamous cell carcinoma in the right lower lobe, followed by initial adjuvant therapy with atezolizumab, an antibody against anti-programmed death-ligand 1 (PD-L1). On day 4 after atezolizumab treatment, the patient developed general malaise and fatigue. He was diagnosed with atezolizumab-induced sclerosing cholangitis. Steroid treatment was started, and patient's condition, including symptoms, laboratory data and imaging findings, improved. Antibiotic treatments were ended on day 40, and the steroid dose was gradually reduced. Multiple liver abscesses were observed on day 106, and another treatment with antibiotics became necessary. The patient eventually recovered from liver abscesses. Sclerosing cholangitis induced by immune checkpoint inhibitor is rare, and the long-term clinical data about this adverse effect is limited. Hence, we think it is important to raise an alarm over sclerosing cholangitis coupled with liver abscesses after immunosuppressive therapy.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2750180-2
    ISSN 2051-3380
    ISSN 2051-3380
    DOI 10.1002/rcr2.1324
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  9. Article ; Online: Discovery of a Plant 14-3-3 Inhibitor Possessing Isoform Selectivity and In Planta Activity.

    Nishiyama, Kotaro / Aihara, Yusuke / Suzuki, Takehiro / Takahashi, Koji / Kinoshita, Toshinori / Dohmae, Naoshi / Sato, Ayato / Hagihara, Shinya

    Angewandte Chemie (International ed. in English)

    2024  , Page(s) e202400218

    Abstract: Synthetic modulators for plant 14-3-3s are promising chemical tools both for understanding the 14-3-3-related signaling pathways and controlling plant physiology. Here, we describe a novel small-molecule inhibitor for 14-3-3 proteins ofArabidopsis ... ...

    Abstract Synthetic modulators for plant 14-3-3s are promising chemical tools both for understanding the 14-3-3-related signaling pathways and controlling plant physiology. Here, we describe a novel small-molecule inhibitor for 14-3-3 proteins ofArabidopsis thaliana. The inhibitor was identified from unexpected products in DMSO stock solution of an in-house chemical library. Mass spectroscopy, mutant-based analyses, fluorescence polarization assays, and thermal shift assaysrevealed that the inhibitor covalently binds to an allosteric site of 14-3-3 with isoform selectivity. Moreover, infiltration of the inhibitor to Arabidopsis leaves suppressed the stomatal aperture. The inhibitor should provide a new insight into the design of potent and isoform-selective 14-3-3 modulators.
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202400218
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  10. Article ; Online: Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C-mannosylation.

    Yoshimoto, Satoshi / Suzuki, Takehiro / Otani, Naoki / Takahashi, Daisuke / Toshima, Kazunobu / Dohmae, Naoshi / Simizu, Siro

    FEBS open bio

    2023  Volume 13, Issue 3, Page(s) 490–499

    Abstract: C-mannosylation is a rare type of protein glycosylation whereby a single mannose is added to the first tryptophan in the consensus sequence Trp-Xaa-Xaa-Trp/Cys (in which Xaa represents any amino acid). Its consensus sequence is mainly found in proteins ... ...

    Abstract C-mannosylation is a rare type of protein glycosylation whereby a single mannose is added to the first tryptophan in the consensus sequence Trp-Xaa-Xaa-Trp/Cys (in which Xaa represents any amino acid). Its consensus sequence is mainly found in proteins containing a thrombospondin type-1 repeat (TSR1) domain and in type I cytokine receptors. In these proteins, C-mannosylation affects protein secretion, intracellular localization, and protein stability; however, the role of C-mannosylation in proteins that are not type I cytokine receptors and/or do not contain a TSR1 domain is less well explored. In this study, we focused on human vitelline membrane outer layer protein 1 homolog (VMO1). VMO1, which possesses two putative C-mannosylation sites, is a 21-kDa secreted protein that does not contain a TSR1 domain and is not a type I cytokine receptor. Mass spectrometry analyses revealed that VMO1 is C-mannosylated at Trp
    MeSH term(s) Humans ; Glycosylation ; Mannose/metabolism ; Vitelline Membrane/metabolism ; Protein Transport ; Receptors, Cytokine/metabolism
    Chemical Substances Mannose (PHA4727WTP) ; Receptors, Cytokine
    Language English
    Publishing date 2023-01-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2651702-4
    ISSN 2211-5463 ; 2211-5463
    ISSN (online) 2211-5463
    ISSN 2211-5463
    DOI 10.1002/2211-5463.13561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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