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  1. Book: MEN AND WOMEN IN MEDICAL SCHOOL

    LESERMAN, JANE

    HOW THEY CHANGE AND HOW THEY COMPARE

    1981  

    Author's details JANE LESERMAN
    Keywords PHYSICIAN-PATIENT RELATIONS ; Physicians, Women / United States ; Schools, Medical / United States ; SEX CHARACTERISTICS
    Size XVI, 239 S.
    Publisher PRAEGER
    Publishing place NEW YORK, N.Y
    Document type Book
    HBZ-ID HT002631534
    ISBN 0-03-058026-9 ; 978-0-03-058026-0
    Database Catalogue ZB MED Medicine, Health

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    1982 A 3261 order for loan Magazin

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  2. Article ; Online: Role of depression, stress, and trauma in HIV disease progression.

    Leserman, Jane

    Psychosomatic medicine

    2008  Volume 70, Issue 5, Page(s) 539–545

    Abstract: Despite advances in HIV treatment, there continues to be great variability in the progression of this disease. This paper reviews the evidence that depression, stressful life events, and trauma account for some of the variation in HIV disease course. ... ...

    Abstract Despite advances in HIV treatment, there continues to be great variability in the progression of this disease. This paper reviews the evidence that depression, stressful life events, and trauma account for some of the variation in HIV disease course. Longitudinal studies both before and after the advent of highly active antiretroviral therapies (HAART) are reviewed. To ensure a complete review, PubMed was searched for all English language articles from January 1990 to July 2007. We found substantial and consistent evidence that chronic depression, stressful events, and trauma may negatively affect HIV disease progression in terms of decreases in CD4 T lymphocytes, increases in viral load, and greater risk for clinical decline and mortality. More research is warranted to investigate biological and behavioral mediators of these psychoimmune relationships, and the types of interventions that might mitigate the negative health impact of chronic depression and trauma. Given the high rates of depression and past trauma in persons living with HIV/AIDS, it is important for healthcare providers to address these problems as part of standard HIV care.
    MeSH term(s) Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count/statistics & numerical data ; Comorbidity ; Depressive Disorder/complications ; Depressive Disorder/epidemiology ; Depressive Disorder/psychology ; Disease Progression ; HIV Infections/epidemiology ; HIV Infections/immunology ; HIV Infections/psychology ; Health Services Needs and Demand/statistics & numerical data ; Humans ; Life Change Events ; Longitudinal Studies ; Patient Care Team ; Patient Compliance/psychology ; Psychoneuroimmunology ; Risk Factors ; Stress, Psychological/complications ; Stress, Psychological/epidemiology ; Stress, Psychological/psychology ; Viral Load/statistics & numerical data
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/PSY.0b013e3181777a5f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sexual abuse history: prevalence, health effects, mediators, and psychological treatment.

    Leserman, Jane

    Psychosomatic medicine

    2005  Volume 67, Issue 6, Page(s) 906–915

    Abstract: Objective: Lifetime history of sexual abuse is estimated to range between 15% and 25% in the general female population. People who are sexually abused are at greater risk for a whole host of physical health disorders that may occur many years after the ... ...

    Abstract Objective: Lifetime history of sexual abuse is estimated to range between 15% and 25% in the general female population. People who are sexually abused are at greater risk for a whole host of physical health disorders that may occur many years after the abusive incident(s). Despite the high prevalence of this trauma and its association with poor health status, abuse history often remains hidden within the context of medical care. The aims of this review are to determine which specific health disorders have been associated with sexual abuse in both women and men, to outline the types of sexual abuse associated with the worst health outcome, to discuss some possible explanations and mediators of the abuse/health relationship, to discuss when and how to talk about abuse within a clinical setting, and to present evidence for which psychological treatments have been shown to improve the mental health of patients with past sexual abuse.
    Method: To meet these objectives, we have reviewed a wide literature on the topic of sexual abuse.
    Results: We demonstrate that abuse appears to be related to greater likelihood of headache and gastrointestinal, gynecologic, and panic-related symptoms; that the poor health effects associated with abuse are also seen in men; that abuse involving penetration and multiple incidents appears to be the most harmful, and that exposure-type therapies with and without cognitive behavioral therapy hold promise for those with abuse history.
    Conclusion: We need more research examining psychological treatments that might be efficacious in treating the physical health problems associated with sexual abuse history.
    MeSH term(s) Adult ; Child ; Child Abuse, Sexual/psychology ; Child Abuse, Sexual/statistics & numerical data ; Cognitive Therapy ; Female ; Health Status ; Humans ; Implosive Therapy ; Life Change Events ; Male ; Mental Disorders/epidemiology ; Mental Disorders/etiology ; Mental Disorders/therapy ; Morbidity ; Prevalence ; Psychotherapy ; Sex Offenses/psychology ; Sex Offenses/statistics & numerical data ; Stress Disorders, Post-Traumatic/epidemiology ; Stress Disorders, Post-Traumatic/psychology ; Stress Disorders, Post-Traumatic/therapy
    Language English
    Publishing date 2005-11
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/01.psy.0000188405.54425.20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: HIV disease progression: depression, stress, and possible mechanisms.

    Leserman, Jane

    Biological psychiatry

    2003  Volume 54, Issue 3, Page(s) 295–306

    Abstract: There is much interest in whether depression and stress may explain the wide variability in the disease course of patients infected with human immunodeficiency virus (HIV). This article summarizes the large body of evidence examining whether depression ... ...

    Abstract There is much interest in whether depression and stress may explain the wide variability in the disease course of patients infected with human immunodeficiency virus (HIV). This article summarizes the large body of evidence examining whether depression and stress may have an impact on immune- and disease-related parameters in HIV disease. Furthermore, we review what is known about the underlying biological mechanisms of HIV disease, such as alterations in glucocorticoids and catecholamines, which may help explain these psychoimmune relationships. Our review of the literature finds substantial evidence that chronic depression and stressful events may affect HIV disease progression. We know little, however, regarding the biological mechanisms that may account for these relationships. More research is warranted to investigate how depression and stress might impact HIV disease progression and what types of interventions might mitigate the negative impact of chronic depression and trauma.
    MeSH term(s) Catecholamines/metabolism ; Depression/complications ; Depression/immunology ; Depression/metabolism ; Disease Progression ; Glucocorticoids/metabolism ; HIV Infections/immunology ; HIV Infections/metabolism ; HIV Infections/psychology ; Humans ; Stress, Psychological/complications ; Stress, Psychological/immunology ; Stress, Psychological/metabolism ; Substance P/metabolism
    Chemical Substances Catecholamines ; Glucocorticoids ; Substance P (33507-63-0)
    Language English
    Publishing date 2003-06-09
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/s0006-3223(03)00323-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The effects of stressful life events, coping, and cortisol on HIV infection.

    Leserman, Jane

    CNS spectrums

    2003  Volume 8, Issue 1, Page(s) 25–30

    Abstract: What is the role of stress and coping in changes in immunologic and clinical indicators of human immunodeficiency virus disease progression? There is substantial evidence that stressful life events and passive coping strategies, such as denial, may have ... ...

    Abstract What is the role of stress and coping in changes in immunologic and clinical indicators of human immunodeficiency virus disease progression? There is substantial evidence that stressful life events and passive coping strategies, such as denial, may have a detrimental effect on HIV disease progression. Given the harmful effects of stress and passive coping, the author reviews the limited research testing the efficacy of interventions, such as cognitive-behavioral therapies for HIV-infected persons. Finally, in trying to understand psychoimmune relationships in HIV, the evidence is examined for the mediating and direct effects of cortisol, a hormone associated with stress, on HIV disease progression. Delineating the role of psychosocial factors and cortisol on HIV disease progression may aid in the development of new interventions for this devastating disease.
    MeSH term(s) Adaptation, Psychological/physiology ; Arousal/physiology ; Cognitive Behavioral Therapy ; Disease Progression ; HIV Infections/immunology ; HIV Infections/psychology ; Humans ; Hydrocortisone/blood ; Life Change Events ; Psychoneuroimmunology
    Chemical Substances Hydrocortisone (WI4X0X7BPJ)
    Language English
    Publishing date 2003-01-22
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/s1092852900023439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 340: Show issues

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  6. Article: Psychiatric comorbidity in women with chronic pelvic pain.

    Meltzer-Brody, Samantha / Leserman, Jane

    CNS spectrums

    2011  Volume 16, Issue 2, Page(s) 29–35

    Abstract: Chronic pain syndromes are often treatment refractory and pose an enormous burden of suffering for the individual. Chronic pelvic pain (CPP) is generally defined as noncyclic pain of at least 6 months duration and severe enough to require medical care or ...

    Abstract Chronic pain syndromes are often treatment refractory and pose an enormous burden of suffering for the individual. Chronic pelvic pain (CPP) is generally defined as noncyclic pain of at least 6 months duration and severe enough to require medical care or cause disability. CPP has been estimated to have a prevalence of 15% among women of reproductive age. Women are at increased risk for both major depression and chronic pain syndromes such as CPP, and are more likely to report antecedent stressful events, have higher rates of physical and sexual abuse, and subsequently develop posttraumatic stress disorder. High rates of sexual and physical abuse and other trauma have been shown among women with CPP, including symptoms of dyspareunia (pain during intercourse), dysmenorrhea (pain during menstruation), and vulvar pain. A detailed and comprehensive evaluation of the patient with CPP should include a thorough gynecologic exam and a full mental health assessment. Treatment of CPP must include an integrated approach targeted at both the psychiatric comorbidity and pain symptoms. A multidisciplinary treatment team offers the best chance for success with CPP, and it is critical to suggest psychiatric treatment (psychopharmacology and/or psychotherapy) in addition to traditional medical and surgical approaches.
    MeSH term(s) Comorbidity ; Depressive Disorder, Major ; Female ; Humans ; Life Change Events ; Pelvic Pain ; Stress Disorders, Post-Traumatic/psychology
    Language English
    Publishing date 2011-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008418-3
    ISSN 2165-6509 ; 1092-8529
    ISSN (online) 2165-6509
    ISSN 1092-8529
    DOI 10.1017/S1092852912000156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Active ghrelin and the postpartum.

    Baker, Jessica H / Pedersen, Cort / Leserman, Jane / Brownley, Kimberly A

    Archives of women's mental health

    2016  Volume 19, Issue 3, Page(s) 515–520

    Abstract: Postpartum depression (PPD) occurs in 10-15 % of women. The appetite hormone ghrelin, which fluctuates during pregnancy, is associated with depression in nonpregnant samples. Here, we examine the association between PPD and active ghrelin from pregnancy ... ...

    Abstract Postpartum depression (PPD) occurs in 10-15 % of women. The appetite hormone ghrelin, which fluctuates during pregnancy, is associated with depression in nonpregnant samples. Here, we examine the association between PPD and active ghrelin from pregnancy to postpartum. We additionally examine whether ghrelin changes from pregnancy to postpartum and differs between breastfeeding and non-breastfeeding women. Sixty women who participated in a survey examining PPD and had information in regard to ghrelin concentrations were included in the study. The Edinburgh Postnatal Depression Scale was used to assess symptoms of PPD. Raw ghrelin levels and ghrelin levels adjusted for creatinine were included as outcomes. Women screening positive for PPD at 12 weeks postpartum had higher pregnancy ghrelin concentrations. Ghrelin concentrations significantly decreased from pregnancy to 6 weeks postpartum and this change differed based on pregnancy depression status. Finally, ghrelin levels were lower in women who breastfed compared with women who were bottle-feeding. No significant findings remained once ghrelin levels were adjusted for creatinine. Although results do not suggest an association between PPD and ghrelin after adjusting for creatinine, future research should continue to explore this possibility extending further across the postpartum period with larger sample sizes.
    Language English
    Publishing date 2016-06
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 1480651-4
    ISSN 1435-1102 ; 1434-1816
    ISSN (online) 1435-1102
    ISSN 1434-1816
    DOI 10.1007/s00737-015-0578-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The influence of early life sexual abuse on oxytocin concentrations and premenstrual symptomatology in women with a menstrually related mood disorder.

    Crowley, Shannon K / Pedersen, Cort A / Leserman, Jane / Girdler, Susan S

    Biological psychology

    2015  Volume 109, Page(s) 1–9

    Abstract: Oxytocin (OT), associated with affiliation and social bonding, social salience, and stress/pain regulation, may play a role in the pathophysiology of stress-related disorders, including menstrually-related mood disorders (MRMD's). Adverse impacts of ... ...

    Abstract Oxytocin (OT), associated with affiliation and social bonding, social salience, and stress/pain regulation, may play a role in the pathophysiology of stress-related disorders, including menstrually-related mood disorders (MRMD's). Adverse impacts of early life sexual abuse (ESA) on adult attachment, affective regulation, and pain sensitivity suggest ESA-related OT dysregulation in MRMD pathophysiology. We investigated the influence of ESA on plasma OT, and the relationship of OT to the clinical phenomenology of MRMD's. Compared to MRMD women without ESA (n=40), those with ESA (n=20) displayed significantly greater OT [5.39pg/mL (SD, 2.4) vs. 4.36pg/mL (SD, 1.1); t (58)=-2.26, p=0.03]. In women with ESA, OT was significantly, inversely correlated with premenstrual psychological and somatic symptoms (r's=-0.45 to -0.64, p's<0.05). The relationship between OT and premenstrual symptomatology was uniformly low and non-significant in women without ESA. In women with ESA, OT may positively modulate MRMD symptomatology.
    MeSH term(s) Adult ; Child ; Child Abuse, Sexual/psychology ; Female ; Humans ; Mood Disorders/blood ; Oxytocin/blood ; Premenstrual Syndrome/blood ; Prospective Studies
    Chemical Substances Oxytocin (50-56-6)
    Language English
    Publishing date 2015-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 185105-6
    ISSN 1873-6246 ; 0301-0511
    ISSN (online) 1873-6246
    ISSN 0301-0511
    DOI 10.1016/j.biopsycho.2015.04.003
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  9. Article ; Online: A road well traveled (although not yet a super highway).

    Leserman, Jane / Temoshok, Lydia R

    Psychosomatic medicine

    2008  Volume 70, Issue 5, Page(s) 521–522

    MeSH term(s) Acquired Immunodeficiency Syndrome/psychology ; Depression/complications ; Depression/therapy ; HIV Infections/psychology ; Humans ; Patient Care Team ; Prognosis ; Stress, Psychological/complications ; Stress, Psychological/therapy ; Survivors/psychology
    Language English
    Publishing date 2008-06
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/PSY.0b013e31817b8ef9
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  10. Article ; Online: Hypothalamic-pituitary-thyroid axis function in women with a menstrually related mood disorder: association with histories of sexual abuse.

    Bunevicius, Adomas / Leserman, Jane / Girdler, Susan S

    Psychosomatic medicine

    2012  Volume 74, Issue 8, Page(s) 810–816

    Abstract: Introduction: We previously reported a unique hypothalamic-pituitary-thyroid (HPT) axis profile in women with a menstrually related mood disorder (MRMD) who also had a history of sexual abuse (SA). In the present study, we sought to extend that work by ... ...

    Abstract Introduction: We previously reported a unique hypothalamic-pituitary-thyroid (HPT) axis profile in women with a menstrually related mood disorder (MRMD) who also had a history of sexual abuse (SA). In the present study, we sought to extend that work by examining the association of an SA history with HPT-axis disturbance in both women with MRMD and women without MRMD.
    Methods: Fifty-seven women met the prospective criteria for MRMD (23 with an SA history), and 52 women were non-MRMD (18 with an SA history). Thyroid-stimulating hormone, thyroxin (T4; total and free), and triiodothyronine (T3; total and free) were evaluated in serum, together with thyroid hormone ratios reflecting T4 to T3 conversion.
    Results: Women with MRMD, compared with women without MRMD, had elevated T3/T4 ratios (p values ≤ .01; reflecting increased conversion of T4 to T3) and lower free and total T4 concentrations (p values = .01). Higher T3/T4 ratios and lower T4 concentrations predicted more severe premenstrual symptoms in all women. An SA history, irrespective of MRMD status, was associated with elevated thyroid-stimulating hormone concentrations (p = .03). However, in women with MRMD, an SA history was associated with elevated T3 concentrations (p = .049), whereas in women without MRMD, an SA history was associated with decreased T3 concentrations (p = .02).
    Conclusions: An MRMD and an SA history are associated with independent and interactive effects on the HPT axis. The evidence that an MRMD moderates the influence of SA on T3 concentrations contributes to a growing body of work suggesting that an SA history may identify a distinct subgroup of women with MRMD.
    MeSH term(s) Adult ; Case-Control Studies ; Female ; Humans ; Hypothalamic Diseases/psychology ; Hypothalamo-Hypophyseal System/physiopathology ; Menstruation Disturbances/physiopathology ; Menstruation Disturbances/psychology ; Mood Disorders/physiopathology ; Mood Disorders/psychology ; Pituitary Diseases/psychology ; Sex Offenses/psychology ; Stress Disorders, Post-Traumatic/physiopathology ; Stress Disorders, Post-Traumatic/psychology ; Thyroid Diseases/psychology ; Thyroid Gland/physiopathology ; Thyroid Hormones/blood ; Thyrotropin/blood ; Thyroxine-Binding Globulin/analysis
    Chemical Substances Thyroid Hormones ; Thyroxine-Binding Globulin ; Thyrotropin (9002-71-5)
    Language English
    Publishing date 2012-09-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3469-1
    ISSN 1534-7796 ; 0033-3174
    ISSN (online) 1534-7796
    ISSN 0033-3174
    DOI 10.1097/PSY.0b013e31826c3397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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