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Article ; Online: Psychological Symptoms in Young Adult Migraineurs

Turgay Akalin / Aysin Sinal

Mediterranean Journal of Social Sciences, Vol 11, Iss

2020 Volume 1

Abstract: ... Correlation Analysis, found no association between age and psychological symptoms. There’s a significant relationship ... between psychological symptoms with somatisation (besides paranoid) (p<.05). There’s a significant ... relationship between depression and other psychological symptoms (p<.05). There’s a significant relationship ...

Abstract	We aimed to reveal psychological symptoms of young university students (18-25 y/o) with no secondary disease with complaints of migraine headaches. We compared the psychological symptoms with a young control group that did not present headaches and other studies examining migraines in different age groups to determine any similarities. The study consisted of 75 migraine cases; 13 with aura and 62 without aura) and 42 non-headache control subjects. The International Classification of Headache Disorders 3 (ICHD-3) with criteria questions and the Psychological Symptom Research Scale were applied to all participants and SPSS Statistics Program evaluated the data. Findings: 1) In the test of Descriptive Statistics for the Sample of Students, average values of both sexes were taken and found the average values of the migraine groups were higher than control group. 2) The Anova Test found differences in the diagnostic group besides depression (Somatisation p<., others p<.01) with no significant difference in depression (p=0.315). 3)The Pearson Correlation Analysis, found no association between age and psychological symptoms. There’s a significant relationship between psychological symptoms with somatisation (besides paranoid) (p<.05). There’s a significant relationship between depression and other psychological symptoms (p<.05). There’s a significant relationship between anxiety, obsession, interpersonal relationships, psychoticism, paranoia, anger, phobia, additional scale and other psychological symptoms (p<.01). Result: The study demonstrated psychological symptoms in young migraineurs. The average psychological symptoms of both migraine groups were higher than the control group, this showed psychological symptom similarities between young migraineurs and migraine patients of different age groups.
Keywords	Social Sciences ; H
Subject code	150
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	richtmann publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hepatocyte expressed chemerin-156 does not protect from experimental non-alcoholic steatohepatitis.

Pohl, Rebekka / Eichelberger, Laura / Feder, Susanne / Haberl, Elisabeth M / Rein-Fischboeck, Lisa / McMullen, Nichole / Sinal, Christopher J / Bruckmann, Astrid / Weiss, Thomas S / Beck, Michael / Höring, Marcus / Krautbauer, Sabrina / Liebisch, Gerhard / Wiest, Reiner / Wanninger, Josef / Buechler, Christa

Molecular and cellular biochemistry

2022 Volume 477, Issue 8, Page(s) 2059–2071

Abstract: ... hepatocytes and hepatic stellate cells within 24 h of incubation. Phosphorylation of p38 kinase was ...

Abstract	Non-alcoholic steatohepatitis (NASH) is a rapidly growing liver disease. The chemoattractant chemerin is abundant in hepatocytes, and hepatocyte expressed prochemerin protected from NASH. Prochemerin is inactive and different active isoforms have been described. Here, the effect of hepatocyte expressed muChem-156, a highly active murine chemerin isoform, was studied in the methionine-choline deficient dietary model of NASH. Mice overexpressing muChem-156 had higher hepatic chemerin protein. Serum chemerin levels and the capability of serum to activate the chemerin receptors was unchanged showing that the liver did not release active chemerin. Notably, activation of the chemerin receptors by hepatic vein blood did not increase in parallel to total chemerin protein in patients with liver cirrhosis. In experimental NASH, muChem-156 had no effect on liver lipids. Accordingly, overexpression of active chemerin in hepatocytes or treatment of hepatocytes with recombinant chemerin did not affect cellular triglyceride and cholesterol levels. Importantly, overexpression of muChem-156 in the murine liver did not change the hepatic expression of inflammatory and profibrotic genes. The downstream targets of chemerin such as p38 kinase were neither activated in the liver of muChem-156 producing mice nor in HepG2, Huh7 and Hepa1-6 cells overexpressing this isoform. Recombinant chemerin had no effect on global gene expression of primary human hepatocytes and hepatic stellate cells within 24 h of incubation. Phosphorylation of p38 kinase was, however, increased upon short-time incubation of HepG2 cells with chemerin. These findings show that muChem-156 overexpression in hepatocytes does not protect from liver steatosis and inflammation.
MeSH term(s)	Animals ; Chemokines ; Disease Models, Animal ; Hepatic Stellate Cells/metabolism ; Hepatocytes/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/genetics ; Intercellular Signaling Peptides and Proteins/metabolism ; Liver/metabolism ; Mice ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Protein Isoforms/metabolism
Chemical Substances	Chemokines ; Intercellular Signaling Peptides and Proteins ; Protein Isoforms ; RARRES2 protein, human ; chemerin protein, mouse
Language	English
Publishing date	2022-04-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	184833-1
ISSN	1573-4919 ; 0300-8177
ISSN (online)	1573-4919
ISSN	0300-8177
DOI	10.1007/s11010-022-04430-3
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Zs.A 892: Show issues

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Article: Sexual abuse of children and adolescents.

Sinal, S H

Southern medical journal

1994 Volume 87, Issue 12, Page(s) 1242–1258

Abstract: Increasingly, clinicians are being asked to help determine whether a child or adolescent has been a victim of sexual abuse. Since the late 1970s numerous articles about sexual abuse have appeared in the literature. This review article will acquaint the ... ...

Abstract	Increasingly, clinicians are being asked to help determine whether a child or adolescent has been a victim of sexual abuse. Since the late 1970s numerous articles about sexual abuse have appeared in the literature. This review article will acquaint the clinician with the definition and incidence of sexual abuse and the characteristics of the abused and the abuser. Practical guidelines are included for interviewing the victim, performing the physical examination, appropriate laboratory testing, treatment, reporting to appropriate authorities, and court testimony.
MeSH term(s)	Adolescent ; Child ; Child Abuse, Sexual/diagnosis ; Child Abuse, Sexual/psychology ; Child Abuse, Sexual/statistics & numerical data ; Child Behavior ; Child, Preschool ; Expert Testimony ; Female ; Forensic Medicine ; Humans ; Incidence ; Male ; Medical History Taking ; Physical Examination ; Poverty ; Prevalence ; Sexually Transmitted Diseases/etiology
Language	English
Publishing date	1994-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
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Article: Evidence for non-genomic transmission of ecological information via maternal behavior in female rats.

McLeod, J / Sinal, C J / Perrot-Sinal, T S

Genes, brain, and behavior

2007 Volume 6, Issue 1, Page(s) 19–29

Abstract: ... for 1 h on the day of parturition. Predator-exposed F0 dams displayed significantly more ...

Abstract	Maternal behavior is flexible and programs offspring development. Using a novel manipulation, we demonstrate that rat maternal behavior is sensitive to ecologically relevant stimuli. Long-Evans hooded rat dams (F0) and pups were exposed to a predator condition (cat odor) or a control condition (no odor) for 1 h on the day of parturition. Predator-exposed F0 dams displayed significantly more maternal behavior (licking/grooming, arched-back nursing) relative to control-exposed dams across five subsequent observation days. Female offspring (F1) were raised to adulthood, bred and maternal behavior was observed. F1 dams reared by a predator-exposed F0 dam displayed significantly higher maternal behavior relative to F1 dams reared by a control-exposed F0 dam across 5 days of observation. Increased levels of maternal behavior in predator-reared (PR) F1 dams were evident even in F1 females that had been cross-fostered (CF) from a control-exposed F0 dam, suggesting a non-genomic transmission of increased levels of maternal behavior. Lactating PR F1 dams had significantly elevated estrogen receptor alpha and beta mRNA in the medial preoptic area relative to control-reared (CR) F1 dams. Furthermore, among CR F1 dams, there was no significant difference between those dams that had been CF from predator-exposed F0 dams and those that had been sham CF. These results support the hypothesis that flexible rat maternal behavior can shape offspring development according to current environmental conditions. The results also suggest that estrogen signaling may be part of an epigenetic mechanism by which changes in maternal behavior are passed from F0 to F1 dams.
MeSH term(s)	Animals ; Avoidance Learning/physiology ; Behavior, Animal/physiology ; Environment ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Female ; Lactation/metabolism ; Lactation/psychology ; Maternal Behavior/physiology ; Maternal Behavior/psychology ; Rats ; Rats, Long-Evans ; Smell/physiology ; Stress, Psychological/metabolism ; Stress, Psychological/psychology
Chemical Substances	Estrogen Receptor alpha ; Estrogen Receptor beta
Language	English
Publishing date	2007-02
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2075819-4
ISSN	1601-183X ; 1601-1848
ISSN (online)	1601-183X
ISSN	1601-1848
DOI	10.1111/j.1601-183X.2006.00214.x
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Zs.A 5642: Show issues

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Article ; Online: The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension.

Watts, Stephanie W / Darios, Emma S / Mullick, Adam E / Garver, Hannah / Saunders, Thomas L / Hughes, Elizabeth D / Filipiak, Wanda E / Zeidler, Michael G / McMullen, Nichole / Sinal, Christopher J / Kumar, Ramya K / Ferland, David J / Fink, Gregory D

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2018 , Page(s) fj201800479

Abstract: ... to a hypertensive challenge.-Watts, S. W., Darios, E. S., Mullick, A. E., Garver, H., Saunders, T. L., Hughes, E. D ... Filipiak, W. E., Zeidler, M. G., McMullen, N., Sinal, C. J., Kumar, R. K., Ferland, D. J., Fink, G. D ...

Abstract	Measures of the adipokine chemerin are elevated in multiple cardiovascular diseases, including hypertension, but little mechanistic work has been done to implicate chemerin as being causative in such diseases. The chemerin knockout (KO) rat was created to test the hypothesis that removal of chemerin would reduce pressure in the normal and hypertensive state. Western analyses confirmed loss of chemerin in the plasma and tissues of the KO vs. wild-type (WT) rats. Chemerin concentration in plasma and tissues was lower in WT females than in WT males, as determined by Western analysis. Conscious male and female KO rats had modest differences in baseline measures vs. the WT that included systolic, diastolic, mean arterial and pulse pressures, and heart rate, all measured telemetrically. The mineralocorticoid deoxycorticosterone acetate (DOCA) and salt water, combined with uninephrectomy as a hypertensive stimulus, elevated mean and systolic blood pressures of the male KO higher than the male WT. By contrast, all pressures in the female KO were lower than their WT throughout DOCA-salt treatment. These results revealed an unexpected sex difference in chemerin expression and the ability of chemerin to modify blood pressure in response to a hypertensive challenge.-Watts, S. W., Darios, E. S., Mullick, A. E., Garver, H., Saunders, T. L., Hughes, E. D., Filipiak, W. E., Zeidler, M. G., McMullen, N., Sinal, C. J., Kumar, R. K., Ferland, D. J., Fink, G. D. The chemerin knockout rat reveals chemerin dependence in female, but not male, experimental hypertension.
Language	English
Publishing date	2018-06-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.201800479
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Physical abuse of children: a review for orthopedic surgeons.

Sinal, S H / Stewart, C D

Journal of the Southern Orthopaedic Association

1998 Volume 7, Issue 4, Page(s) 264–276

Abstract: Statistics show that more than half the victims of child abuse have fractures. The orthopedic surgeon will often be the first person to identify a potentially abused child. In a series at Brenner Children's Hospital, 17% of abused children had a fracture ...

Abstract	Statistics show that more than half the victims of child abuse have fractures. The orthopedic surgeon will often be the first person to identify a potentially abused child. In a series at Brenner Children's Hospital, 17% of abused children had a fracture as the initial manifestation of child abuse. For protection of the child, it is essential that the orthopedic surgeon recognize the signs of child abuse and make a referral to the appropriate child protection agency. In this review article, we discuss recognition of common types of child abuse and outline appropriate management of child abuse cases.
MeSH term(s)	Burns/etiology ; Child Abuse/diagnosis ; Contusions/etiology ; Fractures, Bone/etiology ; Humans ; Infant ; Infant, Newborn ; Male ; Physical Examination ; Risk Factors
Language	English
Publishing date	1998
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1383174-4
ISSN	2158-3811 ; 1059-1052
ISSN (online)	2158-3811
ISSN	1059-1052
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Article: Outcomes and survival following heart retransplantation for cardiac allograft failure: a systematic review and meta-analysis.

Rizvi, Syed-Saif Abbas / Luc, Jessica G Y / Choi, Jae Hwan / Phan, Kevin / Moncho Escrivà, Ester / Patel, Sinal / Massey, H Todd / Tchantchaleishvili, Vakhtang

Annals of cardiothoracic surgery

2018 Volume 7, Issue 1, Page(s) 12–18

Abstract: Background: Long-term efficacy of heart retransplantation (RTx) for end-stage cardiac allograft failure remains unclear given the limited worldwide experience and is an important question to elucidate given the shortage of donor organs. The aim of this ... ...

Abstract	Background: Long-term efficacy of heart retransplantation (RTx) for end-stage cardiac allograft failure remains unclear given the limited worldwide experience and is an important question to elucidate given the shortage of donor organs. The aim of this systematic review was to examine the outcomes of RTx in patients with cardiac allograft failure. Methods: Electronic search was performed to identify all studies in the English literature assessing RTx for cardiac allograft failure. All identified articles were systematically assessed for inclusion and exclusion criteria. Results: Eleven studies were included for analysis, with a total of 7,791 patients. A total of 7,446 patients underwent primary heart transplantation (HTx) whereas 345 patients underwent RTx with average time from primary HTx to RTx interval of 5.03 years (95% CI: 3.13-6.94 years). There were 35.2% of patients received RTx within 30 days of primary transplant. Early mortality was significantly higher among RTx patients (RTx 28.2% Conclusions: Patients who underwent heart RTx had a significant lower survival when compared to those who only underwent primary HTx. There were no significant differences in post-transplantation freedom from rejection. Careful patient selection and perioperative care can make heart RTx a viable option for selected recipients.
Language	English
Publishing date	2018-02-15
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2713627-9
ISSN	2304-1021 ; 2225-319X
ISSN (online)	2304-1021
ISSN	2225-319X
DOI	10.21037/acs.2018.01.09
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Article ; Online: Repair of ischemic ventricular septal defect with and without coronary artery bypass grafting.

Horan, Dylan P / O'Malley, Thomas J / Weber, Matthew P / Maynes, Elizabeth J / Choi, Jae Hwan / Patel, Sinal / Challapalli, Jothika / Luc, Jessica G Y / Entwistle, John W / Todd Massey, H / Morris, Rohinton J / Tchantchaleishvili, Vakhtang

Journal of cardiac surgery

2020 Volume 35, Issue 5, Page(s) 1062–1071

Abstract: Background and aim of the study: Ventricular septal defect (VSD) following myocardial infarction (MI) is a relatively infrequent complication with high mortality. We sought to investigate the effect of concomitant coronary artery bypass graft (CABG) on ... ...

Abstract	Background and aim of the study: Ventricular septal defect (VSD) following myocardial infarction (MI) is a relatively infrequent complication with high mortality. We sought to investigate the effect of concomitant coronary artery bypass graft (CABG) on outcomes following post-MI VSD repair. Methods: Electronic search was performed to identify all relevant studies published from 2000 to 2018. Sixty-seven studies were selected for the analysis comprising 2174 patients with post-MI VSD. Demographic information, perioperative variables, and outcomes including survival data were extracted and pooled for systematic review and meta-analysis. Results: Single-vessel disease was most common (47%, 95% confidence interval [CI], 42-52), left anterior descending coronary artery was the most commonly involved vessel (55%, 95% CI, 46-63), and anterior wall was the most commonly affected territory (57%, 95% CI, 51-63). Concomitant CABG was performed in 52% (95% CI, 46-57) of patients. Of these, infarcted territory was re-vascularized in 54% (95% CI, 23-82). A residual/recurrent shunt was present in 29% (95% CI, 24-34) of patients. Of these, surgical repair was performed in 35% (95% CI, 28-41) and transcatheter repair in 11% (95% CI, 6-21). Thirty-day mortality was 30% (95% CI, 26-35) in patients who had preoperative coronary angiogram, and 58% (95% CI, 43-71) in those who did not (P < .01). No significant survival difference observed between those who had concomitant CABG vs those without CABG. Conclusions: Concomitant CABG did not have a significant effect on survival following VSD repair. Revascularization should be weighed against the risks associated with prolonged cardiopulmonary bypass.
MeSH term(s)	Cardiac Catheterization/methods ; Cardiac Surgical Procedures/methods ; Cardiopulmonary Bypass/adverse effects ; Coronary Artery Bypass ; Female ; Heart Septal Defects, Ventricular/etiology ; Heart Septal Defects, Ventricular/mortality ; Heart Septal Defects, Ventricular/surgery ; Humans ; Male ; Myocardial Infarction/complications ; Survival Rate ; Treatment Outcome
Language	English
Publishing date	2020-04-01
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.14515
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Article ; Online: Outcomes of percutaneous temporary biventricular mechanical support: a systematic review.

Weber, Matthew P / O'Malley, Thomas J / Choi, Jae H / Maynes, Elizabeth J / Prochno, Kyle W / Austin, Melissa A / Wood, Chelsey T / Patel, Sinal / Morris, Rohinton J / Massey, H Todd / Tchantchaleishvili, Vakhtang

Heart failure reviews

2020 Volume 27, Issue 3, Page(s) 879–890

Abstract: Percutaneous biventricular assist devices (BiVAD) are a recently developed treatment option for severe cardiogenic shock. This systematic review sought to identify indications and outcomes of patients placed on percutaneous BiVAD support. An electronic ... ...

Abstract	Percutaneous biventricular assist devices (BiVAD) are a recently developed treatment option for severe cardiogenic shock. This systematic review sought to identify indications and outcomes of patients placed on percutaneous BiVAD support. An electronic search was performed to identify all appropriate studies utilizing a percutaneous BiVAD configuration. Fifteen studies comprising of 20 patients were identified. Individual patient survival and outcomes data were combined for statistical analysis. All 20 patients were supported with a microaxial LVAD, 12/20 (60%) of those patients were supported with a microaxial (RMA) right ventricular assist device (RVAD), and the remaining 8/20 (40%) patients were supported with a centrifugal extracorporeal RVAD (RCF). All patients presented with cardiogenic shock, and of these, 12/20 (60%) presented with a non-ischemic etiology vs 8/20 (40%) with ischemic disease. For the RMA group, RVAD support was significantly longer [RMA 5 (IQR 4-7) days vs RCF 1 (IQR 1-2) days, p = 0.03]. Intravascular hemolysis post-BiVAD occurred in three patients (27.3%) [RMA 3 (33.3%) vs RCF 0 (0%), p = 0.94]. Five patients received a durable left ventricular assist device, one patient received a total artificial heart, and one patient underwent a heart transplantation. Estimated 30-day mortality was 15.0%, and 78.6% were discharged alive. Both strategies for percutaneous BiVAD support appear to be viable options for severe cardiogenic shock.
MeSH term(s)	Heart Failure/surgery ; Heart-Assist Devices/adverse effects ; Humans ; Retrospective Studies ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Treatment Outcome
Language	English
Publishing date	2020-06-20
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	1336499-6
ISSN	1573-7322 ; 1382-4147
ISSN (online)	1573-7322
ISSN	1382-4147
DOI	10.1007/s10741-020-09971-7
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Zs.A 5212: Show issues

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Article ; Online: Characteristics and outcomes of gastrointestinal bleeding in patients with continuous-flow left ventricular assist devices: A systematic review.

Carlson, Laura A / Maynes, Elizabeth J / Choi, Jae Hwan / Hallett, Andrew M / Horan, Dylan P / Weber, Matthew P / Deb, Avijit K / Patel, Sinal / Samuels, Louis E / Morris, Rohinton J / Entwistle, John W / Todd Massey, H / Tchantchaleishvili, Vakhtang

Artificial organs

2020 Volume 44, Issue 11, Page(s) 1150–1161

Abstract: Gastrointestinal bleeding (GIB) is a common adverse event after continuous-flow left ventricular assist device (CF-LVAD) implantation. We sought to evaluate patterns of GIB development and related outcomes in CF-LVAD recipients. An electronic search was ... ...

Abstract	Gastrointestinal bleeding (GIB) is a common adverse event after continuous-flow left ventricular assist device (CF-LVAD) implantation. We sought to evaluate patterns of GIB development and related outcomes in CF-LVAD recipients. An electronic search was performed to identify all articles related to GIB in the setting of CF-LVAD implantation. A total of 34 studies involving 1087 patients were pooled for analysis. Mean patient age was 60 years (95% CI 57-64) and 24% (95% CI 21-28%) were female. The mean time from CF-LVAD implantation to the first GIB was 54 days (95% CI 24-84) with 40% (95% CI 34-45%) of patients having multiple episodes of GIB. Anemia was present in 75% (95% CI 41-93%) and the most common etiology of bleeding was arteriovenous malformations (36% [95% CI 24-50%]). The mean duration of follow-up was 14.6 months (95% CI 6.9-22.3) during which the all-cause mortality rate was 21% (95% CI 12-36%) and the mortality rate from GIB was 4% (95% CI 2-9%). Thromboembolic events occurred in 32% (95% CI 22-44%) of patients with an ischemic stroke rate of 16% (95% CI 3-51%) and a pump thrombosis rate of 8% (95%CI 3-22%). Heart transplantation was performed in 31% (95% CI 18-47%) of patients, after which 0% (95% CI 0-10%) experienced recurrent GIB. GIB is a major source of morbidity among CF-LVAD recipients. While death due to GIB is rare, cessation of anticoagulation during treatment increases the risk of subsequent thrombotic events. Heart transplant in these patients appears to reliably resolve the risk of future GIB.
MeSH term(s)	Gastrointestinal Hemorrhage/etiology ; Heart-Assist Devices/adverse effects ; Humans ; Intensive Care Units ; Length of Stay ; Survival Analysis
Language	English
Publishing date	2020-08-26
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.13725
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